Kornhuber, Johannes

[["dc.bibliographiccitation.artnumber","e13950"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Jones, Lesley"],["dc.contributor.author","Holmans, Peter A."],["dc.contributor.author","Hamshere, Marian L."],["dc.contributor.author","Harold, Denise"],["dc.contributor.author","Moskvina, Valentina"],["dc.contributor.author","Ivanov, Dobril"],["dc.contributor.author","Pocklington, Andrew"],["dc.contributor.author","Abraham, Richard"],["dc.contributor.author","Hollingworth, Paul"],["dc.contributor.author","Sims, Rebecca"],["dc.contributor.author","Gerrish, Amy"],["dc.contributor.author","Pahwa, Jaspreet Singh"],["dc.contributor.author","Jones, Nicola"],["dc.contributor.author","Stretton, Alexandra"],["dc.contributor.author","Morgan, Angharad R."],["dc.contributor.author","Lovestone, Simon"],["dc.contributor.author","Powell, John"],["dc.contributor.author","Proitsi, Petroula"],["dc.contributor.author","Lupton, Michelle K."],["dc.contributor.author","Brayne, Carol"],["dc.contributor.author","Rubinsztein, David C."],["dc.contributor.author","Gill, Michael"],["dc.contributor.author","Lawlor, Brian"],["dc.contributor.author","Lynch, Aoibhinn"],["dc.contributor.author","Morgan, Kevin"],["dc.contributor.author","Brown, Kristelle S."],["dc.contributor.author","Passmore, Peter A."],["dc.contributor.author","Craig, David"],["dc.contributor.author","McGuinness, Bernadette"],["dc.contributor.author","Todd, Stephen"],["dc.contributor.author","Holmes, Clive"],["dc.contributor.author","Mann, David"],["dc.contributor.author","Smith, A. David"],["dc.contributor.author","Love, Seth"],["dc.contributor.author","Kehoe, Patrick G."],["dc.contributor.author","Mead, Simon"],["dc.contributor.author","Fox, Nick"],["dc.contributor.author","Rossor, Martin"],["dc.contributor.author","Collinge, John"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Schürmann, Britta"],["dc.contributor.author","van den Bussche, Hendrik"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Dichgans, Martin"],["dc.contributor.author","Frölich, Lutz"],["dc.contributor.author","Hampel, Harald"],["dc.contributor.author","Hüll, Michael"],["dc.contributor.author","Rujescu, Dan"],["dc.contributor.author","Goate, Alison M."],["dc.contributor.author","Kauwe, John S. K."],["dc.contributor.author","Cruchaga, Carlos"],["dc.contributor.author","Nowotny, Petra"],["dc.contributor.author","Morris, John C."],["dc.contributor.author","Mayo, Kevin"],["dc.contributor.author","Livingston, Gill"],["dc.contributor.author","Bass, Nicholas J."],["dc.contributor.author","Gurling, Hugh"],["dc.contributor.author","McQuillin, Andrew"],["dc.contributor.author","Gwilliam, Rhian"],["dc.contributor.author","Deloukas, Panos"],["dc.contributor.author","Al-Chalabi, Ammar"],["dc.contributor.author","Shaw, Christopher E."],["dc.contributor.author","Singleton, Andrew B."],["dc.contributor.author","Guerreiro, Rita"],["dc.contributor.author","Mühleisen, Thomas W."],["dc.contributor.author","Nöthen, Markus M."],["dc.contributor.author","Moebus, Susanne"],["dc.contributor.author","Jöckel, Karl-Heinz"],["dc.contributor.author","Klopp, Norman"],["dc.contributor.author","Wichmann, H.-Erich"],["dc.contributor.author","Rüther, Eckhard"],["dc.contributor.author","Carrasquillo, Minerva M."],["dc.contributor.author","Pankratz, V. Shane"],["dc.contributor.author","Younkin, Steven G."],["dc.contributor.author","Hardy, John"],["dc.contributor.author","O'Donovan, Michael C."],["dc.contributor.author","Owen, Michael J."],["dc.contributor.author","Williams, Julie"],["dc.date.accessioned","2019-07-09T11:54:00Z"],["dc.date.available","2019-07-09T11:54:00Z"],["dc.date.issued","2010-11-15"],["dc.description.abstract","Background: Late Onset Alzheimer’s disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. Methodology: We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. The principal findings were then tested in an independent GWAS dataset. Principal Findings: We found a significant overrepresentation of association signals in pathways related to cholesterol metabolism and the immune response in both of the two largest genome-wide association studies for LOAD. Significance: Processes related to cholesterol metabolism and the innate immune response have previously been implicated by pathological and epidemiological studies of Alzheimer’s disease, but it has been unclear whether those findings reflected primary aetiological events or consequences of the disease process. Our independent evidence from two large studies now demonstrates that these processes are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches."],["dc.format.extent","11"],["dc.identifier.doi","10.1371/journal.pone.0013950"],["dc.identifier.pmid","21085570"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8307"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60547"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Grunitz, Juliane"],["dc.contributor.author","Stonawski, Valeska"],["dc.contributor.author","Frey, Stefan"],["dc.contributor.author","Wahl, Simone"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Goecke, Tamme W."],["dc.contributor.author","Beckmann, Matthias W."