Wachter, Rolf

[["dc.bibliographiccitation.firstpage","59"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ESC Heart Failure"],["dc.bibliographiccitation.lastpage","74"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Nolte, Kathleen"],["dc.contributor.author","Schwarz, Silja"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Mensching, Steffen"],["dc.contributor.author","Siegmund, Friederike"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Düngen, Hans-Dirk"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Edelmann, Frank"],["dc.date.accessioned","2019-07-09T11:41:03Z"],["dc.date.available","2019-07-09T11:41:03Z"],["dc.date.issued","2014"],["dc.description.abstract","Background The long-term effects of exercise training (ET) in diastolic dysfunction (DD) and heart failure with preserved ejection fraction (HFpEF) are unknown. The present study compared the long-term effects of ET on exercise capacity, diastolic function, and quality of life (QoL) in patients with DD vs. HFpEF. Methods A total of n=43 patients with asymptomatic DD (n=19) or HFpEF [DD and New York Heart Association (NYHA) ≥II, n=24] and left ventricular ejection fraction ≥50% performed a combined endurance/resistance training over 6months (2–3/week) on top of usual care. Cardiopulmonary exercise testing, echocardiography, and QoL were obtained at baseline and follow-up. Results Patients were 62±8 years old (37% female). In the HFpEF group, 67% of patients were in NYHA class II (33% in NYHA III). Exercise capacity (peak oxygen consumption, peak VO2) differed at baseline (DD 29.2±8.7mL/min/kg vs. HFpEF 17.8±4.6 mL/min/kg; P=0.004). After 6months, peak VO2 increased significantly (P<0.044) to 19.7±5.8 mL/min/kg in the HFpEF group and also in the DD group (to 32.8±8.5mL/min/kg; P<0.002) with no overall difference between the groups (P=0.217). E/e′ ratio (left ventricular filling index) decreased from 12.2±3.5 to 10.1±3.0 (P<0.002) in patients with HFpEFand also in patients with DD (10.7±3.1 vs. 9.5±2.3; P=0.03; difference between groups P=0.210). In contrast, left atrial volume index decreased in the HFpEF group (P<0.001) but remained stable within the DD group (difference between groups P=0.015). After 6 months, physical QoL (Minnesota living with heart failure Questionnaire, 36-item short form health survey), general health perception, and 9-item patient health questionnaire score only improved in HFpEF (P<0.05). In contrast, vitality improved in both groups (difference between groups P=0.708). Conclusion A structured 6 months ET programme effectively improves exercise capacity and diastolic function in patients with DD and overt HFpEF. Therefore, controlled lifestylemodification with physical activity is effective both in DD and HFpEF."],["dc.identifier.doi","10.1002/ehf2.12007"],["dc.identifier.fs","610857"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11651"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58349"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1879-0844"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Effects of long-term endurance and resistance training on diastolic function, exercise capacity, and quality of life in asymptomatic diastolic dysfunction vs. heart failure with preserved ejection fraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","540"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Biomarkers"],["dc.bibliographiccitation.lastpage","550"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Baldassarri, Flavia"],["dc.contributor.author","Schwedhelm, Edzard"],["dc.contributor.author","Atzler, Dorothee"],["dc.contributor.author","Böger, Rainer H."],["dc.contributor.author","Cordts, Kathrin"],["dc.contributor.author","Haller, Bernhard"],["dc.contributor.author","Pressler, Axel"],["dc.contributor.author","Müller, Stephan"],["dc.contributor.author","Suchy, Christiane"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Düngen, Hans-Dirk"],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Duvinage, André"],["dc.date.accessioned","2020-12-10T18:15:03Z"],["dc.date.available","2020-12-10T18:15:03Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1080/1354750X.2018.1460762"],["dc.identifier.eissn","1366-5804"],["dc.identifier.issn","1354-750X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74724"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","781"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","JAMA"],["dc.bibliographiccitation.lastpage","791"],["dc.bibliographiccitation.volume","309"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Schmidt, Albrecht G."],["dc.contributor.author","Kraigher-Krainer, Elisabeth"],["dc.contributor.author","Colantonio, Caterina"],["dc.contributor.author","Kamke, Wolfram"],["dc.contributor.author","Duvinage, Andre"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Durstewitz, Kathleen"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Duengen, Hans-Dirk"],["dc.contributor.author","Tschoepe, Carsten"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Pieske, Burkert"],["dc.date.accessioned","2017-09-07T11:47:49Z"],["dc.date.available","2017-09-07T11:47:49Z"],["dc.date.issued","2013"],["dc.description.abstract","Importance Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression. Objective