Kramm, Christof M.

[["dc.bibliographiccitation.artnumber","177"],["dc.bibliographiccitation.journal","Radiation Oncology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Scheithauer, Heike"],["dc.contributor.author","Pietschmann, Sophie"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Roessler, Jochen"],["dc.contributor.author","Graf, Norbert"],["dc.contributor.author","Baumert, Brigitta G."],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.date.accessioned","2018-11-07T09:36:38Z"],["dc.date.available","2018-11-07T09:36:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Background and purpose: The aim of the present analysis was to assess the feasibility, toxicity, and the tumor control of reirradiation as a salvage treatment for progressive pediatric non-pontine high-grade gliomas (HGG). Patients and methods: The database of the Reference Center for Radiation Oncology of the German HIT (HIT = German acronym for brain tumor) treatment network for childhood brain tumors was screened for children who were reirradiated for progressive non-pontine HGG. Results: We identified eight patients (WHO grade III: n = 5; WHO grade IV: n = 3) who underwent reirradiation between April 2006 and July 2012. Median age was 13.5 years at primary diagnosis and 14.8 years at first progression. All patients initially underwent surgery (incomplete resection, n = 7; biopsy, n = 1) followed by radiochemotherapy. Relapses occurred inside (n = 2), at the margin (n = 4), and outside of the preirradiated area (n = 2). In all patients, reirradiation was tolerated well without significant acute toxicity. Temporary clinical improvement and tumor regression on magnetic resonance imaging (MRI) following reirradiation was reported (n = 3). However, all patients finally died by disease progression. Median survival time was 26.2 months from initial diagnosis and 11.4 months after first progression. Median time interval between initial radiotherapy and first reirradiation was 9.0 months. In six patients, all macroscopic tumor deposits were reirradiated. In these patients, median progression-free (overall) survival from the start of reirradiation was 2.4 (4.6) months. Conclusion: Our analysis, although based on a limited patient number, suggests that reirradiation of progressive non-pontine HGG is feasible in children. Benefit in terms of quality of life and/or survival needs to be assessed in a prospective and ideally in a randomized manner."],["dc.identifier.doi","10.1186/1748-717X-9-177"],["dc.identifier.isi","000341198300001"],["dc.identifier.pmid","25112658"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32662"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1748-717X"],["dc.title","Reirradiation as part of a salvage treatment approach for progressive non-pontine pediatric high-grade gliomas: preliminary experiences from the German HIT-HGG study group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Kuehn, Alexander"],["dc.contributor.author","Zimmermann, Martin"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Nowak, Johannes"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Schrappe, Martin"],["dc.contributor.author","Escherich, Gabriele"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:06Z"],["dc.date.available","2018-11-07T10:13:06Z"],["dc.date.issued","2016"],["dc.format.extent","55"],["dc.identifier.isi","000379749000210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","HIGH-GRADE GLIOMA ARISING IN SURVIVORS OF PEDIATRIC ACUTE LYMPHOBLASTIC MALIGNANCIES: A COOPERATIVE ANALYSIS OF THE GERMAN HIT-HGG/-GBM AND ALL-BFM/COALL STUDIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schlamann, Annika"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Hagel, Christian"],["dc.contributor.author","Kramm, Christof"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Mueller, Klaus"],["dc.date.accessioned","2018-11-07T09:17:48Z"],["dc.date.available","2018-11-07T09:17:48Z"],["dc.date.issued","2013"],["dc.format.extent","132"],["dc.identifier.isi","000327456200530"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28253"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","CLINICAL CHARACTERISTICS AND OUTCOME OF PAPILLARY GLIONEURONAL TUMOR, ROSETTE-FORMING GLIONEURONAL TUMOR OF THE FOURTH VENTRICLE AND GLIONEURONAL TUMOR WITH NEUROPIL-LIKE ISLANDSUPDATE OF AN ONGOING INTERNATIONAL INDIVIDUAL PATIENT DATA META-ANALYSIS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","134"],["dc.bibliographiccitation.journal","Pediatric Blood & Cancer"],["dc.bibliographiccitation.lastpage","135"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Wolff, J."],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Faldum, Andreas"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Metz, M. Warmuth"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Slavc, I."],["dc.contributor.author","Graf, Norbert"],["dc.contributor.author","Gnekow, Astrid"],["dc.contributor.author","Kuehl, Joern-Sven"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Kramm, C."],["dc.date.accessioned","2018-11-07T09:20:23Z"],["dc.date.available","2018-11-07T09:20:23Z"],["dc.date.issued","2013"],["dc.identifier.isi","000324735501029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28867"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1545-5017"],["dc.relation.issn","1545-5009"],["dc.title","HIGH-DOSE METHOTREXATE IMPROVED SURVIVAL IN PEDIATRIC GLIOBLASTOMA: RESULTS OF HIT-GBM-D"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Schlamann, Annika"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Pietschmann, Sophie"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.date.accessioned","2018-11-07T09:17:48Z"],["dc.date.available","2018-11-07T09:17:48Z"],["dc.date.issued","2013"],["dc.format.extent","171"],["dc.identifier.isi","000327456200677"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28255"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","CRANIOSPINAL IRRADIATION WITH CONCURRENT METRONOMIC TEMOZOLOMIDE FOR THE TREATMENT OF PRIMARY METASTATIC HIGH-GRADE OR DIFFUSE INTRINSIC PONTINE GLIOMAS IN CHILDREN: EXPERIENCES FROM THE GERMAN MULTICENTER HIT-HGG 2007 TRIAL"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Janssens, Geert O."],["dc.contributor.author","Gandola, Lorenza"],["dc.contributor.author","Bolle, Stephanie"],["dc.contributor.author","Mandeville, Henry"],["dc.contributor.author","Ramos-Albiac, Monica"],["dc.contributor.author","Menten, Johan"],["dc.contributor.author","Benghiat, Helen"],["dc.contributor.author","Hoeben, Bianca"],["dc.contributor.author","La Madrid, Andres Morales"],["dc.contributor.author","Pecori, Emilia"],["dc.contributor.author","Peters, Max"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Hargrave, Darren"],["dc.contributor.author","von Bueren, Andre O."],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:05Z"],["dc.date.available","2018-11-07T10:13:05Z"],["dc.date.issued","2016"],["dc.format.extent","53"],["dc.identifier.isi","000379749000204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40366"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","SURVIVAL BENEFIT FOR PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) UNDERGOING RE-IRRADIATION AT FIRST PROGRESSION: ANALYSIS OF THE SIOP-E-DIPG/HGG WORKING GROUP"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","34"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","35"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Mynarek, Martin"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Witt, Hendrik"],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Schmid, Irene"],["dc.contributor.author","Kramm, Christof"],["dc.contributor.author","Vorwerk, Peter"],["dc.contributor.author","Beilken, Andreas"],["dc.contributor.author","Classen, Carl Friedrich"],["dc.contributor.author","Driever, Pablo Hernaiz"],["dc.contributor.author","Kropshofer, Gabriele"],["dc.contributor.author","Imschweiler, Thomas"],["dc.contributor.author","Juhnke, Bjoern-Ole"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","von Hoff, Katja"],["dc.date.accessioned","2018-11-07T10:13:04Z"],["dc.date.available","2018-11-07T10:13:04Z"],["dc.date.issued","2016"],["dc.identifier.isi","000379749000131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40365"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","NEWLY DIAGNOSED METASTATIC INTRACRANIAL EPENDYMOMA IN CHILDREN: FREQUENCY, TREATMENT AND OUTCOME IN THE POPULATION BASED, PROSPECTIVE HIT-SERIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Seidel, Clemens"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Kordes, Uwe"],["dc.contributor.author","Sander, Annette"],["dc.contributor.author","Roessler, Jochen"],["dc.contributor.author","Graf, Norbert"],["dc.contributor.author","Scheithauer, Heike"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.date.accessioned","2018-11-07T09:39:22Z"],["dc.date.available","2018-11-07T09:39:22Z"],["dc.date.issued","2014"],["dc.format.extent","120"],["dc.identifier.isi","000337924200462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33263"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","SALVAGE TREATMENT OF PROGRESSIVE NON-PONTINE PEDIATRIC HIGH-GRADE