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Fasching, Peter A."],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Eichler, Anna"],["dc.date.accessioned","2019-07-09T11:43:43Z"],["dc.date.available","2019-07-09T11:43:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1038/s41598-017-03326-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58960"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","124"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","135"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Raiser, Theresa"],["dc.contributor.author","Riedl, Lina"],["dc.contributor.author","Riederer, Isabelle"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Grothe, Michel J."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Landwehrmeyer, Bernhard G."],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Danek, Adrian"],["dc.date.accessioned","2018-11-07T10:07:28Z"],["dc.date.available","2018-11-07T10:07:28Z"],["dc.date.issued","2016"],["dc.description.abstract","Primary progressive aphasia (PPA) is characterized by profound destruction of cortical language areas. Anatomical studies suggest an involvement of cholinergic basal forebrain (BF) in PPA syndromes, particularly in the area of the nucleus subputaminalis (NSP). Here we aimed to determine the pattern of atrophy and structural covariance as a proxy of structural connectivity of BF nuclei in PPA variants. We studied 62 prospectively recruited cases with the clinical diagnosis of PPA and 31 healthy older control participants from the cohort study of the German consortium for frontotemporal lobar. degeneration (FTLD). We determined cortical and BF atrophy based on high-resolution magnetic resonance imaging (MRI) scans. Patterns of structural covariance of BF with cortical regions were determined using voxel-based partial least square analysis. We found significant atrophy of total BF and BF subregions in PPA patients compared with controls [F(1, 82) = 20.2, p < .001]. Atrophy was most pronounced in the NSP and the posterior BF, and most severe in the semantic variant and the nonfluent variant of PPA. Structural covariance analysis in healthy controls revealed associations of the BF nuclei, particularly the NSP, with left hemispheric predominant prefrontal, lateral temporal, and parietal cortical areas, including Broca's speech area (p < .001, permutation test). In contrast, the PPA patients showed preserved structural covariance of the BF nuclei mostly with right but not with left hemispheric cortical areas (p < .001, permutation test). Our findings agree with the neuroanatomically proposed involvement of the cholinergic BF, particularly the NSP, in PPA syndromes. We found a shift from a structural covariance of the BF with left hemispheric cortical areas in healthy aging towards right hemispheric cortical areas in PPA, possibly reflecting a consequence of the profound and early destruction of cortical language areas in PPA. (C) 2016 The Author(s). Published by Elsevier Ltd."],["dc.identifier.doi","10.1016/j.cortex.2016.07.004"],["dc.identifier.isi","000385599300011"],["dc.identifier.pmid","27509365"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39287"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","0010-9452"],["dc.relation.issn","1973-8102"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Atrophy and structural covariance of the cholinergic basal forebrain in primary progressive aphasia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","249"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Ophthalmic Research"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Roedl, J. B."],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Schloetzer-Schrehardt, Ursula"],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Naumann, G. O. H."],["dc.contributor.author","Kruse, F. E."],["dc.contributor.author","Juenemann, A. G. M."],["dc.date.accessioned","2018-11-07T11:20:31Z"],["dc.date.available","2018-11-07T11:20:31Z"],["dc.date.issued","2008"],["dc.description.abstract","Aims: We assessed homocysteine (Hcy) levels in tear fluid and plasma of patients with primary open-angle glaucoma (POAG). We determined the association between Hcy levels, dry eye syndrome and B vitamin status. Methods: This prospective case-control study included 36 patients with POAG and 36 controls. Hcy concentrations were measured by high-performance liquid chromatography. Results: Patients with POAG had significantly higher mean Hcy levels both in tear fluid (205 +/- 84 nmol/l; p < 0.001, t test) and in plasma (13.43 +/- 3.53 mu