Foth, Rudi

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Shomroni, Orr"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Hörer, Jürgen"],["dc.contributor.author","Cleuziou, Julie"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Eildermann, Katja"],["dc.date.accessioned","2021-04-14T08:30:16Z"],["dc.date.available","2021-04-14T08:30:16Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1038/s41598-021-81340-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83174"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.title","Screening for potential targets to reduce stenosis in bioprosthetic heart valves"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:24:38Z"],["dc.date.available","2018-11-07T11:24:38Z"],["dc.date.issued","2009"],["dc.format.extent","612"],["dc.identifier.isi","000269926600098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56449"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Histopathology and morphometry of 12 explanted modified Blalock-Taussig shunts"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Circulation Cardiovascular Interventions"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Michel-Behnke, Ina"],["dc.contributor.author","Vogt, Manfred"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Kreischer, Anne"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T08:30:58Z"],["dc.date.available","2018-11-07T08:30:58Z"],["dc.date.issued","2009"],["dc.description.abstract","Background-We sought to evaluate tissue reactions within and at the surface of devices for interventional therapy of septal defects and to identify antigen characteristics of neotissues. Methods and Results-Atrial or ventricular septal defect-occlusion devices (Amplatzer, n=7; Cardioseal/Starflex, n=3) were processed using a uniform protocol after surgical removal from humans (implantation time, 5 days to 4 years). Devices were fixed in formalin and embedded in methylmethacrylate. Serial sections were obtained by sectioning with a diamond cutter and grinding, thus saving the metal/tissue interface for histologic evaluation. Immunohistochemical staining was performed using conventional protocols. Superficial endothelial cells stained positive for von Willebrand factor. Within the newly formed tissues, fibroblast-like cells were identified with a time-dependent expression of smooth muscle cell maturation markers (smooth muscle actin, smooth muscle myosin, h-caldesmon, and desmin) beside extracellular matrix components. Neovascularization of the newly formed tissues was demonstrated with the typical immunohistochemical pattern of capillaries and small vessels. Inflammatory cells could be identified as macrophages (CD68+) and both T-type and B-type lymphocytes (CD3+, CD79+). Conclusions-This is the first presentation of results from serial immunohistochemical staining of a collection of explanted human septal-occlusion devices. A time-dependent maturation pattern of the fibroblast-like cells in the neotissues around the implants could be described. Neoendothelialization was seen in all specimens with implantation times of 10 weeks or more. The time course of neoendothelialization, as seen in our study, further supports the clinical practice of anticoagulant or antiplatelet therapy for 6 months after implantation. This time interval should be sufficient to prevent thromboembolic events due to thrombus formation at the foreign surface of cardiovascular implants. (Circ Cardiovasc Intervent. 2009; 2: 90-96.)"],["dc.identifier.doi","10.1161/CIRCINTERVENTIONS.108.810507"],["dc.identifier.isi","000276051600003"],["dc.identifier.pmid","20031701"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1941-7640"],["dc.title","Immunohistochemical Characterization of Neotissues and Tissue Reactions to Septal Defect-Occlusion Devices"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","113"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","118"],["dc.bibliographiccitation.volume","281"],["dc.contributor.author","Jewgenow, Philipp"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Bökenkamp, Regina"],["dc.contributor.author","Hörer, Jürgen"],["dc.contributor.author","Cleuziou, Julie"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Horke, Alexander Paul"],["dc.contributor.author","Eicken, Andreas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2020-12-10T14:24:33Z"],["dc.date.available","2020-12-10T14:24:33Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.ijcard.2019.01.095"],["dc.identifier.issn","0167-5273"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72290"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Subclinical thrombus formation in bioprosthetic pulmonary valve conduits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T08:59:27Z"],["dc.date.available","2018-11-07T08:59:27Z"],["dc.date.issued","2011"],["dc.identifier.isi","000286334200029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23904"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0340-6199"],["dc.title","Septal defect occlusion devices for congenital heart defects: immunohistochemical study of in vivo neoendothelialization and formation of neotissues"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","538"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Acta Histochemica"],["dc.bibliographiccitation.lastpage","542"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Poppe, Andrea"],["dc.contributor.author","Baer, Karin"],["dc.contributor.author","Sigler, Albrecht"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Michel-Behnke, Ina"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T08:33:37Z"],["dc.date.available","2018-11-07T08:33:37Z"],["dc.date.issued","2009"],["dc.description.abstract","A