Brandes, Ivo Florian

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of the American Heart Association"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Kohlhaas, Madeline"],["dc.contributor.author","Stoppe, Christian"],["dc.contributor.author","Gruenewald, Matthias"],["dc.contributor.author","Renner, Jochen"],["dc.contributor.author","Bein, Berthold"],["dc.contributor.author","Albrecht, Martin"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Coburn, Mark"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, Bernd"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Mutlak, Haitham"],["dc.contributor.author","Westphal, Sabine"],["dc.contributor.author","Laufenberg‐Feldmann, Rita"],["dc.contributor.author","Ferner, Marion"],["dc.contributor.author","Brandes, Ivo F."],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Stehr, Sebastian N."],["dc.contributor.author","Kortgen, Andreas"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Baumgarten, Georg"],["dc.contributor.author","Meyer‐Treschan, Tanja"],["dc.contributor.author","Kienbaum, Peter"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Treskatsch, Sascha"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, Ewa"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Fuernau, Georg"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Stevanovic, Ana"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Felzen, Marc"],["dc.contributor.author","Goetzenich, Andreas"],["dc.contributor.author","Moormann, Tobias"],["dc.contributor.author","Chalk, Katharina"],["dc.contributor.author","Knuefermann, Pascal"],["dc.contributor.author","Recht, Thomas"],["dc.contributor.author","Hoeft, Andreas"],["dc.contributor.author","Winterhalter, Michael"],["dc.contributor.author","Iken, Sonja"],["dc.contributor.author","Wiedenbeck, Carolin"],["dc.contributor.author","Schwarzmann, Gerhard"],["dc.contributor.author","Lindau, Simone"],["dc.contributor.author","Zierer, Andreas"],["dc.contributor.author","Fichtlscherer, Stephan"],["dc.contributor.author","Goerlach, Gerold"],["dc.contributor.author","Wollbrueck, Matthias"],["dc.contributor.author","Boening, Ursula"],["dc.contributor.author","Weigand, Markus"],["dc.contributor.author","Strauchmann, Julia"],["dc.contributor.author","Morsbach, Kai U."],["dc.contributor.author","Paxian, Markus"],["dc.contributor.author","Reinhard, Konrad"],["dc.contributor.author","Scholz, Jens"],["dc.contributor.author","Broch, Ole"],["dc.contributor.author","Francksen, Helga"],["dc.contributor.author","Kuhr, Bernd"],["dc.contributor.author","Heinze, Hermann"],["dc.contributor.author","Paarmann, Hauke"],["dc.contributor.author","Sievers, Hans‐Hinrich"],["dc.contributor.author","Klotz, Stefan"],["dc.contributor.author","Hachenberg, Thomas"],["dc.contributor.author","Werner, Christian"],["dc.contributor.author","Mauff, Susanne"],["dc.contributor.author","Alms, Angela"],["dc.contributor.author","Bergt, Stefan"],["dc.contributor.author","Roewer, Norbert"],["dc.date.accessioned","2020-12-10T18:38:05Z"],["dc.date.available","2020-12-10T18:38:05Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1161/JAHA.117.008077"],["dc.identifier.eissn","2047-9980"],["dc.identifier.issn","2047-9980"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77180"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1423"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Felzen, Marc"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Brandes, Ivo"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Knuefermann, Pascal"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Hachenberg, Thomas"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Maisch, Sonja"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Moormann, Tobias"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Weigand, Markus A."],["dc.contributor.author","Laufenberg, Rita"],["dc.contributor.author","Werner, Christian"],["dc.contributor.author","Winterhalter, Michael"],["dc.contributor.author","Treschan, Tanja"],["dc.contributor.author","Stehr, Sebastian N."],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Bein, Berthold"],["dc.date.accessioned","2018-11-07T09:09:36Z"],["dc.date.available","2018-11-07T09:09:36Z"],["dc.date.issued","2012"],["dc.description.abstract","Aims Transient ischaemia of non-vital tissue has been shown to enhance the tolerance of remote organs to cope with a subsequent prolonged ischaemic event in a number of clinical conditions, a phenomenon known as remote ischaemic preconditioning (RIPC). However, there remains uncertainty about the efficacy of RIPC in patients undergoing cardiac surgery. The purpose of this report is to describe the design and methods used in the 'Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart)-Study'. Methods We are conducting a prospective, randomized, double-blind, multicentre, controlled trial including 2070 adult cardiac surgical patients. All types of surgery in which cardiopulmonary bypass is used will be included. Patients will be randomized either to the RIPC group receiving four 5 min cycles of transient upper limb ischaemia/reperfusion or to the control group receiving four cycles of blood pressure cuff inflation/deflation at a dummy arm. The primary endpoint is a composite outcome (all-cause mortality, non-fatal myocardial infarction, any new stroke, and/or acute renal failure) until hospital discharge. Conclusion The RIPHeart-Study is a multicentre trial to determine whether RIPC may improve clinical outcome in cardiac surgical patients."],["dc.description.sponsorship","German Research Foundation [ME 3559/1-1]"],["dc.identifier.isi","000305423000006"],["dc.identifier.pmid","22880214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26297"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0195-668X"],["dc.title","Remote