mol/l; p = 0.001, t test) than control subjects (130 +/- 53 nmol/l and 10.50 +/- 3.33 mu mol/l, respectively). Hcy in tear fluid was significantly correlated with plasma Hcy in POAG patients (r = 0.459; p = 0.005, Pearson's correlation), but not in controls (r = 0.068; p = 0.695). POAG patients with dry eye disease had significantly higher Hcy levels both in tear fluid and plasma than POAG patients without dry eye disease. There was no association between Hcy levels and B vitamin status in subjects with POAG. Conclusions: The study suggests increased Hcy levels in tear fluid and plasma of patients with POAG. Elevated Hcy levels might be a risk factor for POAG and dry eye syndrome in subjects with glaucoma. Copyright (C) 2008 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000127832"],["dc.identifier.isi","000258318600006"],["dc.identifier.pmid","18437035"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9359"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55551"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0030-3747"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Increased homocysteine levels in tear fluid of patients with primary open-angle glaucoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","256"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Dementia and Geriatric Cognitive Disorders"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bibl, Mirko"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Schneider, Michael"],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Welge, Volker"],["dc.contributor.author","Gross, Martin"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wiltfang, Jens"],["dc.date.accessioned","2018-11-07T11:19:48Z"],["dc.date.available","2018-11-07T11:19:48Z"],["dc.date.issued","2008"],["dc.description.abstract","Background/Aims: The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-beta (A beta) peptides, total tau and phospho-tau among Alzheimer's disease (AD) and vascular dementias (VAD). Methods: A beta-SDS-PAGE immunoblot and commercially available ELISAs were applied to the CSF analysis of 52 patients with probable (n = 21) and possible (n = 16) VAD, AD with cerebrovascular disease (n = 15), 30 patients with probable AD and 30 nondemented disease controls. Results: AD and AD with cerebrovascular disease displayed a similar neurochemical phenotype in contrast to nondemented disease controls and probable VAD with regard to tau, p-tau, A beta-40(ox) and A beta 1-42%. Possible VAD displayed AD-like changes only for A beta 1-40(ox) and A beta 1-42%. Conclusion: CSF neurochemical phenotypes sufficiently discriminate probable AD and VAD from each other, but their diagnostic value is limited in case of no clear-cut clinical appearance, such as possible VAD. Conversely, CSF A beta peptides and p-tau levels may help estimate the involvement of AD-like pathophysiological pathways in VAD subgroups. Copyright (c) 2008 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000115975"],["dc.identifier.isi","000253777500009"],["dc.identifier.pmid","18270488"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9353"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55373"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1420-8008"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cerebrospinal fluid neurochemical phenotypes in vascular dementias: Original data and mini-review"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"],["dc.bibliographiccitation.lastpage","443"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Frölich, Lutz"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Maier, Wolfgang"],["dc.date.accessioned","2017-09-07T11:45:23Z"],["dc.date.available","2017-09-07T11:45:23Z"],["dc.date.issued","2016"],["dc.description.abstract","Hintergrund: Das Kompetenznetz Demenzen (KND) ist ein akademischer Verbund mehrheitlich psychiatrischer Gedächtnissprechstunden und verfolgt drei Ziele: (1) Die Weiterentwicklung der Demenzdiagnostik einschließlich Neuropsychologie, Biomarker, Bildgebung und Genetik. (2) Die Durchführung von Therapiestudien bei kognitiven Störungen und Demenzen. (3) Die Verbesserung der Versorgung von Demenzerkrankten in Deutschland. Ziel der Arbeit: In diesem Beitrag werden die bisherigen Ergebnisse einzelner Teilprojekte des KND zusammengefasst sowie Ausblicke über die laufende Forschung gegeben. Methoden: Es wurden zwei multizentrische Kohorten aufgebaut. In einer ersten Kohorte wurden Menschen mit einer leichten kognitiven Störung und Menschen mit einer beginnenden Demenz klinisch, neuropsychologisch sowie hinsichtlich verschiedener Biomarker untersucht. Ein Teil dieser Kohorte wurde im Rahmen einer Beobachtungsstudie über Jahre nachverfolgt, ein weiterer Teil im Rahmen von zwei Behandlungsstudien untersucht. In der zweiten Kohorte wurden Menschen ohne Demenz klinisch, neuropsychologisch und