Schön, Michael P.

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Nuehnen, V. P."],["dc.contributor.author","Henneke, Marco"],["dc.contributor.author","Freiberg, Clemens"],["dc.contributor.author","Hensen, J."],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Lippert, Undine"],["dc.date.accessioned","2018-11-07T10:25:22Z"],["dc.date.available","2018-11-07T10:25:22Z"],["dc.date.issued","2017"],["dc.identifier.isi","000400154800456"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42845"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Idiopathic Calcinosis Cutis in a Ten-year-old Girl"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Ikoma, Akihiko"],["dc.contributor.author","Cevikbas, F."],["dc.contributor.author","Kempkes, Cordula"],["dc.contributor.author","Sulk, Mathias"],["dc.contributor.author","Akiyama, Tasuku"],["dc.contributor.author","Carstens, Earl"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Elias, P. M."],["dc.contributor.author","Coughlin, S."],["dc.contributor.author","Steinhoff, Martin"],["dc.date.accessioned","2018-11-07T10:00:07Z"],["dc.date.available","2018-11-07T10:00:07Z"],["dc.date.issued","2015"],["dc.format.extent","E1"],["dc.identifier.isi","000351939000002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37729"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","42nd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Ulm, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","Epidermal PAR2 overexpression causes atopic dermatitis-like skin disease: neuro-epidermal communication"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","jdv.18614"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Neesse, Anne K."],["dc.contributor.author","Hoffmann, Johanna C."],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Kempf, Werner"],["dc.date.accessioned","2022-10-04T10:22:01Z"],["dc.date.available","2022-10-04T10:22:01Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/jdv.18614"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114569"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1468-3083"],["dc.relation.issn","0926-9959"],["dc.rights.uri","http://onlinelibrary.wiley.com/termsAndConditions#vor"],["dc.title","Acrodermatitis chronica atrophicans with clonal light chains and heavy chain rearrangement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","861"],["dc.bibliographiccitation.issue","09"],["dc.bibliographiccitation.journal","Zeitschrift für Gastroenterologie"],["dc.bibliographiccitation.lastpage","865"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Broekaert, Sigrid"],["dc.contributor.author","Seitz, Cornelia"],["dc.contributor.author","Schön, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2020-12-10T18:12:26Z"],["dc.date.available","2020-12-10T18:12:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-113833"],["dc.identifier.eissn","1439-7803"],["dc.identifier.issn","0044-2771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74371"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Esomeprazol-induzierter kutaner Lupus erythematodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1432"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:49:13Z"],["dc.date.available","2018-11-07T08:49:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Background Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. Objectives We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. Patients and methods A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post- thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. Results The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). Conclusion Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations."],["dc.identifier.doi","10.1111/j.1468-3083.2011.04001.x"],["dc.identifier.isi","000297952800011"],["dc.identifier.pmid","21392126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21406"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0926-9959"],["dc.title","Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","202"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","204"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Hueffmeier, Ulrike"],["dc.contributor.author","Waetzold, M."],["dc.contributor.author","Mohr, Johannes"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Moessner, R."],["dc.date.accessioned","2018-11-07T09:46:58Z"],["dc.date.available","2018-11-07T09:46:58Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1111/bjd.12548"],["dc.identifier.isi","000329530200014"],["dc.identifier.pmid","23909475"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35002"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2133"],["dc.relation.issn","0007-0963"],["dc.title","Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E4971"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","E4977"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Turriani, Elisa"],["dc.contributor.author","Lázaro, Diana F."],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Schön, Margarete"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Outeiro, Tiago F."],["dc.contributor.author","Arndt-Jovin, Donna J."],["dc.contributor.author","Becker, Dorothea"],["dc.date.accessioned","2018-04-23T11:47:36Z"],["dc.date.available","2018-04-23T11:47:36Z"],["dc.date.issued","2017"],["dc.description.abstract","Recent epidemiological and clinical studies have reported a significantly increased risk for melanoma in people with Parkinson’s disease. Because no evidence could be obtained that genetic factors are the reason for the association between these two diseases, we hypothesized that of the three major Parkinson’s disease-related proteins—α-synuclein, LRRK2, and Parkin—α-synuclein