Now showing 1 - 6 of 6
  • 2013Conference Abstract
    [["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Pathogens and Global Health"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Karak, Somdatta"],["dc.contributor.author","Joo, Seol-hee"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:16:41Z"],["dc.date.available","2018-11-07T09:16:41Z"],["dc.date.issued","2013"],["dc.format.extent","406"],["dc.identifier.isi","000335056200021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27988"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Maney Publishing"],["dc.publisher.place","Leeds"],["dc.relation.issn","2047-7732"],["dc.relation.issn","2047-7724"],["dc.title","DROSOPHILA MELANOGASTER AS A MODEL TO UNDERSTAND HEARING IN DISEASE VECTORS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2014Journal Article Discussion
    [["dc.bibliographiccitation.firstpage","363"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","364"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:36:26Z"],["dc.date.available","2018-11-07T09:36:26Z"],["dc.date.issued","2014"],["dc.description.abstract","Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, which seem to directly push open the channel."],["dc.identifier.doi","10.1016/j.devcel.2014.08.012"],["dc.identifier.isi","000341073500002"],["dc.identifier.pmid","25158850"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32620"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1878-1551"],["dc.relation.issn","1534-5807"],["dc.title","Neuronal Osmotransduction: Push-Activating TRPV1 with Microtubules"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","67"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","74"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Giraldo, Diego"],["dc.contributor.author","Warren, Ben"],["dc.contributor.author","Katana, Radoslaw"],["dc.contributor.author","Andrés, Marta"],["dc.contributor.author","Reddy, Suneel"],["dc.contributor.author","Pauls, Stephanie"],["dc.contributor.author","Schwedhelm-Domeyer, Nicola"],["dc.contributor.author","Geurten, Bart R. H."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2019-07-12T09:33:09Z"],["dc.date.available","2019-07-12T09:33:09Z"],["dc.date.issued","2018"],["dc.description.abstract","Animals rely on mechanosensory feedback from proprioceptors to control locomotory body movements. Unexpectedly, we found that this movement control requires visual opsins. Disrupting the Drosophila opsins NINAE or Rh6 impaired larval locomotion and body contractions, independently of light and vision. Opsins were detected in chordotonal proprioceptors along the larval body, localizing to their ciliated dendrites. Loss of opsins impaired mechanically evoked proprioceptor spiking and cilium ultrastructure. Without NINAE or Rh6, NOMPC mechanotransduction channels leaked from proprioceptor cilia and ciliary Inactive (Iav) channels partly disappeared. Locomotion is shown to require opsins in proprioceptors, and the receptors are found to express the opsin gene Rh7, in addition to ninaE and Rh6. Besides implicating opsins in movement control, this documents roles of non-ciliary, rhabdomeric opsins in cilium organization, providing a model for a key transition in opsin evolution and suggesting that structural roles of rhabdomeric opsins preceded their use for light detection."],["dc.identifier.doi","10.1016/j.neuron.2018.02.028"],["dc.identifier.pmid","29551493"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61475"],["dc.language.iso","en"],["dc.relation.eissn","1097-4199"],["dc.relation.issn","0896-6273"],["dc.title","Proprioceptive Opsin Functions in Drosophila Larval Locomotion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2015Journal Article
    [["dc.bibliographiccitation.firstpage","665"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","671"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Nesterov, Alexandre"],["dc.contributor.author","Spalthoff, Christian"],["dc.contributor.author","Kandasamy, Ramani A."],["dc.contributor.author","Katana, Radoslav"],["dc.contributor.author","Rankl, Nancy B."],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Jaehde, Philipp"],["dc.contributor.author","Dorsch, John A."],["dc.contributor.author","Stam, Lynn F."],["dc.contributor.author","Braun, Franz-Josef"],["dc.contributor.author","Warren, Ben"],["dc.contributor.author","Salgado, Vincent L."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:57:21Z"],["dc.date.available","2018-11-07T09:57:21Z"],["dc.date.issued","2015"],["dc.description.abstract","Defining the molecular targets of insecticides is crucial for assessing their selectivity and potential impact on environment and health. Two commercial insecticides are now shown to target a transient receptor potential (TRP) ion channel complex that is unique to insect stretch receptor cells. Pymetrozine and pyrifluquinazon disturbed Drosophila coordination and hearing by acting on chordotonal stretch receptor neurons. This action required the two TRPs Nanchung (Nan) and Inactive (Iav), which co-occur exclusively within these cells. Nan and Iav together sufficed to confer cellular insecticide responses in vivo and in vitro, and the two insecticides were identified as specific agonists of Nan-Iav complexes that, by promoting cellular calcium influx, silence the stretch receptor cells. This establishes TRPs as insecticide targets and defines specific agonists of insect TRPs. It also shows that TRPs can render insecticides cell-type selective and puts forward TRP targets to reduce side effects on non-target species."],["dc.identifier.doi","10.1016/j.neuron.2015.04.001"],["dc.identifier.isi","000354069800009"],["dc.identifier.pmid","25950634"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37137"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1097-4199"],["dc.relation.issn","0896-6273"],["dc.title","TRP Channels in Insect Stretch Receptors as Insecticide Targets"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article
