Brandes, Ivo Florian

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biomedical Engineering / Biomedizinische Technik"],["dc.bibliographiccitation.lastpage","9"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Braeuer, Anselm"],["dc.date.accessioned","2018-11-07T10:01:19Z"],["dc.date.available","2018-11-07T10:01:19Z"],["dc.date.issued","2015"],["dc.description.abstract","Reliable continuous perioperative core temperature measurement is of major importance. The pulmonary artery catheter is currently the gold standard for measuring core temperature but is invasive and expensive. Using a manikin, we evaluated the new, noninvasive SpotOn (TM) temperature monitoring system (SOT). With a sensor placed on the lateral forehead, SOT uses zero heat flux technology to noninvasively measure core temperature; and because the forehead is devoid of thermoregulatory arteriovenous shunts, a piece of bone cement served as a model of the frontal bone in this study. Bias, limits of agreements, long-term measurement stability, and the lowest measurable temperature of the device were investigated. Bias and limits of agreement of the temperature data of two SOTs and of the thermistor placed on the manikin's surface were calculated. Measurements obtained from SOTs were similar to thermistor values. The bias and limits of agreement lay within a predefined clinically acceptable range. Repeat measurements differed only slightly, and stayed stable for hours. Because of its temperature range, the SOT cannot be used to monitor temperatures below 28 degrees C. In conclusion, the new SOT could provide a reliable, less invasive and cheaper alternative for measuring perioperative core temperature in routine clinical practice. Further clinical trials are needed to evaluate these results."],["dc.identifier.doi","10.1515/bmt-2014-0063"],["dc.identifier.isi","000350406100001"],["dc.identifier.pmid","25389979"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37991"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter Gmbh"],["dc.relation.issn","1862-278X"],["dc.relation.issn","0013-5585"],["dc.title","Evaluation of a novel noninvasive continuous core temperature measurement system with a zero heat flux sensor using a manikin of the human body"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2035"],["dc.bibliographiccitation.issue","45"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Ameen, Abu Hanna"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, José Maria"],["dc.date.accessioned","2018-11-07T09:49:09Z"],["dc.date.available","2018-11-07T09:49:09Z"],["dc.date.issued","2015"],["dc.description.abstract","Hyperglycemia is common during and after Coronary Artery Bypass Graft Surgery (CABGS) and has been shown to be associated with poor clinical outcomes. In this study, we hypothesized that a moderate perioperative mean blood glucose level of<150mg/dL improves long-term survival in cardiac surgery patients. We conducted a prospective, observational cohort study in the heart center of the University Medical Center of Goettingen, Germany. Patients undergoing on-pump cardiac surgery were enrolled in this investigation. After evaluating perioperative blood glucose levels, patients were classified into 2 groups based on mean glucose levels: Glucose 150mg/dL and Glucose<150mg/dL. Patients were followed up for 5 years, and mortality within this period was recorded as the primary outcome parameter. Secondary outcome parameters included the length of ICU stay, the use of inotropic agents, the length of hospital stay, and the in-hospital mortality. A total of 455 consecutive patients who underwent cardiac surgery with cardiopulmonary bypass were enrolled in this investigation. A Kaplan-Meier survival analysis of the 5-year mortality risk revealed a higher mortality risk among patients with glucose levels 150mg/dL (P=0.0043, log-rank test). After adjustment for confounders in a multivariate Cox regression model, the association between glucose 150mg/dL and 5-year mortality remained significant (hazard ratio, 2.10; 95% CI, 1.30-3.39; P=0.0023). This association was corroborated by propensity score matching, in which Kaplan-Meier survival analysis demonstrated significant improvement in the 5-year survival of patients with glucose levels<150mg/dL (P=0.0339). Similarly, in-hospital mortality was significantly higher in patients with glucose 150mg/dL compared with patients with glucose<150mg/dL. Moreover, patients in the Glucose 150mg/dL group required significantly higher doses of the inotropic agent Dobutamine (mg/d) compared with patients in the Glucose<150mg/dL group (20.6 +/- 62.3 and 10.5 +/- 40.7, respectively; P=0.0104). Moreover, patients in the Glucose 150mg/dL group showed a significantly longer hospital stay compared with patients in the Glucose<150mg/dL group (28 +/- 23 and 24 +/- 19, respectively; P=0.0297). We conclude that perioperative blood glucose levels<150mg/dL are associated with improved 5-year survival in patients undergoing cardiac surgery. More studies are warranted to explain this effect."