Großhans, Jörg

[["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Rosenbaum, Jan"],["dc.contributor.author","Zhang, Xiaozhu"],["dc.contributor.author","Mohr, Stephan"],["dc.contributor.author","Preiß, Helen"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Alim, Karen"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Großhans, Jörg"],["dc.date.accessioned","2019-07-15T10:20:26Z"],["dc.date.available","2019-07-15T10:20:26Z"],["dc.date.issued","2019"],["dc.description.abstract","Many aspects in tissue morphogenesis are attributed to the collective behavior of the participating cells. Yet, the mechanism for emergence of dynamic tissue behavior is not understood completely. Here we report the “yo-yo”-like nuclear drift movement in Drosophila syncytial embryo displays typical emergent feature of collective behavior, which is associated with pseudo-synchronous nuclear division cycle. We uncover the direct correlation between the degree of asynchrony of mitosis and the nuclear collective movement. Based on experimental manipulations and numerical simulations, we find the ensemble of spindle elongation, rather than a nucleus’ own spindle, is the main driving force for its drift movement. The cortical F-actin effectively acts as a viscoelastic material dampening the drift movement and ensuring the nuclei return to the original positions. Our study provides insights into how the interactions between cytoskeleton as individual elements leads to collective movement of the nuclear array on a macroscopic scale."],["dc.identifier.doi","10.1101/662965"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61496"],["dc.language.iso","en"],["dc.title","The emergent Yo-yo movement of nuclei driven by collective cytoskeletal remodeling in pseudo-synchronous mitotic cycles"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","jcs210583"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.volume","131"],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Rosenbaum, Jan"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Großhans, Jörg"],["dc.date.accessioned","2020-12-10T18:41:52Z"],["dc.date.available","2020-12-10T18:41:52Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1242/jcs.210583"],["dc.identifier.eissn","1477-9137"],["dc.identifier.issn","0021-9533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77707"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A ‘molecular guillotine’ reveals the interphase function of Kinesin-5"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2564"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","2573.e5"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Rosenbaum, Jan"],["dc.contributor.author","Mohr, Stephan"],["dc.contributor.author","Zhang, Xiaozhu"],["dc.contributor.author","Kong, Deqing"],["dc.contributor.author","Preiß, Helen"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Alim, Karen"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Großhans, Jörg"],["dc.date.accessioned","2021-04-14T08:24:37Z"],["dc.date.available","2021-04-14T08:24:37Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.cub.2020.04.078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81354"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0960-9822"],["dc.title","The Emergent Yo-yo Movement of Nuclei Driven by Cytoskeletal Remodeling in Pseudo-synchronous Mitotic Cycles"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","856"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","868"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Winkler, Franziska"],["dc.contributor.author","Gummalla, Maheshwar"],["dc.contributor.author","Kuenneke, Lutz"],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Zippelius, Annette"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Grosshans, Joerg"],["dc.date.accessioned","2018-11-07T09:52:29Z"],["dc.date.available","2018-11-07T09:52:29Z"],["dc.date.issued","2015"],["dc.description.abstract","The actin and microtubule networks form the dynamic cytoskeleton. Network dynamics is driven by molecular motors applying force onto the networks and the interactions between the networks. Here we assay the dynamics of centrosomes in the scale of seconds as a proxy for the movement of microtubule asters. With this assay we want to detect the role of specific motors and of network interaction. During interphase of syncytial embryos of Drosophila, cortical actin and the microtubule network depend on each other. Centrosomes induce cortical actin to form caps, whereas F-actin anchors microtubules to the cortex. In addition, lateral interactions between microtubule asters are assumed to be important for regular spatial organization of the syncytial embryo. The functional interaction between the microtubule asters and cortical actin has been largely analyzed in a static manner, so far. We recorded the movement of centrosomes at 1 Hz and analyzed their fluctuations for two processes-pair separation and individual movement. We found that F-actin is required for directional movements during initial centrosome pair separation, because separation proceeds in a diffusive manner in latrunculin-injected embryos. For assaying individual movement, we established a fluctuation parameter as the deviation from temporally and spatially slowly varying drift movements. By analysis of mutant and drug-injected embryos, we found that the fluctuations were suppressed by both cortical actin and microtubules. Surprisingly, the microtubule motor Kinesin-1 also suppressed fluctuations to a similar degree as F-actin. Kinesin-1 may mediate linkage of the microtubule (l)-ends to the actin cortex. Consistent with this model is our finding that Kinesin-1-GFP accumulates at the cortical actin caps."],["dc.identifier.doi","10.1016/j.bpj.2015.07.044"],["dc.identifier.isi","000360960500004"],["dc.identifier.pmid","26331244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36133"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1542-0086"],["dc.relation.issn","0006-3495"],["dc.title","Fluctuation Analysis of Centrosomes Reveals a Cortical Function of Kinesin-1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1730"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","1740"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Kaiser, Franz"],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Marques Rodrigues, Daniel"],["dc.contributor.author","Rosenbaum, Jan"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Großhans, Jörg"],["dc.contributor.author","Alim, Karen"],["dc.date.accessioned","2020-12-10T14:22:45Z"],["dc.date.available","2020-12-10T14:22:45Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.bpj.2018.02.018"],["dc.identifier.issn","0006-3495"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71719"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Mechanical Model of Nuclei Ordering in Drosophila Embryos Reveals Dilution of Stochastic Forces"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]