Reinhardt, Manuel

[["dc.bibliographiccitation.firstpage","237"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Geobiology"],["dc.bibliographiccitation.lastpage","251"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Blumenberg, Martin"],["dc.contributor.author","Ostertag-Henning, Christian"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Heim, Christine N."],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2019-07-22T14:14:22Z"],["dc.date.available","2019-07-22T14:14:22Z"],["dc.date.issued","2018"],["dc.description.abstract","Fossil derivatives of isorenieratene, an accessory pigment in brown-colored green sulfur bacteria, are often used as tracers for photic zone anoxia through Earth's history, but their diagenetic behavior is still incompletely understood. Here, we assess the preservation of isorenieratene derivatives in organic-rich shales (1.5-8.4 wt.% TOC) from two Lower Jurassic anoxic systems (Bächental oil shale, Tyrol, Austria; Posidonia Shale, Baden-Württemberg, Germany). Bitumens and kerogens were investigated using catalytic hydropyrolysis (HyPy), closed-system hydrous pyrolysis (in gold capsules), gas chromatography-mass spectrometry (GC-MS) and gas chromatography combustion isotope ratio-mass spectrometry (GC-C-IRMS). Petrography and biomarkers indicate a syngenetic relationship between bitumens and kerogens. All bitumens contain abundant isorenieratane, diverse complex aromatized isorenieratene derivatives, and a pseudohomologous series of 2,3,6-trimethyl aryl isoprenoids. In contrast, HyPy and mild closed-system hydrous pyrolysis of the kerogens yielded only minor amounts of these compounds. Given the overall low maturity of the organic matter (below oil window), it appears that isorenieratene and its abundant derivatives from the bitumen had not been incorporated into the kerogens. Accordingly, sulfur cross-linking, the key mechanism for sequestration of functionalized lipids into kerogens in anoxic systems, was not effective in the Jurassic environments studied. We explain this by (i) early cyclization/aromatization and (ii) hydrogenation reactions that have prevented effective sulfurization. In addition, (iii) sulfide was locally removed via anoxygenic photosynthesis and efficiently trapped by the reaction with sedimentary iron, as further indicated by elevated iron contents (4.0-8.7 wt.%) and the presence of abundant pyrite aggregates in the rock matrix. Although the combined processes have hampered the kerogen incorporation of isorenieratene and its derivatives, they may have promoted the long-term preservation of these biomarkers in the bitumen fraction via early defunctionalization. This particular taphonomy of aromatic carotenoids has to be considered in studies of anoxic iron-rich environments (e.g., the Proterozoic ocean)."],["dc.identifier.doi","10.1111/gbi.12284"],["dc.identifier.pmid","29569335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61823"],["dc.language.iso","en"],["dc.relation.eissn","1472-4669"],["dc.relation.issn","1472-4677"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","The taphonomic fate of isorenieratene in Lower Jurassic shales-controlled by iron?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S149"],["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.lastpage","S150"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Ladewig, G."],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Bendzsus, M."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Wiendl, Heinz"],["dc.contributor.author","Maurer, M."],["dc.date.accessioned","2018-11-07T10:56:28Z"],["dc.date.available","2018-11-07T10:56:28Z"],["dc.date.issued","2005"],["dc.identifier.isi","000232249900544"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50017"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hodder Arnold, Hodder Headline Plc"],["dc.publisher.place","London"],["dc.relation.conference","21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS"],["dc.relation.eventlocation","Thessaloniki, GREECE"],["dc.relation.issn","1352-4585"],["dc.title","Molecular imaging and quantification of adhesion molecules in living animals with experimental autoimmune encephalomyelitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Paläontologische Zeitschrift"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","König, Hannah"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Shuvalova, Julia"],["dc.contributor.author","Parkhaev, Pavel"],["dc.date.accessioned","2021-12-09T08:18:59Z"],["dc.date.available","2021-12-09T08:18:59Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s12542-021-00593-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96607"],["dc.language.iso","en"],["dc.relation.issn","0031-0220"],["dc.relation.issn","1867-6812"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.rights","CC BY 4.0"],["dc.title","Molecular fossils within bitumens and kerogens from the ~ 1 Ga Lakhanda Lagerstätte (Siberia, Russia) and their significance for understanding early eukaryote evolution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Goetz, Walter"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Heim, Christine"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2019-11-12T13:13:18Z"],["dc.date.available","2019-11-12T13:13:18Z"],["dc.date.issued","2019"],["dc.description.abstract","Lake Magadi cherts, analogs for Archean hydrothermal deposits, reveal archeal biomarkers in their kerogens despite deposition in an overall destructive hydrothermal environment."],["dc.identifier.doi","10.3997/2214-4609.201902897"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62601"],["dc.language.iso","en"],["dc.relation.conference","29th International Meeting on Organic Geochemistry (IMOG)"],["dc.relation.eventend","2019-09-06"],["dc.relation.eventlocation","Gothenburg, Sweden"],["dc.relation.eventstart","2019-09-01"],["dc.relation.isbn","978-94-6282-304-4"],["dc.relation.ispartof","29th International Meeting on Organic Geochemistry"],["dc.relation.issn","2214-4609"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","Characterizing Bitumens and Kerogens from Lake Magadi Cherts, Pleistocene Analogs for Archean Hydrothermal Deposits"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Immunology"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Bendszus, M."],["dc.contributor.author","Ladewig, G."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Maurer, M."],["dc.date.accessioned","2018-11-07T08:36:10Z"],["dc.date.available","2018-11-07T08:36:10Z"],["dc.date.issued","2005"],["dc.format.extent","S40"],["dc.identifier.isi","000229104400107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.publisher.place","San diego"],["dc.relation.conference","5th Annual Meeting of the Federation-of-Clinical-Immunology-Society"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1521-6616"],["dc.title","Molecular imaging of adhesion molecules in experimental autoimmune encephalomyelitis (EAE)."