Now showing 1 - 3 of 3
  • 2018Journal Article
    [["dc.bibliographiccitation.journal","Frontiers in Neuroscience"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Foerster, Águida S."],["dc.contributor.author","Rezaee, Zeynab"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Dutta, Anirban"],["dc.date.accessioned","2020-12-10T18:44:34Z"],["dc.date.available","2020-12-10T18:44:34Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fnins.2018.00443"],["dc.identifier.eissn","1662-453X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78508"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Effects of Cathode Location and the Size of Anode on Anodal Transcranial Direct Current Stimulation Over the Leg Motor Area in Healthy Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article
    [["dc.bibliographiccitation.firstpage","779"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","789"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Foerster, Águida"],["dc.contributor.author","Dutta, Anirban"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-10-10T09:34:33Z"],["dc.date.available","2018-10-10T09:34:33Z"],["dc.date.issued","2018"],["dc.description.abstract","Transcranial direct current stimulation (tDCS) is a neuromodulatory technique which alters motor functions in healthy humans and in neurological patients. Most studies so far investigated the effects of tDCS on mechanisms underlying improvements in upper limb performance. To investigate the effect of anodal tDCS over the lower limb motor cortex (M1) on lower limb motor learning in healthy volunteers, we conducted a randomized, single-blind and sham-controlled study. Thirty-three (25.81 ± 3.85, 14 female) volunteers were included, and received anodal or sham tDCS over the left M1 (M1-tDCS); 0.0625 mA/cm2 anodal tDCS was applied for 15 min during performance of a visuo-motor task (VMT) with the right leg. Motor learning was monitored for performance speed and accuracy based on electromyographic recordings. We also investigated the influence of electrode size and baseline responsivity to transcranial magnetic stimulation (TMS) on the stimulation effects. Relative to baseline measures, only M1-tDCS applied with small electrodes and in volunteers with high baseline sensitivity to TMS significantly improved VMT performance. The computational analysis showed that the small anode was more specific to the targeted leg motor cortex volume when compared to the large anode. We conclude that anodal M1-tDCS modulates VMT performance in healthy subjects. As these effects critically depend on sensitivity to TMS and electrode size, future studies should investigate the effects of intensified tDCS and/or model-based different electrode positions in low-sensitivity TMS individuals."],["dc.identifier.doi","10.1111/ejn.13866"],["dc.identifier.pmid","29443433"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15933"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Effects of anodal transcranial direct current stimulation over lower limb primary motor cortex on motor learning in healthy individuals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article
    [["dc.bibliographiccitation.artnumber","21"],["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Otal, Begonya"],["dc.contributor.author","Dutta, Anirban"],["dc.contributor.author","Foerster, Aguida"],["dc.contributor.author","Ripolles, Oscar"],["dc.contributor.author","Kuceyeski, Amy"],["dc.contributor.author","Miranda, Pedro C."],["dc.contributor.author","Edwards, Dylan J."],["dc.contributor.author","Ilic, Tihomir V."],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Ruffini, Giulio"],["dc.date.accessioned","2018-11-07T10:18:03Z"],["dc.date.available","2018-11-07T10:18:03Z"],["dc.date.issued","2016"],["dc.description.abstract","Stroke is a leading cause of serious long-term disability worldwide. Functional outcome depends on stroke location, severity, and early intervention. Conventional rehabilitation strategies have limited effectiveness, and new treatments still fail to keep pace, in part due to a lack of understanding of the different stages in brain recovery and the vast heterogeneity in the poststroke population. Innovative methodologies for restorative neurorehabilitation are required to reduce long-term disability and socioeconomic burden. Neuroplasticity is involved in poststroke functional disturbances and also during rehabilitation. Tackling poststroke neuroplasticity by non-invasive brain stimulation is regarded as promising, but efficacy might be limited because of rather uniform application across patients despite individual heterogeneity of lesions, symptoms, and other factors. Transcranial direct current stimulation (tDCS) induces and modulates neuroplasticity, and has been shown to be able to improve motor and cognitive functions. tDCS is suited to improve poststroke rehabilitation outcomes, but effect sizes are often moderate and suffer from variability. Indeed, the location, extent, and pattern of functional network connectivity disruption should be considered when determining the optimal location sites for tDCS therapies. Here, we present potential opportunities for neuroimaging-guided tDCS-based rehabilitation strategies after stroke that could be personalized. We introduce innovative multimodal intervention protocols based on multichannel tDCS montages, neuroimaging methods, and real-time closed-loop systems to guide therapy. This might help to overcome current treatment limitations in poststroke rehabilitation and increase our general understanding of adaptive neuroplasticity leading to neural reorganization after stroke."],["dc.identifier.doi","10.3389/fneur.2016.00021"],["dc.identifier.isi","000370920000001"],["dc.identifier.pmid","26941708"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41351"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media Sa"],["dc.relation.issn","1664-2295"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Opportunities for Guided Multichannel Non-invasive Transcranial Current Stimulation in Poststroke Rehabilitation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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