To assess the efficacy and safety of long-term aldosterone receptor blockade in heart failure with preserved ejection fraction. The primary objective was to determine whether spironolactone is superior to placebo in improving diastolic function and maximal exercise capacity in patients with heart failure with preserved ejection fraction. Design and Setting The Aldo-DHF trial, a multicenter, prospective, randomized, double-blind, placebo-controlled trial conducted between March 2007 and April 2012 at 10 sites in Germany and Austria that included 422 ambulatory patients (mean age, 67 [SD, 8] years; 52% female) with chronic New York Heart Association class II or III heart failure, preserved left ventricular ejection fraction of 50% or greater, and evidence of diastolic dysfunction. Intervention Patients were randomly assigned to receive 25 mg of spironolactone once daily (n=213) or matching placebo (n=209) with 12 months of follow-up. Main Outcome Measures The equally ranked co-primary end points were changes in diastolic function (E/e') on echocardiography and maximal exercise capacity (peak (V)over dotO(2)) on cardiopulmonary exercise testing, both measured at 12 months. Results Diastolic function (E/e') decreased from 12.7 (SD, 3.6) to 12.1 (SD, 3.7) with spironolactone and increased from 12.8 (SD, 4.4) to 13.6 (SD, 4.3) with placebo (adjusted mean difference, -1.5; 95% CI, -2.0 to -0.9; P<.001). Peak (V)over dotO(2) did not significantly change with spironolactone vs placebo (from 16.3 [SD, 3.6] mL/min/kg to 16.8 [SD, 4.6] mL/min/kg and from 16.4 [SD, 3.5] mL/min/kg to 16.9 [SD, 4.4] mL/min/kg, respectively; adjusted mean difference, +0.1 mL/min/kg; 95% CI, -0.6 to +0.8 mL/min/kg; P=.81). Spironolactone induced reverse remodeling (left ventricular mass index declined; difference, -6 g/m(2); 95% CI, -10 to -1 g/m(2); P=.009) and improved neuroendocrine activation (N-terminal pro-brain-type natriuretic peptide geometric mean ratio, 0.86; 95% CI, 0.75-0.99; P=.03) but did not improve heart failure symptoms or quality of life and slightly reduced 6-minute walking distance (-15m; 95% CI, -27 to -2m; P=.03). Spironolactone also modestly increased serum potassium levels (+0.2 mmol/L; 95% CI, +0.1 to +0.3; P<.001) and decreased estimated glomerular filtration rate (-5 mL/min/1.73m(2); 95% CI, -8 to -3 mL/min/1.73 m(2); P<.001) without affecting hospitalizations. Conclusions and Relevance In this randomized controlled trial, long-term aldosterone receptor blockade improved left ventricular diastolic function but did not affect maximal exercise capacity, patient symptoms, or quality of life in patients with heart failure with preserved ejection fraction. Whether the improved left ventricular function observed in the Aldo-DHF trial is of clinical significance requires further investigation in larger populations."],["dc.identifier.doi","10.1001/jama.2013.905"],["dc.identifier.gro","3142388"],["dc.identifier.isi","000315332200023"],["dc.identifier.pmid","23443441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7730"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Medical Assoc"],["dc.relation.eissn","1538-3598"],["dc.relation.issn","0098-7484"],["dc.title","Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction The Aldo-DHF Randomized Controlled Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Duengen, Hans-Dirk"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Schwarz, Silja"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Edelmann, Frank T."],["dc.date.accessioned","2018-11-07T08:49:44Z"],["dc.date.available","2018-11-07T08:49:44Z"],["dc.date.issued","2011"],["dc.identifier.isi","000299738708002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","Exercise-Induced Improvements in Heart Failure With Preserved Ejection Fraction Correlate With Improved Diastolic Function, but Unchanged Chronotropic Competence - The Ex-DHF-P Trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","874"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","882"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Schmidt, Albrecht G."],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Pieske, Burkert"],["dc.date.accessioned","2017-09-07T11:45:19Z"],["dc.date.available","2017-09-07T11:45:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Aims Increasing evidence suggests that enhanced aldosterone signalling plays a key role in the onset and progression of diastolic heart failure (DHF). Aldo-DHF will test the hypothesis that aldosterone receptor blockade by spironolactone will improve exercise capacity and diastolic function in patients with DHF. Methods Aldo-DHF is a randomized, placebo-controlled, double-blinded, two-armed, multicentre, parallel group study. Four hundred and