Now showing 1 - 10 of 11
  • 2014Conference Abstract
    [["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","zur Muehlen, Anja"],["dc.contributor.author","Wolff, J."],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Kramm, C."],["dc.date.accessioned","2018-11-07T09:35:54Z"],["dc.date.available","2018-11-07T09:35:54Z"],["dc.date.issued","2014"],["dc.format.extent","74"],["dc.identifier.isi","000342165800267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32494"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","18th International Congress of Neuropathology"],["dc.relation.eventlocation","Rio de Janeiro, BRAZIL"],["dc.relation.issn","1750-3639"],["dc.relation.issn","1015-6305"],["dc.title","Histopathological grading according to the WHO classification of CNS tumors and H3.3K27 mutational status represent independent prognostic markers in pediatric high grade gliomas"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","8"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Karremann, Michael"],["dc.contributor.author","Krämer, Nadja"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Wiese, Maria"],["dc.contributor.author","Beilken, Andreas"],["dc.contributor.author","Corbacioglu, Selim"],["dc.contributor.author","Dilloo, Dagmar"],["dc.contributor.author","Hernaiz Driever, Pablo"],["dc.contributor.author","Scheurlen, Wolfram"],["dc.contributor.author","Kulozik, Andreas"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","von Bueren, André"],["dc.contributor.author","Dürken, Matthias"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-10-10T07:47:12Z"],["dc.date.available","2018-10-10T07:47:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Temozolomide (TMZ) is widely used in high-grade glioma (HGG). There is a major concern of treatment-induced secondary haematological malignancies (SHMs). Due to the poor overall survival of HGG patients, the true incidence is yet elusive. Thus, the aim of this study was to determine the risk of SHMs following TMZ in paediatric HGG. We analysed 487 patients from the HIT-HGG database of the German-speaking Society of Pediatric Oncology and Hematology with follow up beyond 1 year. The incidence of SHM was 7.7 ± 3.2% at 10 years. No SHM occurred in 194 patients after first-line TMZ therapy, but four out of 131 patients treated with TMZ for relapse following first-line multiagent chemotherapy experienced SHM (20% at 10 years; p = 0.041). SHMs occurred in two out of 162 patients who underwent multiagent chemotherapy without TMZ (4.1% at 10 years). Gender, patient age and acute haematological toxicity during treatment did not affect the incidence of SHMs. Data of our cohort do not indicate an increased risk of SHM following TMZ treatment when compared to previous chemotherapy regimen. However, if TMZ is administered as a second-line treatment following conventional chemotherapy regimen, the risk might be disproportionately increasing."],["dc.fs.pkfprnr","58469"],["dc.identifier.doi","10.1016/j.ejca.2017.04.023"],["dc.identifier.fs","633320"],["dc.identifier.pmid","28586748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15921"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1879-0852"],["dc.title","Haematological malignancies following temozolomide treatment for paediatric high-grade glioma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","171"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","173"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","von Bueren, André O."],["dc.contributor.author","Karremann, Michael"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Fouladi, Maryam"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","van Zanten, Sophie E. M. Veldhuijzen"],["dc.contributor.author","Hoffman, Lindsey M."],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2020-12-10T14:10:26Z"],["dc.date.available","2020-12-10T14:10:26Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00401-018-1863-6"],["dc.identifier.eissn","1432-0533"],["dc.identifier.issn","0001-6322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70761"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.haserratum","/handle/2/70763"],["dc.title","A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2013Journal Article
