Kramm, Christof M.

[["dc.bibliographiccitation.artnumber","117"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica Communications"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Philippe, Cathy"],["dc.contributor.author","Kergrohen, Thomas"],["dc.contributor.author","Sill, Martin"],["dc.contributor.author","Merlevede, Jane"],["dc.contributor.author","Barret, Emilie"],["dc.contributor.author","Puget, Stéphanie"],["dc.contributor.author","Sainte-Rose, Christian"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Debily, Marie-Anne"],["dc.date.accessioned","2019-07-09T11:51:10Z"],["dc.date.available","2019-07-09T11:51:10Z"],["dc.date.issued","2018"],["dc.description.abstract","Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and infiltrating glial neoplasms of the midline harboring the same canonical mutation at the Lysine 27 of the histones H3 tail.Two hundred and fifteen patients younger than 18 years old with centrally-reviewed pediatric high-grade gliomas (pHGG) were included in this study. Comprehensive transcriptomic (n = 140) and methylation (n = 80) profiling was performed depending on the material available, in order to assess the biological uniqueness of this new entity compared to other midline and hemispheric pHGG.Tumor classification based on gene expression (GE) data highlighted the similarity of K27M DMG independently of their location along the midline. T-distributed Stochastic Neighbor Embedding (tSNE) analysis of methylation profiling confirms the discrimination of DMG from other well defined supratentorial tumor subgroups. Patients with diffuse intrinsic pontine gliomas (DIPG) and thalamic DMG exhibited a similarly poor prognosis (11.1 and 10.8 months median overall survival, respectively). Interestingly, H3.1-K27M and H3.3-K27M primary tumor samples could be distinguished based both on their GE and DNA methylation profiles, suggesting that they might arise from a different precursor or from a different epigenetic reorganization.These differences in DNA methylation profiles were conserved in glioma stem-like cell culture models of DIPG which mimicked their corresponding primary tumor. ChIP-seq profiling of H3K27me3 in these models indicate that H3.3-K27M mutated DIPG stem cells exhibit higher levels of H3K27 trimethylation which are correlated with fewer genes expressed by RNAseq. When considering the global distribution of the H3K27me3 mark, we observed that intergenic regions were more trimethylated in the H3.3-K27M mutated cells compared to the H3.1-K27M mutated ones.H3 K27M-mutant DMG represent a homogenous group of neoplasms compared to other pediatric gliomas that could be further separated based on the type of histone H3 variant mutated and their respective epigenetic landscapes. As these characteristics drive different phenotypes, these findings may have important implication for the design of future trials in these specific types of neoplasms."],["dc.identifier.doi","10.1186/s40478-018-0614-1"],["dc.identifier.pmid","30396367"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59888"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","100"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Suwala, Abigail K."],["dc.contributor.author","Stichel, Damian"],["dc.contributor.author","Schrimpf, Daniel"],["dc.contributor.author","Kloor, Matthias"],["dc.contributor.author","Wefers, Annika K."],["dc.contributor.author","Reinhardt, Annekathrin"],["dc.contributor.author","Maas, Sybren L. N."],["dc.contributor.author","Kratz, Christian P."],["dc.contributor.author","Schweizer, Leonille"],["dc.contributor.author","Hasselblatt, Martin"],["dc.contributor.author","Snuderl, Matija"],["dc.contributor.author","Abedalthagafi, Malak Sameer J."],["dc.contributor.author","Abdullaev, Zied"],["dc.contributor.author","Monoranu, Camelia M."],["dc.contributor.author","Bergmann, Markus"],["dc.contributor.author","Pekrun, Arnulf"],["dc.contributor.author","Freyschlag, Christian"],["dc.contributor.author","Aronica, Eleonora"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Hinz, Felix"],["dc.contributor.author","Sievers, Philipp"],["dc.contributor.author","Korshunov, Andrey"],["dc.contributor.author","Kool, Marcel"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Wick, Wolfgang"],["dc.contributor.author","Unterberg, Andreas"],["dc.contributor.author","Hartmann, Christian"],["dc.contributor.author","Dodgshun, Andrew"],["dc.contributor.author","Tabori, Uri"],["dc.contributor.author","Wesseling, Pieter"],["dc.contributor.author","Sahm, Felix"],["dc.contributor.author","von Deimling, Andreas"],["dc.contributor.author","Reuss, David E."],["dc.date.accessioned","2021-04-14T08:30:48Z"],["dc.date.available","2021-04-14T08:30:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00401-020-02243-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83379"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-0533"],["dc.relation.issn","0001-6322"],["dc.title","Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","5530"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Deng, Maximilian Y."