Göpfert, Martin C.

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Pathogens and Global Health"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Karak, Somdatta"],["dc.contributor.author","Joo, Seol-hee"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:16:41Z"],["dc.date.available","2018-11-07T09:16:41Z"],["dc.date.issued","2013"],["dc.format.extent","406"],["dc.identifier.isi","000335056200021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27988"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Maney Publishing"],["dc.publisher.place","Leeds"],["dc.relation.issn","2047-7732"],["dc.relation.issn","2047-7724"],["dc.title","DROSOPHILA MELANOGASTER AS A MODEL TO UNDERSTAND HEARING IN DISEASE VECTORS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20130528"],["dc.bibliographiccitation.issue","1759"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society B: Biological Sciences"],["dc.bibliographiccitation.volume","280"],["dc.contributor.author","Greggers, Uwe"],["dc.contributor.author","Koch, Gesche"],["dc.contributor.author","Schmidt, Viola"],["dc.contributor.author","Dürr, Aron"],["dc.contributor.author","Floriou-Servou, Amalia"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Menzel, Randolf"],["dc.date.accessioned","2022-03-01T11:46:53Z"],["dc.date.available","2022-03-01T11:46:53Z"],["dc.date.issued","2013"],["dc.description.abstract","Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant and modulated electric fields when flying, landing, walking and during the waggle dance. The electric fields emitted by dancing bees consist of low- and high-frequency components. Both components induce passive antennal movements in stationary bees according to Coulomb's law. Bees learn both the constant and the modulated electric field components in the context of appetitive proboscis extension response conditioning. Using this paradigm, we identify mechanoreceptors in both joints of the antennae as sensors. Other mechanoreceptors on the bee body are potentially involved but are less sensitive. Using laser vibrometry, we show that the electrically charged flagellum is moved by constant and modulated electric fields and more strongly so if sound and electric fields interact. Recordings from axons of the Johnston organ document its sensitivity to electric field stimuli. Our analyses identify electric fields emanating from the surface charge of bees as stimuli for mechanoreceptors, and as biologically relevant stimuli, which may play a role in social communication."],["dc.description.abstract","Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant and modulated electric fields when flying, landing, walking and during the waggle dance. The electric fields emitted by dancing bees consist of low- and high-frequency components. Both components induce passive antennal movements in stationary bees according to Coulomb's law. Bees learn both the constant and the modulated electric field components in the context of appetitive proboscis extension response conditioning. Using this paradigm, we identify mechanoreceptors in both joints of the antennae as sensors. Other mechanoreceptors on the bee body are potentially involved but are less sensitive. Using laser vibrometry, we show that the electrically charged flagellum is moved by constant and modulated electric fields and more strongly so if sound and electric fields interact. Recordings from axons of the Johnston organ document its sensitivity to electric field stimuli. Our analyses identify electric fields emanating from the surface charge of bees as stimuli for mechanoreceptors, and as biologically relevant stimuli, which may play a role in social communication."],["dc.identifier.doi","10.1098/rspb.2013.0528"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103834"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1471-2954"],["dc.relation.issn","0962-8452"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Reception and learning of electric fields in bees"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1042"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","1054"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Senthilan, Pingkalai R."],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Ovezmyradov, Guvanch"],["dc.contributor.author","Nadrowski, Bjoern"],["dc.contributor.author","Bechstedt, Susanne"],["dc.contributor.author","Pauls, Stephanie"],["dc.contributor.author","Winkler, Margret"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Howard, Jonathon"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:07:03Z"],["dc.date.available","2018-11-07T09:07:03Z"],["dc.date.issued","2012"],["dc.description.abstract","The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate hair cells, and both are specified by atonal family genes. Using a whole-organ knockout strategy based on atonal, we have identified 274 Drosophila auditory organ genes. Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders. Mutant analysis of 42 genes shows that more than half of them contribute to auditory organ function, with phenotypes including hearing loss, auditory hypersusceptibility, and ringing ears. We not only discover ion channels and motors important for hearing, but also show that auditory stimulus processing involves chemoreceptor proteins as well as phototransducer components. Our findings demonstrate mechanosensory roles for ionotropic receptors and visual rhodopsins and indicate that different sensory modalities utilize common signaling cascades."],["dc.identifier.doi","10.1016/j.cell.2012.06.043"],["dc.identifier.isi","000308500200017"],["dc.identifier.pmid","22939627"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25700"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0092-8674"],["dc.title","Drosophila Auditory Organ Genes and Genetic Hearing Defects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Senthilan, Pingkalai R."],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Ovezmyradov, Guvanch"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T08:35:54Z"],["dc.date.available","2018-11-07T08:35:54Z"],["dc.date.issued","2010"],["dc.format.extent","30"],["dc.identifier.isi","000284537500077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18186"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.relation.issn","0167-7063"],["dc.title","A reverse genetic approach to identify Deafness genes in Drosophila melanogaster"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1840"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","1840"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Effertz, Thomas"],["dc.contributor.author","Nadrowski, Björn"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Albert, Jörg T."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2022-03-01T11:45:55Z"],["dc.date.available","2022-03-01T11:45:55Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1038/nn1214-1840b"],["dc.identifier.pii","BFnn12141840b"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103496"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1546-1726"],["dc.relation.iserratumof","/handle/2/25638"],["dc.relation.issn","1097-6256"],["dc.rights.uri","http://www.springer.com/tdm"],["dc.title","Erratum: Corrigendum: Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Pingkalai, Senthilan R."