Günther, René

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Statland, Jeffrey M."],["dc.contributor.author","Hussain, Sumaira"],["dc.contributor.author","Hennecke, Christiane"],["dc.contributor.author","Wuu, Joanne"],["dc.contributor.author","Langbein, Thomas"],["dc.contributor.author","Ahmed, Raees"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Ilse, Benjamin"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kollewe, Katja"],["dc.contributor.author","Kuttler, Josua"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Lengenfeld, Teresa"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Neuwirth, Christoph"],["dc.contributor.author","Tostmann, Ralf"],["dc.contributor.author","Benatar, Michael"],["dc.date.accessioned","2021-04-14T08:30:11Z"],["dc.date.available","2021-04-14T08:30:11Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1080/21678421.2021.1879866"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83141"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2167-9223"],["dc.relation.issn","2167-8421"],["dc.title","Challenges and opportunities for Multi-National Investigator-Initiated clinical trials for ALS: European and United States collaborations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","304"],["dc.bibliographiccitation.journal","Frontiers in Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Günther, R."],["dc.contributor.author","Saal, K.-A."],["dc.contributor.author","Suhr, M."],["dc.contributor.author","Scheer, D."],["dc.contributor.author","Koch, J. C."],["dc.contributor.author","Bähr, M."],["dc.contributor.author","Lingor, P."],["dc.contributor.author","Tönges, L."],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motoneurons and their axons which results in a progressive muscle weakness and ultimately death from respiratory failure. The only approved drug, riluzole, lacks clinical efficacy so that more potent treatment options are needed. We have identified rho kinase (ROCK) as a target, which can be manipulated to beneficially influence disease progression in models of ALS. Here, we examined the therapeutic potential of the ROCK inhibitor Y-27632 in both an in vitro and in an in vivo paradigm of motoneuron disease. Application of Y-27632 to primary motoneurons in vitro increased survival and promoted neunte outgrowth. In vivo, SOD1G93A mice were orally treated with 2 or 30 mg/kg body weight of Y-27632. The 2 mg/kg group did not benefit from Y-27632 treatment, whereas treatment with 30 mg/kg resulted in improved motor function in male mice. Female mice showed only limited improvement and overall survival was not modified in both 2 and 30 mg/kg Y-27632 groups. In conclusion, we provide evidence that inhibition of ROCK by Y-27632 is neuroprotective in vitro but has limited beneficial effects in vivo being restricted to male mice. Therefore, the evaluation of ROCK inhibitors in preclinical models of ALS should always take gender differences into account."],["dc.format.extent","9"],["dc.identifier.doi","10.3389/fnins.2014.00304"],["dc.identifier.gro","3142033"],["dc.identifier.isi","000346516800001"],["dc.identifier.pmid","25339858"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3801"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1662-453X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","175628641984605"],["dc.bibliographiccitation.journal","Therapeutic Advances in Neurological Disorders"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Günther, René"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Dreyhaupt, Jens"],["dc.contributor.author","Wollinsky, Kurt"],["dc.contributor.author","Uzelac, Zeljko"],["dc.contributor.author","Witzel, Simon"],["dc.contributor.author","Kocak, Tugrul"],["dc.contributor.author","Winter, Benedikt"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T18:38:37Z"],["dc.date.available","2020-12-10T18:38:37Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1177/1756286419846058"],["dc.identifier.eissn","1756-2864"],["dc.identifier.issn","1756-2864"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16746"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77390"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Neurochemical