Favaro, Plinio D.

[["dc.bibliographiccitation.firstpage","15504"],["dc.bibliographiccitation.issue","39"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","15517"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Krueger, Juliane M."],["dc.contributor.author","Favaro, Plinio D."],["dc.contributor.author","Liu, Mingna"],["dc.contributor.author","Kitlinska, Agata"],["dc.contributor.author","Huang, Xiaojie"],["dc.contributor.author","Raabe, Monika"],["dc.contributor.author","Akad, Derya S."],["dc.contributor.author","Liu, Yanling"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Dong, Yan"],["dc.contributor.author","Xu, Weifeng"],["dc.contributor.author","Schlueter, Oliver M."],["dc.date.accessioned","2018-11-07T09:19:47Z"],["dc.date.available","2018-11-07T09:19:47Z"],["dc.date.issued","2013"],["dc.description.abstract","In the postsynaptic density of glutamatergic synapses, the discs large (DLG)-membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins coordinates a multiplicity of signaling pathways to maintain and regulate synaptic transmission. Postsynaptic density-93 (PSD-93) is the most variable paralog in this family; it exists in six different N-terminal isoforms. Probably because of the structural and functional variability of these isoforms, the synaptic role of PSD-93 remains controversial. To accurately characterize the synaptic role of PSD-93, we quantified the expression of all six isoforms in the mouse hippocampus and examined them individually in hippocampal synapses. Using molecular manipulations, including overexpression, gene knockdown, PSD-93 knock-out mice combined with biochemical assays, and slice electrophysiology both in rat and mice, we demonstrate that PSD-93 is required at different developmental synaptic states to maintain the strength of excitatory synaptic transmission. This strength is differentially regulated by the six isoforms of PSD-93, including regulations of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-active and inactive synapses, and activity-dependent modulations. Collectively, these results demonstrate that alternative combinations of N-terminal PSD-93 isoforms and DLG-MAGUK paralogs can fine-tune signaling scaffolds to adjust synaptic needs to regulate synaptic transmission."],["dc.identifier.doi","10.1523/JNEUROSCI.0019-12.2013"],["dc.identifier.isi","000324912500021"],["dc.identifier.pmid","24068818"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28724"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2006838"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLOS Biology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Favaro, Plinio D."],["dc.contributor.author","Huang, Xiaojie"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Stodieck, Sophia"],["dc.contributor.author","Cui, Lei"],["dc.contributor.author","Liu, Yu-Zhang"],["dc.contributor.author","Engelhardt, Karl-Alexander"],["dc.contributor.author","Schmitz, Frank"],["dc.contributor.author","Dong, Yan"],["dc.contributor.author","Löwel, Siegrid"],["dc.contributor.author","Schlüter, Oliver M."],["dc.date.accessioned","2019-07-09T11:49:59Z"],["dc.date.available","2019-07-09T11:49:59Z"],["dc.date.issued","2018"],["dc.description.abstract","The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental disorders. As is typical for paralogs, the DLG-MAGUK proteins postsynaptic density (PSD)-95 and PSD-93 share similar functional domains and were previously thought to regulate glutamatergic synapses similarly. Here, we show that they play opposing roles in glutamatergic synapse maturation. Specifically, PSD-95 promoted, whereas PSD-93 inhibited maturation of immature α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptor (AMPAR)-silent synapses in mouse cortex during development. Furthermore, through experience-dependent regulation of its protein levels, PSD-93 directly inhibited PSD-95's promoting effect on silent synapse maturation in the visual cortex. The concerted function of these two paralogs governed the critical period of juvenile ocular dominance plasticity (jODP), and fine-tuned visual perception during development. In contrast to the silent synapse-based mechanism of adjusting visual perception, visual acuity improved by different mechanisms. Thus, by controlling the pace of silent synapse maturation, the opposing but properly balanced actions of PSD-93 and PSD-95 are essential for fine-tuning cortical networks for receptive field integration during developmental critical periods, and imply aberrations in either direction of this process as potential causes for neurodevelopmental disorders."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2018"],["dc.identifier.doi","10.1371/journal.pbio.2006838"],["dc.identifier.pmid","30586380"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15797"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59674"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1545-7885"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.subject.ddc","612"],["dc.title","An opposing function of paralogs in balancing developmental synapse maturation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]