    [["dc.bibliographiccitation.firstpage","844"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","British Journal of Cancer"],["dc.bibliographiccitation.lastpage","851"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Karremann, Michael"],["dc.contributor.author","Rausche, U."],["dc.contributor.author","Roth, D."],["dc.contributor.author","Kuehn, A."],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kortmann, R-D"],["dc.contributor.author","Straeter, R."],["dc.contributor.author","Gnekow, Astrid"],["dc.contributor.author","Wolff, J. E. A."],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T09:21:12Z"],["dc.date.available","2018-11-07T09:21:12Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: High-grade glioma (HGG) of the cerebellum accounts for only 5% of paediatric HGG. Since little is known about these tumours, the present study aimed at their further characterisation. Methods: Twenty-nine paediatric patients with centrally reviewed cerebellar HGG were identified from the HIT-GBM/HIT-HGG database. Clinical and epidemiological data were compared with those of 180 paediatric patients with cortical HGG. Results: Patients with cerebellar tumours were younger (median age of 7.6 vs 11.7 years, P = 0.028), but both groups did not differ significantly with regard to gender, tumour predisposing syndromes, secondary HGG, primary metastasis, tumour grading, extent of tumour resection, chemotherapy regimen, or radiotherapy. Except for an increased incidence of anaplastic pilocytic astrocytoma (APA) in the cerebellar subset (20.7% vs 3.3%; P<0.001), histological entities were similarly distributed in both groups. As expected, tumour grading had a prognostic relevance on survival. Compared with cortical HGG, overall survival in the cerebellar location was significantly worse (median overall survival: 0.92+/-0.02 vs 2.03+/-0.32 years; P = 0.0064), and tumour location in the cerebellum had an independent poor prognostic significance as shown by Cox-regression analysis (P = 0.019). Conclusion: High-grade glioma represents a group of tumours with an obviously site-specific heterogeneity associated with a worse survival in cerebellar location."],["dc.description.sponsorship","Deutsche Kinderkrebsstiftung, Bonn, Germany"],["dc.identifier.doi","10.1038/bjc.2013.404"],["dc.identifier.isi","000323417100003"],["dc.identifier.pmid","23868007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29059"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0007-0920"],["dc.title","Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","224"],["dc.bibliographiccitation.volume","194"],["dc.contributor.author","Seidel, Clemens"],["dc.contributor.author","von Bueren, André O."],["dc.contributor.author","Bojko, Sabrina"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Kortmann, Rolf‑D."],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2020-12-10T14:08:04Z"],["dc.date.available","2020-12-10T14:08:04Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00066-017-1218-6"],["dc.identifier.eissn","1439-099X"],["dc.identifier.issn","0179-7158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70366"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Konkomitante Radiochemotherapie mit Temozolomid vs. konkomitante Cisplatin-basierte Radiochemotherapie"],["dc.title.alternative","Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen. Acute toxicity in pediatric high-grade glioma patients"],["dc.title.subtitle","Akuttoxizität bei Kindern mit hochmalignen Gliomen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2014Conference Abstract
    [["dc.bibliographiccitation.firstpage","55"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Muehlen, Anja Zur"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Wolff, Johannes"],["dc.contributor.author","Kramm, Christof"],["dc.date.accessioned","2018-11-07T09:39:21Z"],["dc.date.available","2018-11-07T09:39:21Z"],["dc.date.issued","2014"],["dc.identifier.isi","000337924200210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33258"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","HISTOPATHOLOGICAL GRADING ACCORDING TO THE WHO CLASSIFICATION OF CNS TUMORS AND H3.3K27 MUTATIONAL STATUS REPRESENT INDEPENDENT PROGNOSTIC MARKERS IN PEDIATRIC HIGH GRADE GLIOMAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2016Conference Abstract