genetisch untersucht, und es wurden psychosoziale Faktoren erhoben. In den verschiedenen Teilprojekten des KND werden Daten über Follow-up-Zeiträume bis zu zehn Jahren ausgewertet. Ergebnisse und Diskussion: Das Kompetenznetz Demenzen hat zahlreiche Publikationen zur Diagnostik und Therapie von kognitiven Störungen und Demenzen sowie zur Versorgung von Demenzerkrankten in Deutschland ermöglicht. Der Verbund hat Strukturen sowie eine Daten- und Biomaterialbank geschaffen, die auch weiterhin die Grundlage für nationale und internationale Kooperationen sind. Darüber hinaus hat das KND zur Entstigmatisierung von Demenzerkrankungen beigetragen."],["dc.description.abstract","BACKGROUND: The Dementia Competence Network (DCN) is represented by academic memory clinics and has three major aims: (1) To facilitate the development of diagnostic tools including neuropsychology, biomarkers, imaging and genetics. (2) To implement clinical trials in mild cognitive impairment and dementia and (3) to improve standard care for dementia in Germany. AIMS: This article summarizes the achievements of the DCN so far and highlights future perspectives. METHODS: The DCN has built up two multicentre cohorts. Within the first cohort, patients with mild cognitive impairment or mild dementia were examined longitudinally using multiple neuropsychological assessments and numerous different biomarkers. In a subgroup of the first cohort, patients were treated with antidementive drugs in two placebo-controlled clinical trials. The second cohort included cognitively healthy older people and examined repetitively clinical, neuropsychological and psychosocial parameters for ten years. RESULTS AND DISCUSSION: The DCN has generated a large data and biomaterial bank. Numerous publications have helped to develop further diagnostic procedures and treatment of cognitive disorders and dementia. The DCN has contributed to end stigmatisation of dementia."],["dc.identifier.doi","10.1007/s00103-016-2314-y"],["dc.identifier.gro","3151746"],["dc.identifier.pmid","26979717"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13302"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8569"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","1436-9990"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Das Kompetenznetz Demenzen"],["dc.title.subtitle","Erfolge und Ausblicke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Dementia and Geriatric Cognitive Disorders"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","31"],["dc.contributor.affiliation","Bibl, Mirko; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Mollenhauer, Brit; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Lewczuk, Piotr; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Esselmann, Hermann; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Wolf, Stefanie; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Otto, Markus; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Kornhuber, Johannes; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Rüther, Eckart; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.affiliation","Wiltfang, Jens; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany"],["dc.contributor.author","Bibl, Mirko"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Wolf, Stefanie"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Rüther, Eckart"],["dc.date.accessioned","2018-11-07T09:01:05Z"],["dc.date.available","2018-11-07T09:01:05Z"],["dc.date.issued","2011"],["dc.date.updated","2022-02-09T13:23:15Z"],["dc.description.abstract","Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20). Methods: Commercially available ELISA and electrochemiluminescence methods were applied. Results: High CSF p-tau and low ratios of A beta(1-42)/A beta(1-40) and A beta(1-42)/A beta(1-38), respectively, were specific for AD. CSF A beta(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD. Conclusion: This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations. Copyright (C) 2010 S. Karger AG, Basel"],["dc.description.sponsorship","EU [LSHM-CT-2007-037950, LSHB-CT-2006-037953]"],["dc.identifier","21135556"],["dc.identifier.doi","10.1159/000322370"],["dc.identifier.eissn","1421-9824"],["dc.identifier.isi","000286425500005"],["dc.identifier.issn","1420-8008"],["dc.identifier.pmid","21135556"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9096"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24332"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9824"],["dc.relation.issn","1420-8008"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","40"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Albrecht, Franziska"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Lampe, Leonie"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Jech, Robert"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Lyros, Epameinondas"