Kramm, Christof M.

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","100"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Suwala, Abigail K."],["dc.contributor.author","Stichel, Damian"],["dc.contributor.author","Schrimpf, Daniel"],["dc.contributor.author","Kloor, Matthias"],["dc.contributor.author","Wefers, Annika K."],["dc.contributor.author","Reinhardt, Annekathrin"],["dc.contributor.author","Maas, Sybren L. N."],["dc.contributor.author","Kratz, Christian P."],["dc.contributor.author","Schweizer, Leonille"],["dc.contributor.author","Hasselblatt, Martin"],["dc.contributor.author","Snuderl, Matija"],["dc.contributor.author","Abedalthagafi, Malak Sameer J."],["dc.contributor.author","Abdullaev, Zied"],["dc.contributor.author","Monoranu, Camelia M."],["dc.contributor.author","Bergmann, Markus"],["dc.contributor.author","Pekrun, Arnulf"],["dc.contributor.author","Freyschlag, Christian"],["dc.contributor.author","Aronica, Eleonora"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Hinz, Felix"],["dc.contributor.author","Sievers, Philipp"],["dc.contributor.author","Korshunov, Andrey"],["dc.contributor.author","Kool, Marcel"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Wick, Wolfgang"],["dc.contributor.author","Unterberg, Andreas"],["dc.contributor.author","Hartmann, Christian"],["dc.contributor.author","Dodgshun, Andrew"],["dc.contributor.author","Tabori, Uri"],["dc.contributor.author","Wesseling, Pieter"],["dc.contributor.author","Sahm, Felix"],["dc.contributor.author","von Deimling, Andreas"],["dc.contributor.author","Reuss, David E."],["dc.date.accessioned","2021-04-14T08:30:48Z"],["dc.date.available","2021-04-14T08:30:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00401-020-02243-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83379"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-0533"],["dc.relation.issn","0001-6322"],["dc.title","Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","5530"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Deng, Maximilian Y."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","Sill, Martin"],["dc.contributor.author","Stichel, Damian"],["dc.contributor.author","Balasubramanian, Gnana Prakash"],["dc.contributor.author","Tippelt, Stephan"],["dc.contributor.author","Kramm, Christof"],["dc.contributor.author","Donson, Andrew M."],["dc.contributor.author","Green, Adam L."],["dc.contributor.author","Jones, David T. W."],["dc.date.accessioned","2021-10-01T09:58:43Z"],["dc.date.available","2021-10-01T09:58:43Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2 , uncovering diagnostic markers and potentially actionable targets."],["dc.description.abstract","Abstract Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2 , uncovering diagnostic markers and potentially actionable targets."],["dc.identifier.doi","10.1038/s41467-021-25708-y"],["dc.identifier.pii","25708"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90126"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","2041-1723"],["dc.title","Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","91"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","101"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Worst, Barbara C."],["dc.contributor.author","van Tilburg, Cornelis M."],["dc.contributor.author","Balasubramanian, Gnana Prakash"],["dc.contributor.author","Fiesel, Petra"],["dc.contributor.author","Witt, Ruth"],["dc.contributor.author","Freitag, Angelika"],["dc.contributor.author","Boudalil, Miream"],["dc.contributor.author","Previti, Christopher"],["dc.contributor.author","Wolf, Stephan"],["dc.contributor.author","Schmidt, Sabine"],["dc.contributor.author","Chotewutmontri, Sasithorn"],["dc.contributor.author","Bewerunge-Hudler, Melanie"],["dc.contributor.author","Schick, Matthias"],["dc.contributor.author","Schlesner, Matthias"],["dc.contributor.author","Hutter, Barbara"],["dc.contributor.author","Taylor, Lenka"],["dc.contributor.author","Borst, Tobias"],["dc.contributor.author","Sutter, Christian"],["dc.contributor.author","Bartram, Claus R."],["dc.contributor.author","Milde, Till"],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","Kulozik, Andreas E."],["dc.contributor.author","von Stackelberg, Arend"],["dc.contributor.author","Meisel, Roland"],["dc.contributor.author","Borkhardt, Arndt"],["dc.contributor.author","Reinhardt, Dirk"],["dc.contributor.author","Klusmann, Jan-Henning"],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Tippelt, Stephan"],["dc.contributor.author","Dirksen, Uta"],["dc.contributor.author","Juergens, Heribert"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Westermann, Frank"],["dc.contributor.author","Fischer, Matthias"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Wossmann, Wilhelm"],["dc.contributor.author","Nathrath, Michaela"],["dc.contributor.author","Bielack, Stefan S."],["dc.contributor.author","Fruehwald, Michael C."],["dc.contributor.author","Fulda, Simone"],["dc.contributor.author","Klingebiel, Thomas"],["dc.contributor.author","Koscielniak, Ewa"],["dc.contributor.author","Schwab, Matthias"],["dc.contributor.author","Tremmel, Roman"],["dc.contributor.author","Driever, Pablo