GLIOMAS BY RE-IRRADIATION: PRELIMINARY EXPERIENCES FROM THE GERMAN HIT-HGG STUDY GROUP"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Karremann, Michael"],["dc.contributor.author","Gielen, Gerrit H"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Wiese, Maria"],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Claviez, Alexander"],["dc.contributor.author","van Vuurden, Dannis G"],["dc.contributor.author","von Bueren, André O"],["dc.contributor.author","Gessi, Marco"],["dc.contributor.author","Kühnle, Ingrid"],["dc.contributor.author","Hans, Volkmar H"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Waha, Andreas"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Kramm, Christof M"],["dc.date.accessioned","2020-12-10T18:19:37Z"],["dc.date.available","2020-12-10T18:19:37Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/neuonc/nox149"],["dc.identifier.eissn","1523-5866"],["dc.identifier.issn","1522-8517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75312"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","619"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Journal of Paediatric Neurology"],["dc.bibliographiccitation.lastpage","639"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Tallen, Gesche"],["dc.contributor.author","Resch, Anika"],["dc.contributor.author","Calaminus, Gabriele"],["dc.contributor.author","Wiener, Andreas"],["dc.contributor.author","Leiss, Ulrike"],["dc.contributor.author","Pletschko, Thomas"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Langer, Thorsten"],["dc.contributor.author","Grabow, Desiree"],["dc.contributor.author","Driever, Pablo Hernaiz"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Timmermann, Beate"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Thomale, Ulrich-Wilhelm"],["dc.contributor.author","Krauss, Juergen"],["dc.contributor.author","Mynarek, Martin"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Ottensmeier, Holger"],["dc.contributor.author","Fruehwald, Michael C."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Temming, Petra"],["dc.contributor.author","Mueller, Hermann L."],["dc.contributor.author","Witt, Olaf"],["dc.contributor.author","Kordes, Uwe"],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Gnekow, Astrid"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:49:46Z"],["dc.date.available","2018-11-07T09:49:46Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Tumours of the central nervous system (CNS) are the most frequent solid tumours and the second most frequent type of cancer in children and adolescents. Overall survival has continuously improved in Germany, since an increasing number of patients have been treated according to standardised, multicentre, multimodal treatment recommendations, trials of the German Paediatric Brain Tumour Consortium (HIT-Network) or the International Society of Paediatric Oncology-Europe (SIOP-E) during the last decades. Today, two out of three patients survive. At least 8000 long-term childhood brain tumour survivors (CBTS) are currently living in Germany. They face lifelong disease- and treatment-related late effects (LE) and associated socioeconomic problems more than many other childhood cancer survivors (CCS). Method: We review the LE and resulting special needs of this particular group of CCS. Results: Despite their increasing relevance for future treatment optimisation, neither the diversity of chronic and cumulative LE nor their pertinent risk factors and subsequent impact on quality of survival have yet been comprehensively addressed for CBTS treated according to HIT- or SIOP-E-protocols. Evidence-based information to empower survivors and stakeholders, as well as medical expertise to manage their individual health care, psychosocial and educational/vocational needs must still be generated and established. Conclusion: The establishment of a long-term research- and care network in Germany shall contribute to a European platform, that aims at optimising CBTSs' transition into adulthood as resilient individuals with high quality of survival including optimal levels of activity, participation and acceptance by society. (C) 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejpn.2015.07.011"],["dc.identifier.isi","000363346400003"],["dc.identifier.pmid","26278499"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35570"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1532-2130"],["dc.relation.issn","1090-3798"],["dc.title","Strategies to improve the quality of survival for childhood brain tumour survivors"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]