Huang, Min

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Computational Neuroscience"],["dc.bibliographiccitation.lastpage","75"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Öz, Pinar"],["dc.contributor.author","Huang, Min"],["dc.contributor.author","Wolf, Fred"],["dc.date.accessioned","2017-09-07T11:46:14Z"],["dc.date.available","2017-09-07T11:46:14Z"],["dc.date.issued","2015"],["dc.description.abstract","Somatic action potentials (AP) of cortical pyramidal neurons have characteristically high onset-rapidness. The onset of the AP waveform is an indirect measure for the ability of a neuron to respond to temporally fast-changing stimuli. Theoretical studies on the pyramidal neuron response usually involves a canonical Hodgkin-Huxley (HH) type ion channel gating model, which assumes statistically independent gating of each individual channel. However, cooperative activity of ion channels are observed for various cell types, meaning that the activity (e.g. opening) of one channel triggers the activity (e.g. opening) of a certain fraction of its neighbors and hence, these groups of channels behave as a unit. In this study, we describe a multi-compartmental conductance-based model with cooperatively gating voltage-gated Na channels in the axon initial segment. Our model successfully reproduced the somatic sharp AP onsets of cortical pyramidal neurons. The onset latencies from the initiation site to the soma and the conduction velocities were also in agreement with the previous experimental studies."],["dc.identifier.doi","10.1007/s10827-015-0561-9"],["dc.identifier.gro","3151864"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8694"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","0929-5313"],["dc.title","Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e37629"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Huang, Min"],["dc.contributor.author","Volgushev, Maxim"],["dc.contributor.author","Wolf, Fred"],["dc.date.accessioned","2017-09-07T11:45:40Z"],["dc.date.available","2017-09-07T11:45:40Z"],["dc.date.issued","2012"],["dc.description.abstract","Generation of action potentials (APs) is a crucial step in neuronal information processing. Existing biophysical models for AP generation almost universally assume that individual voltage-gated sodium channels operate statistically independently, and their avalanche-like opening that underlies AP generation is coordinated only through the transmembrane potential. However, biological ion channels of various types can exhibit strongly cooperative gating when clustered. Cooperative gating of sodium channels has been suggested to explain rapid onset dynamics and large threshold variability of APs in cortical neurons. It remains however unknown whether these characteristic properties of cortical APs can be reproduced if only a fraction of channels express cooperativity, and whether the presence of cooperative channels has an impact on encoding properties of neuronal populations. To address these questions we have constructed a conductance-based neuron model in which we continuously varied the size of a fraction of sodium channels expressing cooperativity and the strength of coupling between cooperative channels . We show that starting at a critical value of the coupling strength , the activation curve of sodium channels develops a discontinuity at which opening of all coupled channels becomes an all-or-none event, leading to very rapid AP onsets. Models with a small fraction, , of strongly cooperative channels generate APs with the most rapid onset dynamics. In this regime APs are triggered by simultaneous opening of the cooperative channel fraction and exhibit a pronounced biphasic waveform often observed in cortical neurons. We further show that presence of a small fraction of cooperative Na+ channels significantly improves the ability of neuronal populations to phase-lock their firing to high frequency input fluctuation. We conclude that presence of a small fraction of strongly coupled sodium channels can explain characteristic features of cortical APs and has a functional impact of enhancing the spike encoding of rapidly varying signals."],["dc.identifier.doi","10.1371/journal.pone.0037629"],["dc.identifier.gro","3151841"],["dc.identifier.pmid","22666374"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7915"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8668"],["dc.language.iso","en"],["dc.notes","Supported by grants from the Federal Ministry of Education and Research, Germany (www.bmbf.de,http://www.bmbf.de., grants #01GQ1005B,\r\n#01GQ07113, #01GQ07112) and German-Israeli Foundation for Scientific Research and Development (www.gif.org.il,http://www.gif.org.il., grant #I-906-17.1/\r\n2006) to MV, FW; German Research Foundation (www.dfg.de,http://www.dfg.de., SFB889), Volkswagenstiftung Stiftung (http://www.volkswagenstiftung.de,\r\n#ZN2632) and the Max Planck Society (www.mpg.de,http://www.mpg.de.) to FW; and start-up funds from the University of Connecticut to MV."],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","1932-6203"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 2.5"],["dc.rights.uri","http://creativecommons.org/licenses/by/2.5/"],["dc.title","A Small Fraction of Strongly Cooperative Sodium Channels Boosts Neuronal Encoding of High Frequencies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]