markers in CSF of adolescent and adult SMA patients undergoing nusinersen treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","267"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Uzelac, Zeljko"],["dc.contributor.author","Witzel, Simon"],["dc.contributor.author","Wollinsky, Kurt"],["dc.contributor.author","Winter, Benedikt"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Schreiber-Katz, Olivia"],["dc.contributor.author","Al Shweiki, Rami"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T14:10:34Z"],["dc.date.available","2020-12-10T14:10:34Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00415-019-09547-y"],["dc.identifier.eissn","1432-1459"],["dc.identifier.issn","0340-5354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70801"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Neurofilament light chain in serum of adolescent and adult SMA patients under treatment with nusinersen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","315"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","319"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Neuwirth, Christoph"],["dc.contributor.author","Koch, Jan Christoph"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Braun, Nathalie"],["dc.contributor.author","Untucht, Robert"],["dc.contributor.author","Petzold, Daniel"],["dc.contributor.author","Weber, Markus"],["dc.contributor.author","Hermann, Andreas"],["dc.date.accessioned","2020-12-10T14:23:09Z"],["dc.date.available","2020-12-10T14:23:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.clinph.2018.11.009"],["dc.identifier.issn","1388-2457"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71849"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e3936"],["dc.bibliographiccitation.issue","61"],["dc.bibliographiccitation.journal","Journal of Visualized Experiments"],["dc.contributor.author","Günther, R."],["dc.contributor.author","Suhr, M."],["dc.contributor.author","Koch, J. C."],["dc.contributor.author","Bähr, M."],["dc.contributor.author","Lingor, P."],["dc.contributor.author","Tönges, L."],["dc.date.accessioned","2017-09-07T11:48:58Z"],["dc.date.available","2017-09-07T11:48:58Z"],["dc.date.issued","2012"],["dc.description.abstract","Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder resulting in progressive degeneration of motoneurons. Peak of onset is around 60 years for the sporadic disease and around 50 years for the familial disease. Due to its progressive course, 50% of the patients die within 30 months of symptom onset. In order to evaluate novel treatment options for this disease, genetic mouse models of ALS have been generated based on human familial mutations in the SOD gene, such as the SOD1 (G93A) mutation. Most important aspects that have to be evaluated in the model are overall survival, clinical course and motor function. Here, we demonstrate the clinical evaluation, show the conduction of two behavioural motor tests and provide quantitative scoring systems for all parameters. Because an in depth analysis of the ALS mouse model usually requires an immunohistochemical examination of the spinal cord, we demonstrate its preparation in detail applying the dorsal laminectomy method. Exemplary histological findings are demonstrated. The comprehensive application of the depicted examination methods in studies on the mouse model of ALS will enable the researcher to reliably test future therapeutic options which can provide a basis for later human clinical trials."],["dc.identifier.doi","10.3791/3936"],["dc.identifier.gro","3142575"],["dc.identifier.isi","000209222800054"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8941"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1940-087X"],["dc.title","Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","372"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain Sciences"],["dc.bibliographiccitation.volume","11"],["dc.contributor.affiliation","Peseschkian, Tara; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Peseschkian.Tara@mh-hannover.de"],["dc.contributor.affiliation","Cordts, Isabell; \t\t \r\n\t\t Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany, isabell.cordts@tum.de"],["dc.contributor.affiliation","Günther, René; \t\t \r\n\t\t Department of Neurology, University Hospital Carl Gustav Carus, 01307 Dresden, Germany, Rene.Guenther@uniklinikum-dresden.