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1097/MD.0000000000002035"],["dc.identifier.isi","000369537400066"],["dc.identifier.pmid","26559310"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12570"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35449"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Perioperative Blood Glucose Levels < 150 mg/dL are Associated With Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery A Prospective, Observational Cohort Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","282"],["dc.bibliographiccitation.journal","Journal of Clinical Anesthesia"],["dc.bibliographiccitation.lastpage","289"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Harden, Markus"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Braeuer, Anselm"],["dc.date.accessioned","2018-11-07T10:06:45Z"],["dc.date.available","2018-11-07T10:06:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Study objective: Perioperative hypothermia is a frequently observed phenomenon of general anesthesia and is associated with adverse patient outcome. Recently, a significant influence of core temperature before induction of anesthesia has been reported. However, there are still little existing data on core temperature before induction of anesthesia and no data regarding potential risk factors for developing preoperative hypothermia. The purpose of this investigation was to estimate the incidence of hypothermia before anesthesia and to determine if certain factors predict its incidence. Design/setting/patients: Data from 7 prospective studies investigating core temperature previously initiated at our department were analyzed. Patients undergoing a variety of elective surgical procedures were included. Interventions/measurements: Core temperature was measured before induction of anesthesia with an oral (314 patients), infrared tympanic (143 patients), or tympanic contact thermometer (36 patients). Available potential predictors included American Society of Anesthesiologists status, sex, age, weight, height, body mass index, adipose ratio, and lean body weight. Association with preoperative hypothermia was assessed separately for each predictor using logistic regression. Independent predictors were identified using multivariable logistic regression. Main results: A total of 493 patients were included in the study. Hypothermia was found in 105 patients (21.3%; 95% confidence interval, 17.8%-25.2%). The median core temperature was 36.3 degrees C (25th-75th percentiles, 36.0 degrees C-36.7 degrees C). Two independent factors for preoperative hypothermia were identified: male sex and age (>52 years). Conclusions: As a consequence of the high incidence of hypothermia before anesthesia, measuring core temperature should be mandatory 60 to 120 minutes before induction to identify and provide adequate treatment to hypothermic patients. (C) 2016 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.jclinane.2016.03.065"],["dc.identifier.isi","000384952700058"],["dc.identifier.pmid","27687393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39155"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1873-4529"],["dc.relation.issn","0952-8180"],["dc.title","Unexpectedly high incidence of hypothermia before induction of anesthesia in elective surgical patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of the American Heart Association"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Kohlhaas, Madeline"],["dc.contributor.author","Stoppe, Christian"],["dc.contributor.author","Gruenewald, Matthias"],["dc.contributor.author","Renner, Jochen"],["dc.contributor.author","Bein, Berthold"],["dc.contributor.author","Albrecht, Martin"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Coburn, Mark"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, Bernd"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Mutlak, Haitham"],["dc.contributor.author","Westphal, Sabine"],["dc.contributor.author","Laufenberg‐Feldmann, Rita"],["dc.contributor.author","Ferner, Marion"],["dc.contributor.author","Brandes, Ivo F."],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Stehr, Sebastian N."],["dc.contributor.author","Kortgen, Andreas"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Baumgarten, Georg"],["dc.contributor.author","Meyer‐Treschan, Tanja"],["dc.contributor.author","Kienbaum, Peter"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Treskatsch, Sascha"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, Ewa"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Fuernau, Georg"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Stevanovic, Ana"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Felzen, Marc"],["dc.contributor.author","Goetzenich, Andreas"],["dc.contributor.author","Moormann, Tobias"],["dc.contributor.author","Chalk, Katharina"],["dc.contributor.author","Knuefermann, Pascal"],["dc.contributor.author","Recht, Thomas"],["dc.contributor.author","Hoeft, Andreas"],["dc.contributor.author","Winterhalter, Michael"],["dc.contributor.author","Iken, Sonja"],["dc.contributor.author","Wiedenbeck, Carolin"],["dc.contributor.author","Schwarzmann, Gerhard"],["dc.contributor.author","Lindau, Simone"],["dc.contributor.author","Zierer, Andreas"],["dc.contributor.author","Fichtlscherer, Stephan"],["dc.contributor.author","Goerlach, Gerold"],["dc.contributor.author","Wollbrueck, Matthias"],["dc.contributor.author","Boening, Ursula"],["dc.contributor.author","Weigand, Markus"],["dc.contributor.author","Strauchmann, Julia"],["dc.contributor.author","Morsbach, Kai U."],["dc.contributor.author","Paxian, Markus"],["dc.contributor.author","Reinhard, Konrad"],["dc.contributor.author","Scholz, Jens"],["dc.contributor.author","Broch, Ole"],["dc.contributor.author","Francksen, Helga"],["dc.contributor.author","Kuhr, Bernd"],["dc.contributor.author","Heinze, Hermann"],["dc.contributor.author","Paarmann, Hauke"],["dc.contributor.author","Sievers, Hans‐Hinrich"],["dc.contributor.author","Klotz, Stefan"],["dc.contributor.author","Hachenberg, Thomas"],["dc.contributor.author","Werner, Christian"],["dc.contributor.author","Mauff, Susanne"],["dc.contributor.author","Alms, Angela"],["dc.contributor.author","Bergt, Stefan"],["dc.contributor.author","Roewer, Norbert"],["dc.date.accessioned","2020-12-10T18:38:05Z"],["dc.date.available","2020-12-10T18:38:05Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1161/JAHA.117.008077"],["dc.identifier.eissn","2047-9980"],["dc.identifier.issn","2047-9980"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77180"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1423"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Felzen, Marc"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Brandes, Ivo"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Knuefermann, Pascal"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Hachenberg, Thomas"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Maisch, Sonja"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Moormann, Tobias"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Weigand, Markus