Schön, Michael P.

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Immunology"],["dc.bibliographiccitation.lastpage","205"],["dc.bibliographiccitation.volume","128"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Hardt, Katja"],["dc.contributor.author","Hatting, Max"],["dc.contributor.author","Bistrian, Roxana"],["dc.contributor.author","Diehl, Sandra"],["dc.contributor.author","Radeke, Heinfried H."],["dc.contributor.author","Podda, Maurizio"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kaufmann, Roland"],["dc.contributor.author","Henschler, Reinhard"],["dc.contributor.author","Pfeilschifter, Josef M."],["dc.contributor.author","Santoso, Sentot"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.date.accessioned","2018-11-07T11:23:44Z"],["dc.date.available","2018-11-07T11:23:44Z"],["dc.date.issued","2009"],["dc.description.abstract","P>Junctional adhesion molecule-A (JAM-A), JAM-B and JAM-C have been implicated in leucocyte transmigration. As JAM-B binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1, we hypothesized that JAM-B is also involved in leucocyte rolling and firm adhesion. To test this hypothesis, intravital microscopy of murine skin microvasculature was performed. Rolling interactions of murine leucocytes were significantly affected by blockade of JAM-B [which reduced rolling interactions from 9 center dot 1 +/- 2 center dot 6% to 3 center dot 2 +/- 1 center dot 2% (mean +/- standard deviation)]. To identify putative ligands, T lymphocytes were perfused over JAM-B-coated slides in a dynamic flow chamber system. JAM-B-dependent rolling and sticking interactions were observed at low shear stress [0 center dot 3 dyn/cm(2): 220 +/- 71 (mean +/- standard deviation) versus 165 +/- 88 rolling (P < 0 center dot 001; Mann-Whitney rank sum test) and 2 center dot 6 +/- 1 center dot 3 versus 1 center dot 0 +/- 0 center dot 7 sticking cells/mm(2)/min (P = 0 center dot 026; Mann-Whitney rank sum test) on JAM-B- compared with baseline], but not at higher shear forces (1 center dot 0 dyn/cm(2)). As demonstrated by antibody blocking experiments, JAM-B-mediated rolling and sticking of T lymphocytes was dependent on alpha 4 and beta 1 integrin, but not JAM-C expression. To investigate whether JAM-B-mediated leucocyte-endothelium interactions are involved in a disease-relevant in vivo model, adoptive transfer experiments in 2,4,-dinitrofluorobenzene (DNFB)-induced contact hypersensitivity reactions were performed in mice in the absence or in the presence of a function-blocking JAM-B antibody. In this model, JAM-B blockade during the sensitization phase impaired the generation of the immune response to DNFB, which was assessed as the increase in ear swelling in untreated, DNFB-challenged mice, by close to 40% [P = 0 center dot 037; analysis of variance (anova)]. Overall, JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion."],["dc.description.sponsorship","J.W. Goethe University; Deutsche Forschungsgemeinschaft [Lu877/3-1]"],["dc.identifier.doi","10.1111/j.1365-2567.2009.03100.x"],["dc.identifier.isi","000269580300005"],["dc.identifier.pmid","19740376"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56253"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0019-2805"],["dc.title","Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha 4 beta 1 integrin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Mrowietz, Ulrich"],["dc.contributor.author","Altmeyer, Peter"],["dc.contributor.author","Augustin, Matthias"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Bonnekoh, Bernd"],["dc.contributor.author","Frambach, Yvonne"],["dc.contributor.author","Gambichler, Thilo"],["dc.contributor.author","Ghoreschi, Kamran"],["dc.contributor.author","Hertl, Michael"],["dc.contributor.author","Hund, Anna-Carina"],["dc.contributor.author","Jacobi, Arnd"],["dc.contributor.author","Kuhn, Annegret"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Luger, Thomas A."],["dc.contributor.author","Martin, Stefan F."],["dc.contributor.author","Merk, Hans"],["dc.contributor.author","Norgauer, Johannes"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Rostami-Yazdi, Martin"],["dc.contributor.author","Sabat, Robert"],["dc.contributor.author","Schaekel, Knut"],["dc.contributor.author","Scharffetter-Kochanek, Karin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Scola, Nina"],["dc.contributor.author","Sticherling, Michael"],["dc.contributor.author","Thaci, Diamant"],["dc.contributor.author","Wilsmann-Theis, Dagmar"],["dc.contributor.author","Viehweg, Antje"],["dc.contributor.author","Wozel, Gottfried"],["dc.contributor.author","Zouboulis, Christos C."],["dc.contributor.author","Neureither, Marcus"],["dc.date.accessioned","2018-11-07T09:02:45Z"],["dc.date.available","2018-11-07T09:02:45Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1111/j.1610-0379.2012.08047.x"],["dc.identifier.isi","000312161900001"],["dc.identifier.pmid","23198820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24758"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0379"],["dc.title","New