Hummel, Susanne

[["dc.bibliographiccitation.firstpage","3224"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Archaeological Science"],["dc.bibliographiccitation.lastpage","3229"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Seidenberg, Verena"],["dc.contributor.author","Schilz, Felix"],["dc.contributor.author","Pfister, Daniela"],["dc.contributor.author","Georges, Lea E."],["dc.contributor.author","Fehren-Schmitz, Lars"],["dc.contributor.author","Hummel, Susanne"],["dc.date.accessioned","2018-11-07T09:05:33Z"],["dc.date.available","2018-11-07T09:05:33Z"],["dc.date.issued","2012"],["dc.description.abstract","The analysis of short tandem repeats (STRs) is a useful tool in various contexts of ancient DNA research. Main applications are the reconstruction of kinship, identification, and authentication. Here we describe a short amplicon autosomal short tandem repeat (miniSTR) heptaplex system for the amplification of D13S317, D21S11, D18S51, TH01, D5S818, FGA and Amelogenin from highly degraded DNA as an inexpensive alternative to commercially available kits. All primers were newly designed and the amplicon length of all systems is less than 200 bp, with the exception of some rare alleles in the FGA and D21S11 systems. To validate the suitability of this system for typing STRs from human specimens with low DNA preservation we systematically tested it on 20 skeletal samples from four archaeological sites representing different burial environments and time spans since death. Finally, to test the sensitivity of the heptaplex system, we analyzed serial dilutions of control DNA and ancient DNA extracts. Using the system we were able to reproducibly obtain full STR profiles, down to a concentration of 0.06 ng DNA. Even with 0.004 ng DNA partial profiles could be amplified. The accumulated power of discrimination for the six selected STR loci is 0.99999984, plus the option of genetic sex determination through Amelogenin. The tests conducted prove that the system presented is efficient and especially suited for cases where STRs have to be typed and sex has to be assessed from human specimens with highly degraded DNA. (C) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.jas.2012.05.019"],["dc.identifier.isi","000308452600016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25349"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd- Elsevier Science Ltd"],["dc.relation.issn","0305-4403"],["dc.title","A new miniSTR heptaplex system for genetic fingerprinting of ancient DNA from archaeological human bone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","266"],["dc.bibliographiccitation.journal","Annals of Human Genetics"],["dc.bibliographiccitation.lastpage","283"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Fehren-Schmitz, Lars"],["dc.contributor.author","Warnberg, Ole"],["dc.contributor.author","Reindel, Markus"],["dc.contributor.author","Seidenberg, Verena"],["dc.contributor.author","Tomasto-Cagigao, Elsa"],["dc.contributor.author","Isla-Cuadrado, Johny"],["dc.contributor.author","Hummel, Susanne"],["dc.contributor.author","Herrmann, Bernd"],["dc.date.accessioned","2018-11-07T08:58:54Z"],["dc.date.available","2018-11-07T08:58:54Z"],["dc.date.issued","2011"],["dc.description.abstract","P>This study examines the reciprocal effects of cultural evolution, and population dynamics in pre-Columbian southern Peru by the analysis of DNA from pre-Columbian populations that lived in the fringe area between the Andean highlands and the Pacific coast. The main objective is to reveal whether the transition from the Middle Horizon (MH: 650-1000 AD) to the Late Intermediate Period (LIP: 1000-1400 AD) was accompanied or influenced by population dynamic processes. Tooth samples from 90 individuals from several archaeological sites, dating to the MH and LIP, in the research area were collected to analyse mitochodrial, and Y-chromosomal genetic markers. Coding region polymorphisms were successfully analysed and replicated for 72 individuals, as were control region sequences for 65 individuals and Y-chromosomal single nucleotide polymorphisms (SNPs) for 19 individuals, and these were compared to a large set of ancient and modern indigenous South American populations. The diachronic comparison of the upper valley samples from both time periods reveals no genetic discontinuities accompanying the cultural dynamic processes. A high genetic affinity for other ancient and modern highland populations can be observed, suggesting genetic continuity in the Andean highlands at the latest from the MH. A significant matrilineal differentiation to ancient Peruvian coastal populations can be observed suggesting a differential population history."],["dc.description.sponsorship","German Federal Ministry of Education and Research [01UA0804B]"],["dc.identifier.doi","10.1111/j.1469-1809.2010.00620.x"],["dc.identifier.isi","000287247100008"],["dc.identifier.pmid","21091452"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23756"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0003-4800"],["dc.title","Diachronic Investigations of Mitochondrial and Y-Chromosomal Genetic Markers in Pre-Columbian Andean Highlanders from South Peru"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","208"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.bibliographiccitation.lastpage","221"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Fehren-Schmitz, Lars"],["dc.contributor.author","Reindel, Markus"],["dc.contributor.author","Cagigao, Elsa Tomasto"],["dc.contributor.author","Hummel, Susanne"],["dc.contributor.author","Herrmann, Bernd"],["dc.date.accessioned","2018-11-07T08:45:58Z"],["dc.date.available","2018-11-07T08:45:58Z"],["dc.date.issued","2010"],["dc.description.abstract","Alternative models have been proposed to explain the formation and decline of the south Peruvian Nasca culture, ranging from migration or invasion to autochthonous development and ecological crisis. To reveal to what extent population dynamic processes accounted for cultural development in the Nasca mainland, or were influenced by them, we analyzed ancient mitochondrial DNA of 218 individuals, originating from chronologically successive