Gattinoni, Luciano

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Critical Care Clinics"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Cipulli, Francesco"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2020-12-10T14:22:56Z"],["dc.date.available","2020-12-10T14:22:56Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ccc.2018.03.011"],["dc.identifier.issn","0749-0704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71782"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Extracorporeal Gas Exchange"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Carlesso, Eleonora"],["dc.contributor.author","Caspani, Maria L."],["dc.contributor.author","Marino, Antonella"],["dc.contributor.author","Gallazzi, Elisabetta"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Lazzerini, Marco"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2018-11-07T09:44:43Z"],["dc.date.available","2018-11-07T09:44:43Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive end-expiratory pressure should be limited to patients with high recruitability. We aimed to determine which bedside method would provide positive end-expiratory pressure better related to lung recruitability. Design: Prospective study performed between 2008 and 2011. Setting: Two university hospitals (Italy and Germany). Patients: Fifty-one patients with acute respiratory distress syndrome. Interventions: Whole lung CT scans were taken in static conditions at 5 and 45 cm H2O during an end-expiratory/end-inspiratory pause to measure lung recruitability. To select individual positive end-expiratory pressure, we applied bedside methods based on lung mechanics (ExPress, stress index), esophageal pressure, and oxygenation (higher positive end-expiratory pressure table of lung open ventilation study). Measurements and Main Results: Patients were classified in mild, moderate and severe acute respiratory distress syndrome. Positive end-expiratory pressure levels selected by the ExPress, stress index, and absolute esophageal pressures methods were unrelated with lung recruitability, whereas positive end-expiratory pressure levels selected by the lung open ventilation method showed a weak relationship with lung recruitability (r(2) = 0.29; p < 0.0001). When patients were classified according to the acute respiratory distress syndrome Berlin definition, the lung open ventilation method was the only one which gave lower positive end-expiratory pressure levels in mild and moderate acute respiratory distress syndrome compared with severe acute respiratory distress syndrome (8 2 and 11 +/- 3 cm H2O vs 15 +/- 3 cm H2O; p < 0.05), whereas ExPress, stress index, and esophageal pressure methods gave similar positive end-expiratory pressure values in mild, moderate, and severe acute respiratory distress syndrome. The positive end-expiratory pressure selected by the different methods were unrelated to each other with the exception of the two methods based on lung mechanics (ExPress and stress index). Conclusions: Bedside positive end-expiratory pressure selection methods based on lung mechanics or absolute esophageal pressures provide positive end-expiratory pressure levels unrelated to lung recruitability and similar in mild, moderate, and severe acute respiratory distress syndrome, whereas the oxygenation-based method provided positive end-expiratory pressure levels related with lung recruitability progressively increasing from mild to moderate and severe acute respiratory distress syndrome."],["dc.identifier.doi","10.1097/CCM.0b013e3182a6384f"],["dc.identifier.isi","000329863400020"],["dc.identifier.pmid","24196193"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1530-0293"],["dc.relation.issn","0090-3493"],["dc.title","Bedside Selection of Positive End-Expiratory Pressure in Mild, Moderate, and Severe Acute Respiratory Distress Syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","76"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","78"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Tonetti, Tommaso"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2020-12-10T14:08:46Z"],["dc.date.available","2020-12-10T14:08:46Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00134-017-4770-8"],["dc.identifier.eissn","1432-1238"],["dc.identifier.issn","0342-4642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70555"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Intensive care medicine in 2050: ventilator-induced lung injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","86"],["dc.bibliographiccitation.journal","CRITICAL CARE"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T10:15:38Z"],["dc.date.available","2018-11-07T10:15:38Z"],["dc.date.issued","2016"],["dc.description.abstract","The Berlin definition criteria applied at positive end-expiratory pressure (PEEP) 5 cm H2O reasonably predict lung edema and recruitabilty. To maintain viable gas exchange, the mechanical ventilation becomes progressively more risky going from mild to severe acute respiratory distress syndrome (ARDS). Tidal volume, driving pressure, flow, and respiratory rate have been identified as causes of ventilation-induced lung injury. Taken together, they represent the mechanical power applied to the lung parenchyma. In an inhomogeneous lung, stress risers locally increase the applied mechanical power. Increasing lung homogeneity by PEEP and prone position decreases the harm of mechanical ventilation, particularly in severe ARDS."],["dc.identifier.doi","10.1186/s13054-016-1268-7"],["dc.identifier.isi","000373669800001"],["dc.identifier.pmid","27048605"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40846"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1364-8535"],["dc.relation.issn","1466-609X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","How ARDS should be treated"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2187"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","2196"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Formenti, Paolo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:32:14Z"],["dc.date.available","2021-04-14T08:32:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06281-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83854"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","237"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Critical