Brandes, Ivo Florian

[["dc.bibliographiccitation.artnumber","e2035"],["dc.bibliographiccitation.issue","45"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Ameen, Abu Hanna"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, José Maria"],["dc.date.accessioned","2018-11-07T09:49:09Z"],["dc.date.available","2018-11-07T09:49:09Z"],["dc.date.issued","2015"],["dc.description.abstract","Hyperglycemia is common during and after Coronary Artery Bypass Graft Surgery (CABGS) and has been shown to be associated with poor clinical outcomes. In this study, we hypothesized that a moderate perioperative mean blood glucose level of<150mg/dL improves long-term survival in cardiac surgery patients. We conducted a prospective, observational cohort study in the heart center of the University Medical Center of Goettingen, Germany. Patients undergoing on-pump cardiac surgery were enrolled in this investigation. After evaluating perioperative blood glucose levels, patients were classified into 2 groups based on mean glucose levels: Glucose 150mg/dL and Glucose<150mg/dL. Patients were followed up for 5 years, and mortality within this period was recorded as the primary outcome parameter. Secondary outcome parameters included the length of ICU stay, the use of inotropic agents, the length of hospital stay, and the in-hospital mortality. A total of 455 consecutive patients who underwent cardiac surgery with cardiopulmonary bypass were enrolled in this investigation. A Kaplan-Meier survival analysis of the 5-year mortality risk revealed a higher mortality risk among patients with glucose levels 150mg/dL (P=0.0043, log-rank test). After adjustment for confounders in a multivariate Cox regression model, the association between glucose 150mg/dL and 5-year mortality remained significant (hazard ratio, 2.10; 95% CI, 1.30-3.39; P=0.0023). This association was corroborated by propensity score matching, in which Kaplan-Meier survival analysis demonstrated significant improvement in the 5-year survival of patients with glucose levels<150mg/dL (P=0.0339). Similarly, in-hospital mortality was significantly higher in patients with glucose 150mg/dL compared with patients with glucose<150mg/dL. Moreover, patients in the Glucose 150mg/dL group required significantly higher doses of the inotropic agent Dobutamine (mg/d) compared with patients in the Glucose<150mg/dL group (20.6 +/- 62.3 and 10.5 +/- 40.7, respectively; P=0.0104). Moreover, patients in the Glucose 150mg/dL group showed a significantly longer hospital stay compared with patients in the Glucose<150mg/dL group (28 +/- 23 and 24 +/- 19, respectively; P=0.0297). We conclude that perioperative blood glucose levels<150mg/dL are associated with improved 5-year survival in patients undergoing cardiac surgery. More studies are warranted to explain this effect."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1097/MD.0000000000002035"],["dc.identifier.isi","000369537400066"],["dc.identifier.pmid","26559310"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12570"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35449"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Perioperative Blood Glucose Levels < 150 mg/dL are Associated With Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery A Prospective, Observational Cohort Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","327"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Anaesthesiology"],["dc.bibliographiccitation.lastpage","334"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Schmidt, Johannes"],["dc.contributor.author","Günther, Franziska"],["dc.contributor.author","Weber, Jonas"],["dc.contributor.author","Wirth, Steffen"],["dc.contributor.author","Brandes, Ivo"],["dc.contributor.author","Barnes, Tom"],["dc.contributor.author","Zarbock, Alexander"],["dc.contributor.author","Schumann, Stefan"],["dc.contributor.author","Enk, Dietmar"],["dc.date.accessioned","2020-12-10T18:19:52Z"],["dc.date.available","2020-12-10T18:19:52Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1097/EJA.0000000000000967"],["dc.identifier.issn","0265-0215"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16698"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75408"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Flow-controlled ventilation during ear, nose and throat surgery"],["dc.title.alternative","A prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","55"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Müller, Michaela M."],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Brandes, Ivo F."],["dc.date.accessioned","2019-07-09T11:51:12Z"],["dc.date.available","2019-07-09T11:51:12Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Perioperative hypothermia is still very common and associated with numerous adverse effects. The effects of benzodiazepines, administered as premedication, on thermoregulation have been studied with conflicting results. We investigated the hypotheses that premedication with flunitrazepam would lower the preoperative core temperature and that prewarming could attenuate this effect. Methods After approval by the local research ethics committee 50 adult cardiac surgical patients were included in this prospective, randomized, controlled, single-centre study with two parallel groups in a university hospital setting. Core temperature was measured using a continuous, non-invasive zero-heat flux thermometer from 30 min before administration of the oral premedication until beginning of surgery. An equal number of patients was randomly allocated via a computer-generated list assigning them to either prewarming or