twenty patients with DHF will be randomly assigned to receive spironolactone 25 mg per day or placebo. The main inclusion criteria are: age >= 50 years, New York Heart Association preserved left ventricular ejection fraction (>= 50%), and echocardiographic evidence of diastolic dysfunction. The two primary endpoints are changes in exercise capacity (peak VO(2), spiroergometry) and in diastolic function (E/e, echocardiography) after 12 months. Secondary endpoints include effects of spironolactone on additional parameters of exercise performance and diastolic as well as systolic function, neurohumoral activation, and quality of life. Morbidity and mortality as well as safety aspects will also be assessed. Conclusion Aldo-DHF is the first large-scale clinical trial to evaluate the effects of aldosterone receptor blockade on exercise capacity and diastolic function in patients with DHF. Aldo-DHF will provide important information about the clinical course of this condition and may have significant impact on treatment strategies and future trials in these patients."],["dc.identifier.doi","10.1093/eurjhf/hfq087"],["dc.identifier.gro","3142879"],["dc.identifier.isi","000281200100017"],["dc.identifier.pmid","20538867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/331"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1388-9842"],["dc.title","Rationale and design of the 'aldosterone receptor blockade in diastolic heart failure' trial: a double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in patients with symptomatic diastolic heart failure (Aldo-DHF)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Duengen, Hans-Dirk"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Schwarz, S."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Edelmann, F."],["dc.date.accessioned","2018-11-07T08:39:22Z"],["dc.date.available","2018-11-07T08:39:22Z"],["dc.date.issued","2010"],["dc.format.extent","729"],["dc.identifier.isi","000281531904538"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18977"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","0195-668X"],["dc.title","Improved exercise capacity with exercise training is due to improved diastolic function, but unchanged chronotropic competence"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1780"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.lastpage","1791"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Duengen, Hans-Dirk"],["dc.contributor.author","Froehling, Stefan"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Toepper, Agnieszka"],["dc.contributor.author","Lashki, Diana Jahandar"],["dc.contributor.author","Schwarz, Silja"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Pieske, Burkert"],["dc.date.accessioned","2017-09-07T11:43:21Z"],["dc.date.available","2017-09-07T11:43:21Z"],["dc.date.issued","2011"],["dc.description.abstract","Objectives We sought to determine whether structured exercise training (ET) improves maximal exercise capacity, left ventricular diastolic function, and quality of life (QoL) in patients with heart failure with preserved ejection fraction (HFpEF). Background Nearly one-half of patients with heart failure experience HFpEF, but effective therapeutic strategies are sparse. Methods A total of 64 patients (age 65 +/- 7 years, 56% female) with HFpEF were prospectively randomized (2:1) to supervised endurance/resistance training in addition to usual care (ET, n = 44) or to usual care alone (UC) (n = 20). The primary endpoint was the change in peak V(O2) after 3 months. Secondary endpoints included effects on cardiac structure, diastolic function, and QoL. Results Peak V(O2) increased (16.1 +/- 4.9 ml/min/kg to 18.7 +/- 5.4ml/min/kg; p < 0.001) with ET and remained unchanged (16.7 +/- 4.7 ml/min/kg to 16.0 +/- 6.0 ml/min/kg; p = NS) with UC. The mean benefit of ET was 3.3 ml/min/kg (95% confidence interval [CI]: 1.8 to 4.8, p < 0.001). E/e' (mean difference of changes: -3.2, 95% CI: -4.3 to -2.1, p < 0.001) and left atrial volume index (milliliters per square meter) decreased with ET and remained unchanged with UC (-4.0, 95% CI: -5.9 to -2.2, p < 0.001). The physical functioning score (36-Item Short-Form Health Survey) improved with ET and remained unchanged with UC (15, 95% CI: 7 to 24, p < 0.001). The ET-induced decrease of E/e' was associated with 38% gain in peak V(O2) and 50% of the improvement in physical functioning score. Conclusions Exercise training improves exercise capacity and physical dimensions of QoL in HFpEF. This benefit is associated with atrial reverse remodeling and improved left ventricular diastolic function. (Exercise Training in Diastolic Heart Failure-Pilot Study: A Prospective, Randomised, Controlled Study to Determine the Effects of Physical Training on Exercise Capacity and Quality of Life [Ex-DHF-P]; ISRCTN42524037) (J Am Coll Cardiol 2011;58: 1780-91) (C) 2011 by the American College of Cardiology