Möbius, Wiebke

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Moore, Sharlen"],["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Trevisiol, Andrea"],["dc.contributor.author","Tzvetanova, Iva D."],["dc.contributor.author","Battefeld, Arne"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Kole, Maarten H. P."],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","de Hoz, Livia"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2021-04-14T08:31:48Z"],["dc.date.available","2021-04-14T08:31:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41467-020-19152-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83719"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2041-1723"],["dc.title","A role of oligodendrocytes in information processing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Djannatian, Minou"],["dc.contributor.author","Weikert, Ulrich"],["dc.contributor.author","Safaiyan, Shima"],["dc.contributor.author","Wrede, Christoph"],["dc.contributor.author","Deichsel, Cassandra"],["dc.contributor.author","Kislinger, Georg"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Campbell, Douglas S."],["dc.contributor.author","van Ham, Tjakko"],["dc.contributor.author","Schmid, Bettina"],["dc.contributor.author","Hegermann, Jan"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Schifferer, Martina"],["dc.contributor.author","Simons, Mikael"],["dc.date.accessioned","2022-08-19T08:17:44Z"],["dc.date.available","2022-08-19T08:17:44Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2021.02.02.429485"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113031"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/14"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | B01: The role of inflammatory cytokine signaling for efficient remyelination in multiple sclerosis"],["dc.relation.workinggroup","RG Schifferer"],["dc.relation.workinggroup","RG Simons (The Biology of Glia in Development and Disease)"],["dc.title","Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Berghoff, Stefan A."],["dc.contributor.author","Spieth, Lena"],["dc.contributor.author","Sun, Ting"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Schlaphoff, Lennart"],["dc.contributor.author","Depp, Constanze"],["dc.contributor.author","Düking, Tim"],["dc.contributor.author","Winchenbach, Jan"],["dc.contributor.author","Neuber, Jonathan"],["dc.contributor.author","Ewers, David"],["dc.contributor.author","Scholz, Patricia"],["dc.contributor.author","van der Meer, Franziska"],["dc.contributor.author","Cantuti-Castelvetri, Ludovico"],["dc.contributor.author","Sasmita, Andrew O."],["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Sankowski, Roman"],["dc.contributor.author","Prinz, Marco"],["dc.contributor.author","Huitinga, Inge"],["dc.contributor.author","Sereda, Michael W."],["dc.contributor.author","Odoardi, Francesca"],["dc.contributor.author","Ischebeck, Till"],["dc.contributor.author","Simons, Mikael"],["dc.contributor.author","Stadelmann-Nessler, Christine"],["dc.contributor.author","Edgar, Julia M."],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Saher, Gesine"],["dc.date.accessioned","2021-04-14T08:27:05Z"],["dc.date.available","2021-04-14T08:27:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41593-020-00757-6"],["dc.identifier.pmid","33349711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82162"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/11"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | A04: The role of the meninges in the resolution of acute autoimmune CNS lesions"],["dc.relation.eissn","1546-1726"],["dc.relation.issn","1097-6256"],["dc.relation.workinggroup","RG Cantuti"],["dc.relation.workinggroup","RG Nave (Neurogenetics)"],["dc.relation.workinggroup","RG Odoardi (Echtzeitdarstellung neuroimmunologischer Prozesse)"],["dc.relation.workinggroup","RG Simons (The Biology of Glia in Development and Disease)"],["dc.relation.workinggroup","RG Stadelmann-Nessler"],["dc.title","Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6586"],["dc.bibliographiccitation.issue","29"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","6596"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Weil, Marie-Theres"],["dc.contributor.author","Heibeck, Saskia"],["dc.contributor.author","Töpperwien, Mareike"],["dc.contributor.author","tom Dieck, Susanne"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Rodicio, María C."],["dc.contributor.author","Morgan, Jennifer R."],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Werner, Hauke B."],["dc.date.accessioned","2020-12-10T18:42:35Z"],["dc.date.available","2020-12-10T18:42:35Z"],["dc.date.issued","2018"],["dc.description.abstract","In the nervous system, myelination of axons enables rapid impulse conduction and is a specialized function of glial cells. Myelinating glia are the last cell type to emerge in the evolution of vertebrate nervous systems, presumably in ancient jawed vertebrates (gnathostomata) because jawless vertebrates (agnathans) lack myelin. We have hypothesized that, in these unmyelinated species, evolutionary progenitors of myelinating cells must have existed that should still be present in contemporary agnathan species. Here, we used advanced electron microscopic techniques to reveal axon-glia interactions in the sea lamprey Petromyzon marinus By quantitative assessment of the spinal cord and the peripheral lateral line nerve, we observed a marked maturation-dependent growth of axonal calibers. In