Care"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Meessen, Jennifer"],["dc.contributor.author","Latini, Roberto"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Pesenti, Antonio"],["dc.contributor.author","Fumagalli, Roberto"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2019-03-13T16:08:29Z"],["dc.date.available","2019-03-13T16:08:29Z"],["dc.date.issued","2018"],["dc.description.abstract","A reanalysis of the ALBIOS trial suggested that patients with septic shock - defined by vasopressor-dependent hypotension in the presence of severe sepsis (Shock-2) - had a survival benefit when treated with albumin. The new septic shock definition (Shock-3) added the criterion of a lactate threshold of 2 mmol/L. We investigated how the populations defined according to Shock-2 and Shock-3 differed and whether the albumin benefit would be confirmed."],["dc.identifier.doi","10.1186/s13054-018-2169-8"],["dc.identifier.pmid","30261898"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15358"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57674"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Septic shock-3 vs 2: an analysis of the ALBIOS study"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","675"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Shock"],["dc.bibliographiccitation.lastpage","680"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Masson, Serge"],["dc.contributor.author","Meessen, Jennifer"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Vivona, Luigi"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Macrì, Matteo Maria"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Novelli, Deborah"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Latini, Roberto"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:31:36Z"],["dc.date.available","2021-04-14T08:31:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/SHK.0000000000001543"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83651"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1540-0514"],["dc.relation.issn","1073-2322"],["dc.title","Pentraxin-3, Troponin T, N-Terminal Pro-B-Type Natriuretic Peptide in Septic Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","S1"],["dc.bibliographiccitation.journal","Medizinische Klinik - Intensivmedizin und Notfallmedizin"],["dc.bibliographiccitation.lastpage","1"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Gattinoni, L."],["dc.contributor.author","Quintel, M."],["dc.date.accessioned","2020-12-10T14:07:59Z"],["dc.date.available","2020-12-10T14:07:59Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00063-017-0393-7"],["dc.identifier.eissn","2193-6226"],["dc.identifier.issn","2193-6218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70346"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","New insights in mechanical ventilation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","686"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","698"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Pesenti, Antonio"],["dc.contributor.author","Musch, Guido"],["dc.contributor.author","Lichtenstein, Daniel"],["dc.contributor.author","Mojoli, Francesco"],["dc.contributor.author","Amato, Marcelo B. P."],["dc.contributor.author","Cinnella, Gilda"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T10:15:15Z"],["dc.date.available","2018-11-07T10:15:15Z"],["dc.date.issued","2016"],["dc.description.abstract","Imaging has become increasingly important across medical specialties for diagnostic, monitoring, and investigative purposes in acute respiratory distress syndrome (ARDS). This review addresses the use of imaging techniques for the diagnosis and management of ARDS as well as gaining knowledge about its pathogenesis and pathophysiology. The techniques described in this article are computed tomography, positron emission tomography, and two easily accessible imaging techniques available at the bedside-ultrasound and electrical impedance tomography (EIT). The use of computed tomography has provided new insights into ARDS pathophysiology, demonstrating that ARDS does not homogeneously affect the lung parenchyma and that lung injury severity is widely distributed in the ARDS population. Positron emission tomography is a functional imaging technique whose value resides in adding incremental insights to morphological imaging. It can quantify regional perfusion, ventilation, aeration, lung vascular permeability, edema, and inflammation. Lung ultrasound and EIT are radiation-free, noninvasive tools available at the bedside. Lung ultrasound can provide useful information on ARDS diagnosis when x-rays or CT scan are not available. EIT is a useful tool to monitor lung ventilation and to assess the regional distribution of perfusion. The future of imaging in critical care will probably develop in two main directions: easily accessible imaging techniques that can be used at the bedside and sophisticated imaging methods that will be used to aid in difficult diagnostic cases or to advance our understanding of the pathogenesis and pathophysiology of an array of critical illnesses."],["dc.identifier.doi","10.1007/s00134-016-4328-1"],["dc.identifier.isi","000374176700011"],["dc.identifier.pmid","27033882"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40776"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Imaging in acute respiratory distress syndrome"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Annals of translational medicine"],["dc.bibliographiccitation.lastpage","395"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:42:53Z"],["dc.date.available","2020-12-10T18:42:53Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.21037/atm.2018.09.65"],["dc.identifier.eissn","2305-5847"],["dc.identifier.issn","2305-5839"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78120"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Is the mechanical power the final word on ventilator-induced lung injury?—we are not sure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]