Hernaiz"],["dc.contributor.author","Schulte, Johannes H."],["dc.contributor.author","Brors, Benedikt"],["dc.contributor.author","von Deimling, Andreas"],["dc.contributor.author","Lichter, Peter"],["dc.contributor.author","Eggert, Angelika"],["dc.contributor.author","Capper, David"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Witt, Olaf"],["dc.date.accessioned","2018-11-07T10:09:17Z"],["dc.date.available","2018-11-07T10:09:17Z"],["dc.date.issued","2016"],["dc.description.abstract","The 'Individualized Therapy for Relapsed Malignancies in Childhood' (INFORM) precision medicine study is a nationwide German program for children with high-risk relapsed/refractory malignancies, which aims to identify therapeutic targets on an individualised basis. In a pilot phase, reported here, we developed the logistical and analytical pipelines necessary for rapid and comprehensive molecular profiling in a clinical setting. Fifty-seven patients from 20 centers were prospectively recruited. Malignancies investigated included sarcomas (n = 25), brain tumours (n = 23), and others (n = 9). Whole-exome, low-coverage whole-genome, and RNA sequencing were complemented with methylation and expression microarray analyses. Alterations were assessed for potential targetability according to a customised prioritisation algorithm and subsequently discussed in an interdisciplinary molecular tumour board. Next-generation sequencing data were generated for 52 patients, with the full analysis possible in 46 of 52. Turnaround time from sample receipt until first report averaged 28 d. Twenty-six patients (50%) harbored a potentially druggable alteration with a prioritisation score of 'intermediate' or higher (level 4 of 7). Common targets included receptor tyrosine kinases, phosphoinositide 3-kinase-mammalian target of rapamycin pathway, mitogen-activated protein kinase pathway, and cell cycle control. Ten patients received a targeted therapy based on these findings, with responses observed in some previously treatment-refractory tumours. Comparative primary relapse analysis revealed substantial tumour evolution as well as one case of unsuspected secondary malignancy, highlighting the importance of re-biopsy at relapse. This study demonstrates the feasibility of comprehensive, real-time molecular profiling for high-risk paediatric cancer patients. This extended proof-of-concept, with examples of treatment consequences, expands upon previous personalised oncology endeavors, and presents a model with considerable interest and practical relevance in the burgeoning era of personalised medicine. (C) 2016 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2016.06.009"],["dc.identifier.isi","000382227300010"],["dc.identifier.pmid","27479119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39628"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hoffman, Lindsey M."],["dc.contributor.author","van Zanten, Sophie Veldhuijzen"],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","Lane, Adam"],["dc.contributor.author","Fuller, Christine"],["dc.contributor.author","Miles, Lili"],["dc.contributor.author","Hawkins, Cynthia"],["dc.contributor.author","Bartels, Ute"],["dc.contributor.author","Bouffet, Eric"],["dc.contributor.author","Goldman, Stewart"],["dc.contributor.author","Leary, Sarah"],["dc.contributor.author","Foreman, Nicholas K."],["dc.contributor.author","Packer, Roger"],["dc.contributor.author","Warren, Katherine E."],["dc.contributor.author","Broniscer, Alberto"],["dc.contributor.author","Kieran, Mark W."],["dc.contributor.author","Minturn, Jane"],["dc.contributor.author","Comito, Melanie"],["dc.contributor.author","Broxon, Emmett"],["dc.contributor.author","Shih, Chie-Schin"],["dc.contributor.author","Khatua, Soumen"],["dc.contributor.author","Chintagumpala, Murali"],["dc.contributor.author","Carret, Anne-Sophie"],["dc.contributor.author","Hassall, Timothy"],["dc.contributor.author","Ziegler, David S."],["dc.contributor.author","Gottardo, Nick"],["dc.contributor.author","Dholaria, Hetal"],["dc.contributor.author","Lerme, Brianna"],["dc.contributor.author","Kirkendall, Jenavieve"],["dc.contributor.author","Doughman, Renee"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Wollman, Matthew"],["dc.contributor.author","O'Keefe, Rachel"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Solanki, Guirish"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Cvrlje, Filip Jadrijevic"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Drissi, Rachid"],["dc.contributor.author","Nazarian, Javad"],["dc.contributor.author","Jabado, Nada"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hargrave, Darren"],["dc.contributor.author","Sanchez, Esther"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Leach, James"],["dc.contributor.author","Jones, Blaise"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fouladi, Maryam"],["dc.date.accessioned","2018-11-07T10:13:07Z"],["dc.date.available","2018-11-07T10:13:07Z"],["dc.date.issued","2016"],["dc.identifier.isi","000379749000250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]