Dönitz, Jürgen

[["dc.bibliographiccitation.firstpage","D540"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","D545"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Potapov, Anatolij P."],["dc.contributor.author","Liebich, Ines"],["dc.contributor.author","Doenitz, Juergen"],["dc.contributor.author","Schwarzer, Knut"],["dc.contributor.author","Sasse, Nicole"],["dc.contributor.author","Schoeps, Torsten"],["dc.contributor.author","Crass, Torsten"],["dc.contributor.author","Wingender, Edgar"],["dc.date.accessioned","2018-11-07T10:39:42Z"],["dc.date.available","2018-11-07T10:39:42Z"],["dc.date.issued","2006"],["dc.description.abstract","EndoNet is a new database that provides information about the components of endocrine networks and their relations. It focuses on the endocrine cell-to-cell communication and enables the analysis of intercellular regulatory pathways in humans. In the EndoNet data model, two classes of components span a bipartite directed graph. One class represents the hormones ( in the broadest sense) secreted by defined donor cells. The other class consists of the acceptor or target cells expressing the corresponding hormone receptors. The identity and anatomical environment of cell types, tissues and organs is defined through references to the CYTOMER (R) ontology. With the EndoNet user interface, it is possible to query the database for hormones, receptors or tissues and to combine several items from different search rounds in one complex result set, from which a network can be reconstructed and visualized. For each entity, a detailed characteristics page is available. Some well-established endocrine pathways are offered as showcases in the form of predefined result sets. These sets can be used as a starting point for a more complex query or for obtaining a quick overview. The EndoNet database is accessible at http://endonet.bioinf.med.uni-goettingen.de/."],["dc.identifier.doi","10.1093/nar/gkj121"],["dc.identifier.isi","000239307700117"],["dc.identifier.pmid","16381928"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46112"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","EndoNet: an information resource about endocrine networks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1905"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","1916"],["dc.bibliographiccitation.volume","240"],["dc.contributor.author","Halacheva, Viktoriya"],["dc.contributor.author","Fuchs, Mathias"],["dc.contributor.author","Doenitz, Juergen"],["dc.contributor.author","Reupke, Tobias"],["dc.contributor.author","Pueschel, Bernd"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T08:54:01Z"],["dc.date.available","2018-11-07T08:54:01Z"],["dc.date.issued","2011"],["dc.description.abstract","Formation of the mammalian primitive streak appears to rely on cell proliferation to a minor extent only, but compensating cell movements have not yet been directly observed. This study analyses individual cell migration and proliferation simultaneously, using multiphoton and differential interference contrast time-lapse microscopy of late pregastrulation rabbit blastocysts. Epiblast cells in the posterior gastrula extension area accumulated medially and displayed complex planar movements including U-turns and a novel type of processional cell movement. In the same area metaphase plates tended to be aligned parallel to the anterior-posterior axis, and statistical analysis showed that rotations of metaphase plates causing preferred orientation were near-complete 8 min before anaphase onset; in some cases, rotations were strikingly rapid, achieving up to 45 degrees per min. The mammalian primitive streak appears to be formed initially with its typically minimal anteroposterior elongation by a combination of oriented cell divisions with dedicated planar cell movements. Developmental Dynamics 240:1905-1916, 2011. (C) 2011 Wiley-Liss, Inc."