Gattinoni, Luciano

[["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Carlesso, Eleonora"],["dc.contributor.author","Caspani, Maria L."],["dc.contributor.author","Marino, Antonella"],["dc.contributor.author","Gallazzi, Elisabetta"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Lazzerini, Marco"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2018-11-07T09:44:43Z"],["dc.date.available","2018-11-07T09:44:43Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive end-expiratory pressure should be limited to patients with high recruitability. We aimed to determine which bedside method would provide positive end-expiratory pressure better related to lung recruitability. Design: Prospective study performed between 2008 and 2011. Setting: Two university hospitals (Italy and Germany). Patients: Fifty-one patients with acute respiratory distress syndrome. Interventions: Whole lung CT scans were taken in static conditions at 5 and 45 cm H2O during an end-expiratory/end-inspiratory pause to measure lung recruitability. To select individual positive end-expiratory pressure, we applied bedside methods based on lung mechanics (ExPress, stress index), esophageal pressure, and oxygenation (higher positive end-expiratory pressure table of lung open ventilation study). Measurements and Main Results: Patients were classified in mild, moderate and severe acute respiratory distress syndrome. Positive end-expiratory pressure levels selected by the ExPress, stress index, and absolute esophageal pressures methods were unrelated with lung recruitability, whereas positive end-expiratory pressure levels selected by the lung open ventilation method showed a weak relationship with lung recruitability (r(2) = 0.29; p < 0.0001). When patients were classified according to the acute respiratory distress syndrome Berlin definition, the lung open ventilation method was the only one which gave lower positive end-expiratory pressure levels in mild and moderate acute respiratory distress syndrome compared with severe acute respiratory distress syndrome (8 2 and 11 +/- 3 cm H2O vs 15 +/- 3 cm H2O; p < 0.05), whereas ExPress, stress index, and esophageal pressure methods gave similar positive end-expiratory pressure values in mild, moderate, and severe acute respiratory distress syndrome. The positive end-expiratory pressure selected by the different methods were unrelated to each other with the exception of the two methods based on lung mechanics (ExPress and stress index). Conclusions: Bedside positive end-expiratory pressure selection methods based on lung mechanics or absolute esophageal pressures provide positive end-expiratory pressure levels unrelated to lung recruitability and similar in mild, moderate, and severe acute respiratory distress syndrome, whereas the oxygenation-based method provided positive end-expiratory pressure levels related with lung recruitability progressively increasing from mild to moderate and severe acute respiratory distress syndrome."],["dc.identifier.doi","10.1097/CCM.0b013e3182a6384f"],["dc.identifier.isi","000329863400020"],["dc.identifier.pmid","24196193"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1530-0293"],["dc.relation.issn","0090-3493"],["dc.title","Bedside Selection of Positive End-Expiratory Pressure in Mild, Moderate, and Severe Acute Respiratory Distress Syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2187"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","2196"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Formenti, Paolo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:32:14Z"],["dc.date.available","2021-04-14T08:32:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06281-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83854"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1498"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","1499"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:26:12Z"],["dc.date.available","2021-04-14T08:26:12Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06124-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81865"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","From phenotypes to black holes… and back"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","154092"],["dc.bibliographiccitation.journal","Journal of Critical Care"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Mereto, Elisa"],["dc.contributor.author","Fratti, Isabella"],["dc.contributor.author","Chiodaroli, Elena"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Coppola, Silvia"],["dc.date.accessioned","2022-07-01T07:35:48Z"],["dc.date.available","2022-07-01T07:35:48Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.jcrc.2022.154092"],["dc.identifier.pii","S0883944122001216"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112271"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.issn","0883-9441"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Long term