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Synofzik, Matthis"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Brüggen, Katharina"],["dc.contributor.author","Fischer, Marie"],["dc.contributor.author","Förstl, Hans"],["dc.contributor.author","Hammer, Anke"],["dc.contributor.author","Homola, György"],["dc.contributor.author","Just, Walter"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Marroquin, Nicolai"],["dc.contributor.author","Marschhauser, Anke"],["dc.contributor.author","Nagl, Magdalena"],["dc.contributor.author","Oberstein, Timo"],["dc.contributor.author","Polyakova, Maryna"],["dc.contributor.author","Pellkofer, Hannah"],["dc.contributor.author","Richter-Schmidinger, Tanja"],["dc.contributor.author","Rossmeier, Carola"],["dc.contributor.author","Schuemberg, Katharina"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Thöne-Otto, Angelika"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Zech, Heike"],["dc.date.accessioned","2020-12-10T14:23:17Z"],["dc.date.available","2020-12-10T14:23:17Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.cortex.2019.02.015"],["dc.identifier.issn","0010-9452"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71890"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","87"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Gaignaux, Amélie"],["dc.contributor.author","Kofanova, Olga"],["dc.contributor.author","Ermann, Natalia"],["dc.contributor.author","Betsou, Fay"],["dc.contributor.author","Brandner, Sebastian"],["dc.contributor.author","Mroczko, Barbara"],["dc.contributor.author","Blennow, Kaj"],["dc.contributor.author","Strapagiel, Dominik"],["dc.contributor.author","Paciotti, Silvia"],["dc.contributor.author","Vogelgsang, Jonathan"],["dc.contributor.author","Roehrl, Michael H"],["dc.contributor.author","Mendoza, Sandra"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Teunissen, Charlotte"],["dc.date.accessioned","2019-07-09T11:45:45Z"],["dc.date.available","2019-07-09T11:45:45Z"],["dc.date.issued","2018"],["dc.description.abstract","Abstract Background In this study, we tested to which extent possible between-center differences in standardized operating procedures (SOPs) for biobanking of cerebrospinal fluid (CSF) samples influence the homogeneity of the resulting aliquots and, consequently, the concentrations of the centrally analyzed selected Alzheimer’s disease biomarkers. Methods Proficiency processing samples (PPSs), prepared by pooling of four individual CSF samples, were sent to 10 participating centers, which were asked to perform aliquoting of the PPSs into two secondary aliquots (SAs) under their local SOPs. The resulting SAs were shipped to the central laboratory, where the concentrations of amyloid beta (Aβ) 1–42, pTau181, and albumin were measured in one run with validated routine analytical methods. Total variability of the concentrations, and its within-center and between-center components, were analyzed with hierarchical regression models. Results We observed neglectable variability in the concentrations of pTau181 and albumin across the centers and the aliquots. In contrast, the variability of the Aβ1–42 concentrations was much larger (overall coefficient of variation 31%), with 28% of the between-laboratory component and 10% of the within-laboratory (i.e., between-aliquot) component. We identified duration of the preparation of the aliquots and the centrifugation force as two potential confounders influencing within-center variability and biomarker concentrations, respectively. Conclusions Proficiency processing schemes provide objective evidence for the most critical preanalytical variables. Standardization of these variables may significantly enhance the quality of the collected biospecimens. Studies utilizing retrospective samples collected under different local SOPs need to consider such differences in the statistical evaluations of the data."],["dc.identifier.doi","10.1186/s13195-018-0418-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15311"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59305"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer’s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Einsiedler, Beate"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Huppertz, Hans-Jürgen"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Muche, Rainer"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T18:39:07Z"],["dc.date.available","2020-12-10T18:39:07Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1186/s13195-018-0345-3"],["dc.identifier.eissn","1758-9193"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77549"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15508 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A language-based sum score for the course and therapeutic intervention in primary progressive aphasia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]