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:02:29Z"],["dc.date.available","2018-11-07T09:02:29Z"],["dc.date.issued","2012"],["dc.format.extent","64"],["dc.identifier.isi","000314975100164"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24692"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.relation.issn","0167-7063"],["dc.title","Novel deafness genes in Drosophila"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1276"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.lastpage","1286"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Soulavie, Fabien"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Thomas, Joelle"],["dc.contributor.author","Vieillard, Jennifer"],["dc.contributor.author","Duteyrat, Jean-Luc"],["dc.contributor.author","Cortier, Elisabeth"],["dc.contributor.author","Laurencon, Anne"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Durand, Benedicte"],["dc.date.accessioned","2018-11-07T09:41:14Z"],["dc.date.available","2018-11-07T09:41:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Cilia play major functions in physiology and development, and ciliary dysfunctions are responsible for several diseases in humans called ciliopathies. Cilia motility is required for cell and fluid propulsion in organisms. In humans, cilia motility deficiencies lead to primary ciliary dyskinesia, with upper-airways recurrent infections, left-right asymmetry perturbations, and fertility defects. In Drosophila, we identified hemingway (hmw) as a novel component required for motile cilia function. hmw encodes a 604-amino acid protein characterized by a highly conserved coiled-coil domain also found in the human orthologue, KIAA1430. We show that HMW is conserved in species with motile cilia and that, in Drosophila, hmw is expressed in ciliated sensory neurons and spermatozoa. We created hmw-knockout flies and found that they are hearing impaired and male sterile. hmw is implicated in the motility of ciliated auditory sensory neurons and, in the testis, is required for elongation and maintenance of sperm flagella. Because HMW is absent from mature flagella, we propose that HMW is not a structural component of the motile axoneme but is required for proper acquisition of motile properties. This identifies HMW as a novel, evolutionarily conserved component necessary for motile cilium function and flagella assembly."],["dc.identifier.doi","10.1091/mbc.E13-10-0616"],["dc.identifier.isi","000339649400008"],["dc.identifier.pmid","24554765"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33684"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.relation.issn","1939-4586"],["dc.relation.issn","1059-1524"],["dc.title","hemingway is required for sperm flagella assembly and ciliary motility in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1198"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","U43"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Effertz, Thomas"],["dc.contributor.author","Nadrowski, Bjoern"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Albert, Joerg T."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:06:49Z"],["dc.date.available","2018-11-07T09:06:49Z"],["dc.date.issued","2012"],["dc.description.abstract","The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring."],["dc.identifier.doi","10.1038/nn.3175"],["dc.identifier.isi","000308072600009"],["dc.identifier.pmid","22842145"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25638"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.haserratum","/handle/2/103496"],["dc.relation.issn","1097-6256"],["dc.title","Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.volume","256"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Geurten, Bart R. H."],["dc.contributor.author","Gurvich, Artem"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Kaestner, Anne"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Xing, Guanglin"],["dc.contributor.author","Xie, Wei"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2018-11-07T09:17:53Z"],["dc.date.available","2018-11-07T09:17:53Z"],["dc.date.issued","2013"],["dc.format.extent","690"],["dc.identifier.doi","10.1016/j.bbr.2013.08.019"],["dc.identifier.isi","000328094100084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28278"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-7549"],["dc.relation.issn","0166-4328"],["dc.title","Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour (vol 252, pg 450, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","252"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Geurten, Bart"],["dc.contributor.author","Gurvich, Artem"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Xing, Guanglin"],["dc.contributor.author","Xie, Wei"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2017-09-07T11:46:23Z"],["dc.date.available","2017-09-07T11:46:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Autism spectrum disorders (ASDs) are characterized by deficits in social interactions, language development and repetitive behaviours. Multiple genes involved in the formation, specification and maintenance of synapses have been identified as risk factors for ASDs development. Among these are the neuroligin genes which code for postsynaptic cell adhesion molecules that induce the formation of presynapses, promote their maturation and modulate synaptic functions in both vertebrates and invertebrates. Neuroligin-deficient mice display abnormal social and vocal behaviours that resemble ASDs symptoms.Here we show for the fly Drosophila melanogaster that deletion of the dnl2 gene, coding for one of four Neuroligin isoforms, impairs social interactions, alters acoustic communication signals, and affects the transition between different behaviours. dnl2-Deficient flies maintain larger distances to conspecifics and males perform less female-directed courtship and male-directed aggressive behaviours while the patterns of these behaviours and general locomotor activity were not different from wild type controls. Since tests for olfactory, visual and auditory perception revealed no sensory impairments of dnl2-deficient mutants, reduced social interactions seem to result from altered excitability in central nervous neuropils that initiate social behaviours. Our results demonstrate that Neuroligins are phylogenetically conserved not only regarding their structure and direct function at the synapse but also concerning a shared implication in the regulation of social behaviours that dates back to common ancestors of humans and flies. In addition to previously described mouse models, Drosophila can thus be used to study the contribution of Neuroligins to synaptic function, social interactions and their implication in ASDs."],["dc.identifier.doi","10.1016/j.bbr.2013.06.020"],["dc.identifier.gro","3150491"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7261"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.subject","Drosophila melanogaster; Neuroligin; Social behaviour; Acoustic communication; Behavioural transition; Autism"],["dc.title","Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]