Larionov, Oleg V.

[["dc.bibliographiccitation.firstpage","6363"],["dc.bibliographiccitation.issue","31"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","6374"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","Lygin, Alexander V."],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Graef, Tine"],["dc.contributor.author","Es-Sayed, Mazen"],["dc.date.accessioned","2018-11-07T09:15:11Z"],["dc.date.available","2018-11-07T09:15:11Z"],["dc.date.issued","2012"],["dc.description.abstract","Successful biochemical studies of the natural products belactosin A and C and their acylated congeners have shown a beta-lactonecarboxamide moiety to be a possible core structure of powerful proteasome inhibitors. As a part of further investigations, variously decorated simplified beta-lactonecarboxamides have been synthesized in order to understand structure-biological activity relations in detail, to find ways of improving their biological activity and stability and to reduce the complexity of their preparation. Biological tests showed that the best compounds possess a high potential against phytopathogenic fungi in the greenhouse."],["dc.identifier.doi","10.1039/c2ob25586c"],["dc.identifier.isi","000306480100015"],["dc.identifier.pmid","22735304"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27613"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Synthesis and biological activity of simplified belactosin C analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7791"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","7798"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","Ludwig, Antje"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Lygin, Alexander V."],["dc.contributor.author","Groll, Michael"],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T09:01:51Z"],["dc.date.available","2018-11-07T09:01:51Z"],["dc.date.issued","2011"],["dc.description.abstract","Successful biochemical studies of the natural products belactosin A and C as well as their more stable acylated derivatives have proved them to be powerful proteasome inhibitors and thereby potential candidates as pharmacologically relevant active compounds. In order to understand their structure-biological activity relations in detail and to findways of improving their biological activity, four new modified belactosin congeners have been synthesized and tested. One of them (compound 6) turned out to be a more potent inhibitor against HeLa cells than the known proteasome inhibitor MG132."],["dc.description.sponsorship","Degussa Foundation (Evonik Industries AG)"],["dc.identifier.doi","10.1039/c1ob05661a"],["dc.identifier.isi","000296203700029"],["dc.identifier.pmid","21946808"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10465"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24529"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Synthesis and biological activity of optimized belactosin C congeners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]