control group using the sealed envelope method for blinding. The intervention itself could not be blinded. In the prewarming group patients received active prewarming using an underbody forced-air warming blanket. The data were analysed using Student’s t-test, Mann-Whitney U-test and Fisher’s exact test. Results Of the randomized 25 patients per group 24 patients per group could be analysed. Initial core temperature was 36.7 ± 0.2 °C and dropped significantly after oral premedication to 36.5 ± 0.3 °C when the patients were leaving the ward and to 36.4 ± 0.3 °C before induction of anaesthesia. The patients of the prewarming group had a significantly higher core temperature at the beginning of surgery (35.8 ± 0.4 °C vs. 35.5 ± 0.5 °C, p = 0.027), although core temperature at induction of anaesthesia was comparable. Despite prewarming, core temperature did not reach baseline level prior to premedication (36.7 ± 0.2 °C). Conclusions Oral premedication with benzodiazepines on the ward lowered core temperature significantly at arrival in the operating room. This drop in core temperature cannot be offset by a short period of active prewarming. Trial registration This trial was prospectively registered with the German registry of clinical trials under the trial number DRKS00005790 on 20th February 2014."],["dc.format.extent","7"],["dc.identifier.doi","10.1186/s12871-019-0725-7"],["dc.identifier.pmid","30987594"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59895"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Influence of oral premedication and prewarming on core temperature of cardiac surgical patients: a prospective, randomized, controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","26"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cardiovascular Disorders"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Westphal, Sabine"],["dc.contributor.author","Stoppe, Christian"],["dc.contributor.author","Gruenewald, Matthias"],["dc.contributor.author","Bein, Berthold"],["dc.contributor.author","Renner, Jochen"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Coburn, Mark"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, Bernd"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Laufenberg-Feldmann, Rita"],["dc.contributor.author","Ferner, Marion"],["dc.contributor.author","Brandes, Ivo F"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Kortgen, Andreas"],["dc.contributor.author","Stehr, Sebastian N"],["dc.contributor.author","Wittmann, Maria"],["dc.contributor.author","Baumgarten, Georg"],["dc.contributor.author","Struck, Rafael"],["dc.contributor.author","Meyer-Treschan, Tanja"],["dc.contributor.author","Kienbaum, Peter"],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Sander, Michael"],["dc.contributor.author","Treskatsch, Sascha"],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, Ewa"],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Degenhardt, Frauke"],["dc.contributor.author","Franke, Andre"],["dc.contributor.author","Mucha, Soeren"],["dc.contributor.author","Tittmann, Lukas"],["dc.contributor.author","Kohlhaas, Madeline"],["dc.contributor.author","Fuernau, Georg"],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Meybohm, Patrick"],["dc.date.accessioned","2019-07-09T11:49:54Z"],["dc.date.available","2019-07-09T11:49:54Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10− 5 from the GWAS. Conclusions We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery. Trial registration The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010."],["dc.identifier.doi","10.1186/s12872-019-1002-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15801"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59651"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0528"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Gries, Gereon"],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Brandes, Ivo F."],["dc.date.accessioned","2020-12-10T18:20:04Z"],["dc.date.available","2020-12-10T18:20:04Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/MD.0000000000010528"],["dc.identifier.issn","0025-7974"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75454"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Association between perioperative hypothermia and patient outcomes after thoracic surgery"],["dc.title.alternative","A single center retrospective analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","117"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Jipp, Marc"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Braeuer, Anselm"],["dc.date.accessioned","2018-11-07T08:51:39Z"],["dc.date.available","2018-11-07T08:51:39Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Transcatheter aortic valve implantation via the transapical approach (TAVI-TA) without cardiopulmonary bypass (CPB) is a minimally invasive alternative to open-heart valve replacement. Despite minimal exposure and extensive draping perioperative hypothermia still remains a problem. Methods: In this observational study, we compared the effects of two methods of thermal management on the perioperative course of core temperature. The methods were standard thermal management (STM) with a circulating hot water blanket under the patient, forced-air warming with a lower body blanket and warmed infused fluids, and an intensified thermal management (ITM) with additional prewarming using forced-air in the pre- operative holding area on the awake patient. Results: Nineteen patients received STM and 20 were treated with ITM. On ICU admission, ITM-patients had a higher core temperature (36.4 +/- 0.7 degrees C vs. 35.5 +/- 0.9 