Andreas, Stefan

[["dc.bibliographiccitation.firstpage","186"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Respiratory Journal"],["dc.bibliographiccitation.lastpage","196"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Behr, Juergen"],["dc.contributor.author","Kreuter, Michael"],["dc.contributor.author","Hoeper, Marius M."],["dc.contributor.author","Wirtz, Hubert"],["dc.contributor.author","Klotsche, Jens"],["dc.contributor.author","Koschel, Dirk"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Claussen, Martin"],["dc.contributor.author","Grohe, Christian"],["dc.contributor.author","Wilkens, Henrike"],["dc.contributor.author","Randerath, Winfried J."],["dc.contributor.author","Skowasch, Dirk"],["dc.contributor.author","Meyer, F. Joachim"],["dc.contributor.author","Kirschner, Joachim"],["dc.contributor.author","Glaeser, Sven"],["dc.contributor.author","Herth, Felix J. F."],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Huber, Rudolf Maria"],["dc.contributor.author","Neurohr, Claus"],["dc.contributor.author","Schwaiblmair, Martin"],["dc.contributor.author","Kohlhaeufl, Martin"],["dc.contributor.author","Hoeffken, Gert"],["dc.contributor.author","Held, Matthias"],["dc.contributor.author","Koch, Andrea"],["dc.contributor.author","Bahmer, Thomas"],["dc.contributor.author","Pittrow, David"],["dc.date.accessioned","2018-11-07T09:55:16Z"],["dc.date.available","2018-11-07T09:55:16Z"],["dc.date.issued","2015"],["dc.description.abstract","After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in 2011, we investigated clinical management practices for patients with IPF according to physicians' diagnoses. A prospective, multicenter, noninterventional study with comprehensive quality measures including on-site source data verification was performed in Germany. 502 consecutive patients (171 newly diagnosed, 331 prevalent; mean+-/SD age 68.7+-/9.4 years, 77.9% males) with a mean disease duration of 2.3+-/3.5 years were enrolled. IPF diagnosis was based on clinical assessments and high-resolution computed tomography (HRCT) in 90.2%, and on surgical lung biopsy combined with histology in 34.1% (lavage in 61.8%). The median 6-min walk distance was 320 m (mean 268+-/200 m). The mean forced vital capacity was 72+-/20% pred and diffusing capacity of the lung for carbon monoxide was 35+-/15% pred. No drugs were administered in 17.9%, oral steroids in 23.7%, N-acetylcysteine in 33.7%, pirfenidone in 44.2% and other drugs in 4.6% of patients. Only 2.8% of the cohort was listed for lung transplantation. IPF patients were diagnosed in line with the new guidelines. They had more severe disease than those enrolled in recent randomised controlled trials. In addition to HRCT, the frequency of lung biopsies was surprisingly high. Treatment patterns varied substantially."],["dc.description.sponsorship","Boehringer Ingelheim AG & Co. KG, Germany; FundRef"],["dc.identifier.doi","10.1183/09031936.00217614"],["dc.identifier.isi","000357137300023"],["dc.identifier.pmid","25837040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36705"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","European Respiratory Soc Journals Ltd"],["dc.relation.issn","1399-3003"],["dc.relation.issn","0903-1936"],["dc.title","Management of patients with idiopathic pulmonary fibrosis in clinical practice: the INSIGHTS-IPF registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","139"],["dc.bibliographiccitation.journal","Respiratory Research"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Kreuter, Michael"],["dc.contributor.author","Swigris, Jeff"],["dc.contributor.author","Pittrow, David"],["dc.contributor.author","Geier, Silke"],["dc.contributor.author","Klotsche, Jens"],["dc.contributor.author","Prasse, Antje"],["dc.contributor.author","Wirtz, Hubert"],["dc.contributor.author","Koschel, Dirk"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Claussen, Martin"],["dc.contributor.author","Grohé, Christian"],["dc.contributor.author","Wilkens, Henrike"],["dc.contributor.author","Hagmeyer, Lars"],["dc.contributor.author","Skowasch, Dirk"],["dc.contributor.author","Meyer, Joachim F"],["dc.contributor.author","Kirschner, Joachim"],["dc.contributor.author","Gläser, Sven"],["dc.contributor.author","Herth, Felix J. F."],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Neurohr, Claus"],["dc.contributor.author","Schwaiblmair, Martin"],["dc.contributor.author","Held, Matthias"],["dc.contributor.author","Bahmer, Thomas"],["dc.contributor.author","Frankenberger, Marion"],["dc.contributor.author","Behr, Jürgen"],["dc.date.accessioned","2019-07-09T11:43:48Z"],["dc.date.available","2019-07-09T11:43:48Z"],["dc.date.issued","2017"],["dc.description.abstract","The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary fibrosis (IPF). We aimed to describe associations of various QoL instruments between each other and with patient characteristics at baseline. Six hundred twenty-three IPF patients with available QoL data (St George’s Respiratory Questionnaire SGRQ, UCSD Shortness-of-Breath Questionnaire SoB, EuroQol visual analogue scale and index EQ-5D, Well-being Index WHO-5) were analysed. Mean age was 69.6 ± 8.7 years, 77% were males, mean disease duration 2.0 ± 3.3 years, FVC pred was 67.5 ± 17.8%, DLCO pred 35.6 ± 17%. Mean points were SGRQ total 48.3, UCSD SoB 47.8, EQ-5D VAS 66.8, and WHO-5 13.9. These instruments had a high or very high correlation (exception WHO-5 to EQ-5D VAS with moderate correlation). On bivariate analysis, QoL by SGRQ total was statistically significantly associated with clinical symptoms (NYHA; p < 0.001), number of comorbidities (p < 0.05), hospitalisation rate (p < 0.01) and disease severity (as measured by GAP score, CPI, FVC and 6-min walk test; p < 0.05 each). Multivariate analyses showed a significant association between QoL (by SGRQ total) and IPF duration, FVC, age, NYHA class and indication for long-term oxygen treatment. Overall, IPF patients under real-life conditions have lower QoL compared to those in clinical studies. There is a meaningful relationship between QoL and various patient characteristics."],["dc.identifier.doi","10.1186/s12931-017-0621-y"],["dc.identifier.pmid","28709421"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58970"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1902279"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Respiratory Journal"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Behr, Jürgen"],["dc.contributor.author","Prasse, Antje"],["dc.contributor.author","Wirtz, Hubert"],["dc.contributor.author","Koschel, Dirk"],["dc.contributor.author","Pittrow, David"],["dc.contributor.author","Held, Matthias"],["dc.contributor.author","Klotsche, Jens"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Claussen, Martin"],["dc.contributor.author","Grohé, Christian"],["dc.contributor.author","Wilkens, Henrike"],["dc.contributor.author","Hagmeyer, Lars"],["dc.contributor.author","Skowasch, Dirk"],["dc.contributor.author","Meyer, Joachim F."],["dc.contributor.author","Kirschner, Joachim"],["dc.contributor.author","Gläser, Sven"],["dc.contributor.author","Kahn, Nicolas"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Neurohr, Claus"],["dc.contributor.author","Schwaiblmair, Martin"],["dc.contributor.author","Bahmer, Thomas"],["dc.contributor.author","Oqueka, Tim"],["dc.contributor.author","Frankenberger, Marion"],["dc.contributor.author","Kreuter, Michael"],["dc.date.accessioned","2021-04-14T08:23:58Z"],["dc.date.available","2021-04-14T08:23:58Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1183/13993003.02279-2019"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81115"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1399-3003"],["dc.relation.issn","0903-1936"],["dc.title","Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","59"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Respiratory Research"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kreuter, Michael"],["dc.contributor.author","Swigris, Jeff"],["dc.contributor.author","Pittrow, David"],["dc.contributor.author","Geier, Silke"],["dc.contributor.author","Klotsche, Jens"],["dc.contributor.author","Prasse, Antje"],["dc.contributor.author","Wirtz, Hubert"],["dc.contributor.author","Koschel, Dirk"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Claussen, Martin"],["dc.contributor.author","Grohé, Christian"],["dc.contributor.author","Wilkens, Henrike"],["dc.contributor.author","Hagmeyer, Lars"],["dc.contributor.author","Skowasch, Dirk"],["dc.contributor.author","Meyer, Joachim F."],["dc.contributor.author","Kirschner, Joachim"],["dc.contributor.author","Gläser, Sven"],["dc.contributor.author","Kahn, Nicolas"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Neurohr, Claus"],["dc.contributor.author","Schwaiblmair, Martin"],["dc.contributor.author","Held, Matthias"],["dc.contributor.author","Bahmer, Thomas"],["dc.contributor.author","Oqueka, Tim"],["dc.contributor.author","Frankenberger, Marion"],["dc.contributor.author","Behr, Jürgen"],["dc.date.accessioned","2019-07-09T11:51:09Z"],["dc.date.available","2019-07-09T11:51:09Z"],["dc.date.issued","2019"],["dc.description.abstract","BACKGROUND: Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German INSIGHTS-IPF registry. METHODS: Clinical status and QoL were assessed at enrollment and subsequently at 6- to 12-months intervals. A range of different QoL questionnaires including the St. George's Respiratory Questionnaire (SGRQ) were used. RESULTS: Data from 424 patients were included; 76.9% male; mean age 68.7 ± 9.1 years, mean FVC% predicted 75.9 ± 19.4, mean DLCO% predicted 36.1 ± 15.9. QoL worsened significantly during follow-up with higher total SGRQ scores (increased by 1.47 per year; 95% CI: 1.17 to 1.76; p < 0.001) and higher UCSD-SOBQ scores and lower EQ-5D VAS and WHO-5 scores. An absolute decline in FVC% predicted of > 10% was associated with a significant deterioration in SGRQ (increasing by 9.08 units; 95% CI: 2.48 to 15.67; p = 0.007), while patients with stable or improved FVC had no significantly change in SGRQ. Patients with a > 10% decrease of DLCO % predicted also had a significant increase in SGRQ (+ 7.79 units; 95% CI: 0.85 to 14.73; p = 0.028), while SQRQ was almost stable in patients with stable or improved DLCO. Patients who died had a significant greater increase in SGRQ total scores (mean 11.8 ± 18.6) at their last follow-up visit prior to death compared to survivors (mean 4.2 ± 18.9; HR = 1.03; 95% CI: 1.01 to 1.04; p < 0.001). All QoL scores across the follow-up period were significantly worse in hospitalised patients compared to non-hospitalised patients, with the worst scores reported in those hospitalised for acute exacerbations. CONCLUSIONS: QoL assessments in the INSIGHTS-IPF registry demonstrate a close relationship between QoL and clinically meaningful changes in lung function, comorbidities, disease duration and clinical course of IPF, including hospitalisation and mortalit"],["dc.identifier.doi","10.1186/s12931-019-1020-3"],["dc.identifier.pmid","30876420"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59885"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]