archaeological sites in the Palpa region, the Paracas Peninsula, and the Andean highlands in southern Peru. The sampling strategy allowed a diachronic analysis in a time frame from approximately 800 BC to 800 AD. Mitochondrial coding region polymorphisms were successfully analyzed and replicated for 130 individuals and control region sequences (np 16021-16408) for 104 individuals to determine Native American mitochondrial DNA haplogroups and haplotypes. The results were compared with ancient and contemporary Peruvian populations to reveal genetic relations of the archaeological samples. Frequency data and statistics show clear proximity of the Nasca populations to the populations of the preceding Paracas culture from Palpa and the Peninsula, and suggest, along with archaeological data, that the Nasca culture developed autochthonously in the Rio Grande drainage. Furthermore, the influence of changes in socioeconomic complexity in the Palpa area on the genetic diversity of the local population could be observed. In all, a strong genetic affinity between pre-Columbian coastal populations from southern Peru could be determined, together with a significant differentiation from ancient highland and all present-day Peruvian reference populations, best shown in the differential distribution of mitochondrial haplogroups. Am J Phys Anthropol 141:208-221, 2010. (C) 2009 Wiley-Liss, Inc."],["dc.description.sponsorship","German Federal Ministry of Education and Research (BMBF) [03HEX1VP]"],["dc.identifier.doi","10.1002/ajpa.21135"],["dc.identifier.isi","000273749100004"],["dc.identifier.pmid","19639639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20578"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0002-9483"],["dc.title","Pre-Columbian Population Dynamics in Coastal Southern Peru: A Diachronic Investigation of mtDNA Patterns in the Palpa Region by Ancient DNA Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","242"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.bibliographiccitation.lastpage","249"],["dc.bibliographiccitation.volume","149"],["dc.contributor.author","Georges, Lea E."],["dc.contributor.author","Seidenberg, Verena"],["dc.contributor.author","Hummel, Susanne"],["dc.contributor.author","Fehren-Schmitz, Lars"],["dc.date.accessioned","2018-11-07T09:05:19Z"],["dc.date.available","2018-11-07T09:05:19Z"],["dc.date.issued","2012"],["dc.description.abstract","The majority of Native Americans nearly exclusively belong to group O of the ABO blood group system. Several hypotheses have been formulated to explain this observation, primarily differing by the presumption that the observed patterns of ABO diversity are due to the processes of the initial peopling of the Americas or due to subsequent events, especially the demographic consequences in the wake of European contact. A promising strategy to reveal possible diachronic ABO frequency changes is the molecular genetic analysis of relevant genetic markers in precontact populations. A previous study by Halverson and Bolnick [Am J Phys Anthropol 137 (2008) 342-347] already accomplished this for indigenous North American populations. Here we present the first study to analyze ABO blood types from pre-Columbian individuals from South America using molecular genetic methods and comparing them to several extant South American, North American, and Siberian populations. We tried to determine ABO blood types for 59 individuals from the southern Peruvian highlands dating to similar to 650 to 1250 AD using a newly developed multiplex PCR/SBE assay coamplifying the fragments relevant for blood type determination and three highly discriminating autosomal STRs. Analysis was successful for 31 individuals and revealed that all are exclusively in the O group, predominantly carrying the O02 (01v) allele. No significant difference could be observed between the ancient and modern Native American populations, while all significantly differed from the extant Siberian populations, supporting the suggestion that low ABO diversity results from founder effects during the initial peopling of the Americas. Am J Phys Anthropol 149:242249, 2012. (c) 2012 Wiley Periodicals, Inc."],["dc.description.sponsorship","German Research Foundation (DFG) [FE1161/1-1]"],["dc.identifier.doi","10.1002/ajpa.22115"],["dc.identifier.isi","000308879100009"],["dc.identifier.pmid","22806956"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25288"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0002-9483"],["dc.title","Molecular characterization of ABO blood group frequencies in pre-Columbian Peruvian highlanders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","148"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","146"],["dc.contributor.author","v Grumbkow, Philipp"],["dc.contributor.author","Zipp, Anna"],["dc.contributor.author","Seidenberg, Verena"],["dc.contributor.author","Fehren-Schmitz, Lars"],["dc.contributor.author","Kempf, Volkhard A. J."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Hummel, Susanne"],["dc.date.accessioned","2018-11-07T08:52:45Z"],["dc.date.available","2018-11-07T08:52:45Z"],["dc.date.issued","2011"],["dc.description.abstract","In 2008, a mass grave was found on the grounds of the University of Kassel, Germany. Historians hypothesized that the individuals died in a typhoid fever epidemic in winter 1813/14. To test this hypothesis, the bones were investigated on the presence of specific DNA of pathogens linked to the historical diagnosis of typhoid fever. It was possible to prove the specific DNA of Bartonella quintana in three individuals, suggesting that their cause of death is linked to an epidemic background. Am J Phys Anthropol 146:148-151, 2011. (C) 2011 Wiley-Liss, Inc."],["dc.description.sponsorship","Department of Historical Anthropology"],["dc.identifier.doi","10.1002/ajpa.21551"],["dc.identifier.isi","000294229100014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22249"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0002-9483"],["dc.title","Brief Communication: Evidence of Bartonella quintana Infections in Skeletons of a Historical Mass Grave in Kassel, Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]