Foundation"],["dc.identifier.doi","10.1016/j.jacc.2011.06.054"],["dc.identifier.gro","3142643"],["dc.identifier.isi","000295883900010"],["dc.identifier.pmid","21996391"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0735-1097"],["dc.title","Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction Results of the Ex-DHF (Exercise training in Diastolic Heart Failure) Pilot Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Edelmann, Frank T."],["dc.contributor.author","Duengen, Hans-Dirk"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Schwarz, Silja"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Hermann-Lingen, Christoph"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T08:31:44Z"],["dc.date.available","2018-11-07T08:31:44Z"],["dc.date.issued","2009"],["dc.format.extent","A195"],["dc.identifier.isi","000263864200815"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17183"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.eventlocation","Orlando, FL"],["dc.relation.issn","0735-1097"],["dc.title","Exercise Training in Diastolic Heart Failure: A Prospective, Randomized, Controlled, Multicenter Trial (ISRCTN 42524037)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1067"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","1074"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Bobenko, Anna"],["dc.contributor.author","Gelbrich, Götz"],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Duvinage, André"],["dc.contributor.author","Schwarz, Silja"],["dc.contributor.author","Mende, Meinhard"],["dc.contributor.author","Prettin, Christiane"],["dc.contributor.author","Trippel, Tobias"],["dc.contributor.author","Lindhorst, Ruhdja"],["dc.contributor.author","Morris, Daniel"],["dc.contributor.author","Pieske-Kraigher, Elisabeth"],["dc.contributor.author","Nolte, Kathleen"],["dc.contributor.author","Düngen, Hans-Dirk"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Halle, Martin"],["dc.contributor.author","Pieske, Burkert"],["dc.date.accessioned","2018-04-23T11:48:12Z"],["dc.date.available","2018-04-23T11:48:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Heart failure with preserved ejection fraction (HFpEF) is a common disease with high incidence and increasing prevalence. Patients suffer from functional limitation, poor health‐related quality of life, and reduced prognosis. A pilot study in a smaller group of HFpEF patients showed that structured, supervised exercise training (ET) improves maximal exercise capacity, diastolic function, and physical quality of life. However, the long‐term effects of ET on patient‐related outcomes remain unclear in HFpEF. The primary objective of the Exercise training in Diastolic Heart Failure (Ex‐DHF) trial is to investigate whether a 12 month supervised ET can improve a clinically meaningful composite outcome score in HFpEF patients. Components of the outcome score are all‐cause mortality, hospitalizations, NYHA functional class, global self‐rated health, maximal exercise capacity, and diastolic function. After undergoing baseline assessments to determine whether ET can be performed safely, 320 patients at 11 trial sites with stable HFpEF are randomized 1:1 to supervised ET in addition to usual care or to usual care alone. Patients randomized to ET perform supervised endurance/resistance ET (3 times/week at a certified training centre) for 12 months. At baseline and during follow‐up, anthropometry, echocardiography, cardiopulmonary exercise testing, and health‐related quality of life evaluation are performed. Blood samples are collected to examine various biomarkers. Overall physical activity, training sessions, and adherence are monitored and documented throughout the study using patient diaries, heart rate monitors, and accelerometers. The Ex‐DHF trial is the first multicentre trial to assess the long‐term effects of a supervised ET programme on different outcome measures in patients with HFpEF."],["dc.identifier.doi","10.1002/ejhf.862"],["dc.identifier.gro","3142337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13472"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","1388-9842"],["dc.title","Exercise training in Diastolic Heart Failure (Ex-DHF): rationale and design of a multicentre, prospective, randomized, controlled, parallel group trial"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Schwarz, S."],["dc.contributor.author","Duengen, H.-D."],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Pressler, A."],["dc.contributor.author","Gelbrich, Goetz"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Halle, Martin"],["dc.date.accessioned","2018-11-07T11:24:47Z"],["dc.date.available","2018-11-07T11:24:47Z"],["dc.date.issued","2009"],["dc.format.extent","831"],["dc.identifier.isi","000208702606480"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56483"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Long term exercise training improves diastolic function, exercise capacity and quality of life in patients with diastolic dysfunction and diastolic heart failure- a multi-centre trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]