Sohns, Melanie

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Fehringer, Gord"],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:04:08Z"],["dc.date.available","2018-11-07T09:04:08Z"],["dc.date.issued","2012"],["dc.format.extent","756"],["dc.identifier.isi","000309913200133"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25044"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Stevenson, WA"],["dc.relation.issn","0741-0395"],["dc.title","Application of the Empirical Hierarchical Bayes Approach for Gene-Environment Interaction to TRICL Lung Cancer GWAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Bickeboller, Heike"],["dc.date.accessioned","2018-11-07T09:13:33Z"],["dc.date.available","2018-11-07T09:13:33Z"],["dc.date.issued","2012"],["dc.format.extent","144"],["dc.identifier.isi","000302244900100"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27207"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","20th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Heidelberg, GERMANY"],["dc.relation.issn","0741-0395"],["dc.title","Impact of Population Stratification on Gene-Environment Interaction Analysis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:04:07Z"],["dc.date.available","2018-11-07T09:04:07Z"],["dc.date.issued","2012"],["dc.format.extent","730"],["dc.identifier.isi","000309913200041"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25043"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Stevenson, WA"],["dc.relation.issn","0741-0395"],["dc.title","Principal Component Analysis Corrects for Population Stratification in Studies of Gene-Environment Interactions"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","551"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","559"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Fehringer, Gord"],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Müller-Nurasyid, Martina"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Lewinger, Juan Pablo"],["dc.contributor.author","Thomas, Duncan C."],["dc.contributor.author","Bickeböller, Heike"],["dc.date.accessioned","2018-11-07T09:20:57Z"],["dc.date.available","2018-11-07T09:20:57Z"],["dc.date.issued","2013"],["dc.description.abstract","The analysis of gene-environment (G x E) interactions remains one of the greatest challenges in the postgenome-wide association studies (GWASs) era. Recent methods constitute a compromise between the robust but underpowered case-control and powerful case-only methods. Inferences of the latter are biased when the assumption of gene-environment (G-E) independence in controls fails. We propose a novel empirical hierarchical Bayes approach to G x E interaction (EHB-GE), which benefits from greater rank power while accounting for population-based G-E correlation. Building on Lewinger et al.'s ([2007] Genet Epidemiol 31:871-882) hierarchical Bayes prioritization approach, the method first obtains posterior G-E correlation estimates in controls for each marker, borrowing strength from G-E information across the genome. These posterior estimates are then subtracted from the corresponding case-only G x E estimates. We compared EHB-GE with rival methods using simulation. EHB-GE has similar or greater rank power to detect G x E interactions in the presence of large numbers of G-E correlations with weak to strong effects or only a low number of such correlations with large effect. When there are no or only a few weak G-E correlations, Murcray et al.'s method ([2009] Am J Epidemiol 169:219-226) identifies markers with low G x E interaction effects better. We applied EHB-GE and competing methods to four lung cancer case-control GWAS from the Interdisciplinary Research in Cancer of the Lung/International Lung Cancer Consortium with smoking as environmental factor. A number of genes worth investigating were identified by the EHB-GE approach."],["dc.description.sponsorship","NIH [TRICL 5U19CA148127-03]; DFG GRK [1034]"],["dc.identifier.doi","10.1002/gepi.21741"],["dc.identifier.isi","000322911100003"],["dc.identifier.pmid","23893921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28998"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0741-0395"],["dc.title","Empirical Hierarchical Bayes Approach to Gene-Environment Interactions: Development and Application to Genome-Wide Association Studies of Lung Cancer in TRICL"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","695"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","704"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Knöll, Ralph"],["dc.contributor.author","Kostin, Sawa"],["dc.contributor.author","Klede, Stefanie"],["dc.contributor.author","Savvatis, Kostas"],["dc.contributor.author","Klinge, Lars"],["dc.contributor.author","Stehle, Ina"],["dc.contributor.author","Gunkel, Sylvia"],["dc.contributor.author","Kötter, Sebastian"],["dc.contributor.author","Babicz, Kamila"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Miocic, Snjezana"],["dc.contributor.author","Didie, Michael"],["dc.contributor.author","Knöll, Gudrun"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","Schaper, Wolfgang"],["dc.contributor.author","Schaper, Jutta"],["dc.contributor.author","Kraft, Theresia"],["dc.contributor.author","Tschöpe, Carsten"],["dc.contributor.author","Linke, Wolfgang