Staiger, Jochen

[["dc.bibliographiccitation.artnumber","13664"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Walker, F."],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Feyerabend, M."],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Schubert, D."],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Witte, M."],["dc.date.accessioned","2018-11-07T10:05:39Z"],["dc.date.available","2018-11-07T10:05:39Z"],["dc.date.issued","2016"],["dc.description.abstract","Disinhibition of cortical excitatory cell gate information flow through and between cortical columns. The major contribution of Martinotti cells (MC) is providing dendritic inhibition to excitatory neurons and therefore they are a main component of disinhibitory connections. Here we show by means of optogenetics that MC in layers II/III of the mouse primary somatosensory cortex are inhibited by both parvalbumin (PV)- and vasoactive intestinal polypeptide (VIP)-expressing cells. Paired recordings revealed stronger synaptic input onto MC from PV cells than from VIP cells. Moreover, PV cell input showed frequency-independent depression, whereas VIP cell input facilitated at high frequencies. These differences in the properties of the two unitary connections enable disinhibition with distinct temporal features."],["dc.identifier.doi","10.1038/ncomms13664"],["dc.identifier.isi","000388661600001"],["dc.identifier.pmid","27897179"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2041-1723"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2517"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","2528"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T09:52:22Z"],["dc.date.available","2018-11-07T09:52:22Z"],["dc.date.issued","2015"],["dc.description.abstract","In rodents, layer IV of the primary somatosensory cortex contains the barrel field, where individual, large facial whiskers are represented as a dense cluster of cells. In the reeler mouse, a model of disturbed cortical development characterized by a loss of cortical lamination, the barrel field exists in a distorted manner. Little is known about the consequences of such a highly disturbed lamination on cortical function in this model. We used in vivo intrinsic signal optical imaging together with piezo-controlled whisker stimulation to explore sensory map organization and stimulus representation in the barrel field. We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties. The overall topological order of whisker representations is highly preserved and the functional activation of individual whisker representations is similar in size and strength to wild-type controls. Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences. In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) via CRC [889]"],["dc.identifier.doi","10.1093/cercor/bhu052"],["dc.identifier.isi","000361464000016"],["dc.identifier.pmid","24759695"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12149"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36113"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1427"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","1443"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Hafner, Georg"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Truschow, Pavel"],["dc.contributor.author","Rüppel, Alina"],["dc.contributor.author","Sirmpilatze, Nikoloz"],["dc.contributor.author","Dadarwal, Rakshit"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Staiger, Jochen F"],["dc.date.accessioned","2021-06-01T09:41:52Z"],["dc.date.available","2021-06-01T09:41:52Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract The neocortex is composed of layers. Whether layers constitute an essential framework for the formation of functional circuits is not well understood. We investigated the brain-wide input connectivity of vasoactive intestinal polypeptide (VIP) expressing neurons in the reeler mouse. This mutant is characterized by a migration deficit of cortical neurons so that no layers are formed. Still, neurons retain their properties and reeler mice show little cognitive impairment. We focused on VIP neurons because they are known to receive strong long-range inputs and have a typical laminar bias toward upper layers. In reeler, these neurons are more dispersed across the cortex. We mapped the brain-wide inputs of VIP neurons in barrel cortex of wild-type and reeler mice with rabies virus tracing. Innervation by subcortical inputs was not altered in reeler, in contrast to the cortical circuitry. Numbers of long-range ipsilateral cortical inputs were reduced in reeler, while contralateral inputs were strongly increased. Reeler mice had more callosal projection neurons. Hence, the corpus callosum was larger in reeler as shown by structural imaging. We argue that, in the absence of cortical layers, circuits with subcortical structures are maintained but cortical neurons establish a different network that largely preserves cognitive functions."],["dc.identifier.doi","10.1093/cercor/bhaa280"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85068"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.title","Increased Callosal Connectivity in Reeler Mice Revealed by Brain-Wide Input Mapping of VIP Neurons in Barrel Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Möck, Martin"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Wagener, Robin J."],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2020-12-10T18:18:32Z"],["dc.date.available","2020-12-10T18:18:32Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1093/cercor/bhw281"],["dc.identifier.eissn","1460-2199"],["dc.identifier.issn","1047-3211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75088"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Intracortical Network Effects Preserve Thalamocortical Input Efficacy in a Cortex Without Layers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","820"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","837"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Mingo-Moreno, Nieves"],["dc.contributor.author","Kuegler, Sebastian"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T10:18:31Z"],["dc.date.available","2018-11-07T10:18:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Neuronal wiring is key to proper neural information processing. Tactile information from the rodent's whiskers reaches the cortex via distinct anatomical pathways. The lemniscal pathway relays whisking and touch information from the ventral posteromedial thalamic nucleus to layer IV of the primary somatosensory \"barrel\" cortex. The disorganized neocortex of the reeler mouse is a model system that should severely compromise the ingrowth of thalamocortical axons (TCAs) into the cortex. Moreover, it could disrupt intracortical wiring. We found that neuronal intermingling within the reeler barrel cortex substantially exceeded previous descriptions, leading to the loss of layers. However, viral tracing revealed that TCAs still specifically targeted transgenically labeled spiny layer IV neurons. Slice electrophysiology and optogenetics proved that these connections represent functional synapses. In addition, we assessed intracortical activation via immediate-early-gene expression resulting from a behavioral exploration task. The cellular composition of activated neuronal ensembles suggests extensive similarities in intracolumnar information processing in the wild-type and reeler