Papantonis, Argyris

[["dc.bibliographiccitation.firstpage","5351"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Meier-Soelch, Johanna"],["dc.contributor.author","Mayr-Buro, Christin"],["dc.contributor.author","Juli, Jana"],["dc.contributor.author","Leib, Lisa"],["dc.contributor.author","Linne, Uwe"],["dc.contributor.author","Dreute, Jan"],["dc.contributor.author","Papantonis, Argyris"],["dc.contributor.author","Schmitz, M. Lienhard"],["dc.contributor.author","Kracht, Michael"],["dc.contributor.editor","Kolettas, Evangelos"],["dc.contributor.editor","Marcu, Kenneth B."],["dc.contributor.editor","Schmid, Johannes A."],["dc.date.accessioned","2021-12-01T09:22:47Z"],["dc.date.available","2021-12-01T09:22:47Z"],["dc.date.issued","2021"],["dc.description.abstract","The NF-κB signaling system plays an important regulatory role in the control of many biological processes. The activities of NF-κB signaling networks and the expression of their target genes are frequently elevated in pathophysiological situations including inflammation, infection, and cancer. In these conditions, the outcome of NF-κB activity can vary according to (i) differential activation states, (ii) the pattern of genomic recruitment of the NF-κB subunits, and (iii) cellular heterogeneity. Additionally, the cytosolic NF-κB activation steps leading to the liberation of DNA-binding dimers need to be distinguished from the less understood nuclear pathways that are ultimately responsible for NF-κB target gene specificity. This raises the need to more precisely determine the NF-κB activation status not only for the purpose of basic research, but also in (future) clinical applications. Here we review a compendium of different methods that have been developed to assess the NF-κB activation status in vitro and in vivo. We also discuss recent advances that allow the assessment of several NF-κB features simultaneously at the single cell level."],["dc.description.abstract","The NF-κB signaling system plays an important regulatory role in the control of many biological processes. The activities of NF-κB signaling networks and the expression of their target genes are frequently elevated in pathophysiological situations including inflammation, infection, and cancer. In these conditions, the outcome of NF-κB activity can vary according to (i) differential activation states, (ii) the pattern of genomic recruitment of the NF-κB subunits, and (iii) cellular heterogeneity. Additionally, the cytosolic NF-κB activation steps leading to the liberation of DNA-binding dimers need to be distinguished from the less understood nuclear pathways that are ultimately responsible for NF-κB target gene specificity. This raises the need to more precisely determine the NF-κB activation status not only for the purpose of basic research, but also in (future) clinical applications. Here we review a compendium of different methods that have been developed to assess the NF-κB activation status in vitro and in vivo. We also discuss recent advances that allow the assessment of several NF-κB features simultaneously at the single cell level."],["dc.identifier.doi","10.3390/cancers13215351"],["dc.identifier.pii","cancers13215351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94482"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.publisher","MDPI"],["dc.relation.eissn","2072-6694"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Monitoring the Levels of Cellular NF-κB Activation States"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]