Dräger, Julia

[["dc.bibliographiccitation.firstpage","2923"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Oncogene"],["dc.bibliographiccitation.lastpage","2931"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Nitzki, F."],["dc.contributor.author","Cuvelier, Nicole"],["dc.contributor.author","Draeger, Julia"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Braun, Thomas"],["dc.contributor.author","Hahn, H."],["dc.date.accessioned","2018-11-07T10:12:55Z"],["dc.date.available","2018-11-07T10:12:55Z"],["dc.date.issued","2016"],["dc.description.abstract","Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. In children, the 2 major RMS subtypes are alveolar and embryonal RMS. Aberrant Hedgehog/Patched1 (Hh/Ptch) signaling is a hallmark of embryonal RMS. We demonstrate that mice carrying a Ptch mutation in mesodermal Delta1-expressing cells develop embryonal-like RMS at a similar rate as mice harboring a Ptch mutation in the germline or the brachury-expressing mesoderm. The tumor incidence decreases dramatically when Ptch is mutated in Myf5- or Pax3-expressing cells. No RMS develop from Myogenin/Mef2c-expressing cells. This suggests that Hh/Ptch-associated RMS are derived from Delta1-positive, Myf5-negative, Myogenin-negative and Pax3-negative mesodermal progenitors that can undergo myogenic differentiation but lack stable lineage commitment. Additional preliminary genetic data and data on mesodermal progenitors further imply an interplay of Hh/Ptch and Delta/Notch signaling activity during RMS initiation. In contrast, Wnt signals supposedly suppress RMS formation because RMS multiplicity decreases after inactivation of the Wnt-inhibitor Wif1. Finally, our results strongly suggest that the tumor-initiating event determines the lineage of RMS origin."],["dc.description.sponsorship","DFG [HA2197/7-1]"],["dc.identifier.doi","10.1038/onc.2015.346"],["dc.identifier.isi","000377473700012"],["dc.identifier.pmid","26387541"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40330"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1476-5594"],["dc.relation.issn","0950-9232"],["dc.title","Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]