might be a major link. Our data, presented here, demonstrate that α-synuclein promotes the survival of primary and metastatic melanoma cells, which is the exact opposite of the effect that α-synuclein has on dopaminergic neurons, where its accumulation causes neuronal dysfunction and death. Because this detrimental effect of α-synuclein on neurons can be rescued by the small molecule anle138b, we explored its effect on melanoma cells. We found that treatment with anle138b leads to massive melanoma cell death due to a major dysregulation of autophagy, suggesting that α-synuclein is highly beneficial to advanced melanoma because it ensures that autophagy is maintained at a homeostatic level that promotes and ensures the cell’s survival."],["dc.identifier.doi","10.1073/pnas.1700200114"],["dc.identifier.gro","3142238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13362"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0027-8424"],["dc.title","Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1035"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Clinical Infectious Diseases"],["dc.bibliographiccitation.lastpage","1036"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Mempel, Martin"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2018-11-07T09:11:58Z"],["dc.date.available","2018-11-07T09:11:58Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1093/cid/cir943"],["dc.identifier.isi","000301296200029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26841"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1058-4838"],["dc.title","A 32-Year-Old Man With Ulcerative Mucositis, Skin Lesions, and Nail Dystrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Immunology"],["dc.bibliographiccitation.lastpage","205"],["dc.bibliographiccitation.volume","128"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Hardt, Katja"],["dc.contributor.author","Hatting, Max"],["dc.contributor.author","Bistrian, Roxana"],["dc.contributor.author","Diehl, Sandra"],["dc.contributor.author","Radeke, Heinfried H."],["dc.contributor.author","Podda, Maurizio"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kaufmann, Roland"],["dc.contributor.author","Henschler, Reinhard"],["dc.contributor.author","Pfeilschifter, Josef M."],["dc.contributor.author","Santoso, Sentot"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.date.accessioned","2018-11-07T11:23:44Z"],["dc.date.available","2018-11-07T11:23:44Z"],["dc.date.issued","2009"],["dc.description.abstract","P>Junctional adhesion molecule-A (JAM-A), JAM-B and JAM-C have been implicated in leucocyte transmigration. As JAM-B binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1, we hypothesized that JAM-B is also involved in leucocyte rolling and firm adhesion. To test this hypothesis, intravital microscopy of murine skin microvasculature was performed. Rolling interactions of murine leucocytes were significantly affected by blockade of JAM-B [which reduced rolling interactions from 9 center dot 1 +/- 2 center dot 6% to 3 center dot 2 +/- 1 center dot 2% (mean +/- standard deviation)]. To identify putative ligands, T lymphocytes were perfused over JAM-B-coated slides in a dynamic flow chamber system. JAM-B-dependent rolling and sticking interactions were observed at low shear stress [0 center dot 3 dyn/cm(2): 220 +/- 71 (mean +/- standard deviation) versus 165 +/- 88 rolling (P < 0 center dot 001; Mann-Whitney rank sum test) and 2 center dot 6 +/- 1 center dot 3 versus 1 center dot 0 +/- 0 center dot 7 sticking cells/mm(2)/min (P = 0 center dot 026; Mann-Whitney rank sum test) on JAM-B- compared with baseline], but not at higher shear forces (1 center dot 0 dyn/cm(2)). As demonstrated by antibody blocking experiments, JAM-B-mediated rolling and sticking of T lymphocytes was dependent on alpha 4 and beta 1 integrin, but not JAM-C expression. To investigate whether JAM-B-mediated leucocyte-endothelium interactions are involved in a disease-relevant in vivo model, adoptive transfer experiments in 2,4,-dinitrofluorobenzene (DNFB)-induced contact hypersensitivity reactions were performed in mice in the absence or in the presence of a function-blocking JAM-B antibody. In this model, JAM-B blockade during the sensitization phase impaired the generation of the immune response to DNFB, which was assessed as the increase in ear swelling in untreated, DNFB-challenged mice, by close to 40% [P = 0 center dot 037; analysis of variance (anova)]. Overall, JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion."],["dc.description.sponsorship","J.W. Goethe University; Deutsche Forschungsgemeinschaft [Lu877/3-1]"],["dc.identifier.doi","10.1111/j.1365-2567.2009.03100.x"],["dc.identifier.isi","000269580300005"],["dc.identifier.pmid","19740376"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56253"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0019-2805"],["dc.title","Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha 4 beta 1 integrin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Hund, Anna-Carina"],["dc.contributor.author","Lockmann, Anike"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:27:22Z"],["dc.date.available","2018-11-07T09:27:22Z"],["dc.date.issued","2013"],["dc.format.extent","E9"],["dc.identifier.isi","000316332000051"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30519"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","40th Annual Meeting of the Association-of-Dermatological-Research"],["dc.relation.eventlocation","Dessau, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Dimethylfumarate and NF-kappa B-inhibitors: synergistic effects and implications for future therapies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]