ischaemic preconditioning for heart surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","26"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cardiovascular Disorders"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Westphal, Sabine"],["dc.contributor.author","Stoppe, Christian"],["dc.contributor.author","Gruenewald, Matthias"],["dc.contributor.author","Bein, Berthold"],["dc.contributor.author","Renner, Jochen"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Coburn, Mark"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, Bernd"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Laufenberg-Feldmann, Rita"],["dc.contributor.author","Ferner, Marion"],["dc.contributor.author","Brandes, Ivo F"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Kortgen, Andreas"],["dc.contributor.author","Stehr, Sebastian N"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Baumgarten, Georg"],["dc.contributor.author","Struck, Rafael"],["dc.contributor.author","Meyer-Treschan, Tanja"],["dc.contributor.author","Kienbaum, Peter"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Treskatsch, Sascha"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, Ewa"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Degenhardt, Frauke"],["dc.contributor.author","Franke, Andre"],["dc.contributor.author","Mucha, Soeren"],["dc.contributor.author","Tittmann, Lukas"],["dc.contributor.author","Kohlhaas, Madeline"],["dc.contributor.author","Fuernau, Georg"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Meybohm, Patrick"],["dc.date.accessioned","2019-07-09T11:49:54Z"],["dc.date.available","2019-07-09T11:49:54Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10− 5 from the GWAS. Conclusions We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery. Trial registration The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010."],["dc.identifier.doi","10.1186/s12872-019-1002-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15801"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59651"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1397"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","New England Journal of Medicine"],["dc.bibliographiccitation.lastpage","1407"],["dc.bibliographiccitation.volume","373"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Bein, B."],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Gruenewald, M."],["dc.contributor.author","Stoppe, C."],["dc.contributor.author","Coburn, Marc"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, B."],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Laufenberg-Feldmann, R."],["dc.contributor.author","Ferner, M."],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Stehr, Sebastian N."],["dc.contributor.author","Kortgen, A."],["dc.contributor.author","Wittmann, M."],["dc.contributor.author","Baumgarten, G."],["dc.contributor.author","Meyer-Treschan, T."],["dc.contributor.author","Kienbaum, P."],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Sander, M."],["dc.contributor.author","Treskatsch, S."],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, E."],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Fuernau, G."],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.date.accessioned","2018-11-07T09:50:18Z"],["dc.date.available","2018-11-07T09:50:18Z"],["dc.date.issued","2015"],["dc.description.abstract","BACKGROUND Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of ischemic and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains. METHODS We conducted a prospective, double-blind, multicenter, randomized, controlled trial involving adults who were scheduled for elective cardiac surgery requiring cardiopulmonary bypass under total anesthesia with intravenous propofol. The trial compared upper-limb RIPC with a sham intervention. The primary end point was a composite of death, myocardial infarction, stroke, or acute renal failure up to the time of hospital discharge. Secondary end points included the occurrence of any individual component of the primary end point by day 90. RESULTS A total of 1403 patients underwent randomization. The full analysis set comprised 1385 patients (692 in the RIPC group and 693 in the sham-RIPC group). There was no significant between-group difference in the rate of the composite primary end point (99 patients [14.3%] in the RIPC group and 101 [14.6%] in the sham-RIPC group, P = 0.89) or of any of the individual components: death (9 patients [1.3%] and 4 [0.6%], respectively; P = 0.21), myocardial infarction (47 [6.8%] and 63 [9.1%], P = 0.12), stroke (14 [2.0%] and 15 [2.2%], P = 0.79), and acute renal failure (42 [6.1%] and 35 [5.1%], P = 0.45). The results were similar in the per-protocol analysis. No treatment effect was found in any subgroup analysis. No significant differences between the RIPC group and the sham-RIPC group were seen in the level of troponin release, the duration of mechanical ventilation, the length of stay in the intensive care unit or the hospital, new onset of atrial fibrillation, and the incidence of postoperative delirium. No RIPC-related adverse events were observed. CONCLUSIONS Upper-limb RIPC performed while patients were under propofol-induced anesthesia did not show a relevant benefit among patients undergoing elective cardiac surgery."],["dc.identifier.doi","10.1056/NEJMoa1413579"],["dc.identifier.isi","000362372800006"],["dc.identifier.pmid","26436208"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13833"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35685"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Massachusetts Medical Soc"],["dc.relation.issn","1533-4406"],["dc.relation.issn","0028-4793"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]