Gattinoni, Luciano

[["dc.bibliographiccitation.firstpage","2187"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","2196"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Formenti, Paolo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:32:14Z"],["dc.date.available","2021-04-14T08:32:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06281-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83854"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1203"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","1209"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:24:13Z"],["dc.date.available","2021-04-14T08:24:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/CCM.0000000000004416"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81208"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0090-3493"],["dc.title","Time Course of Evolving Ventilator-Induced Lung Injury: The “Shrinking Baby Lung”"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Annals of Intensive Care"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Camporota, Luigi"],["dc.date.accessioned","2021-04-14T08:31:18Z"],["dc.date.available","2021-04-14T08:31:18Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s13613-020-00756-7"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83554"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2110-5820"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","COVID-19: scientific reasoning, pragmatism and emotional bias"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2329"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","JAMA"],["dc.bibliographiccitation.volume","323"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:26:21Z"],["dc.date.available","2021-04-14T08:26:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1001/jama.2020.6825"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81914"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0098-7484"],["dc.title","Management of COVID-19 Respiratory Distress"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","55"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine Experimental"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Crooke, Philip S."],["dc.contributor.author","Tawfik, Pierre"],["dc.contributor.author","Chatburn, Robert L."],["dc.contributor.author","Dries, David J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-11-25T11:25:12Z"],["dc.date.accessioned","2022-08-18T12:41:27Z"],["dc.date.available","2021-11-25T11:25:12Z"],["dc.date.available","2022-08-18T12:41:27Z"],["dc.date.issued","2021-11-01"],["dc.date.updated","2022-07-29T12:18:45Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n High rates of inflation energy delivery coupled with transpulmonary tidal pressures of sufficient magnitude may augment the risk of damage to vulnerable, stress-focused units within a mechanically heterogeneous lung. Apart from flow amplitude, the clinician-selected flow waveform, a relatively neglected dimension of inflation power, may distribute inflation energy of each inflation cycle non-uniformly among alveoli with different mechanical properties over the domains of time and space. In this initial step in modeling intracycle power distribution, our primary objective was to develop a mathematical model of global intracycle inflation power that uses clinician-measurable inputs to allow comparisons of instantaneous ICP profiles among the flow modes commonly encountered in clinical practice: constant, linearly decelerating, exponentially decelerating (pressure control), and spontaneous (sinusoidal).\r\n \r\n \r\n Methods\r\n We first tested the predictions of our mathematical model of passive inflation with the actual physical performance of a mechanical ventilator–lung system that simulated ventilation to three types of patients: normal, severe ARDS, and severe airflow obstruction. After verification, model predictions were then generated for 5000 ‘virtual ARDS patients’. Holding constant the tidal volume and inflation time between modes, the validated model then varied the flow profile and quantitated the resulting intensity and timing of potentially damaging ‘elastic’ energy and intracycle power (pressure–flow product) developed in response to random combinations of machine settings and severity levels for ARDS.\r\n \r\n \r\n Results\r\n Our modeling indicates that while the varied flow patterns ultimately deliver similar total amounts of alveolar energy during each breath, they differ profoundly regarding the potentially damaging pattern with which that energy distributes over time during inflation. Pressure control imposed relatively high maximal intracycle power.\r\n \r\n \r\n Conclusions\r\n Flow amplitude and waveform may be relatively neglected and modifiable determinants of VILI risk when ventilating ARDS."],["dc.identifier.citation","Intensive Care Medicine Experimental. 2021 Nov 01;9(1):55"],["dc.identifier.doi","10.1186/s40635-021-00420-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93554"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112993"],["dc.language.iso","en"],["dc.publisher","Springer International Publishing"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Mechanical ventilation"],["dc.subject","Mathematical model"],["dc.subject","Ventilator-induced lung injury"],["dc.subject","VILI"],["dc.subject","Power"],["dc.subject","Intracycle power"],["dc.subject","Energetics"],["dc.subject","Modes of ventilation"],["dc.title","Intracycle power and ventilation mode as potential contributors to ventilator-induced lung injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","767"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.lastpage","774"],["dc.bibliographiccitation.volume","201"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Rocco, Patricia R. M."