Reinhardt, Manuel

[["dc.bibliographiccitation.firstpage","1535"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biogeosciences"],["dc.bibliographiccitation.lastpage","1548"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Thiel, Volker"],["dc.contributor.author","Bauersachs, Thorsten"],["dc.contributor.author","Mißbach, Helge"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Schäfer, Nadine"],["dc.contributor.author","Van Kranendonk, Martin J."],["dc.contributor.author","Reitner, Joachim"],["dc.date.accessioned","2019-07-09T11:45:21Z"],["dc.date.available","2019-07-09T11:45:21Z"],["dc.date.issued","2018"],["dc.description.abstract","Archaean hydrothermal chert veins commonly contain abundant organic carbon of uncertain origin (abiotic vs. biotic). In this study, we analysed kerogen contained in a hydrothermal chert vein from the ca. 3.5 Ga Dresser Formation (Pilbara Craton, Western Australia). Catalytic hydropyrolysis (HyPy) of this kerogen yielded n-alkanes up to n-C22, with a sharp decrease in abundance beyond n-C18. This distribution ( n-C18) is very similar to that observed in HyPy products of recent bacterial biomass, which was used as reference material, whereas it differs markedly from the unimodal distribution of abiotic compounds experimentally formed via Fischer–Tropsch-type synthesis. We therefore propose that the organic matter in the Archaean chert veins has a primarily microbial origin. The microbially derived organic matter accumulated in anoxic aquatic (surface and/or subsurface) environments and was then assimilated, redistributed and sequestered by the hydrothermal fluids (“hydrothermal pump hypothesis”)"],["dc.identifier.doi","10.5194/bg-15-1535-2018"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59212"],["dc.language.iso","en"],["dc.relation.issn","1726-4189"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.subject.ddc","550"],["dc.title","Ideas and perspectives: hydrothermally driven redistribution and sequestration of early Archaean biomass – the “hydrothermal pump hypothesis”"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1188"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.lastpage","1192"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Lutterotti, A."],["dc.contributor.author","Jelcic, Ilijas"],["dc.contributor.author","Schulze, Catharina"],["dc.contributor.author","Schippling, Sven"],["dc.contributor.author","Breiden, P."],["dc.contributor.author","Mazzanti, B."],["dc.contributor.author","Reinhardt, S."],["dc.contributor.author","DiGioia, M."],["dc.contributor.author","Repice, A."],["dc.contributor.author","Massacesi, L."],["dc.contributor.author","Sputtek, A."],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Kroeger, Nicolaus M."],["dc.contributor.author","Sospedra, Mireia"],["dc.contributor.author","Saccardi, R."],["dc.contributor.author","Zander, A."],["dc.contributor.author","Martin, R."],["dc.date.accessioned","2018-11-07T09:07:56Z"],["dc.date.available","2018-11-07T09:07:56Z"],["dc.date.issued","2012"],["dc.description.abstract","Autologous hematopoietic stem cell transplantation (aHSCT) has been used as a therapeutic approach in multiple sclerosis (MS). However, it is still unclear if the immune system that emerges from autologous CD34+ hematopoietic progenitor cells (HPC) of MS patients is pre-conditioned to re-develop the proinflammatory phenotype. The objective of this article is to compare the whole genome gene and microRNA expression signature in CD34+ HPC of MS patients and healthy donors (HD). CD34+ HPC were isolated from peripheral blood of eight MS patients and five HD and analyzed by whole genome gene expression and microRNA expression microarray. Among the differentially expressed genes (DEGs) only TNNT1 reached statistical significance (logFC=3.1, p < 0.01). The microRNA expression was not significantly different between MS patients and HD. We did not find significant alterations of gene expression or microRNA profiles in CD34+ HPCs of MS patients. Our results support the use of aHSCT for treatment of MS."],["dc.identifier.doi","10.1177/1352458511434067"],["dc.identifier.isi","000306510600019"],["dc.identifier.pmid","22252466"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10622"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25911"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.relation.issn","1352-4585"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","No proinflammatory signature in CD34+ hematopoietic progenitor cells in multiple sclerosis patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]