degrees C, p = 0.001), required less time to achieve normothermia (median (IQR) in min: 0 (0-15) vs. 150 (0-300), p = 0.003) and a shorter period of ventilatory support (median (IQR) in min: 0 (0-0) vs. 246 (0-451), p = 0.001). Conclusion: ITM during TAVI-TA reduces the incidence of hypothermia and allows for faster recovery with less need of ventilatory support."],["dc.identifier.doi","10.1186/1749-8090-6-117"],["dc.identifier.isi","000296505600001"],["dc.identifier.pmid","21943183"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6990"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21985"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Intensified thermal management for patients undergoing transcatheter aortic valve implantation (TAVI)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Fazliu, Albulena"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Heise, Daniel"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.date.accessioned","2021-04-14T08:26:44Z"],["dc.date.available","2021-04-14T08:26:44Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1038/s41598-020-78753-w"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17818"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82055"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2045-2322"],["dc.relation.orgunit","Klinik für Anästhesiologie"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Accuracy of zero-heat-flux thermometry and bladder temperature measurement in critically ill patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1397"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","New England Journal of Medicine"],["dc.bibliographiccitation.lastpage","1407"],["dc.bibliographiccitation.volume","373"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Bein, B."],["dc.contributor.author","Brosteanu, Oana"],["dc.contributor.author","Cremer, Jochen"],["dc.contributor.author","Gruenewald, M."],["dc.contributor.author","Stoppe, C."],["dc.contributor.author","Coburn, Marc"],["dc.contributor.author","Schaelte, Gereon"],["dc.contributor.author","Boening, Andreas"],["dc.contributor.author","Niemann, B."],["dc.contributor.author","Roesner, Jan"],["dc.contributor.author","Kletzin, Frank"],["dc.contributor.author","Strouhal, Ulrich"],["dc.contributor.author","Reyher, Christian"],["dc.contributor.author","Laufenberg-Feldmann, R."],["dc.contributor.author","Ferner, M."],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Stehr, Sebastian N."],["dc.contributor.author","Kortgen, A."],["dc.contributor.author","Wittmann, M."],["dc.contributor.author","Baumgarten, G."],["dc.contributor.author","Meyer-Treschan, T."],["dc.contributor.author","Kienbaum, P."],["dc.contributor.author","Heringlake, Matthias"],["dc.contributor.author","Schoen, Julika"],["dc.contributor.author","Sander, M."],["dc.contributor.author","Treskatsch, S."],["dc.contributor.author","Smul, Thorsten"],["dc.contributor.author","Wolwender, E."],["dc.contributor.author","Schilling, Thomas"],["dc.contributor.author","Fuernau, G."],["dc.contributor.author","Hasenclever, Dirk"],["dc.contributor.author","Zacharowski, Kai"],["dc.date.accessioned","2018-11-07T09:50:18Z"],["dc.date.available","2018-11-07T09:50:18Z"],["dc.date.issued","2015"],["dc.description.abstract","BACKGROUND Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of ischemic and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains. METHODS We conducted a prospective, double-blind, multicenter, randomized, controlled trial involving adults who were scheduled for elective cardiac surgery requiring cardiopulmonary bypass under total anesthesia with intravenous propofol. The trial compared upper-limb RIPC with a sham intervention. The primary end point was a composite of death, myocardial infarction, stroke, or acute renal failure up to the time of hospital discharge. Secondary end points included the occurrence of any individual component of the primary end point by day 90. RESULTS A total of 1403 patients underwent randomization. The full analysis set comprised 1385 patients (692 in the RIPC group and 693 in the sham-RIPC group). There was no significant between-group difference in the rate of the composite primary end point (99 patients [14.3%] in the RIPC group and 101 [14.6%] in the sham-RIPC group, P = 0.89) or of any of the individual components: death (9 patients [1.3%] and 4 [0.6%], respectively; P = 0.21), myocardial infarction (47 [6.8%] and 63 [9.1%], P = 0.12), stroke (14 [2.0%] and 15 [2.2%], P = 0.79), and acute renal failure (42 [6.1%] and 35 [5.1%], P = 0.45). The results were similar in the per-protocol analysis. No treatment effect was found in any subgroup analysis. No significant differences between the RIPC group and the sham-RIPC group were seen in the level of troponin release, the duration of mechanical ventilation, the length of stay in the intensive care unit or the hospital, new onset of atrial fibrillation, and the incidence of postoperative delirium. No RIPC-related adverse events were observed. CONCLUSIONS Upper-limb RIPC performed while patients were under propofol-induced anesthesia did not show a relevant benefit among patients undergoing elective cardiac surgery."],["dc.identifier.doi","10.1056/NEJMoa1413579"],["dc.identifier.isi","000362372800006"],["dc.identifier.pmid","26436208"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13833"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35685"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Massachusetts Medical Soc"],["dc.relation.issn","1533-4406"],["dc.relation.issn","0028-4793"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]