peripheral nerves, all axons are ensheathed by glial cells either in bundles or, when larger than the threshold caliber of 3 μm, individually. The ensheathing glia are covered by a basal lamina and express SoxE-transcription factors, features of mammalian Remak-type Schwann cells. In larval lamprey, the ensheathment of peripheral axons leaves gaps that are closed in adults. CNS axons are also covered to a considerable extent by glial processes, which contain a high density of intermediate filaments, glycogen particles, large lipid droplets, and desmosomes, similar to mammalian astrocytes. Indeed, by in situ hybridization, these glial cells express the astrocyte marker Aldh1l1 Specimens were of unknown sex. Our observations imply that radial sorting, ensheathment, and presumably also metabolic support of axons are ancient functions of glial cells that predate the evolutionary emergence of myelin in jawed vertebrates.SIGNIFICANCE STATEMENT We used current electron microscopy techniques to examine axon-glia units in a nonmyelinated vertebrate species, the sea lamprey. In the PNS, lamprey axons are fully ensheathed either individually or in bundles by cells ortholog to Schwann cells. In the CNS, axons associate with astrocyte orthologs, which contain glycogen and lipid droplets. We suggest that ensheathment, radial sorting, and metabolic support of axons by glial cells predate the evolutionary emergence of myelin in ancient jawed vertebrates."],["dc.identifier.doi","10.1523/JNEUROSCI.1034-18.2018"],["dc.identifier.eissn","1529-2401"],["dc.identifier.issn","0270-6474"],["dc.identifier.pmid","29941446"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78012"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","biomedical tomography"],["dc.title","Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","355"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Structural Biology"],["dc.bibliographiccitation.lastpage","360"],["dc.bibliographiccitation.volume","184"],["dc.contributor.author","Schertel, Andreas"],["dc.contributor.author","Snaidero, Nicolas"],["dc.contributor.author","Han, Hong-Mei"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Laue, Michael"],["dc.contributor.author","Grabenbauer, Markus"],["dc.contributor.author","Möbius, Wiebke"],["dc.date.accessioned","2022-03-01T11:45:15Z"],["dc.date.available","2022-03-01T11:45:15Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1016/j.jsb.2013.09.024"],["dc.identifier.pii","S1047847713002657"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103266"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1047-8477"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Cryo FIB-SEM: Volume imaging of cellular ultrastructure in native frozen specimens"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","Steyer, Anna M."],["dc.contributor.author","Weil, Marie-Theres"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Piepkorn, Lars"],["dc.contributor.author","Agüi-Gonzalez, Paola"],["dc.contributor.author","Ngoc Phan, Nhu Thi"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Sadowski, Boguslawa"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.contributor.author","Werner, Hauke B."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Möbius, Wiebke"],["dc.date.accessioned","2022-02-23T16:35:22Z"],["dc.date.available","2022-02-23T16:35:22Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.09.02.279612"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100374"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/443"],["dc.identifier.url","https://for2848.gwdguser.de/literature/publications/4"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","FOR 2848: Architektur und Heterogenität der inneren mitochondrialen Membran auf der Nanoskala"],["dc.relation","FOR 2848 | P08: Strukturelle und funktionale Veränderungen der inneren mitochondrialen Membran axonaler Mitochondrien in vivo in einem dymyelinisierenden Mausmodell"],["dc.relation.workinggroup","RG Möbius"],["dc.title","White matter integrity requires continuous myelin synthesis at the inner tongue"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.volume","12242"],["dc.contributor.author","Reichmann, Jakob"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.editor","Müller, Bert"],["dc.contributor.editor","Wang, Ge"],["dc.date.accessioned","2022-12-07T11:46:36Z"],["dc.date.available","2022-12-07T11:46:36Z"],["dc.date.issued","2022-10-14"],["dc.identifier.doi","10.1117/12.2627682"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118460"],["dc.language.iso","en"],["dc.publisher.place","Proc. SPIE 12242"],["dc.relation","SFB 1456 | Cluster A | A03: Dimensionality reduction and regression in Wasserstein space for quantitative 3D histology"],["dc.relation","SFB 1456: Mathematik des Experiments: Die Herausforderung indirekter Messungen in den Naturwissenschaften"],["dc.relation.conference","SPIE Optical Engineering + Applications, Developments in X-Ray Tomography XIV"],["dc.relation.eventend","2022-08-26"],["dc.relation.eventlocation","San Diego"],["dc.relation.eventstart","2022-08-21"],["dc.relation.isbn","9781510654686"],["dc.relation.isbn","9781510654693"],["dc.relation.ispartof","Proceeding of SPIE"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.title","Neodymium acetate as a contrast agent for x-ray phase-contrast