Wagner, Daniela Melanie

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Wagner, D. M."],["dc.contributor.author","Anton, M."],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Vorwerk, Hilke"],["dc.date.accessioned","2018-11-07T08:29:41Z"],["dc.date.available","2018-11-07T08:29:41Z"],["dc.date.issued","2009"],["dc.format.extent","88"],["dc.identifier.isi","000268225500216"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16710"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","15th Annual Conference of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Bremen, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","In vivo alanine/electron spin resonance (ESR) dosimetry in radiotherapy in patients with head and neck tumor"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","31"],["dc.bibliographiccitation.journal","Radiation Oncology"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.date.accessioned","2018-11-07T11:10:55Z"],["dc.date.available","2018-11-07T11:10:55Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Intensity modulated radiotherapy (IMRT) using sliding window technique utilises a leaf sequencing algorithm, which takes some control system limitations like dose rates (DR) and velocity of the leafs (LV) into account. The effect of altering these limitations on the number of monitor units and radiation dose to the organs at risk (OAR) were analysed. Methods: IMRT plans for different LVs from 1.0 cm/sec to 10.0 cm/sec and different DRs from 100 MU/min to 600 MU/min for two patients with prostate cancer and two patients with squamous cell cancer of the scalp (SCCscalp) were calculated using the same \"optimal fluence map\". For each field the number of monitor units, the dose volume histograms and the differences in the \"actual fluence maps\" of the fields were analysed. Results: With increase of the DR and decrease of the LV the number of monitor units increased and consequentially the radiation dose given to the OAR. In particular the serial OARs of patients with SCCscalp, which are located outside the end position of the leafs and inside the open field, received an additional dose of a higher DR and lower LV is used. Conclusion: For best protection of organs at risk, a low DR and high LV should be applied. But the consequence of a low DR is both a long treatment time and also that a LV of higher than 3.0 cm/sec is mechanically not applicable. Our recommendation for an optimisation of the discussed parameters is a leaf velocity of 2.5 cm/sec and a dose rate of 300-400 MU/min (prostate cancer) and 100-200 MU/min (SCCscalp) for best protection of organs at risk, short treatment time and number of monitor units."],["dc.identifier.doi","10.1186/1748-717X-3-31"],["dc.identifier.isi","000260418200001"],["dc.identifier.pmid","18811954"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53311"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Impact of different leaf velocities and dose rates on the number of monitor units and the dose-volume-histograms using intensity modulated radiotherapy with sliding-window technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","821"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","829"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Seitz, Bjoern"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.date.accessioned","2018-11-07T11:21:48Z"],["dc.date.available","2018-11-07T11:21:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: To analyze different control-system limitations on the measured dose distributions in Low-dose regions of simplified intensity fields with an electronic portal imaging device to ascertain the optimal settings for the control-system limitations in the planning system. Material and Methods: The authors created one field with an \"optimal fluence\" of intensity 1.0 (full dose) and one field with intensity 0.0 (no dose) in the central part of the field. The influence of different dose rates (DRs) and maximum leaf speeds (LS) on the calculated and measured dose and dose profiles were analyzed. Results: Good agreement between calculated and measured dose in the case of a field of intensity 1.0 was found. For the field with intensity 0.0, the measured dose was 20-60% tower than the dose calculated by the \"actual fluence\". The results were found dependent on the DR and LS. Conclusion: The overestimation in regions of optimal intensity 0.0 by the planning system cannot be resolved by the user. Taking the measured dose in the region of desired intensity 1.0 and other technical limitations (like beam hold interrupts or spikes in the cross and longitudinal profiles) into consideration, the application of an LS of 2.5 cm/s and a DR of 500 MU/min is recommended in order to minimize radiation dose applied to organs at risk, which are located in regions of low intensity, like, for example, the spinal cord."],["dc.identifier.doi","10.1007/s00066-009-2028-2"],["dc.identifier.isi","000272525100007"],["dc.identifier.pmid","20013092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55861"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Overestimation of Low-Dose Radiation in Intensity-Modulated Radiotherapy with Sliding-Window Technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Wagner, D. M."],["dc.contributor.author","Anton, M."],["dc.contributor.author","Selbach, Hans-Joachim"],["dc.contributor.author","Hackel, Thomas"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Vorwerk, Hilke"],["dc.date.accessioned","2018-11-07T08:29:40Z"],["dc.date.available","2018-11-07T08:29:40Z"],["dc.date.issued","2009"],["dc.format.extent","20"],["dc.identifier.isi","000268225500042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16703"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","15th Annual Conference of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Bremen, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","In vivo alanin/electron spin resonance (ESR) dosimetry in the urethra during (192)lr HDR brachtherapy in patients with prostate carcinoma: a phantom study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","187"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Wagner, D. M."],["dc.contributor.author","Conradi, L.