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [Vi 151/8-1]"],["dc.identifier.doi","10.1002/dvdy.22687"],["dc.identifier.isi","000292772400004"],["dc.identifier.pmid","21761476"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22567"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1058-8388"],["dc.title","Planar Cell Movements and Oriented Cell Division During Early Primitive Streak Formation in the Mammalian Embryo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Kurz, Nadine S."],["dc.contributor.author","Perera-Bel, Júlia"],["dc.contributor.author","Höltermann, Charlotte"],["dc.contributor.author","Tucholski, Tim"],["dc.contributor.author","Yang, Jingyu"],["dc.contributor.author","Beissbarth, Tim"],["dc.contributor.author","Dönitz, Jürgen"],["dc.contributor.editor","Röhrig, Rainer"],["dc.contributor.editor","Grabe, Niels"],["dc.contributor.editor","Hoffmann, Verena S."],["dc.contributor.editor","Hübner, Ursula"],["dc.contributor.editor","König, Jochem"],["dc.contributor.editor","Sax, Ulrich"],["dc.contributor.editor","Schreiweis, Björn"],["dc.contributor.editor","Sedlmayr, Martin"],["dc.date.accessioned","2022-10-04T10:21:42Z"],["dc.date.available","2022-10-04T10:21:42Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.3233/SHTI220806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114480"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","IOS Press"],["dc.relation.crisseries","Studies in Health Technology and Informatics"],["dc.relation.eisbn","9781643683034"],["dc.relation.isbn","9781643683027"],["dc.relation.ispartof","German Medical Data Sciences 2022 – Future Medicine: More Precise, More Integrative, More Sustainable! : Proceedings of the Joint Conference of the 67th Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (gmds) and the 14th Annual Meeting of the TMF – Technology, Methods, and Infrastructure for Networked Medical Research e.V. 2022 online in Kiel, Germany"],["dc.title","Identifying Actionable Variants in Cancer – The Dual Web and Batch Processing Tool MTB-Report"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1300"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Genes & Development"],["dc.bibliographiccitation.lastpage","1312"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Nemajerova, Alice"],["dc.contributor.author","Kramer, Daniela"],["dc.contributor.author","Siller, Saul S."],["dc.contributor.author","Herr, Christian"],["dc.contributor.author","Shomroni, Orr"],["dc.contributor.author","Pena, Tonatiuh"],["dc.contributor.author","Suazo, Cristina Gallinas"],["dc.contributor.author","Glaser, Katharina"],["dc.contributor.author","Wildung, Merit"],["dc.contributor.author","Steffen, Henrik"],["dc.contributor.author","Sriraman, Anusha"],["dc.contributor.author","Oberle, Fabian"],["dc.contributor.author","Wienken, Magdalena"],["dc.contributor.author","Hennion, Magali"],["dc.contributor.author","Vidal, Ramon"],["dc.contributor.author","Royen, Bettina"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Schild, Detlev"],["dc.contributor.author","Bals, Robert"],["dc.contributor.author","Doenitz, Juergen"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Bonn, Stefan"],["dc.contributor.author","Takemaru, Ken-Ichi"],["dc.contributor.author","Moll, Ute M."],["dc.contributor.author","Lize, Muriel"],["dc.date.accessioned","2018-11-07T10:13:24Z"],["dc.date.available","2018-11-07T10:13:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Motile multiciliated cells (MCCs) have critical roles in respiratory health and disease and are essential for cleaning inhaled pollutants and pathogens from airways. Despite their significance for human disease, the transcriptional control that governs multiciliogenesis remains poorly understood. Here we identify TP73, a p53 homolog, as governing the program for airway multiciliogenesis. Mice with TP73 deficiency suffer from chronic respiratory tract infections due to profound defects in ciliogenesis and complete loss of mucociliary clearance. Organotypic airway cultures pinpoint TAp73 as necessary and sufficient for basal body docking, axonemal extension, and motility during the differentiation of MCC progenitors. Mechanistically, cross-species genomic analyses and complete ciliary rescue of knockout MCCs identify TAp73 as the conserved central transcriptional integrator of multiciliogenesis. TAp73 directly activates the key regulators FoxJ1, Rfx2, Rfx3, and miR34bc plus nearly 50 structural and functional ciliary genes, some of which are associated with human ciliopathies. Our results position TAp73 as a novel central regulator of MCC differentiation."],["dc.identifier.doi","10.1101/gad.279836.116"],["dc.identifier.isi","000378084000006"],["dc.identifier.pmid","27257214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40428"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cold Spring Harbor Lab Press, Publications Dept"],["dc.relation.issn","1549-5477"],["dc.relation.issn","0890-9369"],["dc.title","TAp73 is a central transcriptional regulator of airway multiciliogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]