Staiger, Jochen

[["dc.bibliographiccitation.firstpage","15700"],["dc.bibliographiccitation.issue","46"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","15709"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","David, Csaba"],["dc.contributor.author","Zhao, Shanting"],["dc.contributor.author","Haas, Carola A."],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T08:36:49Z"],["dc.date.available","2018-11-07T08:36:49Z"],["dc.date.issued","2010"],["dc.description.abstract","Sensory information acquired via the large facial whiskers is processed and relayed in the whisker-to-barrel pathway, which shows multiple somatotopic maps of the receptor periphery. These maps consist of individual structural modules, the development of which may require intact cortical lamination. In the present study we examined the whisker-to-barrel pathway in the reeler mouse and thus used a model with disturbed cortical organization. A combination of histological (fluorescent Nissl and cytochrome oxidase staining) as well as molecular methods (c-Fos and laminar markers Rgs8, RORB, and ER81 expression) revealed wild type-equivalent modules in reeler. At the neocortical level, however, we found extensive alterations in the layout of the individual modules of the map. Nevertheless, they showed a columnar organization that included compartments equivalent to those of their wild-type counterparts. Moreover, all examined modules showed distinct activation as a consequence of behavioral whisker stimulation. Analysis of the magnitude of the cortical lamination defect surprisingly revealed an extensive disorganization, rather than an inversion, as assumed previously. Striking developmental plasticity of thalamic innervation, as suggested by vGluT2 immunohistochemistry, seems to ensure the proper formation of columnar modules and topological maps even under highly disorganized conditions."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB 780, TP C1]"],["dc.identifier.doi","10.1523/JNEUROSCI.3707-10.2010"],["dc.identifier.isi","000284358500036"],["dc.identifier.pmid","21084626"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18395"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The Somatosensory Cortex of reeler Mutant Mice Shows Absent Layering But Intact Formation and Behavioral Activation of Columnar Somatotopic Maps"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4854"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","4868"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Proenneke, Alvar"],["dc.contributor.author","Scheuer, Bianca"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T09:48:24Z"],["dc.date.available","2018-11-07T09:48:24Z"],["dc.date.issued","2015"],["dc.description.abstract","Neocortical GABAergic interneurons have a profound impact on cortical circuitry and its information processing capacity. Distinct subgroups of inhibitory interneurons can be distinguished by molecular markers, such as parvalbumin, somatostatin, and vasoactive intestinal polypeptide (VIP). Among these, VIP-expressing interneurons sparked a substantial interest since these neurons seem to operate disinhibitory circuit motifs found in all major neocortical areas. Several of these recent studies used transgenic Vip-ires-cre mice to specifically target the population of VIP-expressing interneurons. This makes it necessary to elucidate in detail the sensitivity and specificity of Cre expression for VIP neurons in these animals. Thus, we quantitatively compared endogenous tdTomato with Vip fluorescence in situ hybridization and alpha VIP immunohistochemistry in the barrel cortex of VIPcre/tdTomato mice in a layer-specific manner. We show that VIPcre/tdTomato mice are highly sensitive and specific for the entire population of VIP-expressing neurons. In the barrel cortex, approximately 13% of all GABAergic neurons are VIP expressing. Most VIP neurons are found in layer II/III (similar to 60%), whereas approximately 40% are found in the other layers of the barrel cortex. Layer II/III VIP neurons are significantly different from VIP neurons in layers IV-VI in several morphological and membrane properties, which suggest layer-dependent differences in functionality."],["dc.identifier.doi","10.1093/cercor/bhv202"],["dc.identifier.isi","000366463800019"],["dc.identifier.pmid","26420784"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35296"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Characterizing VIP Neurons in the Barrel Cortex of VIPcre/tdTomato Mice Reveals Layer-Specific Differences"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","13664"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Walker, F."],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Feyerabend, M."],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Schubert, D."],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Witte, M."],["dc.date.accessioned","2018-11-07T10:05:39Z"],["dc.date.available","2018-11-07T10:05:39Z"],["dc.date.issued","2016"],["dc.description.abstract","Disinhibition of cortical excitatory cell gate information flow through and between cortical columns. The major contribution of Martinotti cells (MC) is providing dendritic inhibition to excitatory neurons and therefore they are a main component of disinhibitory connections. Here we show by means of optogenetics that MC in layers II/III of the mouse primary somatosensory cortex are inhibited by both parvalbumin (PV)- and vasoactive intestinal polypeptide (VIP)-expressing cells. Paired recordings revealed stronger synaptic input onto MC from PV cells than from VIP cells. Moreover, PV cell input showed frequency-independent depression, whereas VIP cell input facilitated at high frequencies. These differences in the properties of the two unitary connections enable disinhibition with distinct temporal