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","267"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","278"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Briel, A."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Rieckmann, Peter"],["dc.contributor.author","Becker, G."],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Maurer, M."],["dc.contributor.author","Schirner, M."],["dc.date.accessioned","2018-11-07T10:56:48Z"],["dc.date.available","2018-11-07T10:56:48Z"],["dc.date.issued","2005"],["dc.description.abstract","Molecular imaging requires, not only the identification of an appropriate marker, but also its quantitative analysis. We used the Sensitive Particle Acoustic Quantification (SPAQ) technology - a novel ultrasound technique - for detection and quantification of cell adhesion molecules in isolated tissue and in live animals. By conjugating gasfilled microparticles (MPs) with antibodies to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), we were able to depict and quantify ICAM-1 and VCAM-I in isolated brain and spinal cord from rats with autoimmune encephalomyelitis (EAE), an established inflammatory disease model of human multiple sclerosis (MS). Depiction and quantification of specific MPs were also feasible in living animals with AT-EAE with similar results. After treatment with methylprednisolone, the measured number of targeted anti-ICAM-1 and VCAM-1-MPs was significantly lower (P < 0.01) compared to untreated animals demonstrating the high sensitivity of this imaging technique. Depending on the antibody linked to the surface of the MPs, the technique can be used to quantify the expression of any accessible antigen expressed on the luminal surface of endothelial cells and is therefore a promising tool for the noninvasive and dynamic assessment of disease-related molecules. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2005.04.019"],["dc.identifier.isi","000231154900002"],["dc.identifier.pmid","15905104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50101"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Communications Earth & Environment"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Drake, Henrik"],["dc.contributor.author","Roberts, Nick M. W."],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Whitehouse, Martin"],["dc.contributor.author","Ivarsson, Magnus"],["dc.contributor.author","Karlsson, Andreas"],["dc.contributor.author","Kooijman, Ellen"],["dc.contributor.author","Kielman-Schmitt, Melanie"],["dc.date.accessioned","2021-12-03T16:48:14Z"],["dc.date.available","2021-12-03T16:48:14Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1038/s43247-021-00170-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95235"],["dc.relation.issn","2662-4435"],["dc.title","Biosignatures of ancient microbial life are present across the igneous crust of the Fennoscandian shield"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","415"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Astrobiology"],["dc.bibliographiccitation.lastpage","428"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Goetz, Walter"],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2020-12-10T18:16:01Z"],["dc.date.available","2020-12-10T18:16:01Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1089/ast.2019.2143"],["dc.identifier.eissn","1557-8070"],["dc.identifier.issn","1531-1074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75029"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","Testing Flight-like Pyrolysis Gas Chromatography–Mass Spectrometry as Performed by the Mars Organic Molecule Analyzer Onboard the ExoMars 2020 Rover on Oxia Planum Analog Samples"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2443"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Biogeosciences"],["dc.bibliographiccitation.lastpage","2465"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Goetz, Walter"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Heim, Christine"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2019-07-22T13:48:30Z"],["dc.date.available","2019-07-22T13:48:30Z"],["dc.date.issued","2019"],["dc.description.abstract","Organic matter in Archean hydrothermal cherts may provide an important archive for molecular traces of the earliest life on Earth. The geobiological interpretation of this archive, however, requires a sound understanding of organic matter preservation and alteration in hydrothermal systems. Here we report on organic matter (including molecular biosignatures) enclosed in hydrothermally influenced cherts of the Pleistocene Lake Magadi (Kenya; High Magadi Beds and Green Beds). The Magadi cherts contain low organic carbon (< 0.4 wt %) that occurs in the form of finely dispersed clots, layers, or encapsulated within microscopic carbonate rhombs. Both extractable (bitumen) and non-extractable organic matter (kerogen) were analyzed. The bitumens contain immature “biolipids” like glycerol mono- and diethers (e.g., archaeol and extended archaeol), fatty acids, and alcohols indicative for, inter alia, thermophilic cyanobacteria, sulfate reducers, and haloarchaea. However, co-occurring “geolipids” such as n-alkanes, hopanes, and polycyclic aromatic hydrocarbons (PAHs) indicate that a fraction of the bitumen has been thermally altered to early or peak oil window maturity. This more mature fraction likely originated from defunctionalization of dissolved organic matter and/or hydrothermal petroleum formation at places of higher thermal flux. Like the bitumens, the kerogens also show variations in thermal maturities, which can partly be explained by admixture of thermally pre-altered macromolecules. However, findings of archaea-derived isoprenoid moieties (C20 and C25 chains) in kerogen pyrolysates indicate rapid sequestration of some archaeal lipids into kerogen while hydrothermal alteration was active. We posit that such early sequestration may enhance the resistance of molecular biosignatures against in situ hydrothermal and post-depositional alteration. Furthermore, the co-occurrence of organic matter with different thermal maturities in the Lake Magadi cherts suggests that similar findings in Archean hydrothermal deposits could partly reflect original environmental conditions and not exclusively post-depositional overprint or contamination. Our results support the view that kerogen in Archean hydrothermal cherts may contain important information on early life. Our study also highlights the suitability of Lake Magadi as an analog system for hydrothermal chert environments on the Archean Earth."],["dc.identifier.doi","10.5194/bg-16-2443-2019"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61810"],["dc.language.iso","en"],["dc.relation.issn","1726-4189"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","Organic signatures in Pleistocene cherts from Lake Magadi (Kenya) – implications for early Earth hydrothermal deposits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]