Insights into Tumaric Acid Esters (Fumaderm (R)): Results of the second Expert Workshops"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","238"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","245"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Giegold, Oliver"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Hardt, Katja"],["dc.contributor.author","Will, Jutta"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Oostingh, Gertie J."],["dc.contributor.author","Pfeilschifter, Josef M."],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Radeke, Heinfried H."],["dc.date.accessioned","2018-11-07T08:32:00Z"],["dc.date.available","2018-11-07T08:32:00Z"],["dc.date.issued","2009"],["dc.description.abstract","Experimentally, initial steps of leucocyte extravasation, including tethering and rolling, are analysed in endothelial cell flow chambers. Given the complexity and speed of endothelial-immune cell interaction, computer-aided advances of this analysis are highly desirable. Herein, we compared two established methods, hand counting and tracking software, with novel analysis software using defined movies recorded at standard conditions of endothelial-leucocyte interactions. As a first validation, cell counts and velocity parameters determined by seven experienced experts revealed no statistic differences to both semi-automated tracking and fully computerized analyses. Nevertheless, interindividual variations were substantial for hand counting. In additional experiments, velocity distributions between 1 and 800 mu m/s picked up by the fully computerized analysis matched well with the tracking software as indicated by speed vector histograms. With respect to the time consumed for a defined set of movies, hand counting took 3.6 +/- 1.6 h, tracking software 4.5 +/- 1.2 h, whereas fully automated analysis consumed less than 15 min, reaching real-time mode. Thus, a validated and fully computerized method yielded functional flow chamber data unbiased, independent from an examiner, and reaching high-throughput level, which in turn will allow a substantial progress in understanding this process central for skin inflammation."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.1111/j.1600-0625.2008.00793.x"],["dc.identifier.isi","000263520200008"],["dc.identifier.pmid","19054063"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17247"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0906-6705"],["dc.title","Computer-aided analysis of cell interactions under dynamic flow conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","857"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","859"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Rubant, Simone"],["dc.contributor.author","Hardt, Katja"],["dc.contributor.author","Santoso, Sentot"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Ludwig, Ralf J."],["dc.date.accessioned","2018-11-07T08:44:57Z"],["dc.date.available","2018-11-07T08:44:57Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1160/TH09-08-0572"],["dc.identifier.isi","000277031700025"],["dc.identifier.pmid","20135068"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20316"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0340-6245"],["dc.title","Constitutive and functionally relevant expression of JAM-C on platelets"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e11911"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","JMIR Research Protocols"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kromer, Christian"],["dc.contributor.author","Nühnen, Viktoria P"],["dc.contributor.author","Pfützner, Wolfgang"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Laubach, Hans-Joachim"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Liebmann, Joerg"],["dc.contributor.author","Born, Matthias"],["dc.contributor.author","Schön, Michael P"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2020-12-10T18:43:05Z"],["dc.date.available","2020-12-10T18:43:05Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.2196/11911"],["dc.identifier.eissn","1929-0748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78189"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1192"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.lastpage","1202"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Alban, Susanne"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Bendas, Gerd"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Oostingh, Gertie J."],["dc.contributor.author","Radeke, Heinfried H."],["dc.contributor.author","Fritzsche, Juliane"],["dc.contributor.author","Pfeilschifter, Josef M."],["dc.contributor.author","Kaufmann, Roland"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.date.accessioned","2018-11-07T08:30:22Z"],["dc.date.available","2018-11-07T08:30:22Z"],["dc.date.issued","2009"],["dc.description.abstract","Leukocyte