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany, Rene.Guenther@uniklinikum-dresden.de"],["dc.contributor.affiliation","Stolte, Benjamin; \t\t \r\n\t\t Department of Neurology, University Medicine Essen, 45147 Essen, Germany, benjamin.stolte@uk-essen.de"],["dc.contributor.affiliation","Zeller, Daniel; \t\t \r\n\t\t Department of Neurology, University of Würzburg, 97080 Würzburg, Germany, Zeller_D@ukw.de"],["dc.contributor.affiliation","Schröter, Carsten; \t\t \r\n\t\t Hoher Meißner Clinic, Neurology, 37242 Bad Sooden-Allendorf, Germany, Schroeter@reha-klinik.de"],["dc.contributor.affiliation","Weyen, Ute; \t\t \r\n\t\t Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, 44789 Bochum, Germany, ute.weyen@bergmannsheil.de"],["dc.contributor.affiliation","Regensburger, Martin; \t\t \r\n\t\t Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany, Martin.Regensburger@uk-erlangen.de"],["dc.contributor.affiliation","Wolf, Joachim; \t\t \r\n\t\t Department of Neurology, Diakonissen Hospital Mannheim, 68163 Mannheim, Germany, j.wolf@diako-mannheim.de"],["dc.contributor.affiliation","Schneider, Ilka; \t\t \r\n\t\t Department of Neurology, Martin-Luther University Halle/Saale, 06120 Halle, Germany, Ilka.Schneider@sanktgeorg.de\t\t \r\n\t\t Department of Neurology, Klinikum Sankt Georg, 04129 Leipzig, Germany, Ilka.Schneider@sanktgeorg.de"],["dc.contributor.affiliation","Hermann, Andreas; \t\t \r\n\t\t Translational Neurodegeneration Section “Albrecht-Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany, Andreas.Hermann@med.uni-rostock.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases Rostock/Greifswald, 18147 Rostock, Germany, Andreas.Hermann@med.uni-rostock.de"],["dc.contributor.affiliation","Metelmann, Moritz; \t\t \r\n\t\t Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany, Moritz.Metelmann@medizin.uni-leipzig.de"],["dc.contributor.affiliation","Kohl, Zacharias; \t\t \r\n\t\t Department of Neurology, University of Regensburg, 93053 Regensburg, Germany, zacharias.kohl@klinik.uni-regensburg.de"],["dc.contributor.affiliation","Linker, Ralf A.; \t\t \r\n\t\t Department of Neurology, University of Regensburg, 93053 Regensburg, Germany, Ralf.Linker@klinik.uni-regensburg.de"],["dc.contributor.affiliation","Koch, Jan Christoph; \t\t \r\n\t\t Department of Neurology, University Medicine Göttingen, 37075 Göttingen, Germany, jkoch@med.uni-goettingen.de"],["dc.contributor.affiliation","Büchner, Boriana; \t\t \r\n\t\t Friedrich-Baur Institute, Department of Neurology, University Hospital, Ludwig Maximilian University of Munich, 80336 Munich, Germany, Boriana.Buechner@med.uni-muenchen.de"],["dc.contributor.affiliation","Weiland, Ulrike; \t\t \r\n\t\t Department of Neurology, University of Ulm, 89081 Ulm, Germany, Ulrike.Weiland@uniklinik-ulm.de"],["dc.contributor.affiliation","Schönfelder, Erik; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Erik.Schoenfelder@stud.mh-hannover.de"],["dc.contributor.affiliation","Heinrich, Felix; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Felix.Heinrich@stud.mh-hannover.de"],["dc.contributor.affiliation","Osmanovic, Alma; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, dr.almaosmanovic@gmail.com"],["dc.contributor.affiliation","Klopstock, Thomas; \t\t \r\n\t\t Friedrich-Baur Institute, Department of Neurology, University Hospital, Ludwig Maximilian University of Munich, 80336 Munich, Germany, Thomas.Klopstock@med.uni-muenchen.de\t\t \r\n\t\t Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany, Thomas.Klopstock@med.uni-muenchen.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 80336 Munich, Germany, Thomas.Klopstock@med.uni-muenchen.de"],["dc.contributor.affiliation","Dorst, Johannes; \t\t \r\n\t\t Department of Neurology, University of Ulm, 89081 Ulm, Germany, johannes.dorst@rku.de"],["dc.contributor.affiliation","Ludolph, Albert C.; \t\t \r\n\t\t Department of Neurology, University of Ulm, 89081 Ulm, Germany, albert.ludolph@rku.