Zapf, Antonia

[["dc.bibliographiccitation.artnumber","84"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Koerner, Sonja"],["dc.contributor.author","Kollewe, Katja"],["dc.contributor.author","Abdulla, Susanne"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Dengler, Reinhard"],["dc.contributor.author","Petri, Susanne"],["dc.date.accessioned","2018-11-07T09:57:12Z"],["dc.date.available","2018-11-07T09:57:12Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identify factors which are associated with reduced QoL and increased depression. Methods: 159 ALS patients answered standardized questionnaires (Beck Depression Inventory-II, SF-36 Health Survey questionnaire, revised ALS functional rating scale). Multiple regression analysis was used to identify correlations between clinical features of ALS patients and depression/QoL scores. In addition, QoL data from ALS patients were compared to age-matched reference values representing the German normal population. Results: QoL of ALS patients was reduced in nearly all SF-36-categories. Progression of physical impairment was positively correlated with depression but reduced QoL scores only in items directly related to physical function. However, QoL was considerably influenced by depression, independently from physical impairment. Regarding distinct patient characteristics one of the most interesting findings was that increasing age was correlated with significantly worse QoL results regarding social functioning. Conclusions: Depressive symptoms had a strong influence on QoL, hence their detection and treatment is of particular importance. Different domains of QoL are differently affected in subgroups of ALS patients. Being aware of these differences can be valuable for both ALS professional and family caregivers and physicians."],["dc.identifier.doi","10.1186/s12883-015-0340-2"],["dc.identifier.isi","000354920600001"],["dc.identifier.pmid","25982050"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12315"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37109"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Interaction of physical function, quality of life and depression in Amyotrophic lateral sclerosis: characterization of a large patient cohort"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","84"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Koerner, Sonja"],["dc.contributor.author","Hendricks, Melanie"],["dc.contributor.author","Kollewe, Katja"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Dengler, Reinhard"],["dc.contributor.author","Silani, Vincenzo"],["dc.contributor.author","Petri, Susanne"],["dc.date.accessioned","2018-11-07T09:22:24Z"],["dc.date.available","2018-11-07T09:22:24Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Weight loss is a frequent feature in the motor neuron disease Amyotrophic lateral sclerosis (ALS). In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) and the benefit of high calorie nutritional/other dietary supplements and percutaneous endoscopic gastrostomy (PEG). Methods: 121 ALS patients were interviewed and answered standardized questionnaires (Beck depression inventory - II, SF36 Health Survey questionnaire, revised ALS functional rating scale). Two years after the initial survey we performed a follow-up interview. Results: In our ALS-cohort, 56.3% of the patients suffered from weight loss. Weight loss had a negative impact on QOL and was associated with a shorter survival. Patients who took high calorie nutritional supplements respectively had a PEG stated a great benefit regarding weight stabilization and/or QOL. 38.2% of our patients had significant weight loss without suffering from dysphagia. To clarify the reasons for weight loss in these patients, we compared them with patients without weight loss. The two groups did not differ regarding severity of disease, depression, frontotemporal dementia or fasciculations, but patients with weight loss declared more often increased respiratory work. Conclusions: Weight loss is a serious issue in ALS and cannot always be attributed to dysphagia. Symptomatic treatment of weight loss (high calorie nutritional supplements and/or PEG) should be offered more frequently."],["dc.identifier.doi","10.1186/1471-2377-13-84"],["dc.identifier.isi","000321957300001"],["dc.identifier.pmid","23848967"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29338"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]