Mollenhauer, Brit

[["dc.bibliographiccitation.artnumber","121"],["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.affiliation","Lerche, Stefanie;"],["dc.contributor.affiliation","Heinzel, Sebastian;"],["dc.contributor.affiliation","Alves, Guido W.;"],["dc.contributor.affiliation","Barone, Paolo;"],["dc.contributor.affiliation","Behnke, Stefanie;"],["dc.contributor.affiliation","Ben-Shlomo, Yoav;"],["dc.contributor.affiliation","Berendse, Henk;"],["dc.contributor.affiliation","Bloem, Bastiaan R.;"],["dc.contributor.affiliation","Burn, David;"],["dc.contributor.affiliation","Dodel, Richard;"],["dc.contributor.affiliation","Grosset, Donald G.;"],["dc.contributor.affiliation","Hipp, Geraldine;"],["dc.contributor.affiliation","Hu, Michele T.;"],["dc.contributor.affiliation","Kasten, Meike;"],["dc.contributor.affiliation","Krüger, Rejko;"],["dc.contributor.affiliation","Liepelt-Scarfone, Inga;"],["dc.contributor.affiliation","Maetzler, Walter;"],["dc.contributor.affiliation","Moccia, Marcello;"],["dc.contributor.affiliation","Mollenhauer, Brit;"],["dc.contributor.affiliation","Oertel, Wolfgang;"],["dc.contributor.affiliation","Roeben, Benjamin;"],["dc.contributor.affiliation","Walter, Uwe;"],["dc.contributor.affiliation","Wirdefeldt, Karin;"],["dc.contributor.affiliation","Berg, Daniela;"],["dc.contributor.author","Lerche, Stefanie"],["dc.contributor.author","Heinzel, Sebastian"],["dc.contributor.author","Alves, Guido W."],["dc.contributor.author","Barone, Paolo"],["dc.contributor.author","Behnke, Stefanie"],["dc.contributor.author","Ben-Shlomo, Yoav"],["dc.contributor.author","Berendse, Henk W."],["dc.contributor.author","Bloem, Bastiaan R."],["dc.contributor.author","Burns, David J."],["dc.contributor.author","Dodel, Richard"],["dc.contributor.author","Grosset, Donald G."],["dc.contributor.author","Hipp, Geraldine"],["dc.contributor.author","Hu, Michele T. M."],["dc.contributor.author","Kasten, Meike"],["dc.contributor.author","Krüger, Rejko"],["dc.contributor.author","Liepelt-Scarfone, Inga"],["dc.contributor.author","Moccia, Marcello"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Oertel, Wolfgang"],["dc.contributor.author","Roeben, Benjamin"],["dc.contributor.author","Walter, Uwe"],["dc.contributor.author","Wirdefeldt, Karin"],["dc.contributor.author","Maetzler, Walter"],["dc.contributor.author","Berg, Daniela"],["dc.date.accessioned","2018-11-07T10:14:05Z"],["dc.date.available","2018-11-07T10:14:05Z"],["dc.date.issued","2016"],["dc.date.updated","2022-02-09T13:23:10Z"],["dc.identifier.doi","10.3389/fnagi.2016.00121"],["dc.identifier.eissn","1663-4365"],["dc.identifier.isi","000376574700001"],["dc.identifier.pmid","27303289"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40560"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1663-4365"],["dc.relation.issn","1663-4365"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","593"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","596"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Lawton, Michael"],["dc.contributor.author","Kasten, Meike"],["dc.contributor.author","May, Margaret T."],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Schaumburg, Martina"],["dc.contributor.author","Liepelt-Scarfone, Inga"],["dc.contributor.author","Maetzler, Walter"],["dc.contributor.author","Vollstedt, Eva-Juliane"],["dc.contributor.author","Hu, Michele T. M."],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Ben-Shlomo, Yoav"],["dc.date.accessioned","2018-11-07T10:16:04Z"],["dc.date.available","2018-11-07T10:16:04Z"],["dc.date.issued","2016"],["dc.description.abstract","IntroductionHarmonizing data across cohorts is important for validating findings or combining data in meta-analyses. We replicate and validate a previous conversion of MoCA to MMSE in PD. MethodsWe used five studies with 1,161 PD individuals and 2,091 observations measured with both the MoCA and MMSE. We compared a previously published conversion table using equipercentile equating with log-linear smoothing to our internally derived scores. ResultsBoth conversions found good agreement within and across the studies when comparing true and converted MMSE (mean difference: 0.05; standard deviation: 1.84; median difference: 0; interquartile range: -1 to 1, using internal conversion). ConclusionsThese results show that one can get a reliable and valid conversion between two commonly used measures of cognition in PD studies. These approaches need to be applied to other scales and domains to enable large-scale collaborative analyses across multiple PD cohorts. (c) 2016 International Parkinson and Movement Disorder Society"],["dc.identifier.doi","10.1002/mds.26498"],["dc.identifier.isi","000374546300026"],["dc.identifier.pmid","26861697"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40959"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1531-8257"],["dc.relation.issn","0885-3185"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Validation of conversion between mini-mental state examination and montreal cognitive assessment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","147"],["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Heinzel, Sebastian"],["dc.contributor.author","Roeben, Benjamin"],["dc.contributor.author","Ben-Shlomo, Yoav"],["dc.contributor.author","Lerche, Stefanie"],["dc.contributor.author","Alves, Guido"],["dc.contributor.author","Barone, Paolo"],["dc.contributor.author","Behnke, Stefanie"],["dc.contributor.author","Berendse, Henk W."],["dc.contributor.author","Bloem, Bastiaan R."],["dc.contributor.author","Burns, David J."],["dc.contributor.author","Dodel, Richard"],["dc.contributor.author","Grosset, Donald G."],["dc.contributor.author","Hu, Michele