Kramm, Christof M.

[["dc.bibliographiccitation.firstpage","64564"],["dc.bibliographiccitation.issue","38"],["dc.bibliographiccitation.journal","Oncotarget"],["dc.bibliographiccitation.lastpage","64578"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","El-Ayadi, Moatasem"],["dc.contributor.author","Ansari, Marc"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre O."],["dc.date.accessioned","2021-06-01T10:48:31Z"],["dc.date.available","2021-06-01T10:48:31Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.18632/oncotarget.18478"],["dc.identifier.eissn","1949-2553"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85962"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1949-2553"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","High-grade glioma in very young children: a rare and particular patient population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","27300"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Oncotarget"],["dc.bibliographiccitation.lastpage","27313"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Wiese, Maria"],["dc.contributor.author","Walther, Neele"],["dc.contributor.author","Diederichs, Christopher"],["dc.contributor.author","Schill, Fabian"],["dc.contributor.author","Monecke, Sebastian"],["dc.contributor.author","Salinas, Gabriella"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfister, Stefan"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Johnsen, Steven Arthur"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-10-10T07:29:11Z"],["dc.date.available","2018-10-10T07:29:11Z"],["dc.date.issued","2017-04-18"],["dc.description.abstract","Pediatric high-grade gliomas (pedHGG) belong to the most aggressive cancers in children with a poor prognosis due to a lack of efficient therapeutic strategies. The β-catenin/Wnt-signaling pathway was shown to hold promising potential as a treatment target in adult high-grade gliomas by abrogating tumor cell invasion and the acquisition of stem cell-like characteristics. Since pedHGG differ from their adult counterparts in genetically and biologically we aimed to investigate the effects of β-catenin/Wnt-signaling pathway-inhibition by the β-catenin/CBP antagonist ICG-001 in pedHGG cell lines. In contrast to adult HGG, pedHGG cells displayed minimal detectable canonical Wnt-signaling activity. Nevertheless, low doses of ICG-001 inhibited cell migration/invasion, tumorsphere- and colony formation, proliferation in vitro as well as tumor growth in vivo/ovo, suggesting that ICG-001 affects pedHGG tumor cell characteristics independent of β-catenin/Wnt-signaling. RNA-sequencing analyses support a Wnt/β-catenin-independent effect of ICG-001 on target gene transcription, revealing strong effects on genes involved in cellular metabolic/biosynthetic processes and cell cycle progression. Among these, high mRNA expression of cell cycle regulator JDP2 was found to confer a better prognosis for pedHGG patients. In conclusion, ICG-001 might offer an effective treatment option for pedHGG patients functioning to regulate cell phenotype and gene expression programs in absence of Wnt/β-catenin signaling-activity."],["dc.fs.pkfprnr","86261"],["dc.identifier.doi","10.18632/oncotarget.15934"],["dc.identifier.fs","633047"],["dc.identifier.pmid","28460484"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14424"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15920"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1949-2553"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.contributor.author","Veldhuijzen van Zanten, Sophie E. M."],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","De Jongh, Dennis"],["dc.contributor.author","Sanchez Aliaga, Esther"],["dc.contributor.author","Barkhof, Frederik"],["dc.contributor.author","Noltes, Johan"],["dc.contributor.author","De Wolf, Ruben"],["dc.contributor.author","Van Dijk, Jet"],["dc.contributor.author","Cannarozzo, Antonio"],["dc.contributor.author","Damen-Korbijn, Carin M."],["dc.contributor.author","Lieverst, Jan A."],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Jones, David T. W."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Calmon, Raphael"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Giraud, Géraldine"],["dc.contributor.author","Slavc, Irene"],["dc.contributor.author","Van Gool, Stefaan"],["dc.contributor.author","Jacobs, Sandra"],["dc.contributor.author","Jadrijevic-Cvrlje, Filip"],["dc.contributor.author","Sumerauer, David"],["dc.contributor.author","Nysom, Karsten"],["dc.contributor.author","Pentikainen, Virve"],["dc.contributor.author","Kivivuori, Sanna-Maria"],["dc.contributor.author","Leblond, Pierre"],["dc.contributor.author","Entz-Werle, Natasha"],["dc.contributor.author","von Bueren, Andre O."],["dc.contributor.author","Kattamis, Antonis"],["dc.contributor.author","Hargrave, Darren R."],["dc.contributor.author","Hauser, Péter"],["dc.contributor.author","Garami, Miklos"],["dc.contributor.author","Thorarinsdottir, Halldora K."],["dc.contributor.author","Pears, Jane"],["dc.contributor.author","Gandola, Lorenza"],["dc.contributor.author","Rutkauskiene, Giedre"],["dc.contributor.author","Janssens, Geert O."],["dc.contributor.author","Torsvik, Ingrid K."],["dc.contributor.author","Perek-Polnik, Marta"],["dc.contributor.author","Gil-da-Costa, Maria J."],["dc.contributor.author","Zheludkova, Olga"],["dc.contributor.author","Shats, Liudmila"],["dc.contributor.author","Deak, Ladislav"],["dc.contributor.author","Kitanovski, Lidija"],["dc.contributor.author","Cruz, Ofelia"],["dc.contributor.author","Morales La Madrid, Andres"],["dc.contributor.author","Holm, Stefan"],["dc.contributor.author","Gerber, Nicolas"],["dc.contributor.author","Kebudi, Rejin"],["dc.contributor.author","Grundy, Richard"],["dc.contributor.author","Lopez-Aguilar, Enrique"],["dc.contributor.author","Zapata-Tarres, Marta"],["dc.contributor.author","Emmerik, John"],["dc.contributor.author","Hayden, Tim"],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Vandertop, William P."],["dc.contributor.author","Kaspers, Gertjan J. L."],["dc.contributor.author","Fouladi, Maryam"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","van Vuurden, Dannis G."],["dc.date.accessioned","2019-07-09T11:43:15Z"],["dc.date.available","2019-07-09T11:43:15Z"],["dc.date.issued","2017"],["dc.description.abstract","Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network. By bringing together biomedical professionals and parents as patient representatives, several collaborative DIPG-related projects have been realized. With help from experts in the fields of information technology, and legal advisors, an international, web-based comprehensive database was developed, The SIOPE DIPG Registry and Imaging Repository, to centrally collect data of DIPG patients. As for April 2016, clinical data as well as MR-scans of 694 patients have been entered into the SIOPE DIPG Registry/Imaging Repository. The median progression free survival is 6.0 months (95% Confidence Interval (CI) 5.6–6.4 months) and the median overall survival is 11.0 months (95% CI 10.5–11.5 months). At two and five years post-diagnosis, 10 and 2% of patients are alive, respectively. The establishment of the SIOPE DIPG Network and SIOPE DIPG Registry means a paradigm shift towards collaborative research into DIPG. This is seen as an essential first step towards understanding the disease, improving care and (ultimately) cure for children with DIPG."],["dc.identifier.doi","10.1007/s11060-016-2363-y"],["dc.identifier.pmid","28110411"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58845"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1573-7373"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

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