Günther, René

[["dc.bibliographiccitation.firstpage","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","267"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Uzelac, Zeljko"],["dc.contributor.author","Witzel, Simon"],["dc.contributor.author","Wollinsky, Kurt"],["dc.contributor.author","Winter, Benedikt"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Schreiber-Katz, Olivia"],["dc.contributor.author","Al Shweiki, Rami"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T14:10:34Z"],["dc.date.available","2020-12-10T14:10:34Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00415-019-09547-y"],["dc.identifier.eissn","1432-1459"],["dc.identifier.issn","0340-5354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70801"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Neurofilament light chain in serum of adolescent and adult SMA patients under treatment with nusinersen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"],["dc.bibliographiccitation.lastpage","10"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Spittel, Susanne"],["dc.contributor.author","Grehl, Torsten"],["dc.contributor.author","Weyen, Ute"],["dc.contributor.author","Steinbach, Robert"],["dc.contributor.author","Kettemann, Dagmar"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Weydt, Patrick"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Baum, Petra"],["dc.contributor.author","Maier, André"],["dc.date.accessioned","2022-09-01T09:50:25Z"],["dc.date.available","2022-09-01T09:50:25Z"],["dc.date.issued","2022"],["dc.description.sponsorship","Boris Canessa ALS Stiftung"],["dc.description.sponsorship","Bremer ALS Stiftung"],["dc.description.sponsorship","BMBF"],["dc.identifier.doi","10.1080/21678421.2022.2104649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113709"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2167-9223"],["dc.relation.issn","2167-8421"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Remote digital assessment of amyotrophic lateral sclerosis functional rating scale – a multicenter observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","acn3.51645"],["dc.bibliographiccitation.journal","Annals of Clinical and Translational Neurology"],["dc.contributor.author","Freigang, Maren"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Schreiber‐Katz, Olivia"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Rostásy, Kevin"],["dc.contributor.author","Huss, André"],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Günther, René"],["dc.date.accessioned","2022-09-01T09:51:18Z"],["dc.date.available","2022-09-01T09:51:18Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/acn3.51645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113929"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2328-9503"],["dc.relation.issn","2328-9503"],["dc.title","Glial fibrillary acidic protein in cerebrospinal fluid of patients with spinal muscular atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JAMA Neurology"],["dc.contributor.author","Witzel, Simon"],["dc.contributor.author","Maier, André"],["dc.contributor.author","Steinbach, Robert"],["dc.contributor.author","Grosskreutz, Julian"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Sarikidi, Anastasia"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Wolf, Joachim"],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.authorgroup","German Motor Neuron Disease Network (MND-NET)"],["dc.date.accessioned","2022-02-01T10:31:06Z"],["dc.date.available","2022-02-01T10:31:06Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1001/jamaneurol.2021.4893"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98785"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.issn","2168-6149"],["dc.title","Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","330"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Orphanet Journal of Rare Diseases"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Freigang, Maren"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Wurster, Claudia Diana"],["dc.contributor.author","Schreiber-Katz, Olivia"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Koch, Jan Christoph"],["dc.contributor.author","Rostásy, Kevin"],["dc.contributor.author","Falkenburger, Björn"],["dc.contributor.author","Ludolph, Albert Christian"],["dc.contributor.author","Günther, René"],["dc.date.accessioned","2021-09-01T06:38:26Z"],["dc.date.available","2021-09-01T06:38:26Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background Studies regarding the impact of (neuro)inflammation and inflammatory response following repetitive, intrathecally administered antisense oligonucleotides (ASO) in 5q-associated spinal muscular atrophy (SMA) are sparse. Increased risk of hydrocephalus in untreated SMA patients and a marginal but significant increase of the serum/CSF albumin ratio (Qalb) with rare cases of communicating hydrocephalus during nusinersen treatment were reported, which