extravasation is initiated by an interaction of selectin adhesion molecules and appropriate carbohydrate ligands. Targeting those interactions seems a promising approach to treat chronic inflammation. We developed a beta-1, 3-glucan sulfate (PS3) with inhibitory activity toward L and P-selectins under static conditions. Here, detailed investigation showed inhibition of P-and L-selectins, but not E-selectin under flow conditions (relative reduction of interaction with appropriate ligands to 34.4 +/- 16.6, 8.5 +/- 3.6, or 99.5 +/- 9.9%, respectively, by PS3 for P-, L-or E-selectin). Intravital microscopy revealed reduction of leukocyte rolling in skin microvasculature from 22.7 +/- 5.0 to 12.6 +/- 4.0% after injection of PS3. In the next experiments, mice were sensitized with 2,4,-dinitrofluorobenzene (DNFB), and lymphocytes were transferred into syngeneic recipients, which were challenged by DNFB. Inflammatory responses were reduced when immunity was generated in mice treated with PS3 or in L-selectin-deficient mice. No effect was observed when L-selectin-deficient donor mice were treated with PS3, further suggesting that PS3 acted primarily through inhibition of L-selectin. Elicitation of a contact hypersensitivity response was reduced in P-selectin-deficient and in PS3-treated mice. Again, PS3 had no effect in P-selectin-deficient mice. PS3 is a potent P-and L-selectin inhibitor that may add to the therapy of inflammatory diseases."],["dc.identifier.doi","10.1038/jid.2008.358"],["dc.identifier.isi","000266218000019"],["dc.identifier.pmid","19052560"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16883"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0022-202X"],["dc.title","PS3, A Semisynthetic beta-1,3-Glucan Sulfate, Diminishes Contact Hypersensitivity Responses Through Inhibition of L- and P-Selectin Functions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","983"],["dc.bibliographiccitation.issue","9997"],["dc.bibliographiccitation.journal","The Lancet"],["dc.bibliographiccitation.lastpage","994"],["dc.bibliographiccitation.volume","386"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:51:46Z"],["dc.date.available","2018-11-07T09:51:46Z"],["dc.date.issued","2015"],["dc.description.abstract","Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated comorbidity. Understanding the role of immune function in psoriasis and the interplay between the innate and adaptive immune system has helped to manage this complex disease, which affects patients far beyond the skin. In this Seminar, we highlight the clinical diversity of psoriasis and associated comorbid diseases. We describe recent developments in psoriasis epidemiology, pathogenesis, and genetics to better understand present trends in psoriasis management. Our key objective is to raise awareness of the complexity of this multifaceted disease, the potential of state-of-the-art therapeutic approaches, and the need for early diagnosis and comprehensive management of patients with psoriasis."],["dc.description.sponsorship","AbbVie; Biogen Idec"],["dc.identifier.doi","10.1016/S0140-6736(14)61909-7"],["dc.identifier.isi","000361182700031"],["dc.identifier.pmid","26025581"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35978"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1474-547X"],["dc.relation.issn","0140-6736"],["dc.title","Psoriasis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1133"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","1134"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:17:13Z"],["dc.date.available","2018-11-07T09:17:13Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1111/ddg.12243"],["dc.identifier.isi","000327256600001"],["dc.identifier.pmid","24267011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28110"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Discussion on the Role of Psoriasis as a Risk Factor for associated Diseases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","200"],["dc.bibliographiccitation.journal","BMJ (Clinical research ed.)"],["dc.bibliographiccitation.lastpage","203"],["dc.bibliographiccitation.volume","340"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Boehncke, Sandra"],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2019-07-10T08:13:38Z"],["dc.date.available","2019-07-10T08:13:38Z"],["dc.date.issued","2010"],["dc.identifier.fs","544664"],["dc.identifier.pmid","20080817"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6931"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61294"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1468-5833"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.mesh","Arthritis, Psoriatic"],["dc.subject.mesh","Cardiovascular Diseases"],["dc.subject.mesh","Decision Making"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Psoriasis"],["dc.title","Managing comorbid disease in patients with psoriasis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]