T. M."],["dc.contributor.author","Kasten, Meike"],["dc.contributor.author","Krueger, Rejko"],["dc.contributor.author","Moccia, Marcello"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Oertel, Wolfgang"],["dc.contributor.author","Suenkel, Ulrike"],["dc.contributor.author","Walter, Uwe"],["dc.contributor.author","Wirdefeldt, Karin"],["dc.contributor.author","Liepelt-Scarfone, Inga"],["dc.contributor.author","Maetzler, Walter"],["dc.contributor.author","Berg, Daniela"],["dc.date.accessioned","2018-11-07T10:12:40Z"],["dc.date.available","2018-11-07T10:12:40Z"],["dc.date.issued","2016"],["dc.description.abstract","A growing body of evidence supports a prodromal neurodegenerative process preceding the clinical onset of Parkinson's disease (PD). Studies have identified several different prodromal markers that may have the potential to predict the conversion from healthy to clinical PD but use considerably different approaches. We systematically reviewed 35 longitudinal studies reporting prodromal PD features and evaluated the methodological quality across 10 different predefined domains. We found limitations in the following domains: PD diagnosis (57% of studies), prodromal marker assessments (51%), temporal information on prodromal markers or PD diagnosis (34%), generalizability of results (17%), statistical methods (accounting for at least age as confounder; 17%), study design (14%), and sample size (9%). However, no limitations regarding drop-out (or bias investigation), or report of inclusion/exclusion criteria or prodromal marker associations were revealed. Lessons learned from these limitations and additional aspects of current prodromal marker studies in PD are discussed to provide a basis for the evaluation of findings and the improvement of future research in prodromal PD. The observed heterogeneity of studies, limitations and analyses might be addressed in future longitudinal studies using a, yet to be established, modular minimal set of assessments improving comparability of findings and enabling data sharing and combined analyses across studies."],["dc.identifier.doi","10.3389/fnagi.2016.00147"],["dc.identifier.isi","000378534100002"],["dc.identifier.pmid","27445791"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13476"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40281"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media Sa"],["dc.relation.issn","1663-4365"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1859"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Genes"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Koch, Sebastian"],["dc.contributor.author","Laabs, Björn-Hergen"],["dc.contributor.author","Kasten, Meike"],["dc.contributor.author","Vollstedt, Eva-Juliane"],["dc.contributor.author","Becktepe, Jos"],["dc.contributor.author","Brüggemann, Norbert"],["dc.contributor.author","Franke, Andre"],["dc.contributor.author","Krämer, Ulrike M."],["dc.contributor.author","Kuhlenbäumer, Gregor"],["dc.contributor.author","Lieb, Wolfgang"],["dc.contributor.author","Caliebe, Amke"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Neis, Miriam"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Schäffer, Eva"],["dc.contributor.author","Usnich, Tatiana"],["dc.contributor.author","Wittig, Michael"],["dc.contributor.author","Klein, Christine"],["dc.contributor.author","König, Inke R."],["dc.contributor.author","Lohmann, Katja"],["dc.contributor.author","Krawczak, Michael"],["dc.contributor.editor","Ebert, Allison D."],["dc.date.accessioned","2022-01-11T14:08:06Z"],["dc.date.available","2022-01-11T14:08:06Z"],["dc.date.issued","2021"],["dc.description.abstract","Idiopathic Parkinson’s disease (PD) is a complex multifactorial disorder caused by the interplay of both genetic and non-genetic risk factors. Polygenic risk scores (PRSs) are one way to aggregate the effects of a large number of genetic variants upon the risk for a disease like PD in a single quantity. However, reassessment of the performance of a given PRS in independent data sets is a precondition for establishing the PRS as a valid tool to this end. We studied a previously proposed PRS for PD in a separate genetic data set, comprising 1914 PD cases and 4464 controls, and were able to replicate its ability to differentiate between cases and controls. We also assessed theoretically the prognostic value of the PD-PRS, i.e., its ability to predict the development of PD in later life for healthy individuals. As it turned out, the PD-PRS alone can be expected to perform poorly in this regard. Therefore, we conclude that the PD-PRS could serve as an important research tool, but that meaningful PRS-based prognosis of PD at an individual level is not feasible."],["dc.description.abstract","Idiopathic Parkinson’s disease (PD) is a complex multifactorial disorder caused by the interplay of both genetic and non-genetic risk factors. Polygenic risk scores (PRSs) are one way to aggregate the effects of a large number of genetic variants upon the risk for a disease like PD in a single quantity. However, reassessment of the performance of a given PRS in independent data sets is a precondition for establishing the PRS as a valid tool to this end. We studied a previously proposed PRS for PD in a separate genetic data set, comprising 1914 PD cases and 4464 controls, and were able to replicate its ability to differentiate between cases and controls. We also assessed theoretically the prognostic value of the PD-PRS, i.e., its ability to predict the development of PD in later life for healthy individuals. As it turned out, the PD-PRS alone can be expected to perform poorly in this regard. Therefore, we conclude that the PD-PRS could serve as an important research tool, but that meaningful PRS-based prognosis of PD at an individual level is not feasible."],["dc.identifier.doi","10.3390/genes12121859"],["dc.identifier.pii","genes12121859"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97934"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.publisher","MDPI"],["dc.relation.eissn","2073-4425"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Validity and Prognostic Value of a Polygenic Risk Score for Parkinson’s Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]