Kramm, Christof M.

[["dc.bibliographiccitation.artnumber","117"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica Communications"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Philippe, Cathy"],["dc.contributor.author","Kergrohen, Thomas"],["dc.contributor.author","Sill, Martin"],["dc.contributor.author","Merlevede, Jane"],["dc.contributor.author","Barret, Emilie"],["dc.contributor.author","Puget, Stéphanie"],["dc.contributor.author","Sainte-Rose, Christian"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Debily, Marie-Anne"],["dc.date.accessioned","2019-07-09T11:51:10Z"],["dc.date.available","2019-07-09T11:51:10Z"],["dc.date.issued","2018"],["dc.description.abstract","Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and infiltrating glial neoplasms of the midline harboring the same canonical mutation at the Lysine 27 of the histones H3 tail.Two hundred and fifteen patients younger than 18 years old with centrally-reviewed pediatric high-grade gliomas (pHGG) were included in this study. Comprehensive transcriptomic (n = 140) and methylation (n = 80) profiling was performed depending on the material available, in order to assess the biological uniqueness of this new entity compared to other midline and hemispheric pHGG.Tumor classification based on gene expression (GE) data highlighted the similarity of K27M DMG independently of their location along the midline. T-distributed Stochastic Neighbor Embedding (tSNE) analysis of methylation profiling confirms the discrimination of DMG from other well defined supratentorial tumor subgroups. Patients with diffuse intrinsic pontine gliomas (DIPG) and thalamic DMG exhibited a similarly poor prognosis (11.1 and 10.8 months median overall survival, respectively). Interestingly, H3.1-K27M and H3.3-K27M primary tumor samples could be distinguished based both on their GE and DNA methylation profiles, suggesting that they might arise from a different precursor or from a different epigenetic reorganization.These differences in DNA methylation profiles were conserved in glioma stem-like cell culture models of DIPG which mimicked their corresponding primary tumor. ChIP-seq profiling of H3K27me3 in these models indicate that H3.3-K27M mutated DIPG stem cells exhibit higher levels of H3K27 trimethylation which are correlated with fewer genes expressed by RNAseq. When considering the global distribution of the H3K27me3 mark, we observed that intergenic regions were more trimethylated in the H3.3-K27M mutated cells compared to the H3.1-K27M mutated ones.H3 K27M-mutant DMG represent a homogenous group of neoplasms compared to other pediatric gliomas that could be further separated based on the type of histone H3 variant mutated and their respective epigenetic landscapes. As these characteristics drive different phenotypes, these findings may have important implication for the design of future trials in these specific types of neoplasms."],["dc.identifier.doi","10.1186/s40478-018-0614-1"],["dc.identifier.pmid","30396367"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59888"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.contributor.author","Veldhuijzen van Zanten, Sophie E. M."],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","De Jongh, Dennis"],["dc.contributor.author","Sanchez Aliaga, Esther"],["dc.contributor.author","Barkhof, Frederik"],["dc.contributor.author","Noltes, Johan"],["dc.contributor.author","De Wolf, Ruben"],["dc.contributor.author","Van Dijk, Jet"],["dc.contributor.author","Cannarozzo, Antonio"],["dc.contributor.author","Damen-Korbijn, Carin M."],["dc.contributor.author","Lieverst, Jan A."],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Calmon, Raphael"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Giraud, Géraldine"],["dc.contributor.author","Slavc, Irene"],["dc.contributor.author","Van Gool, Stefaan"],["dc.contributor.author","Jacobs, Sandra"],["dc.contributor.author","Jadrijevic-Cvrlje, Filip"],["dc.contributor.author","Sumerauer, David"],["dc.contributor.author","Nysom, Karsten"],["dc.contributor.author","Pentikainen, Virve"],["dc.contributor.author","Kivivuori, Sanna-Maria"],["dc.contributor.author","Leblond, Pierre"],["dc.contributor.author","Entz-Werle, Natasha"],["dc.contributor.author","von Bueren, Andre O."],["dc.contributor.author","Kattamis, Antonis"],["dc.contributor.author","Hargrave, Darren R."],["dc.contributor.author","Hauser, Péter"],["dc.contributor.author","Garami, Miklos"],["dc.contributor.author","Thorarinsdottir, Halldora K."],["dc.contributor.author","Pears, Jane"],["dc.contributor.author","Gandola, Lorenza"],["dc.contributor.author","Rutkauskiene, Giedre"],["dc.contributor.author","Janssens, Geert O."],["dc.contributor.author","Torsvik, Ingrid K."],["dc.contributor.author","Perek-Polnik, Marta"],["dc.contributor.author","Gil-da-Costa, Maria J."],["dc.contributor.author","Zheludkova, Olga"],["dc.contributor.author","Shats, Liudmila"],["dc.contributor.author","Deak, Ladislav"],["dc.contributor.author","Kitanovski, Lidija"],["dc.contributor.author","Cruz, Ofelia"],["dc.contributor.author","Morales La Madrid, Andres"],["dc.contributor.author","Holm, Stefan"],["dc.contributor.author","Gerber, Nicolas"],["dc.contributor.author","Kebudi, Rejin"],["dc.contributor.author","Grundy, Richard"],["dc.contributor.author","Lopez-Aguilar, Enrique"],["dc.contributor.author","Zapata-Tarres, Marta"],["dc.contributor.author","Emmerik, John"],["dc.contributor.author","Hayden, Tim"],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Vandertop, William P."],["dc.contributor.author","Kaspers, Gertjan J. L."],["dc.contributor.author","Fouladi, Maryam"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","van Vuurden, Dannis