Hosang, Leon

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Berghoff, Stefan A."],["dc.contributor.author","Spieth, Lena"],["dc.contributor.author","Sun, Ting"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Schlaphoff, Lennart"],["dc.contributor.author","Depp, Constanze"],["dc.contributor.author","Düking, Tim"],["dc.contributor.author","Winchenbach, Jan"],["dc.contributor.author","Neuber, Jonathan"],["dc.contributor.author","Ewers, David"],["dc.contributor.author","Scholz, Patricia"],["dc.contributor.author","van der Meer, Franziska"],["dc.contributor.author","Cantuti-Castelvetri, Ludovico"],["dc.contributor.author","Sasmita, Andrew O."],["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Sankowski, Roman"],["dc.contributor.author","Prinz, Marco"],["dc.contributor.author","Huitinga, Inge"],["dc.contributor.author","Sereda, Michael W."],["dc.contributor.author","Odoardi, Francesca"],["dc.contributor.author","Ischebeck, Till"],["dc.contributor.author","Simons, Mikael"],["dc.contributor.author","Stadelmann-Nessler, Christine"],["dc.contributor.author","Edgar, Julia M."],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Saher, Gesine"],["dc.date.accessioned","2021-04-14T08:27:05Z"],["dc.date.available","2021-04-14T08:27:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41593-020-00757-6"],["dc.identifier.pmid","33349711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82162"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/11"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | A04: The role of the meninges in the resolution of acute autoimmune CNS lesions"],["dc.relation.eissn","1546-1726"],["dc.relation.issn","1097-6256"],["dc.relation.workinggroup","RG Cantuti"],["dc.relation.workinggroup","RG Nave (Neurogenetics)"],["dc.relation.workinggroup","RG Odoardi (Echtzeitdarstellung neuroimmunologischer Prozesse)"],["dc.relation.workinggroup","RG Simons (The Biology of Glia in Development and Disease)"],["dc.relation.workinggroup","RG Stadelmann-Nessler"],["dc.title","Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E3131"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","E3140"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Huang, Xiaojie"],["dc.contributor.author","Stodieck, Sophia Katharina"],["dc.contributor.author","Goetze, Bianka"],["dc.contributor.author","Cui, Lei"],["dc.contributor.author","Wong, Man Ho"],["dc.contributor.author","Wenzel, Colin"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Dong, Yan"],["dc.contributor.author","Loewel, Siegrid"],["dc.contributor.author","Schlueter, Oliver M."],["dc.date.accessioned","2018-11-07T09:55:51Z"],["dc.date.available","2018-11-07T09:55:51Z"],["dc.date.issued","2015"],["dc.description.abstract","During critical periods, all cortical neural circuits are refined to optimize their functional properties. The prevailing notion is that the balance between excitation and inhibition determines the onset and closure of critical periods. In contrast, we show that maturation of silent glutamatergic synapses onto principal neurons was sufficient to govern the duration of the critical period for ocular dominance plasticity in the visual cortex of mice. Specifically, postsynaptic density protein-95 (PSD-95) was absolutely required for experience-dependent maturation of silent synapses, and its absence before the onset of critical periods resulted in lifelong juvenile ocular dominance plasticity. Loss of PSD-95 in the visual cortex after the closure of the critical period reinstated silent synapses, resulting in reopening of juvenile-like ocular dominance plasticity. Additionally, silent synapse-based ocular dominance plasticity was largely independent of the inhibitory tone, whose developmental maturation was independent of PSD-95. Moreover, glutamatergic synaptic transmission onto parvalbumin-positive interneurons was unaltered in PSD-95 KO mice. These findings reveal not only that PSD-95-dependent silent synapse maturation in visual cortical principal neurons terminates the critical period for ocular dominance plasticity but also indicate that, in general, once silent synapses are consolidated in any neural circuit, initial experience-dependent functional optimization and critical periods end."],["dc.identifier.doi","10.1073/pnas.1506488112"],["dc.identifier.isi","000356251800009"],["dc.identifier.pmid","26015564"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36839"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Progressive maturation of silent synapses governs the duration of a critical period"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","S2211124721013590"],["dc.bibliographiccitation.firstpage","109889"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Berghoff, Stefan A."],["dc.contributor.author","Spieth, Lena"],["dc.contributor.author","Sun, Ting"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Depp, Constanze"],["dc.contributor.author","Sasmita, Andrew O."],["dc.contributor.author","Vasileva, Martina H."],["dc.contributor.author","Scholz, Patricia"],["dc.contributor.author","Zhao, Yu"],["dc.contributor.author","Krueger-Burg, Dilja"],["dc.contributor.author","Saher, Gesine"],["dc.date.accessioned","2021-12-01T09:23:54Z"],["dc.date.available","2021-12-01T09:23:54Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.celrep.2021.109889"],["dc.identifier.pii","S2211124721013590"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94788"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.issn","2211-1247"],["dc.title","Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","138"],["dc.bibliographiccitation.issue","7899"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","603"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Canals, Roger