Wagner, Daniela Melanie

[["dc.bibliographiccitation.firstpage","821"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","829"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Seitz, Bjoern"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.date.accessioned","2018-11-07T11:21:48Z"],["dc.date.available","2018-11-07T11:21:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: To analyze different control-system limitations on the measured dose distributions in Low-dose regions of simplified intensity fields with an electronic portal imaging device to ascertain the optimal settings for the control-system limitations in the planning system. Material and Methods: The authors created one field with an \"optimal fluence\" of intensity 1.0 (full dose) and one field with intensity 0.0 (no dose) in the central part of the field. The influence of different dose rates (DRs) and maximum leaf speeds (LS) on the calculated and measured dose and dose profiles were analyzed. Results: Good agreement between calculated and measured dose in the case of a field of intensity 1.0 was found. For the field with intensity 0.0, the measured dose was 20-60% tower than the dose calculated by the \"actual fluence\". The results were found dependent on the DR and LS. Conclusion: The overestimation in regions of optimal intensity 0.0 by the planning system cannot be resolved by the user. Taking the measured dose in the region of desired intensity 1.0 and other technical limitations (like beam hold interrupts or spikes in the cross and longitudinal profiles) into consideration, the application of an LS of 2.5 cm/s and a DR of 500 MU/min is recommended in order to minimize radiation dose applied to organs at risk, which are located in regions of low intensity, like, for example, the spinal cord."],["dc.identifier.doi","10.1007/s00066-009-2028-2"],["dc.identifier.isi","000272525100007"],["dc.identifier.pmid","20013092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55861"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Overestimation of Low-Dose Radiation in Intensity-Modulated Radiotherapy with Sliding-Window Technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","30"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","37"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Wagner, Daniela Melanie"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T09:15:41Z"],["dc.date.available","2018-11-07T09:15:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Background and purpose: Ongoing clinical trials aim to improve local control and overall survival rates by intensification of therapy regimen for patients with locally advanced rectal cancer. It is well known that whenever treatment is intensified, risk of therapy-related toxicity rises. An irradiation with protons could possibly present an approach to solve this dilemma by lowering the exposure to the organs-at-risk (OAR) without compromising tumor response. Material and methods: Twenty five consecutive patients were treated from 04/2009 to 5/2010. For all patients, four different treatment plans including protons, RapidArc, IMRT and 3D-conformal-technique were retrospectively calculated and analyzed according to dosimetric aspects. Results: Detailed DVH-analyses revealed that protons clearly reduced the dose to the OAR and entire normal tissue when compared to other techniques. Furthermore, the conformity index was significantly better and target volumes were covered consistent with the ICRU guidelines. Conclusions: Planning results suggest that treatment with protons can improve the therapeutic tolerance for the irradiation of rectal cancer, particularly for patients scheduled for an irradiation with an intensified chemotherapy regimen and identified to be at high risk for acute therapy-related toxicity. However, clinical experiences and long-term observation are needed to assess tumor response and related toxicity rates. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 102 (2012) 30-37"],["dc.description.sponsorship","German Research Foundation (DFG) [KFO 179]"],["dc.identifier.doi","10.1016/j.radonc.2011.10.018"],["dc.identifier.isi","000300654700006"],["dc.identifier.pmid","22112780"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27756"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.title","Irradiation with protons for the individualized treatment of patients with locally advanced rectal cancer: A planning study with clinical implications"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","140"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","147"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Anton, Mathias"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Gsaenger, Tammo"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Poppe, Bjoern"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Hermann, Robert Michael"],["dc.date.accessioned","2018-11-07T11:13:48Z"],["dc.date.available","2018-11-07T11:13:48Z"],["dc.date.issued","2008"],["dc.description.abstract","Purpose: We have developed a device to evaluate the potential of alanine/electron spin resonance (ESR) dosimetry for quality assurance in 3D conformal radiotherapy for prostate cancer. It consists of a rectal balloon carrying eight alanine dosimeter probes and two metal markers to document the exact position of the balloon. We measured the effects of an air-filled rectal balloon on the dose at the rectal wall and compared these results with the applied dose distribution of the treatment planning system. Materials and methods: During 10 fractions with 2.0 Gy per fraction, the accumulated doses were measured in 3 patients. The results of the ESR measurements were compared to the applied doses. Results: It was possible to insert the device without clinical complications and without additional rectal discomfort for the patients. The measurements of the dose accumulated at the anterior and the posterior rectal wall agreed with the applied dose within a mean deviation of 1.5% (overestimation of the dose) and 3.5% (underestimation of the dose), respectively. However, clinically significant differences between applied and measured rectal doses were seen in a patient with a hip prosthesis. In this case, the dose at the anterior rectal wall was overestimated by the TPS by about 11% and the dose at the posterior rectal wall was underestimated by approximately 7%. Conclusion: The method presented in this study is useful for quality control of irradiations in vivo. (c) 2008 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.radonc.2008.03.017"],["dc.identifier.isi","000258053600019"],["dc.identifier.pmid","18420296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53983"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.title","In vivo alanine/electron spin resonance (ESR) dosimetry in radiotherapy of prostate cancer: A feasibility study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","473"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","477"],["dc.bibliographiccitation.volume","184"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Hermann, Robert Michael"],["dc.date.accessioned","2018-11-07T11:11:56Z"],["dc.date.available","2018-11-07T11:11:56Z"],["dc.date.issued","2008"],["dc.description.abstract","Purpose: For radiation treatment of patients with cervical cancer and a high risk for paraaortic lymph node involvement, an easy three-dimensional (3-D) conformal irradiation technique (partial half-beam [PHB]) for protection of organs at risk, especially of renal tissue, was developed. Patients and Methods: In five consecutive female patients a computed tomography scan was performed. Dose-volume histograms of the renal tissue and other organs at risk were analyzed for PHB, three other 3-D conformal techniques, and an intensity-modulated radiotherapy (IMRT) technique. Results:The PHB technique reduced the renal volume and volumes of other organs at risk exposed to radiation doses when comparing all patients to the other 3-D conformal techniques. With use of the IMRT technique more renal tissue volume received very tow radiation doses (<= 6.8 Gy) whereas the D-10 was Lower than with the PHB technique. Conclusion: In female patients with cervical cancer and high risk for paraaortic Lymph node involvement, the use of the PHB technique is recommended to reduce renal radiation exposure, if no IMRT technique should be applied. The PHB technique is very easily and fast applicable."],["dc.identifier.doi","10.1007/s00066-008-1814-6"],["dc.identifier.isi","000258948900005"],["dc.identifier.pmid","19016026"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53545"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","An easy irradiation technique (partial half-beam) to reduce renal dose in radiotherapy of cervical cancer including paraaortic lymph nodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]