    [["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hoffman, Lindsey M."],["dc.contributor.author","van Zanten, Sophie Veldhuijzen"],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","Lane, Adam"],["dc.contributor.author","Fuller, Christine"],["dc.contributor.author","Miles, Lili"],["dc.contributor.author","Hawkins, Cynthia"],["dc.contributor.author","Bartels, Ute"],["dc.contributor.author","Bouffet, Eric"],["dc.contributor.author","Goldman, Stewart"],["dc.contributor.author","Leary, Sarah"],["dc.contributor.author","Foreman, Nicholas K."],["dc.contributor.author","Packer, Roger"],["dc.contributor.author","Warren, Katherine E."],["dc.contributor.author","Broniscer, Alberto"],["dc.contributor.author","Kieran, Mark W."],["dc.contributor.author","Minturn, Jane"],["dc.contributor.author","Comito, Melanie"],["dc.contributor.author","Broxon, Emmett"],["dc.contributor.author","Shih, Chie-Schin"],["dc.contributor.author","Khatua, Soumen"],["dc.contributor.author","Chintagumpala, Murali"],["dc.contributor.author","Carret, Anne-Sophie"],["dc.contributor.author","Hassall, Timothy"],["dc.contributor.author","Ziegler, David S."],["dc.contributor.author","Gottardo, Nick"],["dc.contributor.author","Dholaria, Hetal"],["dc.contributor.author","Lerme, Brianna"],["dc.contributor.author","Kirkendall, Jenavieve"],["dc.contributor.author","Doughman, Renee"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Wollman, Matthew"],["dc.contributor.author","O'Keefe, Rachel"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Solanki, Guirish"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Cvrlje, Filip Jadrijevic"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Drissi, Rachid"],["dc.contributor.author","Nazarian, Javad"],["dc.contributor.author","Jabado, Nada"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hargrave, Darren"],["dc.contributor.author","Sanchez, Esther"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Leach, James"],["dc.contributor.author","Jones, Blaise"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fouladi, Maryam"],["dc.date.accessioned","2018-11-07T10:13:07Z"],["dc.date.available","2018-11-07T10:13:07Z"],["dc.date.issued","2016"],["dc.identifier.isi","000379749000250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","1963"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.lastpage","1972"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Hoffman, Lindsey M."],["dc.contributor.author","Veldhuijzen van Zanten, Sophie E.M."],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Lane, Adam"],["dc.contributor.author","Fuller, Christine"],["dc.contributor.author","Miles, Lili"],["dc.contributor.author","Hawkins, Cynthia"],["dc.contributor.author","Bartels, Ute"],["dc.contributor.author","Bouffet, Eric"],["dc.contributor.author","Goldman, Stewart"],["dc.contributor.author","Leary, Sarah"],["dc.contributor.author","Foreman, Nicholas K."],["dc.contributor.author","Packer, Roger"],["dc.contributor.author","Warren, Katherine E."],["dc.contributor.author","Broniscer, Alberto"],["dc.contributor.author","Kieran, Mark W."],["dc.contributor.author","Minturn, Jane"],["dc.contributor.author","Comito, Melanie"],["dc.contributor.author","Broxson, Emmett"],["dc.contributor.author","Shih, Chie-Schin"],["dc.contributor.author","Khatua, Soumen"],["dc.contributor.author","Chintagumpala, Murali"],["dc.contributor.author","Carret, Anne Sophie"],["dc.contributor.author","Escorza, Nancy Yanez"],["dc.contributor.author","Hassall, Timothy"],["dc.contributor.author","Ziegler, David S."],["dc.contributor.author","Gottardo, Nicholas"],["dc.contributor.author","Dholaria, Hetal"],["dc.contributor.author","Doughman, Renee"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Drissi, Rachid"],["dc.contributor.author","Nazarian, Javad"],["dc.contributor.author","Jabado, Nada"],["dc.contributor.author","Boddaert, Nathalie"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Giraud, Géraldine"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Puget, Stephanie"],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Modena, Piergiorgio"],["dc.contributor.author","Giagnacovo, Marzia"],["dc.contributor.author","Antonelli, Manila"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Jones, David T.W."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Grotzer, Michael A."],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","von Bueren, André O."],["dc.contributor.author","Hargrave, Darren"],["dc.contributor.author","Solanki, Guirish A."],["dc.contributor.author","Jadrijevic Cvrlje, Filip"],["dc.contributor.author","Kaspers, Gertjan J.L."],["dc.contributor.author","Vandertop, William P."],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Calmon, Raphaël"],["dc.contributor.author","Sanchez, Esther"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Leach, James"],["dc.contributor.author","Jones, Blaise"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fouladi, Maryam"],["dc.date.accessioned","2020-12-10T18:41:35Z"],["dc.date.available","2020-12-10T18:41:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1200/JCO.2017.75.9308"],["dc.identifier.eissn","1527-7755"],["dc.identifier.issn","0732-183X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77619"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2015Journal Article