major technical problem in the processing of resin-embedded tissues is the adhesion of the tissue sample on glass slides for immunohistochemical. labelling. We therefore established a novel protocol for processing such specimens with improved attachment of the tissue sample during resin removal (deplastification). In order to demonstrate the feasibility of the procedure we employed a panel of smooth muscle cell maturation markers. The technique makes use of a silicone glue (Elastosil E41; Wacker Chemie, Munchen, Germany) to attach the tissue samples to the glass slides. This allows resin dissolution in xylene/2-methoxyethylacetate without detachment of the sample from the slide. Our results demonstrate successful immunohistochemical labelling with primary antibodies directed against: smooth muscle actin, smooth muscle myosin, h-caldesmon, desmin, vimentin and von Willebrand factor. In conclusion, we have established a new and successful method for resin-embedded sample adhesion on glass slides. The developed protocol is feasible for investigation of cells which are involved in intimal proliferation following stent implantation. (C) 2008 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.acthis.2008.04.001"],["dc.identifier.isi","000272502200007"],["dc.identifier.pmid","18554687"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17619"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0065-1281"],["dc.title","A novel method for processing resin-embedded specimens with metal implants for immunohistochemical labelling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:52:35Z"],["dc.date.available","2018-11-07T08:52:35Z"],["dc.date.issued","2011"],["dc.format.extent","853"],["dc.identifier.isi","000294690900114"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22203"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Consistent Pattern of Tissue Reactions to Implants in the Cardiovascular System"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","124"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","189"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Vogt, Manfred"],["dc.contributor.author","Boekenkamp, Regina"],["dc.contributor.author","Hoerer, Juergen"],["dc.contributor.author","Eicken, Andreas"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T09:55:52Z"],["dc.date.available","2018-11-07T09:55:52Z"],["dc.date.issued","2015"],["dc.description.abstract","Objectives: We examined interventionally implanted valved Melody conduits after surgical explantation by means of histology and immunohistochemistry and matched these findings with clinical data in order to assess in vivo biocompatibility and to identify risk factors for graft failure. Methods: 9 Melody valves had been implanted in 8 patients (pulmonary n = 7, tricuspid position n = 1). Indication for explantation included significant obstruction in 7 patients and valve insufficiency in 1 patient. 4 of 8 patients had suffered from endocarditis. Mean interval between implantation and explantation was 3.2 (1.8-5.2) years. All explants were worked up using a uniform protocol with fixation in formalin and embedding in methylmethacrylate. Results: All but one valve of the explanted Melody grafts were thin and histologically intact without any pathological findings. Complete neo-endothelialization could be demonstrated by means of immunohistochemistry. All 4 Melody valves from patients with endocarditis showed dense granulocytic infiltrations, 3 of these showed thrombotic material within the valves. Conclusion: This report covers the first series of explanted Melody valves from humans applying a uniform protocol for histopathological examination. Good biocompatibility of the Melody valves could be demonstrated after a mid-term follow-up. Factors for graft failure included endocarditis, outgrowth, and residual stenosis. These findings may have significant implications for the implant procedure as well as care of the patients during long-term follow-up. (C) 2015 Elsevier Ireland Ltd. All rights reserved."],["dc.description.sponsorship","Medtronic Inc."],["dc.identifier.doi","10.1016/j.ijcard.2015.04.067"],["dc.identifier.isi","000355108300027"],["dc.identifier.pmid","25889442"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36845"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","1874-1754"],["dc.relation.issn","0167-5273"],["dc.title","Melody transcatheter valve: Histopathology and clinical implications of nine explanted devices"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T10:58:49Z"],["dc.date.available","2018-11-07T10:58:49Z"],["dc.date.issued","2007"],["dc.format.extent","690"],["dc.identifier.isi","000249258500119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50552"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Darmstadt"],["dc.relation.issn","1861-0684"],["dc.title","ASD- and VSD occluder: Immunohistochemical characterisation of newly formed tissues"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Michel-Behnke, Ina"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Vogt, M."],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:11:16Z"],["dc.date.available","2018-11-07T11:11:16Z"],["dc.date.issued","2008"],["dc.format.extent","6"],["dc.identifier.isi","000208702500014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53395"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Histopathology of cardiovascular devices for interventional therapy of congenital heart defects"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]