A."],["dc.contributor.author","Chien, Kenneth R."],["dc.date.accessioned","2017-09-07T11:46:07Z"],["dc.date.available","2017-09-07T11:46:07Z"],["dc.date.issued","2010"],["dc.description.abstract","Rationale: We previously discovered the human 10T -> C (Trp4Arg) missense mutation in exon 2 of the muscle LIM protein (MLP, CSRP3) gene. Objective: We sought to study the effects of this single-nucleotide polymorphism in the in vivo situation. Methods and Results: We now report the generation and detailed analysis of the corresponding Mlp(W4R/+) and Mlp(W4R/W4R) knock-in animals, which develop an age-and gene dosage-dependent hypertrophic cardiomyopathy and heart failure phenotype, characterized by almost complete loss of contractile reserve under catecholamine induced stress. In addition, evidence for skeletal muscle pathology, which might have implications for human mutation carriers, was observed. Importantly, we found significantly reduced MLP mRNA and MLP protein expression levels in hearts of heterozygous and homozygous W4R-MLP knock-in animals. We also detected a weaker in vitro interaction of telethonin with W4R-MLP than with wild-type MLP. These alterations may contribute to an increased nuclear localization of W4R-MLP, which was observed by immunohistochemistry. Conclusions: Given the well-known high frequency of this mutation in Caucasians of up to 1%, our data suggest that W4R-MLP might contribute significantly to human cardiovascular disease. (Circ Res. 2010; 106: 695-704.)"],["dc.identifier.doi","10.1161/CIRCRESAHA.109.206243"],["dc.identifier.gro","3142953"],["dc.identifier.isi","000275190500010"],["dc.identifier.pmid","20044516"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/414"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0009-7330"],["dc.title","A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","137"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Dermatology"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","212"],["dc.contributor.author","Sohn, S."],["dc.contributor.author","Schoeffski, O."],["dc.contributor.author","Prinz, J."],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Schubert, E."],["dc.contributor.author","Waldorf, K."],["dc.contributor.author","Augustin, M."],["dc.date.accessioned","2018-11-07T10:33:16Z"],["dc.date.available","2018-11-07T10:33:16Z"],["dc.date.issued","2006"],["dc.description.abstract","Background: There is little information concerning the costs of psoriasis and patients' quality of life (QoL) in Germany. Objective: To obtain data on the annual costs and QoL ( to follow in a further publication) of patients with moderate to severe plaque psoriasis. Methods: Between October 2003 and February 2004, six office-based dermatologists and eight dermatology outpatient departments retrospectively documented cost-of-illness data from a societal cost perspective in 184 patients over a 12-month period. Patients were stratified into three subgroups according to their treatment scheme. Results: Mean total costs amounted to Euro 6,709 per patient and year. The mean PASI score was 18.2 and PBSA 28.9%. Annual costs were highest with Euro 8,831 in high-need patients. They also showed the highest PASI score (22.2). Conclusion: Moderate to severe plaque psoriasis is associated with tremendous costs, particularly in patients not adequately controlled by conventional therapies, while the outcomes of patients were unsatisfactory."],["dc.identifier.doi","10.1159/000090654"],["dc.identifier.isi","000235383600009"],["dc.identifier.pmid","16484820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44568"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-8665"],["dc.title","Cost of moderate to severe plaque psoriasis in Germany: A Multicenter cost-of-illness study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","920"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","921"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Lewinger, Juan Pablo"],["dc.contributor.author","Bickeboller, Heike"],["dc.contributor.author","Thomas, Duncan C."],["dc.date.accessioned","2018-11-07T08:35:53Z"],["dc.date.available","2018-11-07T08:35:53Z"],["dc.date.issued","2010"],["dc.identifier.isi","000284719100027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18183"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.conference","19th Annual Meeting of the International-Genetic-Epidemiology-Society"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","0741-0395"],["dc.title","An Efficient Test of Gene-Environment Interaction for Genomewide Association Studies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]