Andreas, Stefan

[["dc.bibliographiccitation.firstpage","7749"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","23"],["dc.contributor.affiliation","Wildung, Merit; 1Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany; meritwildung@web.de (M.W.); cornelia.wiedwald@biontech.de (C.W.); heimerl.maren@mh-hannover.de (M.H.); lvolcea@gwdg.de (L.V.-H.); stefan.andreas@med.uni-goettingen.de (S.A.)"],["dc.contributor.affiliation","Herr, Christian; 3Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany; christian.herr@uks.eu (C.H.); christoph.beisswenger@uks.eu (C.B.); m5.sekr@uks.eu (R.B.)"],["dc.contributor.affiliation","Riedel, Dietmar; 4Laboratory for Electron Microscopy, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany; driedel@mpinat.mpg.de"],["dc.contributor.affiliation","Wiedwald, Cornelia; 1Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany; meritwildung@web.de (M.W.); cornelia.wiedwald@biontech.de (C.W.); heimerl.maren@mh-hannover.de (M.H.); lvolcea@gwdg.de (L.V.-H.); stefan.andreas@med.uni-goettingen.de (S.A.)"],["dc.contributor.affiliation","Moiseenko, Alena; 5Immunology & Respiratory Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany; alena.moiseenko@boehringer-ingelheim.com"],["dc.contributor.affiliation","Ramírez, Fidel; 6Global Computational Biology and Digital Sciences Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany; fidel.ramirez@boehringer-ingelheim.com"],["dc.contributor.affiliation","Tasena, Hataitip; 7Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands; h.tasena@nus.edu.sg (H.T.); w.timens@umcg.nl (W.T.); c.a.brandsma@umcg.nl (C.-A.B.); h.i.heijink@umcg.nl (I.H.H.)"],["dc.contributor.affiliation","Heimerl, Maren; 1Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany; meritwildung@web.de (M.W.); cornelia.wiedwald@biontech.de (C.W.); heimerl.maren@mh-hannover.de (M.H.); lvolcea@gwdg.de (L.V.-H.); stefan.andreas@med.uni-goettingen.de (S.A.)"],["dc.contributor.affiliation","Alevra, Mihai; 9Institute of Neuro- and Sensory Physiology, Goettingen University, 37073 Goettingen, Germany; malevra@gwdg.de"],["dc.contributor.affiliation","Movsisyan, Naira; 10Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany; nairamovsisian@gmail.com (N.M.); urrego.dianae@gmail.com (D.U.); pardo@mpinat.mpg.de (L.A.P.)"],["dc.contributor.affiliation","Schuldt, Maike; 2Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany; maikeschuldt@web.de (M.S.); bernard.freytag@stud.uni-goettingen.de (B.F.)"],["dc.contributor.affiliation","Volceanov-Hahn, Larisa; 1Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany; meritwildung@web.de (M.W.); cornelia.wiedwald@biontech.de (C.W.); heimerl.maren@mh-hannover.de (M.H.); lvolcea@gwdg.de (L.V.-H.); stefan.andreas@med.uni-goettingen.de (S.A.)"],["dc.contributor.affiliation","Provoost, Sharen; 11Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium; sharenprovoost@hotmail.com (S.P.); tania.maes@ugent.be (T.M.)"],["dc.contributor.affiliation","Nöthe-Menchen, Tabea; 12Department of General Pediatrics, University Hospital Muenster, 48149 Muenster, Germany; tabea.noethe-menchen@ukmuenster.de (T.N.-M.); julia.wallmeier@ukmuenster.de (J.W.)"],["dc.contributor.affiliation","Urrego, Diana; 10Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany; nairamovsisian@gmail.com (N.M.); urrego.dianae@gmail.com (D.U.); pardo@mpinat.mpg.de (L.A.P.)"],["dc.contributor.affiliation","Freytag, Bernard; 2Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany; maikeschuldt@web.de (M.S.); bernard.freytag@stud.uni-goettingen.de (B.F.)"],["dc.contributor.affiliation","Wallmeier, Julia; 12Department of General Pediatrics, University Hospital Muenster, 48149 Muenster, Germany; tabea.noethe-menchen@ukmuenster.de (T.N.-M.); julia.wallmeier@ukmuenster.de (J.W.)"],["dc.contributor.affiliation","Beisswenger, Christoph; 3Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany; christian.herr@uks.eu (C.H.); christoph.beisswenger@uks.eu (C.B.); m5.sekr@uks.eu (R.B.)"],["dc.contributor.affiliation","Bals, Robert; 3Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany; christian.herr@uks.eu (C.H.); christoph.beisswenger@uks.eu (C.B.); m5.sekr@uks.eu (R.B.)"],["dc.contributor.affiliation","van den Berge, Maarten; 8Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands; m.van.den.berge@umcg.nl"],["dc.contributor.affiliation","Timens, Wim; 7Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands; h.tasena@nus.edu.sg (H.T.); w.timens@umcg.nl (W.T.); c.a.brandsma@umcg.nl (C.-A.B.); h.i.heijink@umcg.nl (I.H.H.)"],["dc.contributor.affiliation","Hiemstra, Pieter S.; 14Department of Pulmonology, Leiden University Medical Centre, 2333 Leiden, The Netherlands; p.s.hiemstra@lumc.nl"],["dc.contributor.affiliation","Brandsma, Corry-Anke; 7Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands; h.tasena@nus.edu.sg (H.T.); w.timens@umcg.nl (W.T.); c.a.brandsma@umcg.nl (C.-A.B.); h.i.heijink@umcg.nl (I.H.H.)"],["dc.contributor.affiliation","Maes, Tania; 11Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium; sharenprovoost@hotmail.com (S.P.); tania.maes@ugent.be (T.M.)"],["dc.contributor.affiliation","Andreas, Stefan; 1Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany; meritwildung@web.de (M.W.); cornelia.wiedwald@biontech.de (C.W.); heimerl.maren@mh-hannover.de (M.H.); lvolcea@gwdg.de (L.V.