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","Sill, Martin"],["dc.contributor.author","Stichel, Damian"],["dc.contributor.author","Balasubramanian, Gnana Prakash"],["dc.contributor.author","Tippelt, Stephan"],["dc.contributor.author","Kramm, Christof"],["dc.contributor.author","Donson, Andrew M."],["dc.contributor.author","Green, Adam L."],["dc.contributor.author","Jones, David T. W."],["dc.date.accessioned","2021-10-01T09:58:43Z"],["dc.date.available","2021-10-01T09:58:43Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2 , uncovering diagnostic markers and potentially actionable targets."],["dc.description.abstract","Abstract Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2 , uncovering diagnostic markers and potentially actionable targets."],["dc.identifier.doi","10.1038/s41467-021-25708-y"],["dc.identifier.pii","25708"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90126"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","2041-1723"],["dc.title","Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.contributor.author","Veldhuijzen van Zanten, Sophie E. M."],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","De Jongh, Dennis"],["dc.contributor.author","Sanchez Aliaga, Esther"],["dc.contributor.author","Barkhof, Frederik"],["dc.contributor.author","Noltes, Johan"],["dc.contributor.author","De Wolf, Ruben"],["dc.contributor.author","Van Dijk, Jet"],["dc.contributor.author","Cannarozzo, Antonio"],["dc.contributor.author","Damen-Korbijn, Carin M."],["dc.contributor.author","Lieverst, Jan A."],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Calmon, Raphael"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Giraud, Géraldine"],["dc.contributor.author","Slavc, Irene"],["dc.contributor.author","Van Gool, Stefaan"],["dc.contributor.author","Jacobs, Sandra"],["dc.contributor.author","Jadrijevic-Cvrlje, Filip"],["dc.contributor.author","Sumerauer, David"],["dc.contributor.author","Nysom, Karsten"],["dc.contributor.author","Pentikainen, Virve"],["dc.contributor.author","Kivivuori, Sanna-Maria"],["dc.contributor.author","Leblond, Pierre"],["dc.contributor.author","Entz-Werle, Natasha"],["dc.contributor.author","von Bueren, Andre O."],["dc.contributor.author","Kattamis, Antonis"],["dc.contributor.author","Hargrave, Darren R."],["dc.contributor.author","Hauser, Péter"],["dc.contributor.author","Garami, Miklos"],["dc.contributor.author","Thorarinsdottir, Halldora K."],["dc.contributor.author","Pears, Jane"],["dc.contributor.author","Gandola, Lorenza"],["dc.contributor.author","Rutkauskiene, Giedre"],["dc.contributor.author","Janssens, Geert O."],["dc.contributor.author","Torsvik, Ingrid K."],["dc.contributor.author","Perek-Polnik, Marta"],["dc.contributor.author","Gil-da-Costa, Maria J."],["dc.contributor.author","Zheludkova, Olga"],["dc.contributor.author","Shats, Liudmila"],["dc.contributor.author","Deak, Ladislav"],["dc.contributor.author","Kitanovski, Lidija"],["dc.contributor.author","Cruz, Ofelia"],["dc.contributor.author","Morales La Madrid, Andres"],["dc.contributor.author","Holm, Stefan"],["dc.contributor.author","Gerber, Nicolas"],["dc.contributor.author","Kebudi, Rejin"],["dc.contributor.author","Grundy, Richard"],["dc.contributor.author","Lopez-Aguilar, Enrique"],["dc.contributor.author","Zapata-Tarres, Marta"],["dc.contributor.author","Emmerik, John"],["dc.contributor.author","Hayden, Tim"],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Vandertop, William P."],["dc.contributor.author","Kaspers, Gertjan J. L."],["dc.contributor.author","Fouladi, Maryam"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","van Vuurden, Dannis G."],["dc.date.accessioned","2019-07-09T11:43:15Z"],["dc.date.available","2019-07-09T11:43:15Z"],["dc.date.issued","2017"],["dc.description.abstract","Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network. By bringing together biomedical professionals and parents as patient representatives, several collaborative DIPG-related projects have been realized. With help from experts in the fields of information technology, and legal advisors, an international, web-based comprehensive database was developed, The SIOPE DIPG Registry and Imaging Repository, to centrally collect data of DIPG patients. As for April 2016, clinical data as well as MR-scans of 694 patients have been entered into the SIOPE DIPG Registry/Imaging Repository. The median progression free