Gliem, Nina

[["dc.bibliographiccitation.journal","Japanese Journal of Radiology"],["dc.contributor.author","Biggemann, Lorenz"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Al-Bourini, Omar"],["dc.contributor.author","Wedi, Edris"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Streit, Ulrike"],["dc.date.accessioned","2022-01-11T14:05:34Z"],["dc.date.available","2022-01-11T14:05:34Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Purpose To assess the esophagogastric junction (EGJ) on real-time MRI and compare imaging parameters to EGJ morphology on high-resolution manometry (HRM). Methods A total of 105 of 117 eligible patients who underwent real-time MRI and high-resolution manometry for GERD-like symptoms between 2015 and 2018 at a single center were retrospectively evaluated (male n  = 57; female n  = 48; mean age 52.5 ± 15.4 years). Real-time MRI was performed at a median investigation time of 15 min (1 frame/40 ms). On HRM, EGJ morphology was assessed according to the Chicago classification of esophageal motility disorders. Real-time MRI was performed at 3 T using highly undersampled radial fast low-angle shot acquisitions with NLINV image reconstruction. A 10 mL pineapple juice bolus served as oral contrast agent at supine position. Real-time MRI films of the EGJ were acquired during swallowing events and during Valsalva maneuver. Anatomic and functional MRI parameters were compared to EGJ morphology on HRM. Results On HRM, n  = 42 patients presented with EGJ type I (40.0%), n  = 33 with EGJ type II (31.4%), and n  = 30 with EGJ type III (28.6%). On real-time MRI, hiatal hernia was more common in patients with EGJ type III (66.7%) than in patients with EGJ type I (26.2%) and EGJ type II (30.3%; p  < 0.001). Sliding hiatal hernia was more frequent in patients with EGJ type II (33.3%) than in patients with EGJ type III (16.7%) and EGJ type I (7.1%; p  = 0.017). The mean esophagus–fundus angle of patients was 85 ± 31° at rest and increased to 101 ± 36° during Valsalva maneuver. Conclusion Real-time MRI is a non-invasive imaging method for assessment of the esophagogastric junction. Real-time MRI can visualize dynamic changes of the EGJ during swallowing events."],["dc.identifier.doi","10.1007/s11604-021-01210-9"],["dc.identifier.pii","1210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97695"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1867-108X"],["dc.relation.issn","1867-1071"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.relation.orgunit","Institut für Diagnostische und Interventionelle Neuroradiologie"],["dc.relation.orgunit","Max-Planck-Institut für biophysikalische Chemie"],["dc.title","Assessment of esophagogastric junction morphology by dynamic real-time MRI: comparison of imaging features to high-resolution manometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","108856"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Streit, Ulrike"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Wedi, Edris"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Ahmed, Saheeb"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Biggemann, Lorenz"],["dc.date.accessioned","2020-05-13T13:44:06Z"],["dc.date.available","2020-05-13T13:44:06Z"],["dc.date.issued","2020-04"],["dc.description.abstract","Purpose To evaluate the diagnostic potential of real-time MRI for dynamic assessment of gastroesophageal reflux in patients with GERD (gastroesophageal reflux disease)-like symptoms compared to pH-metry and impedance. Methods Patients who underwent real-time MRI and pH-metry between 2015–2018 were included in this retrospective study. Real-time MRI at 3 T was achieved by undersampled radial FLASH acquisitions with iterative image reconstruction by NLINV. Real-time MRI visualized transit of pineapple juice through the gastroesophageal junction and during Valsalva maneuver. MRI results were compared to 24 h pH-metry to assess acidic reflux (following Lyon Consensus guidelines) and to impedance to assess non-acidic reflux. A standard 2 × 2 table was chosen to calculate diagnostic performance. Results 91/93 eligible patients fulfilled inclusion criteria (male n = 49; female n = 42; median age 55 y). All MRI studies were successfully completed without adverse events at a mean examination time of 15 min. On real-time MRI, reflux was evident in 60 patients (66 %). pH-metry revealed reflux in 41 patients (45 %), and impedance in 54 patients (59 %). Compared to pH-metry and impedance, real-time MRI sensitivity was 0.78 (95 % CI: 0.66-0.87), specificity 0.67 (95 % CI: 0.45-0.84) and PPV 0.87 (95 % CI: 0.75-0.94). Conclusion Real-time MRI is an imaging method for assessment of gastroesophageal reflux in patients with GERD-like symptoms. Considering its high positive predictive value, real-time MRI can accurately identify patients in which further invasive testing with pH-metry and impedance might be considered."],["dc.identifier.doi","10.1016/j.ejrad.2020.108856"],["dc.identifier.pmid","32062571"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/65362"],["dc.language.iso","en"],["dc.relation.eissn","1872-7727"],["dc.relation.issn","0720-048X"],["dc.title","Real-time MRI for dynamic assessment of gastroesophageal reflux disease: Comparison to pH-metry and impedance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109265"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Biggemann, Lorenz"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Al-Bourini, Omar"],["dc.contributor.author","Wedi, Edris"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Streit, Ulrike"],["dc.date.accessioned","2021-03-08T07:14:06Z"],["dc.date.available","2021-03-08T07:14:06Z"],["dc.date.issued","2020-11"],["dc.description.abstract","To investigate imaging findings of esophageal motility disorders on dynamic real-time."],["dc.identifier.doi","10.1016/j.ejrad.2020.109265"],["dc.identifier.pmid","33010683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80478"],["dc.language.iso","en"],["dc.relation.eissn","1872-7727"],["dc.relation.issn","0720-048X"],["dc.title","Assessment of esophageal motility disorders by real-time MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]