Göpfert, Martin C.

[["dc.bibliographiccitation.firstpage","697"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","703"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Kamikouchi, Azusa"],["dc.contributor.author","Albert, Joerg T."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T08:46:12Z"],["dc.date.available","2018-11-07T08:46:12Z"],["dc.date.issued","2010"],["dc.description.abstract","Vertebrate inner-ear hair cells use mechanical feedback to amplify sound-induced vibrations. The gain of this 'cochlear amplifier' is centrally controlled via efferent fibres that, making synaptic contacts with the hair cells, modulate the feedback gain. The sensory neurons of the Drosophila ear likewise employ mechanical feedback to assist sound-evoked vibrations, yet whether this neuron-based feedback is also subject to efferent control has remained uncertain. We show here that the function of Drosophila auditory neurons is independent of efferent modulation, and that no synaptic transmission is needed to control the gain of mechanical feedback amplification. Immunohistochemical, mechanical and electrophysiological analyses revealed that the Drosophila auditory organ lacks peripheral synapses and efferent innervations, and that blocking synaptic transmission in a pan-neural manner does not affect the afferent electrical activity of the sensory neurons or the mechanical feedback gain. Hence, unlike the cochlear amplifier of vertebrates, mechanical feedback amplification in Drosophila is not associated with an efferent control system but seems to be a purely local process that is solely controlled peripherally within the ear itself."],["dc.identifier.doi","10.1111/j.1460-9568.2010.07099.x"],["dc.identifier.isi","000274549500010"],["dc.identifier.pmid","20384813"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20630"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0953-816X"],["dc.title","Mechanical feedback amplification in Drosophila hearing is independent of synaptic transmission"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1198"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","U43"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Effertz, Thomas"],["dc.contributor.author","Nadrowski, Bjoern"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Albert, Joerg T."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:06:49Z"],["dc.date.available","2018-11-07T09:06:49Z"],["dc.date.issued","2012"],["dc.description.abstract","The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring."],["dc.identifier.doi","10.1038/nn.3175"],["dc.identifier.isi","000308072600009"],["dc.identifier.pmid","22842145"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25638"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.haserratum","/handle/2/103496"],["dc.relation.issn","1097-6256"],["dc.title","Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","11"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Bechstedt, Susanne"],["dc.contributor.author","Albert, Joerg T."],["dc.contributor.author","Kreil, D. P."],["dc.contributor.author","Mueller-Reichert, T."],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Howard, J."],["dc.date.accessioned","2018-11-07T08:44:46Z"],["dc.date.available","2018-11-07T08:44:46Z"],["dc.date.issued","2010"],["dc.description.abstract","Mechanoreceptors are sensory cells that transduce mechanical stimuli into electrical signals and mediate the perception of sound, touch and acceleration. Ciliated mechanoreceptors possess an elaborate microtubule cytoskeleton that facilitates the coupling of external forces to the transduction apparatus. In a screen for genes preferentially expressed in Drosophila campaniform mechanoreceptors, we identified DCX-EMAP, a unique member of the EMAP family (echinoderm-microtubule-associated proteins) that contains two doublecortin domains. DCX-EMAP localizes to the tubular body in campaniform receptors and to the ciliary dilation in chordotonal mechanoreceptors in Johnston's organ, the fly's auditory organ. Adult flies carrying a piggyBac insertion in the DCX-EMAP gene are uncoordinated and deaf and display loss of mechanosensory transduction and amplification. Electron microscopy of mutant sensilla reveals loss of electron-dense materials within the microtubule cytoskeleton in the tubular body and ciliary dilation. Our results establish a catalogue of candidate genes for Drosophila mechanosensation and show that one candidate, DCX-EMAP, is likely to be required for mechanosensory transduction and amplification."],["dc.identifier.doi","10.1038/ncomms1007"],["dc.identifier.isi","000281781400011"],["dc.identifier.pmid","20975667"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20276"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.haserratum","/handle/2/103478"],["dc.relation.issn","2041-1723"],["dc.title","A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]