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany, albert.ludolph@rku.de"],["dc.contributor.affiliation","Boentert, Matthias; \t\t \r\n\t\t Department of Neurology with the Institute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany, Matthias.Boentert@ukmuenster.de\t\t \r\n\t\t Department of Medicine, UKM Marienhospital, 48565 Steinfurt, Germany, Matthias.Boentert@ukmuenster.de"],["dc.contributor.affiliation","Hagenacker, Tim; \t\t \r\n\t\t Department of Neurology, University Medicine Essen, 45147 Essen, Germany, tim.hagenacker@uk-essen.de"],["dc.contributor.affiliation","Deschauer, Marcus; \t\t \r\n\t\t Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany, marcus.deschauer@mri.tum.de"],["dc.contributor.affiliation","Lingor, Paul; \t\t \r\n\t\t Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany, paul.lingor@tum.de"],["dc.contributor.affiliation","Petri, Susanne; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Petri.Susanne@mh-hannover.de"],["dc.contributor.affiliation","Schreiber-Katz, Olivia; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Schreiber-Katz.Olivia@mh-hannover.de"],["dc.contributor.author","Peseschkian, Tara"],["dc.contributor.author","Cordts, Isabell"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Stolte, Benjamin"],["dc.contributor.author","Zeller, Daniel"],["dc.contributor.author","Schröter, Carsten"],["dc.contributor.author","Weyen, Ute"],["dc.contributor.author","Regensburger, Martin"],["dc.contributor.author","Wolf, Joachim"],["dc.contributor.author","Schneider, Ilka"],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Metelmann, Moritz"],["dc.contributor.author","Kohl, Zacharias"],["dc.contributor.author","Linker, Ralf A."],["dc.contributor.author","Koch, Jan Christoph"],["dc.contributor.author","Büchner, Boriana"],["dc.contributor.author","Weiland, Ulrike"],["dc.contributor.author","Schönfelder, Erik"],["dc.contributor.author","Heinrich, Felix"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Klopstock, Thomas"],["dc.contributor.author","Dorst, Johannes"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Boentert, Matthias"],["dc.contributor.author","Hagenacker, Tim"],["dc.contributor.author","Deschauer, Marcus"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Schreiber-Katz, Olivia"],["dc.date.accessioned","2021-04-14T08:27:57Z"],["dc.date.available","2021-04-14T08:27:57Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:17Z"],["dc.description.sponsorship","German Neuromuscular Society “Deutsche Gesellschaft fuer Muskelkranke\" e.V."],["dc.identifier.doi","10.3390/brainsci11030372"],["dc.identifier.eissn","2076-3425"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82457"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-3425"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","A Nation-Wide, Multi-Center Study on the Quality of Life of ALS Patients in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Wurster, Claudia Diana"],["dc.contributor.author","Cordts, Isabell"],["dc.contributor.author","Koch, Jan Christoph"],["dc.contributor.author","Kamm, Christoph"],["dc.contributor.author","Petzold, Daniel"],["dc.contributor.author","Aust, Elisa"],["dc.contributor.author","Deschauer, Marcus"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Ludolph, Albert Christian"],["dc.contributor.author","Hermann, Andreas"],["dc.date.accessioned","2020-12-10T18:44:33Z"],["dc.date.available","2020-12-10T18:44:33Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3389/fneur.2019.01098"],["dc.identifier.eissn","1664-2295"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16912"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78498"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Patient-Reported Prevalence of Non-motor Symptoms Is Low in Adult Patients Suffering From 5q Spinal Muscular Atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","acn3.51645"],["dc.bibliographiccitation.journal","Annals of Clinical and Translational