tomography"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e20336"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Mersmann, Nadine"],["dc.contributor.author","Tkachev, Dmitri"],["dc.contributor.author","Jelinek, Ruth"],["dc.contributor.author","Röth, Philipp Thomas"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Rühle, Sabine"],["dc.contributor.author","Weber-Fahr, Wolfgang"],["dc.contributor.author","Sartorius, Alexander"],["dc.contributor.author","Klugmann, Matthias"],["dc.contributor.editor","Cooney, Austin John"],["dc.date.accessioned","2022-03-01T11:44:10Z"],["dc.date.available","2022-03-01T11:44:10Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1371/journal.pone.0020336"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102948"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1932-6203"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1130"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Nature Medicine"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Saher, Gesine"],["dc.contributor.author","Rudolphi, Fabian"],["dc.contributor.author","Corthals, Kristina"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Schmidt, Karl-Friedrich"],["dc.contributor.author","Loewel, Siegrid"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Barrette, Benoit"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2018-11-07T09:08:43Z"],["dc.date.available","2018-11-07T09:08:43Z"],["dc.date.issued","2012"],["dc.description.abstract","Duplication of PLP1 (proteolipid protein gene 1) and the subsequent overexpression of the myelin protein PLP (also known as DM20) in oligodendrocytes is the most frequent cause of Pelizaeus-Merzbacher disease (PMD), a fatal leukodystrophy(1) without therapeutic options(2,3). PLP binds cholesterol and is contained within membrane lipid raft microdomains(4). Cholesterol availability is the rate-limiting factor of central nervous system myelin synthesis(5). Transgenic mice with extra copies of the Plp1 gene(6) are accurate models of PMD. Dysmyelination(6-8) followed by demyelination(9,10), secondary inflammation and axon damage contribute to the severe motor impairment in these mice(9,10). The finding that in Plp1-transgenic oligodendrocytes, PLP and cholesterol accumulate in late endosomes and lysosomes (endo/lysosomes)(9,11-13), prompted us to further investigate the role of cholesterol in PMD. Here we show that cholesterol itself promotes normal PLP trafficking and that dietary cholesterol influences PMD pathology. In a preclinical trial, PMD mice were fed a cholesterol-enriched diet. This restored oligodendrocyte numbers and ameliorated intracellular PLP accumulation. Moreover, myelin content increased, inflammation and gliosis were reduced and motor defects improved. Even after onset of clinical symptoms, cholesterol treatment prevented disease progression. Dietary cholesterol did not reduce Plp1 overexpression but facilitated incorporation of PLP into myelin membranes. These findings may have implications for therapeutic interventions in patients with PMD."],["dc.identifier.doi","10.1038/nm.2833"],["dc.identifier.isi","000306121600044"],["dc.identifier.pmid","22706386"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26092"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1078-8956"],["dc.title","Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","111130N"],["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Eckermann, Marina"],["dc.contributor.author","Töpperwien, Mareike"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.editor","Müller-Myhsok, Bertram"],["dc.contributor.editor","Wang, Geng"],["dc.date.accessioned","2020-03-10T15:20:27Z"],["dc.date.available","2020-03-10T15:20:27Z"],["dc.date.issued","2019"],["dc.description.abstract","In the present work, we evaluate and compare the contrast and resolution obtained on different neuronal tissues with propagation-based x-ray phase contrast computed tomography (PB-CT). At our laboratory-based liquid metal-jet setup, we obtain overview datasets at sub-micron resolution of mm3 -sized volumes. In order to evaluate these parameters down to the sub-cellular level, we utilize the synchrotron endstation GINIX at P10, DESY. At this dedicated endstation1 developed and operated by our group, we utilize x-ray waveguide optics for highresolution cone-beam scans at strong geometrical magnification M. Exploiting this multi-scale approach, we investigate the image quality of cerebellum tissue treated by different heavy-metal stains. In addition, we study the electron density contrast in unstained tissues. Different embedding media are utilized depending on the stain, which also significantly affects contrast and image quality. With this work, we want to contribute to an optimized sample preparation to study the neuronal architecture of the brain tissue in greater detail in three dimensions (3d). © (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only."],["dc.identifier.doi","10.1117/12.2528432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63286"],["dc.language.iso","en"],["dc.relation.eventend","2019-08-15"],["dc.relation.eventlocation","San Diego, California, United States"],["dc.relation.eventstart","2019-08-11"],["dc.relation.isbn","978-1-5106-2919-6"],["dc.relation.isbn","978-1-5106-2920-2"],["dc.relation.ispartof","Proc. SPIE 11113"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","biomedical tomography"],["dc.title","Evaluation of different heavy-metal stains and embedding media for phase contrast tomography of neuronal tissue"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]