Gattinoni, Luciano

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.journal","European Journal of Internal Medicine"],["dc.bibliographiccitation.lastpage","33"],["dc.bibliographiccitation.volume","92"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Camporota, Luigi"],["dc.date.accessioned","2022-04-01T10:02:24Z"],["dc.date.available","2022-04-01T10:02:24Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.ejim.2021.09.004"],["dc.identifier.pii","S0953620521003046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105899"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0953-6205"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Standardised PaO2/FiO2 ratio in COVID-19: Added value or risky assumptions?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2187"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","2196"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Formenti, Paolo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:32:14Z"],["dc.date.available","2021-04-14T08:32:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06281-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83854"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","675"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Shock"],["dc.bibliographiccitation.lastpage","680"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Masson, Serge"],["dc.contributor.author","Meessen, Jennifer"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Vivona, Luigi"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Macrì, Matteo Maria"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Novelli, Deborah"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Latini, Roberto"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:31:36Z"],["dc.date.available","2021-04-14T08:31:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/SHK.0000000000001543"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83651"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1540-0514"],["dc.relation.issn","1073-2322"],["dc.title","Pentraxin-3, Troponin T, N-Terminal Pro-B-Type Natriuretic Peptide in Septic Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1498"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","1499"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:26:12Z"],["dc.date.available","2021-04-14T08:26:12Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06124-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81865"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","From phenotypes to black holes… and back"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","865"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.bibliographiccitation.lastpage","876"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Gasperetti, Alessio"],["dc.contributor.author","Di Girolamo, Luca"],["dc.contributor.author","Martinelli, Alessandra"],["dc.contributor.author","Sonzogni, Aurelio"],["dc.contributor.author","Lorini, Luca"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-06-01T09:42:09Z"],["dc.date.available","2021-06-01T09:42:09Z"],["dc.date.issued","2021"],["dc.description.abstract","Hypothesizing that the non-aerated lung fraction as evaluated by the quantitative analysis of the lung computed tomography (CT) equals shunt (V A /Q = 0), we used a computational approach to estimate the magnitude of the ventilation–perfusion mismatch in severe COVID-19. The results show that a severe hyperperfusion of poorly ventilated lung region is likely the cause of the hypoxemia observed. The extensive microthrombosis of the pulmonary circulation may represent the pathophysiological mechanism of such V A /Q distribution."],["dc.description.abstract","COVID-19 infection may lead to acute respiratory distress syndrome (CARDS) where severe gas exchange derangements may be associated, at least in the early stages, only with minor pulmonary infiltrates. This may suggest that the shunt associated to the gasless lung parenchyma is not sufficient to explain CARDS hypoxemia. We designed an algorithm (Vent ri Q lar ), based on the same conceptual grounds described by J.B. West in 1969. We set 498 ventilation–perfusion (V A /Q) compartments and, after calculating their blood composition (PO 2 , PCO 2 , and pH), we randomly chose 10 6 combinations of five parameters controlling a bimodal distribution of blood flow. The solutions were accepted if the predicted PaO 2 and PaCO 2 were within 10% of the patient’s values. We assumed that the shunt fraction equaled the fraction of non-aerated lung tissue at the CT quantitative analysis. Five critically-ill patients later deceased were studied. The PaO 2 /FiO 2 was 91.1 ± 18.6 mmHg and PaCO 2 69.0 ± 16.1 mmHg. Cardiac output was 9.58 ± 0.99 L/min. The fraction of non-aerated tissue was 0.33 ± 0.06. The model showed that a large fraction of the blood flow was likely distributed in regions with very low V A /Q (Q mean  = 0.06 ± 0.02) and a smaller fraction in regions with moderately high V A /Q. Overall LogSD, Q was 1.66 ± 0.14, suggestive of high V A /Q inequality. Our data suggest that shunt alone cannot completely account for the observed hypoxemia and a significant V A /Q inequality must be present in COVID-19. The high cardiac output and the extensive microthrombosis later found in the autopsy further support the hypothesis of a pathological perfusion of non/poorly ventilated lung tissue. NEW & NOTEWORTHY Hypothesizing that the non-aerated lung fraction as evaluated by the quantitative analysis of the lung computed tomography (CT) equals shunt (V A /Q = 0), we used a computational approach to estimate the magnitude of the ventilation–perfusion inequality in severe COVID-19. The results show that a severe hyperperfusion of poorly ventilated lung region is likely the cause of the observed hypoxemia. The extensive microthrombosis or abnormal vasodilation of the pulmonary circulation may represent the pathophysiological mechanism of such V A /Q distribution."],["dc.identifier.doi","10.1152/japplphysiol.00871.2020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85160"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.title","The impact of ventilation–perfusion inequality in COVID-19: a computational