Neurology"],["dc.contributor.author","Freigang, Maren"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Schreiber‐Katz, Olivia"],["dc.contributor.author","Osmanovic, Alma"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Rostásy, Kevin"],["dc.contributor.author","Huss, André"],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Günther, René"],["dc.date.accessioned","2022-09-01T09:51:18Z"],["dc.date.available","2022-09-01T09:51:18Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/acn3.51645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113929"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2328-9503"],["dc.relation.issn","2328-9503"],["dc.title","Glial fibrillary acidic protein in cerebrospinal fluid of patients with spinal muscular atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","748"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Sciences"],["dc.bibliographiccitation.volume","11"],["dc.contributor.affiliation","Schischlevskij, Pavel; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Schischlevskij.Pavel@mh-hannover.de"],["dc.contributor.affiliation","Cordts, Isabell; \t\t \r\n\t\t Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany, isabell.cordts@tum.de"],["dc.contributor.affiliation","Günther, René; \t\t \r\n\t\t Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany, Rene.Guenther@uniklinikum-dresden.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany, Rene.Guenther@uniklinikum-dresden.de"],["dc.contributor.affiliation","Stolte, Benjamin; \t\t \r\n\t\t Department of Neurology, University Medicine Essen, 45147 Essen, Germany, benjamin.stolte@uk-essen.de"],["dc.contributor.affiliation","Zeller, Daniel; \t\t \r\n\t\t Department of Neurology, University of Würzburg, 97080 Würzburg, Germany, Zeller_D@ukw.de"],["dc.contributor.affiliation","Schröter, Carsten; \t\t \r\n\t\t Hoher Meißner Clinic, Neurology, 37242 Bad Sooden-Allendorf, Germany, Schroeter@reha-klinik.de"],["dc.contributor.affiliation","Weyen, Ute; \t\t \r\n\t\t Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, 44789 Bochum, Germany, ute.weyen@bergmannsheil.de"],["dc.contributor.affiliation","Regensburger, Martin; \t\t \r\n\t\t Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany, Martin.Regensburger@uk-erlangen.de"],["dc.contributor.affiliation","Wolf, Joachim; \t\t \r\n\t\t Department of Neurology, Diakonissen Hospital Mannheim, 68163 Mannheim, Germany, j.wolf@diako-mannheim.de"],["dc.contributor.affiliation","Schneider, Ilka; \t\t \r\n\t\t Department of Neurology, Martin-Luther University Halle/Saale, 06120 Halle, Germany, Ilka.Schneider@sanktgeorg.de\t\t \r\n\t\t Department of Neurology, Klinikum Sankt Georg, 04129 Leipzig, Germany, Ilka.Schneider@sanktgeorg.de"],["dc.contributor.affiliation","Hermann, Andreas; \t\t \r\n\t\t Translational Neurodegeneration Section “Albrecht-Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany, Andreas.Hermann@med.uni-rostock.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, 18147 Rostock, Germany, Andreas.Hermann@med.uni-rostock.de"],["dc.contributor.affiliation","Metelmann, Moritz; \t\t \r\n\t\t Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany, Moritz.Metelmann@medizin.uni-leipzig.de"],["dc.contributor.affiliation","Kohl, Zacharias; \t\t \r\n\t\t Department of Neurology, University of Regensburg, 93053 Regensburg, Germany, zacharias.kohl@klinik.uni-regensburg.de"],["dc.contributor.affiliation","Linker, Ralf A.; \t\t \r\n\t\t Department of Neurology, University of Regensburg, 93053 Regensburg, Germany, Ralf.Linker@klinik.uni-regensburg.de"],["dc.contributor.affiliation","Koch, Jan Christoph; \t\t \r\n\t\t Department of Neurology, University Medicine Göttingen, 37075 Göttingen, Germany, jkoch@med.uni-goettingen.de"],["dc.contributor.affiliation","Stendel, Claudia; \t\t \r\n\t\t Department of Neurology, Friedrich-Baur Institute, University Hospital, Ludwig Maximilian University of Munich, 80336 Munich, Germany, Claudia.Stendel@med.uni-muenchen.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 80336 Munich, Germany, Claudia.Stendel@med.uni-muenchen.de"],["dc.contributor.affiliation","Müschen, Lars H.; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Mueschen.Lars@mh-hannover.de"],["dc.contributor.affiliation","Osmanovic, Alma; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, dr.almaosmanovic@gmail.com"],["dc.contributor.affiliation","Binz, Camilla; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Binz.Camilla@mh-hannover.de"],["dc.contributor.affiliation","Klopstock, Thomas; \t\t \r\n\t\t Department of Neurology, Friedrich-Baur Institute, University Hospital, Ludwig Maximilian University of Munich, 80336 Munich, Germany, Thomas.Klopstock@med.uni-muenchen.