survival is 6.0 months (95% Confidence Interval (CI) 5.6–6.4 months) and the median overall survival is 11.0 months (95% CI 10.5–11.5 months). At two and five years post-diagnosis, 10 and 2% of patients are alive, respectively. The establishment of the SIOPE DIPG Network and SIOPE DIPG Registry means a paradigm shift towards collaborative research into DIPG. This is seen as an essential first step towards understanding the disease, improving care and (ultimately) cure for children with DIPG."],["dc.identifier.doi","10.1007/s11060-016-2363-y"],["dc.identifier.pmid","28110411"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58845"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1573-7373"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","91"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","101"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Worst, Barbara C."],["dc.contributor.author","van Tilburg, Cornelis M."],["dc.contributor.author","Balasubramanian, Gnana Prakash"],["dc.contributor.author","Fiesel, Petra"],["dc.contributor.author","Witt, Ruth"],["dc.contributor.author","Freitag, Angelika"],["dc.contributor.author","Boudalil, Miream"],["dc.contributor.author","Previti, Christopher"],["dc.contributor.author","Wolf, Stephan"],["dc.contributor.author","Schmidt, Sabine"],["dc.contributor.author","Chotewutmontri, Sasithorn"],["dc.contributor.author","Bewerunge-Hudler, Melanie"],["dc.contributor.author","Schick, Matthias"],["dc.contributor.author","Schlesner, Matthias"],["dc.contributor.author","Hutter, Barbara"],["dc.contributor.author","Taylor, Lenka"],["dc.contributor.author","Borst, Tobias"],["dc.contributor.author","Sutter, Christian"],["dc.contributor.author","Bartram, Claus R."],["dc.contributor.author","Milde, Till"],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","Kulozik, Andreas E."],["dc.contributor.author","von Stackelberg, Arend"],["dc.contributor.author","Meisel, Roland"],["dc.contributor.author","Borkhardt, Arndt"],["dc.contributor.author","Reinhardt, Dirk"],["dc.contributor.author","Klusmann, Jan-Henning"],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Tippelt, Stephan"],["dc.contributor.author","Dirksen, Uta"],["dc.contributor.author","Juergens, Heribert"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Westermann, Frank"],["dc.contributor.author","Fischer, Matthias"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Wossmann, Wilhelm"],["dc.contributor.author","Nathrath, Michaela"],["dc.contributor.author","Bielack, Stefan S."],["dc.contributor.author","Fruehwald, Michael C."],["dc.contributor.author","Fulda, Simone"],["dc.contributor.author","Klingebiel, Thomas"],["dc.contributor.author","Koscielniak, Ewa"],["dc.contributor.author","Schwab, Matthias"],["dc.contributor.author","Tremmel, Roman"],["dc.contributor.author","Driever, Pablo Hernaiz"],["dc.contributor.author","Schulte, Johannes H."],["dc.contributor.author","Brors, Benedikt"],["dc.contributor.author","von Deimling, Andreas"],["dc.contributor.author","Lichter, Peter"],["dc.contributor.author","Eggert, Angelika"],["dc.contributor.author","Capper, David"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Witt, Olaf"],["dc.date.accessioned","2018-11-07T10:09:17Z"],["dc.date.available","2018-11-07T10:09:17Z"],["dc.date.issued","2016"],["dc.description.abstract","The 'Individualized Therapy for Relapsed Malignancies in Childhood' (INFORM) precision medicine study is a nationwide German program for children with high-risk relapsed/refractory malignancies, which aims to identify therapeutic targets on an individualised basis. In a pilot phase, reported here, we developed the logistical and analytical pipelines necessary for rapid and comprehensive molecular profiling in a clinical setting. Fifty-seven patients from 20 centers were prospectively recruited. Malignancies investigated included sarcomas (n = 25), brain tumours (n = 23), and others (n = 9). Whole-exome, low-coverage whole-genome, and RNA sequencing were complemented with methylation and expression microarray analyses. Alterations were assessed for potential targetability according to a customised prioritisation algorithm and subsequently discussed in an interdisciplinary molecular tumour board. Next-generation sequencing data were generated for 52 patients, with the full analysis possible in 46 of 52. Turnaround time from sample receipt until first report averaged 28 d. Twenty-six patients (50%) harbored a potentially druggable alteration with a prioritisation score of 'intermediate' or higher (level 4 of 7). Common targets included receptor tyrosine kinases, phosphoinositide 3-kinase-mammalian target of rapamycin pathway, mitogen-activated protein kinase pathway, and cell cycle control. Ten patients