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:38:17Z"],["dc.date.available","2020-12-10T18:38:17Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1164/rccm.201908-1545CI"],["dc.identifier.eissn","1535-4970"],["dc.identifier.issn","1073-449X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77260"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Static and Dynamic Contributors to Ventilator-induced Lung Injury in Clinical Practice. Pressure, Energy, and Power"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Critical Care"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Brochard, Laurent"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Slutsky, Arthur S."],["dc.contributor.author","Mancebo, Jordi"],["dc.contributor.author","Ranieri, V. Marco"],["dc.contributor.author","Thompson, B. Taylor"],["dc.contributor.author","Papazian, Laurent"],["dc.contributor.author","Schultz, Marcus J."],["dc.contributor.author","Amato, Marcelo"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Mercat, Alain"],["dc.contributor.author","Pesenti, Antonio"],["dc.contributor.author","Talmor, Daniel"],["dc.contributor.author","Vincent, Jean-Louis"],["dc.date.accessioned","2019-07-09T11:43:51Z"],["dc.date.available","2019-07-09T11:43:51Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1186/s13054-017-1820-0"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58986"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15162 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Respiratory support in patients with acute respiratory distress syndrome: an expert opinion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","210138"],["dc.bibliographiccitation.issue","162"],["dc.bibliographiccitation.journal","European Respiratory Review"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Camporota, Luigi"],["dc.date.accessioned","2022-04-01T10:02:45Z"],["dc.date.available","2022-04-01T10:02:45Z"],["dc.date.issued","2021"],["dc.description.abstract","Coronavirus disease 2019 (COVID-19) pneumonia is an evolving disease. We will focus on the development of its pathophysiologic characteristics over time, and how these time-related changes determine modifications in treatment. In the emergency department: the peculiar characteristic is the coexistence, in a significant fraction of patients, of severe hypoxaemia, near-normal lung computed tomography imaging, lung gas volume and respiratory mechanics. Despite high respiratory drive, dyspnoea and respiratory rate are often normal. The underlying mechanism is primarily altered lung perfusion. The anatomical prerequisites for PEEP (positive end-expiratory pressure) to work (lung oedema, atelectasis, and therefore recruitability) are lacking. In the high-dependency unit: the disease starts to worsen either because of its natural evolution or additional patient self-inflicted lung injury (P-SILI). Oedema and atelectasis may develop, increasing recruitability. Noninvasive supports are indicated if they result in a reversal of hypoxaemia and a decreased inspiratory effort. Otherwise, mechanical ventilation should be considered to avert P-SILI. In the intensive care unit: the primary characteristic of the advance of unresolved COVID-19 disease is a progressive shift from oedema or atelectasis to less reversible structural lung alterations to lung fibrosis. These later characteristics are associated with notable impairment of respiratory mechanics, increased arterial carbon dioxide tension ( P aCO 2 ), decreased recruitability and lack of response to PEEP and prone positioning."],["dc.identifier.doi","10.1183/16000617.0138-2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105996"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1600-0617"],["dc.relation.issn","0905-9180"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","COVID-19 pneumonia: pathophysiology and management"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1438"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","1440"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Marini, John J."],["dc.date.accessioned","2021-04-14T08:26:12Z"],["dc.date.available","2021-04-14T08:26:12Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06103-5"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81866"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","The baby lung and the COVID-19 era"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1079"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.lastpage","1080"],["dc.bibliographiccitation.volume","202"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Camporota, Luigi"],["dc.date.accessioned","2021-04-14T08:31:22Z"],["dc.date.available","2021-04-14T08:31:22Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1164/rccm.202008-3142ED"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83573"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1535-4970"],["dc.relation.issn","1073-449X"],["dc.title","The Respiratory Drive: An Overlooked Tile of COVID-19 Pathophysiology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]