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 80336 Munich, Germany, Thomas.Klopstock@med.uni-muenchen.de\t\t \r\n\t\t Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany, Thomas.Klopstock@med.uni-muenchen.de"],["dc.contributor.affiliation","Dorst, Johannes; \t\t \r\n\t\t Department of Neurology, University of Ulm, 89081 Ulm, Germany, johannes.dorst@rku.de"],["dc.contributor.affiliation","Ludolph, Albert C.; \t\t \r\n\t\t Department of Neurology, University of Ulm, 89081 Ulm, Germany, albert.ludolph@rku.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany, albert.ludolph@rku.de"],["dc.contributor.affiliation","Boentert, Matthias; \t\t \r\n\t\t Department of Neurology, Institute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany, Matthias.Boentert@ukmuenster.de\t\t \r\n\t\t Department of Medicine, UKM Marienhospital, 48565 Steinfurt, Germany, Matthias.Boentert@ukmuenster.de"],["dc.contributor.affiliation","Hagenacker, Tim; \t\t \r\n\t\t Department of Neurology, University Medicine Essen, 45147 Essen, Germany, tim.hagenacker@uk-essen.de"],["dc.contributor.affiliation","Deschauer, Marcus; \t\t \r\n\t\t Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany, marcus.deschauer@mri.tum.de"],["dc.contributor.affiliation","Lingor, Paul; \t\t \r\n\t\t Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany, paul.lingor@tum.de"],["dc.contributor.affiliation","Petri, Susanne; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, Petri.Susanne@mh-hannover.de"],["dc.contributor.affiliation","Schreiber-Katz, Olivia; \t\t \r\n\t\t Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, dr.schreiber-katz@t-online.de"],["dc.contributor.author","Schischlevskij, Pavel"],["dc.contributor.author","Cordts, Isabell"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Stolte, Benjamin"],["dc.contributor.author","Zeller, Daniel"],["dc.contributor.author","Schröter, Carsten"],["dc.contributor.author","Weyen, Ute"],["dc.contributor.author","Regensburger, Martin"],["dc.contributor.author","Wolf, Joachim"],["dc.contributor.author","Schreiber-Katz, Olivia"],["dc.contributor.author","Koch, Jan Christoph"],["dc.contributor.author","Lingor, Paul"],["dc.date.accessioned","2021-08-12T07:45:51Z"],["dc.date.available","2021-08-12T07:45:51Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:20:52Z"],["dc.description.abstract","Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive autonomy loss and need for care. This does not only affect patients themselves, but also the patients’ informal caregivers (CGs) in their health, personal and professional lives. The big efforts of this multi-center study were not only to evaluate the caregivers’ burden and to identify its predictors, but it also should provide a specific understanding of the needs of ALS patients’ CGs and fill the gap of knowledge on their personal and work lives. Using standardized questionnaires, primary data from patients and their main informal CGs (n = 249) were collected. Patients’ functional status and disease severity were evaluated using the Barthel Index, the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and the King’s Stages for ALS. The caregivers’ burden was recorded by the Zarit Burden Interview (ZBI). Comorbid anxiety and depression of caregivers were assessed by the Hospital Anxiety and Depression Scale. Additionally, the EuroQol Five Dimension Five Level Scale evaluated their health-related quality of life. The caregivers’ burden was high (mean ZBI = 26/88, 0 = no burden, ≥24 = highly burdened) and correlated with patients’ functional status (rp = −0.555, p < 0.001, n = 242). It was influenced by the CGs’ own mental health issues due to caregiving (+11.36, 95% CI [6.84; 15.87], p < 0.001), patients’ wheelchair dependency (+9.30, 95% CI [5.94; 12.66], p < 0.001) and was interrelated with the CGs’ depression (rp = 0.627, p < 0.001, n = 234), anxiety (rp = 0.550, p < 0.001, n = 234), and poorer physical condition (rp = −0.362, p < 0.001, n = 237). Moreover, female CGs showed