received a targeted therapy based on these findings, with responses observed in some previously treatment-refractory tumours. Comparative primary relapse analysis revealed substantial tumour evolution as well as one case of unsuspected secondary malignancy, highlighting the importance of re-biopsy at relapse. This study demonstrates the feasibility of comprehensive, real-time molecular profiling for high-risk paediatric cancer patients. This extended proof-of-concept, with examples of treatment consequences, expands upon previous personalised oncology endeavors, and presents a model with considerable interest and practical relevance in the burgeoning era of personalised medicine. (C) 2016 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2016.06.009"],["dc.identifier.isi","000382227300010"],["dc.identifier.pmid","27479119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39628"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1109"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","1113"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Kergrohen, Thomas"],["dc.contributor.author","Tauziède-Espariat, Arnault"],["dc.contributor.author","Mackay, Alan"],["dc.contributor.author","Ghermaoui, Samia"],["dc.contributor.author","Lechapt, Emmanuèle"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Boddaert, Nathalie"],["dc.contributor.author","Blauwblomme, Thomas"],["dc.contributor.author","Puget, Stéphanie"],["dc.contributor.author","Beccaria, Kévin"],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Debily, Marie-Anne"],["dc.date.accessioned","2020-12-10T14:10:28Z"],["dc.date.available","2020-12-10T14:10:28Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00401-020-02142-w"],["dc.identifier.eissn","1432-0533"],["dc.identifier.issn","0001-6322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70768"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","507"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","516"],["dc.bibliographiccitation.volume","134"],["dc.contributor.author","Korshunov, Andrey"],["dc.contributor.author","Schrimpf, Daniel"],["dc.contributor.author","Ryzhova, Marina"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Chavez, Lukas"],["dc.contributor.author","Hovestadt, Volker"],["dc.contributor.author","Sharma, Tanvi"],["dc.contributor.author","Habel, Antje"],["dc.contributor.author","Burford, Anna"],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Zheludkova, Olga"],["dc.contributor.author","Kumirova, Ella"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Golanov, Andrey"],["dc.contributor.author","Capper, David"],["dc.contributor.author","von Deimling, Andreas"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Jones, David T. W."],["dc.date.accessioned","2020-12-10T14:10:26Z"],["dc.date.available","2020-12-10T14:10:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00401-017-1710-1"],["dc.identifier.eissn","1432-0533"],["dc.identifier.issn","0001-6322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70760"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hoffman, Lindsey M."],["dc.contributor.author","van Zanten, Sophie Veldhuijzen"],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","Lane, Adam"],["dc.contributor.author","Fuller, Christine"],["dc.contributor.author","Miles, Lili"],["dc.contributor.author","Hawkins, Cynthia"],["dc.contributor.author","Bartels, Ute"],["dc.contributor.author","Bouffet, Eric"],["dc.contributor.author","Goldman, Stewart"],["dc.contributor.author","Leary, Sarah"],["dc.contributor.author","Foreman, Nicholas K."],["dc.contributor.author","Packer, Roger"],["dc.contributor.author","Warren, Katherine E."],["dc.contributor.author","Broniscer, Alberto"],["dc.contributor.author","Kieran, Mark W."],["dc.contributor.author","Minturn, Jane"],["dc.contributor.author","Comito, Melanie"],["dc.contributor.author","Broxon, Emmett"],["dc.contributor.author","Shih, Chie-Schin"],["dc.contributor.author","Khatua, Soumen"],["dc.contributor.author","Chintagumpala, Murali"],["dc.contributor.author","Carret, Anne-Sophie"],["dc.contributor.author","Hassall, Timothy"],["dc.contributor.author","Ziegler, David S."],["dc.contributor.author","Gottardo, Nick"],["dc.contributor.author","Dholaria, Hetal"],["dc.contributor.author","Lerme, Brianna"],["dc.contributor.author","Kirkendall, Jenavieve"],["dc.contributor.author","Doughman, Renee"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Wollman, Matthew"],["dc.contributor.author","O'Keefe, Rachel"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Solanki, Guirish"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Cvrlje, Filip