brains. We conclude that extensive ectopic positioning of neuronal partners can be compensated for by cell-autonomous mechanisms that allow for the establishment of proper connectivity. Thus, genetic neuronal fate seems to be of greater importance for correct cortical wiring than radial neuronal position."],["dc.identifier.doi","10.1093/cercor/bhv257"],["dc.identifier.isi","000371522500030"],["dc.identifier.pmid","26564256"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14147"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41460"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Thalamocortical Connections Drive Intracortical Activation of Functional Columns in the Mislaminated Reeler Somatosensory Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3450"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","3461.e8"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Hafner, Georg"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Subhashini, Nidhi"],["dc.contributor.author","Fenno, Lief E."],["dc.contributor.author","Ramakrishnan, Charu"],["dc.contributor.author","Kim, Yoon Seok"],["dc.contributor.author","Deisseroth, Karl"],["dc.contributor.author","Callaway, Edward M."],["dc.contributor.author","Oberhuber, Martina"],["dc.contributor.author","Conzelmann, Karl-Klaus"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2020-12-10T14:23:02Z"],["dc.date.available","2020-12-10T14:23:02Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.celrep.2019.08.064"],["dc.identifier.issn","2211-1247"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16830"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71810"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Mapping Brain-Wide Afferent Inputs of Parvalbumin-Expressing GABAergic Neurons in Barrel Cortex Reveals Local and Long-Range Circuit Motifs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","54"],["dc.bibliographiccitation.journal","Frontiers in neuroanatomy"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Staiger, Jochen F"],["dc.date.accessioned","2019-07-09T11:43:39Z"],["dc.date.available","2019-07-09T11:43:39Z"],["dc.date.issued","2017"],["dc.description.abstract","A major hallmark of cortical organization is the existence of a variable number of layers, i.e., sheets of neurons stacked on top of each other, in which neurons have certain commonalities. However, even for the neocortex, variable numbers of layers have been described and it is just a convention to distinguish six layers from each other. Whether cortical layers are a structural epiphenomenon caused by developmental dynamics or represent a functionally important modularization of cortical computation is still unknown. Here we present our insights from the reeler mutant mouse, a model for a developmental, \"molecular lesion\"-induced loss of cortical layering that could serve as ground truth of what an intact layering adds to the cortex in terms of functionality. We could demonstrate that the reeler neocortex shows no inversion of cortical layers but rather a severe disorganization that in the primary somatosensory cortex leads to the complete loss of layers. Nevertheless, the somatosensory system is well organized. When exploring an enriched environment with specific sets of whiskers, activity-dependent gene expression takes place in the corresponding modules. Precise whisker stimuli lead to the functional activation of somatotopically organized barrel columns as visualized by intrinsic signal optical imaging. Similar results were obtained in the reeler visual system. When analyzing pathways that could be responsible for preservation of tactile perception, lemniscal thalamic projections were found to be largely intact, despite the smearing of target neurons across the cortical mantle. However, with optogenetic experiments we found evidence for a mild dispersion of thalamic synapse targeting on layer IV-spiny stellate cells, together with a general weakening in thalamocortical input strength. This weakening of thalamic inputs was compensated by intracortical mechanisms involving increased recurrent excitation and/or reduced feedforward inhibition. In conclusion, a layer loss so far only led to the detection of subtle defects in sensory processing by reeler mice. This argues in favor of a view in which cortical layers are not an essential component for basic perception and cognition. A view also supported by recent studies in birds, which can have remarkable cognitive capacities despite the lack of a neocortex with multiple cortical layers. In conclusion, we suggest that future studies directed toward understanding cortical functions should rather focus on circuits specified by functional cell type composition than mere laminar location."],["dc.identifier.doi","10.3389/fnana.2017.00054"],["dc.identifier.pmid","28747874"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58936"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1662-5129"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","The Functioning of a Cortex without Layers."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","81"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biomedical Microdevices"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hassler, Christina"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Nietzschmann, Max"],["dc.contributor.author","Plachta, Dennis T. T."],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Stieglitz, Thomas"],["dc.date.accessioned","2018-11-07T10:07:31Z"],["dc.date.available","2018-11-07T10:07:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Polyimide based shaft electrodes were coated with a bioresorbable layer to stiffen them for intracortical insertion and to reduce the mechanical mismatch between the target tissue and the implanted device after degradation of the coating. Molten saccharose was used as coating material. In a proof-of-concept study, the electrodes were implanted into the cortex of Wistar rats and the insertion forces during implantation were recorded. Electrochemical impedance spectroscopy was performed immediately after implantation and up to 13 weeks after implantation to monitor the tissue response to the implanted electrodes. The recorded spectra were modeled with an equivalent circuit to differentiate the influence of the single components. In one rat, a peak in the encapsulation resistance was observable after two weeks of implantation, indicating the peak of the acute inflammatory response. In another rat, the lowest resistances were observed after four weeks, indicating the termination of the acute inflammatory response. Multiunit activity was recorded with an adequate signal to noise ratio to allow spike sorting. Histology was performed after 7, 45 and 201 days of implantation. The results showed the highest tissue reaction after 45 days and confirmed impedance data that acute inflammatory reactions terminate over time."],["dc.description.sponsorship","German Federal Ministry of Education and Research (BMBF) [01GQ0830]"],["dc.identifier.doi","10.1007/s10544-016-0106-7"],["dc.identifier.isi","000386555500007"],["dc.identifier.pmid","27534649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39298"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1572-8781"],["dc.relation.issn","1387-2176"],["dc.title","Intracortical polyimide electrodes with a bioresorbable coating"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]