    [["dc.bibliographiccitation.firstpage","409"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","417"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Gessi, Marco"],["dc.contributor.author","Buttarelli, Francesca R."],["dc.contributor.author","Baldi, Caterina"],["dc.contributor.author","Hammes, Jennifer"],["dc.contributor.author","zur Muehlen, Anja"],["dc.contributor.author","Doerner, Evelyn"],["dc.contributor.author","Denkhaus, Dorota"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Giangaspero, Felice"],["dc.contributor.author","Lauriola, Libero"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Waha, Andreas"],["dc.contributor.author","Pietsch, Torsten"],["dc.date.accessioned","2018-11-07T09:55:21Z"],["dc.date.available","2018-11-07T09:55:21Z"],["dc.date.issued","2015"],["dc.description.abstract","Pediatric high-grade gliomas are considered to be different when compared to adult high-grade gliomas in their pathogenesis and biological behavior. Recently, common genetic alterations, including mutations in the H3F3A/ATRX/DAXX pathway, have been described in approximately 30% of the pediatric cases. However, only few cases of infant high-grade gliomas have been analyzed so far. We investigated the molecular features of 35 infants with diffuse high-grade astrocytomas, including 8 anaplastic astrocytomas [World Health Organization (WHO) grade III] and 27 glioblastomas (WHO grade IV) by immunohistochemistry, multiplex ligation probe-dependent amplification (MLPA), pyrosequencing of glioma-associated genes and molecular inversion probe (MIP) assay. MIP and MLPA analyses showed that chromosomal alterations are significantly less frequent in infants compared with high-grade gliomas in older children and adults. We only identified H3F3A K27M in 2 of 34 cases (5.9%), with both tumors located in the posterior fossa. PDGFRA amplifications were absent, and CDKN2A loss could be observed only in two cases. Conversely, 1q gain (22.7%) and 6q loss (18.2%) were identified in a subgroup of tumors. Loss of SNORD located on chromosome 14q32 was observed in 27.3% of the infant tumors, a focal copy number change not previously described in gliomas. Our findings indicate that infant high-grade gliomas appear to represent a distinct genetic entity suggesting a different pathogenesis and biological behavior."],["dc.identifier.doi","10.1111/bpa.12210"],["dc.identifier.isi","000356679600004"],["dc.identifier.pmid","25231549"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36721"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1750-3639"],["dc.relation.issn","1015-6305"],["dc.title","Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2020Conference Paper
    [["dc.bibliographiccitation.firstpage","LB-216"],["dc.bibliographiccitation.lastpage","LB-216"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Vokuhl, Christian"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","von Bueren, Andre O."],["dc.contributor.author","Dörner, Evelyn"],["dc.contributor.author","Kristiansen, Glen"],["dc.contributor.author","Waha, Andreas"],["dc.contributor.author","Kramm, Christof"],["dc.date.accessioned","2021-04-22T06:16:03Z"],["dc.date.available","2021-04-22T06:16:03Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1158/1538-7445.AM2020-LB-216"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84285"],["dc.notes.intern","DOI-Import GROB-399"],["dc.publisher","American Association for Cancer Research"],["dc.relation.conference","Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA"],["dc.relation.ispartof","Bioinformatics, Convergence Science, and Systems Biology"],["dc.title","Abstract LB-216: Frequent oncogenic tyrosine kinase gene fusions in supratentorial glioblastomas of young children"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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