confirms the unmet need of an inflammatory biomarker in SMA. The aim of this study was to investigate the (neuro)inflammatory marker chitotriosidase 1 (CHIT1) in SMA patients before and following the treatment with the ASO nusinersen. Methods In this prospective, multicenter observational study, we studied CSF CHIT1 concentrations in 58 adult and 21 pediatric patients with SMA type 1, 2 or 3 before treatment initiation in comparison to age- and sex-matched controls and investigated its dynamics during nusinersen treatment. Concurrently, motor performance and disease severity were assessed. Results CHIT1 concentrations were elevated in treatment-naïve SMA patients as compared to controls, but less pronounced than described for other neurodegenerative diseases such as amyotrophic lateral sclerosis. CHIT1 concentration did not correlate with disease severity and did not distinguish between clinical subtypes. CHIT1 concentration did show a significant increase during nusinersen treatment that was unrelated to the clinical response to nusinersen therapy. Conclusions CHIT1 elevation in treatment-naïve SMA patients indicates the involvement of (neuro)inflammation in SMA. The lacking correlation of CHIT1 concentration with disease severity argues against its use as a marker of disease progression. The observed CHIT1 increase during nusinersen treatment may indicate an immune response-like, off-target reaction. Since antisense oligonucleotides are an establishing approach in the treatment of neurodegenerative diseases, this observation needs to be further evaluated."],["dc.description.abstract","Abstract Background Studies regarding the impact of (neuro)inflammation and inflammatory response following repetitive, intrathecally administered antisense oligonucleotides (ASO) in 5q-associated spinal muscular atrophy (SMA) are sparse. Increased risk of hydrocephalus in untreated SMA patients and a marginal but significant increase of the serum/CSF albumin ratio (Qalb) with rare cases of communicating hydrocephalus during nusinersen treatment were reported, which confirms the unmet need of an inflammatory biomarker in SMA. The aim of this study was to investigate the (neuro)inflammatory marker chitotriosidase 1 (CHIT1) in SMA patients before and following the treatment with the ASO nusinersen. Methods In this prospective, multicenter observational study, we studied CSF CHIT1 concentrations in 58 adult and 21 pediatric patients with SMA type 1, 2 or 3 before treatment initiation in comparison to age- and sex-matched controls and investigated its dynamics during nusinersen treatment. Concurrently, motor performance and disease severity were assessed. Results CHIT1 concentrations were elevated in treatment-naïve SMA patients as compared to controls, but less pronounced than described for other neurodegenerative diseases such as amyotrophic lateral sclerosis. CHIT1 concentration did not correlate with disease severity and did not distinguish between clinical subtypes. CHIT1 concentration did show a significant increase during nusinersen treatment that was unrelated to the clinical response to nusinersen therapy. Conclusions CHIT1 elevation in treatment-naïve SMA patients indicates the involvement of (neuro)inflammation in SMA. The lacking correlation of CHIT1 concentration with disease severity argues against its use as a marker of disease progression. The observed CHIT1 increase during nusinersen treatment may indicate an immune response-like, off-target reaction. Since antisense oligonucleotides are an establishing approach in the treatment of neurodegenerative diseases, this observation needs to be further evaluated."],["dc.identifier.doi","10.1186/s13023-021-01961-8"],["dc.identifier.pii","1961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88933"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1750-1172"],["dc.title","Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1049"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of Clinical and Translational Neurology"],["dc.bibliographiccitation.lastpage","1063"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Freigang, Maren"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Hagenacker, Tim"],["dc.contributor.author","Stolte, Benjamin"],["dc.contributor.author","Weiler, Markus"],["dc.contributor.author","Kamm, Christoph"],["dc.contributor.author","Schreiber‐Katz, Olivia"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Günther, René"],["dc.date.accessioned","2021-06-01T09:41:44Z"],["dc.date.available","2021-06-01T09:41:44Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1002/acn3.51340"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85020"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2328-9503"],["dc.relation.issn","2328-9503"],["dc.title","Serum creatine kinase and creatinine in adult spinal muscular atrophy under nusinersen treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]