    [["dc.bibliographiccitation.firstpage","2028"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","2036"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Seifert, Marvin"],["dc.contributor.author","Spalthoff, Christian"],["dc.contributor.author","Warren, Ben"],["dc.contributor.author","Weiss, Lukas"],["dc.contributor.author","Giraldo, Diego"],["dc.contributor.author","Winkler, Margret"],["dc.contributor.author","Pauls, Stephanie"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T10:10:16Z"],["dc.date.available","2018-11-07T10:10:16Z"],["dc.date.issued","2016"],["dc.description.abstract","The performance of vertebrate ears is controlled by auditory efferents that originate in the brain and innervate the ear, synapsing onto hair cell somata and auditory afferent fibers [1-3]. Efferent activity can provide protection from noise and facilitate the detection and discrimination of sound by modulating mechanical amplification by hair cells and transmitter release as well as auditory afferent action potential firing [1-3]. Insect auditory organs are thought to lack efferent control [4-7], but when we inspected mosquito ears, we obtained evidence for its existence. Antibodies against synaptic proteins recognized rows of bouton-like puncta running along the dendrites and axons of mosquito auditory sensory neurons. Electron microscopy identified synaptic and non-synaptic sites of vesicle release, and some of the innervating fibers co-labeled with somata in the CNS. Octopamine, GABA, and serotonin were identified as efferent neurotransmitters or neuromodulators that affect auditory frequency tuning, mechanical amplification, and sound-evoked potentials. Mosquito brains thus modulate mosquito ears, extending the use of auditory efferent systems from vertebrates to invertebrates and adding new levels of complexity to mosquito sound detection and communication."],["dc.identifier.doi","10.1016/j.cub.2016.05.077"],["dc.identifier.isi","000381241100026"],["dc.identifier.pmid","27476597"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39818"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1879-0445"],["dc.relation.issn","0960-9822"],["dc.title","Auditory Efferent System Modulates Mosquito Hearing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2014Journal Article
    [["dc.bibliographiccitation.firstpage","1091"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Genetics"],["dc.bibliographiccitation.lastpage","1102"],["dc.bibliographiccitation.volume","196"],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Turiegano, Enrique"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Canal, Inmaculada"],["dc.contributor.author","Torroja, Laura"],["dc.date.accessioned","2018-11-07T09:41:38Z"],["dc.date.available","2018-11-07T09:41:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Sensory cilia are often encapsulated by an extracellular matrix (ECM). In Caenorhabditis elegans, Drosophila melanogaster, and vertebrates, this ECM is thought to be directly involved in ciliary mechanosensing by coupling external forces to the ciliary membrane. Drosophila mechano- and chemosensory cilia are both associated with an ECM, indicating that the ECM may have additional roles that go beyond mechanosensory cilium function. Here, we identify Artichoke (ATK), an evolutionarily conserved leucine-rich repeat ECM protein that is required for normal morphogenesis and function of ciliated sensilla in Drosophila. atk is transiently expressed in accessory cells in all ciliated sensory organs during their late embryonic development. Antibody stainings show ATK protein in the ECM that surrounds sensory cilia. Loss of ATK protein in atk null mutants leads to cilium deformation and disorientation in chordotonal organs, apparently without uncoupling the cilia from the ECM, and consequently to locomotion defects. Moreover, impaired chemotaxis in atk mutant larvae suggests that, based on ATK protein localization, the ECM is also crucial for the correct assembly of chemosensory receptors. In addition to defining a novel ECM component, our findings show the importance of ECM integrity for the proper morphogenesis of ciliated organs in different sensory modalities."],["dc.identifier.doi","10.1534/genetics.113.156323"],["dc.identifier.isi","000334179300016"],["dc.identifier.pmid","24496014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33778"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Genetics Soc Am"],["dc.relation.issn","1943-2631"],["dc.relation.issn","0016-6731"],["dc.title","The Extracellular Matrix Protein Artichoke Is Required for Integrity of Ciliated Mechanosensory and Chemosensory Organs in Drosophila Embryos"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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