Cugota"],["dc.contributor.author","van der Flier, Felicia Joy"],["dc.contributor.author","Hollensteiner, Jacqueline"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Flügel, Alexander"],["dc.contributor.author","Odoardi, Francesca"],["dc.date.accessioned","2022-04-01T10:00:47Z"],["dc.date.available","2022-04-01T10:00:47Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1038/s41586-022-04427-4"],["dc.identifier.pii","4427"],["dc.identifier.pmid","35197636"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105512"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/58"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | A03: Checkpoints determining recovery from acute autoimmune CNS grey matter lesions"],["dc.relation","TRR 274 | A04: The role of the meninges in the resolution of acute autoimmune CNS lesions"],["dc.relation.eissn","1476-4687"],["dc.relation.issn","0028-0836"],["dc.relation.workinggroup","RG Flügel"],["dc.relation.workinggroup","RG Odoardi (Echtzeitdarstellung neuroimmunologischer Prozesse)"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","The lung microbiome regulates brain autoimmunity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","eabo7639"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","Science Advances"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Düking, Tim"],["dc.contributor.author","Spieth, Lena"],["dc.contributor.author","Berghoff, Stefan A."],["dc.contributor.author","Piepkorn, Lars"],["dc.contributor.author","Schmidke, Annika M."],["dc.contributor.author","Mitkovski, Miso"],["dc.contributor.author","Kannaiyan, Nirmal"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Scholz, Patricia"],["dc.contributor.author","Shaib, Ali H."],["dc.contributor.author","Saher, Gesine"],["dc.date.accessioned","2022-10-04T10:21:32Z"],["dc.date.available","2022-10-04T10:21:32Z"],["dc.date.issued","2022"],["dc.description.abstract","To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. Here, we generated a proteome atlas of the major central nervous system (CNS) cell types from young and adult mice, after feeding the therapeutically relevant low-carbohydrate, high-fat ketogenic diet (KD) and during neuroinflammation. Under steady-state conditions, CNS cell types prefer distinct modes of energy metabolism. Unexpectedly, the comparison with KD revealed distinct cell type–specific strategies to manage the altered availability of energy metabolites. Astrocytes and neurons but not oligodendrocytes demonstrated metabolic plasticity. Moreover, inflammatory demyelinating disease changed the neuronal metabolic signature in a similar direction as KD. Together, these findings highlight the importance of the metabolic cross-talk between CNS cells and between the periphery and the brain to manage altered nutrition and neurological disease."],["dc.description.abstract","Differential metabolic flexibility of brain cells facilitates managing nutritional or pathologic challenges."],["dc.identifier.doi","10.1126/sciadv.abo7639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114437"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","2375-2548"],["dc.title","Ketogenic diet uncovers differential metabolic plasticity of brain cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","ENEURO.0289-17.2017"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","eneuro"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Yusifov, Rashad"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2020-12-10T18:42:33Z"],["dc.date.available","2020-12-10T18:42:33Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1523/ENEURO.0289-17.2017"],["dc.identifier.eissn","2373-2822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78003"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Long-Term Visual Training Increases Visual Acuity and Long-Term Monocular Deprivation Promotes Ocular Dominance Plasticity in Adult Standard Cage-Raised Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","118988"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta. Molecular Cell Research"],["dc.bibliographiccitation.volume","1868"],["dc.contributor.author","Löhndorf, Anke"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Dohle, Wolfgang"],["dc.contributor.author","Odoardi, Francesca"],["dc.contributor.author","Waschkowski, Sissy-Alina"],["dc.contributor.author","Rosche, Anette"],["dc.contributor.author","Bauche, Andreas"],["dc.contributor.author","Winzer, Riekje"],["dc.contributor.author","Tolosa, Eva"],["dc.contributor.author","Guse, Andreas H."],["dc.date.accessioned","2021-06-01T09:41:11Z"],["dc.date.available","2021-06-01T09:41:11Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.bbamcr.2021.118988"],["dc.identifier.pmid","33581218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84840"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/21"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | A03: Checkpoints determining recovery from acute autoimmune CNS grey matter lesions"],["dc.relation.issn","0167-4889"],["dc.relation.workinggroup","RG Flügel"],["dc.relation.workinggroup","RG Odoardi (Echtzeitdarstellung neuroimmunologischer Prozesse)"],["dc.title","2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: Identification of a new and potent inhibitor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]