-C."],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Christiansen, H."],["dc.date.accessioned","2018-11-07T08:55:29Z"],["dc.date.available","2018-11-07T08:55:29Z"],["dc.date.issued","2011"],["dc.format.extent","47"],["dc.identifier.isi","000291236200127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22912"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","17th Annual Meeting of the German-Society-for-Radiation-Oncology"],["dc.relation.eventlocation","Wiesbaden, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Comparison of Protons, RapidArc, IMRT and 3D conformal radiotherapy planning for individualized Therapy in Patients with locally advanced Rectal cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","455"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","460"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Beckmann, Gabriele"],["dc.contributor.author","Bremer, Michael"],["dc.contributor.author","Degen, Maria"],["dc.contributor.author","Dietl, Barbara"],["dc.contributor.author","Fietkau, Rainer"],["dc.contributor.author","Gsaenger, Tammo"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Herrmann, Markus Karl Alfred"],["dc.contributor.author","Hoeller, Ulrike"],["dc.contributor.author","van Kampen, Michael"],["dc.contributor.author","Koerber, Wolfgang"],["dc.contributor.author","Maier, Burkhard"],["dc.contributor.author","Martin, Thomas"],["dc.contributor.author","Metz, Michael"],["dc.contributor.author","Richter, Ronald"],["dc.contributor.author","Siekmeyer, Birgit"],["dc.contributor.author","Steder, Martin"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:29:37Z"],["dc.date.available","2018-11-07T08:29:37Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods: In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and M in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results: Agreement (overlap >= 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion: A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group RO1D where due to repeated discussions and uniform teaching a better agreement was achieved. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 455-460"],["dc.identifier.doi","10.1016/j.radonc.2009.03.014"],["dc.identifier.isi","000266749200028"],["dc.identifier.pmid","19339069"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16693"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The delineation of target volumes for radiotherapy of lung cancer patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2915"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Physics in Medicine and Biology"],["dc.bibliographiccitation.lastpage","2931"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Anton, Mathias"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Selbach, Hans-Joachim"],["dc.contributor.author","Hackel, Thomas"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Vorwerk, Hilke"],["dc.date.accessioned","2018-11-07T08:29:59Z"],["dc.date.available","2018-11-07T08:29:59Z"],["dc.date.issued","2009"],["dc.description.abstract","A phantom study for dosimetry in the urethra using alanine/ESR during Ir-192 HDR brachytherapy of prostate cancer is presented. The measurement method of the secondary standard of the Physikalisch-Technische Bundesanstalt had to be slightly modified in order to be able to measure inside a Foley catheter. The absorbed dose to water response of the alanine dosimetry system to 192Ir was determined with a reproducibility of 1.8% relative to Co-60. The resulting uncertainty for measurements inside the urethra was estimated to be 3.6%, excluding the uncertainty of the dose rate constant Lambda. The applied dose calculated by a treatment planning system is compared to the measured dose for a small series of Ir-192 HDR irradiations in a gel phantom. The differences between the measured and applied dose are well within the limits of uncertainty. Therefore, the method is considered to be suitable for measurements in vivo."],["dc.identifier.doi","10.1088/0031-9155/54/9/022"],["dc.identifier.isi","000265350300022"],["dc.identifier.pmid","19384000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16786"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1361-6560"],["dc.relation.issn","0031-9155"],["dc.title","In vivo dosimetry in the urethra using alanine/ESR during Ir-192 HDR brachytherapy of prostate cancer-a phantom study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","30"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","37"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Wagner, Daniela Melanie"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T09:15:41Z"],["dc.date.available","2018-11-07T09:15:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Background