A."],["dc.contributor.author","Laufenberg, Rita"],["dc.contributor.author","Werner, Christian"],["dc.contributor.author","Winterhalter, Michael"],["dc.contributor.author","Treschan, Tanja"],["dc.contributor.author","Stehr, Sebastian N."],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Bein, Berthold"],["dc.date.accessioned","2018-11-07T09:09:36Z"],["dc.date.available","2018-11-07T09:09:36Z"],["dc.date.issued","2012"],["dc.description.abstract","Aims Transient ischaemia of non-vital tissue has been shown to enhance the tolerance of remote organs to cope with a subsequent prolonged ischaemic event in a number of clinical conditions, a phenomenon known as remote ischaemic preconditioning (RIPC). However, there remains uncertainty about the efficacy of RIPC in patients undergoing cardiac surgery. The purpose of this report is to describe the design and methods used in the 'Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart)-Study'. Methods We are conducting a prospective, randomized, double-blind, multicentre, controlled trial including 2070 adult cardiac surgical patients. All types of surgery in which cardiopulmonary bypass is used will be included. Patients will be randomized either to the RIPC group receiving four 5 min cycles of transient upper limb ischaemia/reperfusion or to the control group receiving four cycles of blood pressure cuff inflation/deflation at a dummy arm. The primary endpoint is a composite outcome (all-cause mortality, non-fatal myocardial infarction, any new stroke, and/or acute renal failure) until hospital discharge. Conclusion The RIPHeart-Study is a multicentre trial to determine whether RIPC may improve clinical outcome in cardiac surgical patients."],["dc.description.sponsorship","German Research Foundation [ME 3559/1-1]"],["dc.identifier.isi","000305423000006"],["dc.identifier.pmid","22880214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26297"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0195-668X"],["dc.title","Remote ischaemic preconditioning for heart surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","26"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cardiovascular Disorders"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Westphal, Sabine"],["dc.contributor.author","Stoppe, Christian"],["dc.contributor.author","Gruenewald, Matthias"],["dc.contributor.author","Bein, Berthold"],["dc.contributor.author","Renner, Jochen"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Coburn, Mark"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, Bernd"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Laufenberg-Feldmann, Rita"],["dc.contributor.author","Ferner, Marion"],["dc.contributor.author","Brandes, Ivo F"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Kortgen, Andreas"],["dc.contributor.author","Stehr, Sebastian N"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Baumgarten, Georg"],["dc.contributor.author","Struck, Rafael"],["dc.contributor.author","Meyer-Treschan, Tanja"],["dc.contributor.author","Kienbaum, Peter"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Treskatsch, Sascha"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, Ewa"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Degenhardt, Frauke"],["dc.contributor.author","Franke, Andre"],["dc.contributor.author","Mucha, Soeren"],["dc.contributor.author","Tittmann, Lukas"],["dc.contributor.author","Kohlhaas, Madeline"],["dc.contributor.author","Fuernau, Georg"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Meybohm, Patrick"],["dc.date.accessioned","2019-07-09T11:49:54Z"],["dc.date.available","2019-07-09T11:49:54Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10− 5 from the GWAS. Conclusions We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery. Trial registration The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010."],["dc.identifier.doi","10.1186/s12872-019-1002-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15801"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59651"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","362"],["dc.bibliographiccitation.issue","05"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","366"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Franke, Robert"],["dc.contributor.author","Brandes, Ivo"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Danner, Bernhard"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Bräuer, Anselm"],["dc.date.accessioned","2020-12-10T18:12:15Z"],["dc.date.available","2020-12-10T18:12:15Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0036-1583766"],["dc.identifier.eissn","1439-1902"],["dc.identifier.issn","0171-6425"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74300"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Comparison of Conductive and Convective Warming in Patients Undergoing Video-Assisted Thoracic Surgery: A Prospective Randomized Clinical Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]