Göpfert, Martin C.

[["dc.bibliographiccitation.firstpage","79"],["dc.bibliographiccitation.journal","Current Opinion in Neurobiology"],["dc.bibliographiccitation.lastpage","85"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Albert, Joerg T."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:51:02Z"],["dc.date.available","2018-11-07T09:51:02Z"],["dc.date.issued","2015"],["dc.description.abstract","The dissection of the Drosophila auditory system has revealed multiple parallels between fly and vertebrate hearing. Recent studies have analyzed the operation of auditory sensory cells and the processing of sound in the fly's brain. Neuronal responses to sound have been characterized, and novel classes of auditory neurons have been defined; transient receptor potential (TRP) channels were implicated in auditory transduction, and genetic and environmental causes of auditory dysfunctions have been identified. This review discusses the implications of these recent advances on our understanding of how hearing happens in the fly."],["dc.identifier.doi","10.1016/j.conb.2015.02.001"],["dc.identifier.isi","000362139300013"],["dc.identifier.pmid","25710304"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12278"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35829"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Current Biology Ltd"],["dc.relation.issn","1873-6882"],["dc.relation.issn","0959-4388"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Hearing in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","201"],["dc.contributor.author","Kavlie, Ryan G."],["dc.contributor.author","Fritz, Janice L."],["dc.contributor.author","Nies, Florian"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Oliver, Dominik"],["dc.contributor.author","Albert, Joerg T."],["dc.contributor.author","Eberl, Daniel F."],["dc.date.accessioned","2018-11-07T10:04:00Z"],["dc.date.available","2018-11-07T10:04:00Z"],["dc.date.issued","2015"],["dc.description.abstract","In mammals, the membrane-based protein Prestin confers unique electromotile properties to cochlear outer hair cells, which contribute to the cochlear amplifier. Like mammals, the ears of insects, such as those of Drosophila melanogaster, mechanically amplify sound stimuli and have also been reported to express Prestin homologs. To determine whether the D. melanogaster Prestin homolog (dpres) is required for auditory amplification, we generated and analyzed dpres mutant flies. We found that dpres is robustly expressed in the fly's antennal ear. However, dpres mutant flies show normal auditory nerve responses, and intact non-linear amplification. Thus we conclude that, in D. melanogaster, auditory amplification is independent of Prestin. This finding resonates with prior phylogenetic analyses, which suggest that the derived motor function of mammalian Prestin replaced, or amended, an ancestral transport function. Indeed, we show that dpres encodes a functional anion transporter. Interestingly, the acquired new motor function in the phylogenetic lineage leading to birds and mammals coincides with loss of the mechanotransducer channel NompC (=TRPN1), which has been shown to be required for auditory amplification in flies. The advent of Prestin (or loss of NompC, respectively) may thus mark an evolutionary transition from a transducer-based to a Prestin-based mechanism of auditory amplification."],["dc.identifier.doi","10.1007/s00359-014-0960-9"],["dc.identifier.isi","000347289700005"],["dc.identifier.pmid","25412730"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11154"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38599"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1351"],["dc.relation.issn","0340-7594"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]