G."],["dc.date.accessioned","2019-07-09T11:43:15Z"],["dc.date.available","2019-07-09T11:43:15Z"],["dc.date.issued","2017"],["dc.description.abstract","Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network. By bringing together biomedical professionals and parents as patient representatives, several collaborative DIPG-related projects have been realized. With help from experts in the fields of information technology, and legal advisors, an international, web-based comprehensive database was developed, The SIOPE DIPG Registry and Imaging Repository, to centrally collect data of DIPG patients. As for April 2016, clinical data as well as MR-scans of 694 patients have been entered into the SIOPE DIPG Registry/Imaging Repository. The median progression free survival is 6.0 months (95% Confidence Interval (CI) 5.6–6.4 months) and the median overall survival is 11.0 months (95% CI 10.5–11.5 months). At two and five years post-diagnosis, 10 and 2% of patients are alive, respectively. The establishment of the SIOPE DIPG Network and SIOPE DIPG Registry means a paradigm shift towards collaborative research into DIPG. This is seen as an essential first step towards understanding the disease, improving care and (ultimately) cure for children with DIPG."],["dc.identifier.doi","10.1007/s11060-016-2363-y"],["dc.identifier.pmid","28110411"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58845"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1573-7373"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","321"],["dc.bibliographiccitation.issue","7696"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","555"],["dc.contributor.author","Gröbner, Susanne N."],["dc.contributor.author","Worst, Barbara C."],["dc.contributor.author","Weischenfeldt, Joachim"],["dc.contributor.author","Buchhalter, Ivo"],["dc.contributor.author","Kleinheinz, Kortine"],["dc.contributor.author","Rudneva, Vasilisa A."],["dc.contributor.author","Johann, Pascal D."],["dc.contributor.author","Balasubramanian, Gnana Prakash"],["dc.contributor.author","Segura-Wang, Maia"],["dc.contributor.author","Brabetz, Sebastian"],["dc.contributor.author","Bender, Sebastian"],["dc.contributor.author","Hutter, Barbara"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","Hübschmann, Daniel"],["dc.contributor.author","Zipprich, Gideon"],["dc.contributor.author","Heinold, Michael"],["dc.contributor.author","Eils, Jürgen"],["dc.contributor.author","Lawerenz, Christian"],["dc.contributor.author","Erkek, Serap"],["dc.contributor.author","Lambo, Sander"],["dc.contributor.author","Waszak, Sebastian"],["dc.contributor.author","Blattmann, Claudia"],["dc.contributor.author","Borkhardt, Arndt"],["dc.contributor.author","Kuhlen, Michaela"],["dc.contributor.author","Eggert, Angelika"],["dc.contributor.author","Fulda, Simone"],["dc.contributor.author","Gessler, Manfred"],["dc.contributor.author","Wegert, Jenny"],["dc.contributor.author","Kappler, Roland"],["dc.contributor.author","Baumhoer, Daniel"],["dc.contributor.author","Burdach, Stefan"],["dc.contributor.author","Kirschner-Schwabe, Renate"],["dc.contributor.author","Kontny, Udo"],["dc.contributor.author","Kulozik, Andreas E."],["dc.contributor.author","Lohmann, Dietmar"],["dc.contributor.author","Hettmer, Simone"],["dc.contributor.author","Eckert, Cornelia"],["dc.contributor.author","Bielack, Stefan"],["dc.contributor.author","Nathrath, Michaela"],["dc.contributor.author","Niemeyer, Charlotte"],["dc.contributor.author","Richter, Günther H."],["dc.contributor.author","Schulte, Johannes"],["dc.contributor.author","Siebert, Reiner"],["dc.contributor.author","Westermann, Frank"],["dc.contributor.author","Molenaar, Jan J."],["dc.contributor.author","Vassal, Gilles"],["dc.contributor.author","Witt, Hendrik"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kratz, Christian P."],["dc.contributor.author","Witt, Olaf"],["dc.contributor.author","van Tilburg, Cornelis M."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Dirksen, Uta"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Frühwald, Michael"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Wolf, Stephan"],["dc.contributor.author","Klingebiel, Thomas"],["dc.contributor.author","Koscielniak, Ewa"],["dc.contributor.author","Landgraf, Pablo"],["dc.contributor.author","Koster, Jan"],["dc.contributor.author","Resnick, Adam C."],["dc.contributor.author","Zhang, Jinghui"],["dc.contributor.author","Liu, Yanling"],["dc.contributor.author","Zhou, Xin"],["dc.contributor.author","Waanders, Angela J."],["dc.contributor.author","Zwijnenburg, Danny A."],["dc.contributor.author","Raman, Pichai"],["dc.contributor.author","Brors, Benedikt"],["dc.contributor.author","Weber, Ursula D."],["dc.contributor.author","Northcott, Paul A."],["dc.contributor.author","Pajtler, Kristian W."],["dc.contributor.author","Kool, Marcel"],["dc.contributor.author","Piro, Rosario M."],["dc.contributor.author","Korbel, Jan O."],["dc.contributor.author","Schlesner, Matthias"],["dc.contributor.author","Eils, Roland"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Lichter, Peter"],["dc.contributor.author","Chavez, Lukas"],["dc.contributor.author","Zapatka, Marc"],["dc.contributor.author","Pfister, Stefan M."],["dc.date.accessioned","2020-12-10T18:09:29Z"],["dc.date.available","2020-12-10T18:09:29Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/nature25480"],["dc.identifier.eissn","1476-4687"],["dc.identifier.issn","0028-0836"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15624"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73666"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The landscape of genomic alterations across childhood cancers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]