Wachter, Rolf

[["dc.bibliographiccitation.firstpage","248"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychosomatics"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Stanske, Beate"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Cordes, Andreas"],["dc.contributor.author","Yüksel, Iraz"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Lüers, Claus"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2019-07-09T11:52:56Z"],["dc.date.available","2019-07-09T11:52:56Z"],["dc.date.issued","2010"],["dc.description.abstract","BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines. OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors. METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively. RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected]. CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion."],["dc.identifier.doi","10.1176/appi.psy.51.3.248"],["dc.identifier.fs","573439"],["dc.identifier.pmid","20484723"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60303"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1545-7206"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Austria"],["dc.subject.mesh","Cardiovascular Diseases"],["dc.subject.mesh","Cohort Studies"],["dc.subject.mesh","Coronary Disease"],["dc.subject.mesh","Fatigue"],["dc.subject.mesh","Female"],["dc.subject.mesh","Heart Failure"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Interleukin-10"],["dc.subject.mesh","Interleukin-6"],["dc.subject.mesh","Irritable Mood"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Morale"],["dc.subject.mesh","Personality Inventory"],["dc.subject.mesh","Primary Health Care"],["dc.subject.mesh","Psychometrics"],["dc.subject.mesh","Risk Factors"],["dc.subject.mesh","Tumor Necrosis Factor-alpha"],["dc.title","Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]