feasibility of ultraprotective lung ventilation with low-flow extracorporeal carbon dioxide removal in ARDS patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1254"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.lastpage","1263"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Marino, Antonella"],["dc.contributor.author","Brioni, Matteo"],["dc.contributor.author","Cigada, Irene"],["dc.contributor.author","Menga, Federica"],["dc.contributor.author","Colombo, Andrea"],["dc.contributor.author","Crimella, Francesco"],["dc.contributor.author","Algieri, Ilaria"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Carlesso, Eleonora"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:38:15Z"],["dc.date.available","2020-12-10T18:38:15Z"],["dc.date.issued","2016"],["dc.description.abstract","Rationale: The assessment of lung recruitability in patients with acute respiratory distress syndrome (ARDS) may be important for planning recruitment maneuvers and setting positive end-expiratory pressure (PEEP). Objectives: To determine whether lung recruitment measured by respiratory mechanics is comparable with lung recruitment measured by computed tomography (CT). Methods: In 22 patients with ARDS, lung recruitment was assessed at 5 and 15 cm H2O PEEP by using respiratory mechanics-based methods: (1) increase in gas volume between two pressure-volume curves (P-Vrs curve); (2) increase in gas volume measured and predicted on the basis of expected end-expiratory lung volume and static compliance of the respiratory system (EELV-Cst,rs); as well as by CT scan: (3) decrease in noninflated lung tissue (CT [not inflated]); and (4) decrease in noninflated and poorly inflated tissue (CT [not + poorly inflated]). Measurements and Main Results: The P-Vrs curve recruitment was significantly higher than EELV-Cst,rs recruitment (423 +/- 223 ml vs. 315 +/- 201 ml; P < 0.001), but these measures were significantly related to each other (R-2 = 0.93; P < 0.001). CT (not inflated) recruitment was 77 +/- 86 g and CT (not + poorly inflated) was 80 +/- 67 g (P = 0.856), and these measures were also significantly related to each other (R-2 = 0.20; P = 0.04). Recruitment measured by respiratory mechanics was 54 +/- 28% (P-Vrs curve) and 39 +/- 25% (EELV-Cst,rs) of the gas volume at 5 cm H2O PEEP. Recruitment measured by CT scan was 5 +/- 5% (CT [not inflated]) and 6 +/- 6% (CT [not + poorly inflated]) of lung tissue. Conclusions: Respiratory mechanics and CT measure under the same term, \"recruitment\"-two different entities. The respiratory mechanics-based methods include gas entering in already open pulmonary units that improve their mechanical properties at higher PEEP. Consequently, they can be used to assess the overall improvement of inflation. The CT scan measures the amount of collapsed tissue that regains inflation."],["dc.identifier.doi","10.1164/rccm.201507-1413OC"],["dc.identifier.eissn","1535-4970"],["dc.identifier.isi","000377052900014"],["dc.identifier.issn","1073-449X"],["dc.identifier.pmid","26699672"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77248"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Thoracic Soc"],["dc.relation.issn","1535-4970"],["dc.relation.issn","1073-449X"],["dc.title","Lung Recruitment Assessed by Respiratory Mechanics and Computed Tomography in Patients with Acute Respiratory Distress Syndrome. What Is the Relationship?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1315"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.lastpage","1316"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Carlesso, Eleonora"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Cressoni, Massimo"],["dc.date.accessioned","2018-11-07T10:13:35Z"],["dc.date.available","2018-11-07T10:13:35Z"],["dc.date.issued","2016"],["dc.identifier.isi","000377052900026"],["dc.identifier.pmid","27248593"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40462"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Thoracic Soc"],["dc.relation.issn","1535-4970"],["dc.relation.issn","1073-449X"],["dc.title","Different Definitions of Lung Recruitment by Computed Tomography Scan Reply"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","572"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","580"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Grasselli, Giacomo"],["dc.contributor.author","Scaravilli, Vittorio"],["dc.contributor.author","Tubiolo, Daniela"],["dc.contributor.author","Russo, Riccarda"],["dc.contributor.author","Crimella, Francesco"],["dc.contributor.author","Bichi, Francesca"],["dc.contributor.author","Corinna Morlacchi, Letizia"],["dc.contributor.author","Scotti, Eleonora"],["dc.contributor.author","Patrini, Lorenzo"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Pesenti, Antonio"],["dc.contributor.author","Chiumello, Davide"],["dc.date.accessioned","2020-12-10T18:19:48Z"],["dc.date.available","2020-12-10T18:19:48Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1097/ALN.0000000000002624"],["dc.identifier.issn","0003-3022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75383"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","391"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Anesthesia & Analgesia"],["dc.bibliographiccitation.lastpage","401"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Formenti, Paolo"],["dc.contributor.author","Bolgiaghi, Luca"],["dc.contributor.author","Mistraletti, Giovanni"],["dc.contributor.author","Gotti, Miriam"],["dc.contributor.author","Vetrone, Francesco"],["dc.contributor.author","Baisi, Alessandro"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Umbrello, Michele"],["dc.date.accessioned","2020-12-10T18:41:46Z"],["dc.date.available","2020-12-10T18:41:46Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1213/ANE.0000000000004192"],["dc.identifier.issn","0003-2999"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77671"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Body Position Alters Mechanical Power and Respiratory Mechanics During Thoracic Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giola, Emanuele"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Roli, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-10-01T09:58:50Z"],["dc.date.available","2021-10-01T09:58:50Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00134-021-06519-7"],["dc.identifier.pii","6519"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90156"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1432-1238"],["dc.relation.haserratum","/handle/2/97655"],["dc.relation.issn","0342-4642"],["dc.title","Role of total lung stress on the progression of early COVID-19 pneumonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","944"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Marino, Antonella"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Mietto, Cristina"],["dc.contributor.author","Berto, Virna"],["dc.contributor.author","Gallazzi, Elisabetta"],["dc.contributor.author","Chiurazzi, Chiara"],["dc.contributor.author","Lazzerini, Marco"],["dc.contributor.author","Cadringher, Paolo"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2018-11-07T09:26:38Z"],["dc.date.available","2018-11-07T09:26:38Z"],["dc.date.issued","2013"],["dc.description.abstract","Objectives: Pleural effusion is a frequent finding in patients with acute respiratory distress syndrome. To assess the effects of pleural effusion in patients with acute lung injury on lung volume, respiratory mechanics, gas exchange, lung recruitability, and response to positive end-expiratory pressure. Design, Setting, and Patients: A total of 129 acute lung injury or acute respiratory distress syndrome patients, 68 analyzed retrospectively and 61 prospectively, studied at two University Hospitals. Interventions: Whole-lung CT was performed during two breath-holding pressures (5 and 45 cm H2O). Two levels of positive end-expiratory pressure (5 and 15 cm H2O) were randomly applied. Measurements: Pleural effusion volume was determined on each CT scan section; respiratory system mechanics, gas exchange, and hemodynamics were measured at 5 and 15 cm H2O positive end-expiratory pressure. In 60 patients, elastances of lung and chest wall were computed, and lung and chest wall displacements were estimated. Results: Patients were divided into higher and lower pleural effusion groups according to the median value (287 mL). Patients with higher pleural effusion were older (62 +/- 16 yr vs. 54 +/- 17 yr, p < 0.01) with a lower minute ventilation (8.8 +/- 2.2 L/min vs. 10.1 +/- 2.9 L/min, p < 0.01) and respiratory rate (16 +/- 5 bpm vs. 19 +/- 6 bpm, p < 0.01) than those with lower pleural effusion. Both at 5 and 15 cm H2O of positive end-expiratory pressure Pao(2)/Fio(2), respiratory system elastance, lung weight, normally aerated tissue, collapsed tissue, and lung and chest wall elastances were similar between the two groups. The thoracic cage expansion (405 +/- 172 mL vs. 80 +/- 87 mL, p < 0.0001, for higher pleural effusion group vs. lower pleural effusion group) was greater than the estimated lung compression (178 +/- 124 mL vs. 23 +/- 29 mL, p < 0.0001 for higher pleural effusion group vs. lower pleural effusion group, respectively). Conclusions: Pleural effusion in acute lung injury or acute respiratory distress syndrome patients is of modest entity and leads to a greater chest wall expansion than lung reduction, without affecting gas exchange or respiratory mechanics. (Crit Care Med 2013; 41: 935-944)"],["dc.identifier.doi","10.1097/CCM.0b013e318275892c"],["dc.identifier.isi","000316731800011"],["dc.identifier.pmid","23385101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30345"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0090-3493"],["dc.title","Pleural Effusion in Patients With Acute Lung Injury: A CT Scan Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]