model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","japplphysiol.00426.2022"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Zinnato, Carmelo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Palumbo, Michela"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Sonzogni, Aurelio"],["dc.contributor.author","Gersmann, Ann-Kathrin"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-10-04T10:21:51Z"],["dc.date.available","2022-10-04T10:21:51Z"],["dc.date.issued","2022"],["dc.description.abstract","The amount of energy delivered to the respiratory system is recognized as a cause of Ventilator Induced Lung Injury (VILI). How energy dissipation within the lung causes damage is still a matter of debate. Expiratory flow control has been proposed as a strategy to reduce the energy dissipated into the respiratory system during expiration and, possibly, VILI. We studied 22 healthy pigs (29±2 kg), which were randomized into a control (n=11) and a valve group (n=11), where the expiratory flow was controlled through a variable resistor. Both groups were ventilated with the same tidal volume, PEEP and inspiratory flow. Electric impedance tomography was continuously acquired. At completion, lung weight, wet to dry ratios and histology were evaluated. The total mechanical power was similar in the control and valve groups (8.54±0.83 J min\n -1\n and 8.42±0.54 J min\n -\n 1\n respectively, p=0.552). The total energy dissipated within the whole system (circuit + respiratory system) was remarkably different (4.34±0.66 vs 2.62±0.31 J/min, p<0.001). However, most of this energy was dissipated across the endotracheal tube (2.87±0.3 vs 1.88±0.2 J/min, p<0.001). The amount dissipated into the respiratory system averaged 1.45±0.5 in controls vs 0.73±0.16 J min\n -1\n in the valve group, p<0.001. Although respiratory mechanics, gas exchange, hemodynamics, wet to dry ratios and histology were similar in the two groups, the decrease of end-expiratory lung impedance was significantly greater in the control group (p=0.02). We conclude that with our experimental conditions, the reduction of energy dissipated in the respiratory system did not lead to appreciable differences in VILI."],["dc.identifier.doi","10.1152/japplphysiol.00426.2022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114520"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.title","Energy dissipation during expiration and Ventilator Induced Lung Injury: an experimental animal study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Current Opinion in Critical Care"],["dc.bibliographiccitation.lastpage","16"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Cronin, John N."],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Formenti, Federico"],["dc.date.accessioned","2022-01-11T14:05:55Z"],["dc.date.available","2022-01-11T14:05:55Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1097/MCC.0000000000000911"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97776"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1531-7072"],["dc.relation.issn","1070-5295"],["dc.title","Pathophysiology of coronavirus-19 disease acute lung injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giola, Emanuele"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Roli, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-10-01T09:58:50Z"],["dc.date.available","2021-10-01T09:58:50Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00134-021-06519-7"],["dc.identifier.pii","6519"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90156"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1432-1238"],["dc.relation.haserratum","/handle/2/97655"],["dc.relation.issn","0342-4642"],["dc.title","Role of total lung stress on the progression of early COVID-19 pneumonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","210138"],["dc.bibliographiccitation.issue","162"],["dc.bibliographiccitation.journal","European Respiratory Review"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Camporota, Luigi"],["dc.date.accessioned","2022-04-01T10:02:45Z"],["dc.date.available","2022-04-01T10:02:45Z"],["dc.date.issued","2021"],["dc.description.abstract","Coronavirus disease 2019 (COVID-19) pneumonia is an evolving disease. We will focus on the development of its pathophysiologic characteristics over time, and how these time-related changes determine modifications in treatment. In the emergency department: the peculiar characteristic is the coexistence, in a significant fraction of patients, of severe hypoxaemia, near-normal lung computed tomography imaging, lung gas volume and respiratory mechanics. Despite high respiratory drive, dyspnoea and respiratory rate are often normal. The underlying mechanism is primarily altered lung perfusion. The anatomical prerequisites for PEEP (positive end-expiratory pressure) to work (lung oedema, atelectasis, and therefore recruitability) are lacking. In the high-dependency unit: the disease starts to worsen either because of its natural evolution or additional patient self-inflicted lung injury (P-SILI). Oedema and atelectasis may develop, increasing recruitability. Noninvasive supports are indicated if they result in a reversal of hypoxaemia and a decreased inspiratory effort. Otherwise, mechanical ventilation should be considered to avert P-SILI. In the intensive care unit: the primary characteristic of the advance of unresolved COVID-19 disease is a progressive shift from oedema or atelectasis to less reversible structural lung alterations to lung fibrosis. These later characteristics are associated with notable impairment of respiratory mechanics, increased arterial carbon dioxide tension ( P aCO 2 ), decreased recruitability and lack of response to PEEP and prone positioning."],["dc.identifier.doi","10.1183/16000617.0138-2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105996"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1600-0617"],["dc.relation.issn","0905-9180"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","COVID-19 pneumonia: pathophysiology and management"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Costamagna, Andrea"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-04-01T10:02:54Z"],["dc.date.available","2022-04-01T10:02:54Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1097/CCM.0000000000005479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106031"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0090-3493"],["dc.title","Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]