and purpose: Ongoing clinical trials aim to improve local control and overall survival rates by intensification of therapy regimen for patients with locally advanced rectal cancer. It is well known that whenever treatment is intensified, risk of therapy-related toxicity rises. An irradiation with protons could possibly present an approach to solve this dilemma by lowering the exposure to the organs-at-risk (OAR) without compromising tumor response. Material and methods: Twenty five consecutive patients were treated from 04/2009 to 5/2010. For all patients, four different treatment plans including protons, RapidArc, IMRT and 3D-conformal-technique were retrospectively calculated and analyzed according to dosimetric aspects. Results: Detailed DVH-analyses revealed that protons clearly reduced the dose to the OAR and entire normal tissue when compared to other techniques. Furthermore, the conformity index was significantly better and target volumes were covered consistent with the ICRU guidelines. Conclusions: Planning results suggest that treatment with protons can improve the therapeutic tolerance for the irradiation of rectal cancer, particularly for patients scheduled for an irradiation with an intensified chemotherapy regimen and identified to be at high risk for acute therapy-related toxicity. However, clinical experiences and long-term observation are needed to assess tumor response and related toxicity rates. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 102 (2012) 30-37"],["dc.description.sponsorship","German Research Foundation (DFG) [KFO 179]"],["dc.identifier.doi","10.1016/j.radonc.2011.10.018"],["dc.identifier.isi","000300654700006"],["dc.identifier.pmid","22112780"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27756"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.title","Irradiation with protons for the individualized treatment of patients with locally advanced rectal cancer: A planning study with clinical implications"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S99"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","S100"],["dc.bibliographiccitation.volume","191"],["dc.contributor.author","Huettenrauch, Petra"],["dc.contributor.author","Anton, M."],["dc.contributor.author","von Voigts-Rhetz, Philip"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Wagner, D. M."],["dc.date.accessioned","2018-11-07T09:56:06Z"],["dc.date.available","2018-11-07T09:56:06Z"],["dc.date.issued","2015"],["dc.identifier.isi","000362544800220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36894"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","21st Annual Meeting of the German-Society-for-Radiation-Oncology"],["dc.relation.eventlocation","Hamburg, GERMANY"],["dc.relation.issn","1439-099X"],["dc.relation.issn","0179-7158"],["dc.title","Evaluation of Dose Load, of the contralateral Irradiation Side, induced by VMAT in Breast-Carcinoma Patients by means of in vivo Alanine/ESR Dosimetry"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","140"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","147"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Anton, Mathias"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Gsaenger, Tammo"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Poppe, Bjoern"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Hermann, Robert Michael"],["dc.date.accessioned","2018-11-07T11:13:48Z"],["dc.date.available","2018-11-07T11:13:48Z"],["dc.date.issued","2008"],["dc.description.abstract","Purpose: We have developed a device to evaluate the potential of alanine/electron spin resonance (ESR) dosimetry for quality assurance in 3D conformal radiotherapy for prostate cancer. It consists of a rectal balloon carrying eight alanine dosimeter probes and two metal markers to document the exact position of the balloon. We measured the effects of an air-filled rectal balloon on the dose at the rectal wall and compared these results with the applied dose distribution of the treatment planning system. Materials and methods: During 10 fractions with 2.0 Gy per fraction, the accumulated doses were measured in 3 patients. The results of the ESR measurements were compared to the applied doses. Results: It was possible to insert the device without clinical complications and without additional rectal discomfort for the patients. The measurements of the dose accumulated at the anterior and the posterior rectal wall agreed with the applied dose within a mean deviation of 1.5% (overestimation of the dose) and 3.5% (underestimation of the dose), respectively. However, clinically significant differences between applied and measured rectal doses were seen in a patient with a hip prosthesis. In this case, the dose at the anterior rectal wall was overestimated by the TPS by about 11% and the dose at the posterior rectal wall was underestimated by approximately 7%. Conclusion: The method presented in this study is useful for quality control of irradiations in vivo. (c) 2008 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.radonc.2008.03.017"],["dc.identifier.isi","000258053600019"],["dc.identifier.pmid","18420296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53983"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.title","In vivo alanine/electron spin resonance (ESR) dosimetry in radiotherapy of prostate cancer: A feasibility study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]