symptoms of anxiety more often, which also correlated with the patients’ impairment in daily routine (rs = −0.280, p < 0.001, n = 169). As increasing disease severity, along with decreasing autonomy, was the main predictor of caregiver burden and showed to create relevant (negative) implications on CGs’ lives, patient care and supportive therapies should address this issue. Moreover, in order to preserve the mental and physical health of the CGs, new concepts of care have to focus on both, on not only patients but also their CGs and gender-associated specific issues. As caregiving in ALS also significantly influences the socioeconomic status by restrictions in CGs’ work lives and income, and the main reported needs being lack of psychological support and a high bureaucracy, the situation of CGs needs more attention. Apart from their own multi-disciplinary medical and psychological care, more support in care and patient management issues is required."],["dc.description.abstract","Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive autonomy loss and need for care. This does not only affect patients themselves, but also the patients’ informal caregivers (CGs) in their health, personal and professional lives. The big efforts of this multi-center study were not only to evaluate the caregivers’ burden and to identify its predictors, but it also should provide a specific understanding of the needs of ALS patients’ CGs and fill the gap of knowledge on their personal and work lives. Using standardized questionnaires, primary data from patients and their main informal CGs (n = 249) were collected. Patients’ functional status and disease severity were evaluated using the Barthel Index, the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and the King’s Stages for ALS. The caregivers’ burden was recorded by the Zarit Burden Interview (ZBI). Comorbid anxiety and depression of caregivers were assessed by the Hospital Anxiety and Depression Scale. Additionally, the EuroQol Five Dimension Five Level Scale evaluated their health-related quality of life. The caregivers’ burden was high (mean ZBI = 26/88, 0 = no burden, ≥24 = highly burdened) and correlated with patients’ functional status (rp = −0.555, p < 0.001, n = 242). It was influenced by the CGs’ own mental health issues due to caregiving (+11.36, 95% CI [6.84; 15.87], p < 0.001), patients’ wheelchair dependency (+9.30, 95% CI [5.94; 12.66], p < 0.001) and was interrelated with the CGs’ depression (rp = 0.627, p < 0.001, n = 234), anxiety (rp = 0.550, p < 0.001, n = 234), and poorer physical condition (rp = −0.362, p < 0.001, n = 237). Moreover, female CGs showed symptoms of anxiety more often, which also correlated with the patients’ impairment in daily routine (rs = −0.280, p < 0.001, n = 169). As increasing disease severity, along with decreasing autonomy, was the main predictor of caregiver burden and showed to create relevant (negative) implications on CGs’ lives, patient care and supportive therapies should address this issue. Moreover, in order to preserve the mental and physical health of the CGs, new concepts of care have to focus on both, on not only patients but also their CGs and gender-associated specific issues. As caregiving in ALS also significantly influences the socioeconomic status by restrictions in CGs’ work lives and income, and the main reported needs being lack of psychological support and a high bureaucracy, the situation of CGs needs more attention. Apart from their own multi-disciplinary medical and psychological care, more support in care and patient management issues is required."],["dc.description.sponsorship","German Neuromuscular Society (Deutsche Gesellschaft fuer Muskelkranke e.V.)"],["dc.identifier.doi","10.3390/brainsci11060748"],["dc.identifier.eissn","2076-3425"],["dc.identifier.pii","brainsci11060748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88560"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-3425"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Informal Caregiving in Amyotrophic Lateral Sclerosis (ALS): A High Caregiver Burden and Drastic Consequences on Caregivers’ Lives"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]