features."],["dc.identifier.doi","10.1038/ncomms13664"],["dc.identifier.isi","000388661600001"],["dc.identifier.pmid","27897179"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2041-1723"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2517"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","2528"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T09:52:22Z"],["dc.date.available","2018-11-07T09:52:22Z"],["dc.date.issued","2015"],["dc.description.abstract","In rodents, layer IV of the primary somatosensory cortex contains the barrel field, where individual, large facial whiskers are represented as a dense cluster of cells. In the reeler mouse, a model of disturbed cortical development characterized by a loss of cortical lamination, the barrel field exists in a distorted manner. Little is known about the consequences of such a highly disturbed lamination on cortical function in this model. We used in vivo intrinsic signal optical imaging together with piezo-controlled whisker stimulation to explore sensory map organization and stimulus representation in the barrel field. We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties. The overall topological order of whisker representations is highly preserved and the functional activation of individual whisker representations is similar in size and strength to wild-type controls. Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences. In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) via CRC [889]"],["dc.identifier.doi","10.1093/cercor/bhu052"],["dc.identifier.isi","000361464000016"],["dc.identifier.pmid","24759695"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12149"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36113"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3449"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Structure and Function"],["dc.bibliographiccitation.lastpage","3467"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Martens, Ann-Kristin"],["dc.contributor.author","Goetze, Bianka"],["dc.contributor.author","Schmidt, Karl-Friedrich"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:49:57Z"],["dc.date.available","2018-11-07T09:49:57Z"],["dc.date.issued","2015"],["dc.description.abstract","A hallmark of neocortical circuits is the segregation of processing streams into six distinct layers. The importance of this layered organization for cortical processing and plasticity is little understood. We investigated the structure, function and plasticity of primary visual cortex (V1) of adult mice deficient for the glycoprotein reelin and their wild-type littermates. In V1 of rl-/- mice, cells with different laminar fates are present at all cortical depths. Surprisingly, the (vertically) disorganized cortex maintains a precise retinotopic (horizontal) organization. Rl-/- mice have normal basic visual capabilities, but are compromised in more challenging perceptual tasks, such as orientation discrimination. Additionally, rl-/- animals learn and memorize a visual task as well as their wild-type littermates. Interestingly, reelin deficiency enhances visual cortical plasticity: juvenile-like ocular dominance plasticity is preserved into late adulthood. The present data offer an important insight into the capabilities of a disorganized cortical system to maintain basic functional properties."],["dc.identifier.doi","10.1007/s00429-014-0866-x"],["dc.identifier.isi","000361566000023"],["dc.identifier.pmid","25119525"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35606"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1863-2661"],["dc.relation.issn","1863-2653"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The disorganized visual cortex in reelin-deficient mice is functional and allows for enhanced plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","820"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","837"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Mingo-Moreno, Nieves"],["dc.contributor.author","Kuegler, Sebastian"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T10:18:31Z"],["dc.date.available","2018-11-07T10:18:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Neuronal wiring is key to proper neural information processing. Tactile information from the rodent's whiskers reaches the cortex via distinct anatomical pathways. The lemniscal pathway relays whisking and touch information from the ventral posteromedial thalamic nucleus to layer IV of the primary somatosensory \"barrel\" cortex. The disorganized neocortex of the reeler mouse is a model system that should severely compromise the ingrowth of thalamocortical axons (TCAs) into the cortex. Moreover, it could disrupt intracortical wiring. We found that neuronal intermingling within the reeler barrel cortex substantially exceeded previous descriptions, leading to the loss of layers. However, viral tracing revealed that TCAs still specifically targeted transgenically labeled spiny layer IV neurons. Slice electrophysiology and optogenetics proved that these connections represent functional synapses. In addition, we assessed intracortical activation via immediate-early-gene expression resulting from a behavioral exploration task. The cellular composition of activated neuronal ensembles suggests extensive similarities in intracolumnar information processing in the wild-type and reeler brains. We conclude that extensive ectopic positioning of neuronal partners can be compensated for by cell-autonomous mechanisms that allow for the establishment of proper connectivity. Thus, genetic neuronal fate seems to be of greater importance for correct cortical wiring than radial neuronal position."],["dc.identifier.doi","10.1093/cercor/bhv257"],["dc.identifier.isi","000371522500030"],["dc.identifier.pmid","26564256"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14147"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41460"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Thalamocortical Connections Drive Intracortical Activation of Functional Columns in the Mislaminated Reeler Somatosensory Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]