Lankeit, Mareike

[["dc.bibliographiccitation.artnumber","https://creativecommons.org/licenses/by/4.0/"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","22"],["dc.contributor.author","Ebner, Matthias"],["dc.contributor.author","Kresoja, Karl-Patrik"],["dc.contributor.author","Keller, Karsten"],["dc.contributor.author","Hobohm, Lukas"],["dc.contributor.author","Rogge, Nina I. J."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Konstantinides, Stavros V."],["dc.contributor.author","Lankeit, Mareike"],["dc.date.accessioned","2019-07-09T11:51:32Z"],["dc.date.available","2019-07-09T11:51:32Z"],["dc.date.issued","2019"],["dc.description.abstract","BACKGROUND: Real-world data on the impact of advances in risk-adjusted management on the outcome of patients with pulmonary embolism (PE) are limited. METHODS: To investigate temporal trends in treatment, in-hospital adverse outcomes and 1-year mortality, we analysed data from 605 patients [median age, 70 years (IQR 56-77) years, 53% female] consecutively enrolled in a single-centre registry between 09/2008 and 08/2016. RESULTS: Over the 8-year period, more patients were classified to lower risk classes according to the European Society of Cardiology (ESC) 2014 guideline algorithm while the number of high-risk patients with out-of-hospital cardiac arrest (OHCA) increased. Although patients with OHCA had an exceptionally high in-hospital mortality rate of 59.3%, the rate of PE-related in-hospital adverse outcomes (12.2%) in the overall patient cohort remained stable over time. The rate of reperfusion treatment was 9.6% and tended to increase in high-risk patients. We observed a decrease in the median duration of in-hospital stay from 10 (IQR 6-14) to 7 (IQR 4-15) days, an increase of patients discharged early from 2.1 to 12.2% and an increase in the use of non-vitamin K-dependent oral anticoagulants (NOACs) from 12.6 to 57.2% in the last 2 years (09/2014-08/2016) compared to first 6 years (09/2008-08/2014). The 1-year mortality rate (16.9%) remained stable throughout the study period. CONCLUSION: In-hospital adverse outcomes and 1-year mortality remained stable despite more patients with OHCA, shorter in-hospital stays, more patients discharged early and a more frequent NOAC use."],["dc.identifier.doi","10.1007/s00392-019-01489-9"],["dc.identifier.pmid","31065790"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59967"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1861-0692"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Temporal trends in management and outcome of pulmonary embolism: a single-centre experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.contributor.author","Barco, Stefano"],["dc.contributor.author","Russo, Mariaconcetta"],["dc.contributor.author","Vicaut, Eric"],["dc.contributor.author","Becattini, Cecilia"],["dc.contributor.author","Bertoletti, Laurent"],["dc.contributor.author","Beyer-Westendorf, Jan"],["dc.contributor.author","Bouvaist, Hélène"],["dc.contributor.author","Couturaud, Francis"],["dc.contributor.author","Danays, Thierry"],["dc.contributor.author","Dellas, Claudia"],["dc.contributor.author","Duerschmied, Daniel"],["dc.contributor.author","Empen, Klaus"],["dc.contributor.author","Ferrari, Emile"],["dc.contributor.author","Galiè, Nazzareno"],["dc.contributor.author","Jiménez, David"],["dc.contributor.author","Klok, Frederikus A."],["dc.contributor.author","Kostrubiec, Maciej"],["dc.contributor.author","Kozak, Matija"],["dc.contributor.author","Kupatt, Christian"],["dc.contributor.author","Lang, Irene M."],["dc.contributor.author","Lankeit, Mareike"],["dc.contributor.author","Meneveau, Nicolas"],["dc.contributor.author","Palazzini, Massimiliano"],["dc.contributor.author","Pruszczyk, Piotr"],["dc.contributor.author","Rugolotto, Matteo"],["dc.contributor.author","Salvi, Aldo"],["dc.contributor.author","Sanchez, Olivier"],["dc.contributor.author","Schellong, Sebastian"],["dc.contributor.author","Sobkowicz, Bozena"],["dc.contributor.author","Meyer, Guy"],["dc.contributor.author","Konstantinides, Stavros V."],["dc.date.accessioned","2019-07-09T11:51:00Z"],["dc.date.available","2019-07-09T11:51:00Z"],["dc.date.issued","2018"],["dc.description.abstract","INTRODUCTION: Symptoms and functional limitation are frequently reported by survivors of acute pulmonary embolism (PE). However, current guidelines provide no specific recommendations on which patients should be followed after acute PE, when follow-up should be performed, and which tests it should include. Definition and classification of late PE sequelae are evolving, and their predictors remain to be determined. METHODS: In a post hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial, we focused on 219 survivors of acute intermediate-risk PE with clinical and echocardiographic follow-up 6 months after randomisation as well as over the long term (median, 3 years after acute PE). The primary outcome was a composite of (1) confirmed chronic thromboembolic pulmonary hypertension (CTEPH) or (2) 'post-PE impairment' (PPEI), defined by echocardiographic findings indicating an intermediate or high probability of pulmonary hypertension along with New York Heart Association functional class II-IV. RESULTS: Confirmed CTEPH or PPEI occurred in 29 (13.2%) patients, (6 with CTEPH and 23 with PPEI). A history of chronic heart failure at baseline and incomplete or absent recovery of echocardiographic parameters at 6 months predicted CTEPH or PPEI at long-term follow-up. CONCLUSIONS: CTEPH or PPEI occurs in almost one out of seven patients after acute intermediate-risk PE. Six-month echocardiographic follow-up may be useful for timely detection of late sequelae."],["dc.identifier.doi","10.1007/s00392-018-1405-1"],["dc.identifier.pmid","30564950"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59856"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1861-0692"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]