Jadrijevic"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Drissi, Rachid"],["dc.contributor.author","Nazarian, Javad"],["dc.contributor.author","Jabado, Nada"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hargrave, Darren"],["dc.contributor.author","Sanchez, Esther"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Leach, James"],["dc.contributor.author","Jones, Blaise"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fouladi, Maryam"],["dc.date.accessioned","2018-11-07T10:13:07Z"],["dc.date.available","2018-11-07T10:13:07Z"],["dc.date.issued","2016"],["dc.identifier.isi","000379749000250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","321"],["dc.bibliographiccitation.issue","7696"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","555"],["dc.contributor.author","Gröbner, Susanne N."],["dc.contributor.author","Worst, Barbara C."],["dc.contributor.author","Weischenfeldt, Joachim"],["dc.contributor.author","Buchhalter, Ivo"],["dc.contributor.author","Kleinheinz, Kortine"],["dc.contributor.author","Rudneva, Vasilisa A."],["dc.contributor.author","Johann, Pascal D."],["dc.contributor.author","Balasubramanian, Gnana Prakash"],["dc.contributor.author","Segura-Wang, Maia"],["dc.contributor.author","Brabetz, Sebastian"],["dc.contributor.author","Bender, Sebastian"],["dc.contributor.author","Hutter, Barbara"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","Hübschmann, Daniel"],["dc.contributor.author","Zipprich, Gideon"],["dc.contributor.author","Heinold, Michael"],["dc.contributor.author","Eils, Jürgen"],["dc.contributor.author","Lawerenz, Christian"],["dc.contributor.author","Erkek, Serap"],["dc.contributor.author","Lambo, Sander"],["dc.contributor.author","Waszak, Sebastian"],["dc.contributor.author","Blattmann, Claudia"],["dc.contributor.author","Borkhardt, Arndt"],["dc.contributor.author","Kuhlen, Michaela"],["dc.contributor.author","Eggert, Angelika"],["dc.contributor.author","Fulda, Simone"],["dc.contributor.author","Gessler, Manfred"],["dc.contributor.author","Wegert, Jenny"],["dc.contributor.author","Kappler, Roland"],["dc.contributor.author","Baumhoer, Daniel"],["dc.contributor.author","Burdach, Stefan"],["dc.contributor.author","Kirschner-Schwabe, Renate"],["dc.contributor.author","Kontny, Udo"],["dc.contributor.author","Kulozik, Andreas E."],["dc.contributor.author","Lohmann, Dietmar"],["dc.contributor.author","Hettmer, Simone"],["dc.contributor.author","Eckert, Cornelia"],["dc.contributor.author","Bielack, Stefan"],["dc.contributor.author","Nathrath, Michaela"],["dc.contributor.author","Niemeyer, Charlotte"],["dc.contributor.author","Richter, Günther H."],["dc.contributor.author","Schulte, Johannes"],["dc.contributor.author","Siebert, Reiner"],["dc.contributor.author","Westermann, Frank"],["dc.contributor.author","Molenaar, Jan J."],["dc.contributor.author","Vassal, Gilles"],["dc.contributor.author","Witt, Hendrik"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kratz, Christian P."],["dc.contributor.author","Witt, Olaf"],["dc.contributor.author","van Tilburg, Cornelis M."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Dirksen, Uta"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Frühwald, Michael"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Wolf, Stephan"],["dc.contributor.author","Klingebiel, Thomas"],["dc.contributor.author","Koscielniak, Ewa"],["dc.contributor.author","Landgraf, Pablo"],["dc.contributor.author","Koster, Jan"],["dc.contributor.author","Resnick, Adam C."],["dc.contributor.author","Zhang, Jinghui"],["dc.contributor.author","Liu, Yanling"],["dc.contributor.author","Zhou, Xin"],["dc.contributor.author","Waanders, Angela J."],["dc.contributor.author","Zwijnenburg, Danny A."],["dc.contributor.author","Raman, Pichai"],["dc.contributor.author","Brors, Benedikt"],["dc.contributor.author","Weber, Ursula D."],["dc.contributor.author","Northcott, Paul A."],["dc.contributor.author","Pajtler, Kristian W."],["dc.contributor.author","Kool, Marcel"],["dc.contributor.author","Piro, Rosario M."],["dc.contributor.author","Korbel, Jan O."],["dc.contributor.author","Schlesner, Matthias"],["dc.contributor.author","Eils, Roland"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Lichter, Peter"],["dc.contributor.author","Chavez, Lukas"],["dc.contributor.author","Zapatka, Marc"],["dc.contributor.author","Pfister, Stefan M."],["dc.date.accessioned","2020-12-10T18:09:29Z"],["dc.date.available","2020-12-10T18:09:29Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/nature25480"],["dc.identifier.eissn","1476-4687"],["dc.identifier.issn","0028-0836"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15624"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73666"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The landscape of genomic alterations across childhood cancers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]