-H.); stefan.andreas@med.uni-goettingen.de (S.A.)"],["dc.contributor.affiliation","Heijink, Irene H.; 7Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands; h.tasena@nus.edu.sg (H.T.); w.timens@umcg.nl (W.T.); c.a.brandsma@umcg.nl (C.-A.B.); h.i.heijink@umcg.nl (I.H.H.)"],["dc.contributor.affiliation","Pardo, Luis A.; 10Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany; nairamovsisian@gmail.com (N.M.); urrego.dianae@gmail.com (D.U.); pardo@mpinat.mpg.de (L.A.P.)"],["dc.contributor.affiliation","Lizé, Muriel; 1Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany; meritwildung@web.de (M.W.); cornelia.wiedwald@biontech.de (C.W.); heimerl.maren@mh-hannover.de (M.H.); lvolcea@gwdg.de (L.V.-H.); stefan.andreas@med.uni-goettingen.de (S.A.)"],["dc.contributor.author","Wildung, Merit"],["dc.contributor.author","Herr, Christian"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Wiedwald, Cornelia"],["dc.contributor.author","Moiseenko, Alena"],["dc.contributor.author","Ramírez, Fidel"],["dc.contributor.author","Tasena, Hataitip"],["dc.contributor.author","Heimerl, Maren"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Movsisyan, Naira"],["dc.contributor.author","Lizé, Muriel"],["dc.contributor.author","Schuldt, Maike"],["dc.contributor.author","Volceanov-Hahn, Larisa"],["dc.contributor.author","Provoost, Sharen"],["dc.contributor.author","Nöthe-Menchen, Tabea"],["dc.contributor.author","Urrego, Diana"],["dc.contributor.author","Freytag, Bernard"],["dc.contributor.author","Wallmeier, Julia"],["dc.contributor.author","Beisswenger, Christoph"],["dc.contributor.author","Bals, Robert"],["dc.contributor.author","van den Berge, Maarten"],["dc.contributor.author","Timens, Wim"],["dc.contributor.author","Hiemstra, Pieter S."],["dc.contributor.author","Brandsma, Corry-Anke"],["dc.contributor.author","Maes, Tania"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Heijink, Irene H."],["dc.contributor.author","Pardo, Luis A."],["dc.date.accessioned","2022-09-01T09:51:11Z"],["dc.date.available","2022-09-01T09:51:11Z"],["dc.date.issued","2022"],["dc.date.updated","2022-09-03T22:18:07Z"],["dc.description.abstract","Airway mucociliary regeneration and function are key players for airway defense and are impaired in chronic obstructive pulmonary disease (COPD). Using transcriptome analysis in COPD-derived bronchial biopsies, we observed a positive correlation between cilia-related genes and microRNA-449 (miR449). In vitro, miR449 was strongly increased during airway epithelial mucociliary differentiation. In vivo, miR449 was upregulated during recovery from chemical or infective insults. miR0449−/− mice (both alleles are deleted) showed impaired ciliated epithelial regeneration after naphthalene and Haemophilus influenzae exposure, accompanied by more intense inflammation and emphysematous manifestations of COPD. The latter occurred spontaneously in aged miR449−/− mice. We identified Aurora kinase A and its effector target HDAC6 as key mediators in miR449-regulated ciliary homeostasis and epithelial regeneration. Aurora kinase A is downregulated upon miR449 overexpression in vitro and upregulated in miR449−/− mouse lungs. Accordingly, imaging studies showed profoundly altered cilia length and morphology accompanied by reduced mucociliary clearance. Pharmacological inhibition of HDAC6 rescued cilia length and coverage in miR449−/− cells, consistent with its tubulin-deacetylating function. Altogether, our study establishes a link between miR449, ciliary dysfunction, and COPD pathogenesis."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.description.sponsorship","UMG Goettingen"],["dc.description.sponsorship","EMBO"],["dc.description.sponsorship","Interdisziplinaeres Zentrum für Klinische Forschung (IZKF) Muenster"],["dc.description.sponsorship","University of Muenster Medical School"],["dc.description.sponsorship","Belgian Interuniversity Attraction Poles"],["dc.description.sponsorship","Research foundation Flanders (FWO)"],["dc.identifier.doi","10.3390/ijms23147749"],["dc.identifier.pii","ijms23147749"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113901"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.title","miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2163"],["dc.bibliographiccitation.journal","International Journal of Chronic Obstructive Pulmonary Disease"],["dc.bibliographiccitation.lastpage","2172"],["dc.bibliographiccitation.volume","Volume 14"],["dc.contributor.author","Alter, Peter"],["dc.contributor.author","Mayerhofer, Barbara A"],["dc.contributor.author","Kahnert, Kathrin"],["dc.contributor.author","Watz, Henrik"],["dc.contributor.author","Waschki, Benjamin"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Biertz, Frank"],["dc.contributor.author","Bals, Robert"],["dc.contributor.author","Vogelmeier, Claus F"],["dc.contributor.author","Jörres, Rudolf A"],["dc.date.accessioned","2021-06-01T10:48:32Z"],["dc.date.available","2021-06-01T10:48:32Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.2147/COPD.S209343"],["dc.identifier.pmid","31571852"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85971"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1178-2005"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Prevalence of cardiac comorbidities, and their underdetection and contribution to exertional symptoms in COPD: results from the COSYCONET cohort"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]