Usher, Juliana

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Troendle, F."],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Leucht, Stefan"],["dc.date.accessioned","2018-11-07T11:13:32Z"],["dc.date.available","2018-11-07T11:13:32Z"],["dc.date.issued","2008"],["dc.format.extent","181"],["dc.identifier.isi","000258855501042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53918"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.conference","26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1461-1457"],["dc.title","Are all mood-stabilizers efficacious in the treatment of acute mania?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Bipolar Disorders"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Kraft, Susanne"],["dc.contributor.author","Kemmer, Claudia"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:01:38Z"],["dc.date.available","2018-11-07T11:01:38Z"],["dc.date.issued","2007"],["dc.format.extent","95"],["dc.identifier.isi","000253284000263"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51194"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","International Conference on Bipolar Disorder"],["dc.relation.eventlocation","Pittsburgh, PA"],["dc.relation.issn","1398-5647"],["dc.title","Dopamine transporter genotype influences N-acetylaspartate in left putamen"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","119"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","124"],["dc.bibliographiccitation.volume","121"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Menzel, Patrick"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Kemmer, Claudia"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Scherk, Harald"],["dc.date.accessioned","2018-11-07T08:45:58Z"],["dc.date.available","2018-11-07T08:45:58Z"],["dc.date.issued","2010"],["dc.description.abstract","Objective: The amygdala plays a major role in processing emotional stimuli. Fourteen studies using structural magnetic resonance imaging (MRI) have examined the amygdala volume in paediatric and adult patients with bipolar disorder (BD) compared with healthy controls (HC) and reported inconsistent findings. Lithium has been found to increase grey matter volume, and first evidence points towards an effect on regional brain volume such as the amygdala. Method: We examined the amygdala volume of euthymic patients with BD treated with lithium (n = 15), without lithium (n = 24) and HC (n = 41) using structural MRI. Results: Patients treated with lithium exhibited in comparison to HC a larger right absolute (+17.9%, P = 0.015) and relative (+18%, P = 0.017) amygdala volume. There was no significant difference in amygdala volume between patients without lithium treatment and HC. Conclusion: Lithium appears to have a sustained effect on a central core region of emotional processing and should therefore be considered in studies examining BD."],["dc.description.sponsorship","Saarland University Hospital, Germany [HOMFOR A/2003/21]"],["dc.identifier.doi","10.1111/j.1600-0447.2009.01428.x"],["dc.identifier.isi","000273300500006"],["dc.identifier.pmid","19573050"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20576"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0001-690X"],["dc.title","Increased right amygdala volume in lithium-treated patients with bipolar I disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","283"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","288"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Kemmer, Claudia"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:16:17Z"],["dc.date.available","2018-11-07T11:16:17Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent. Method: N-acetyl-aspartate, choline (Cho), creatine (Cr) and myo-inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated. Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen. Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder."],["dc.identifier.doi","10.1111/j.1600-0447.2007.01142.x"],["dc.identifier.isi","000253757000007"],["dc.identifier.pmid","18205896"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54546"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0001-690X"],["dc.title","Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Menzel, Patrick"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T10:59:21Z"],["dc.date.available","2018-11-07T10:59:21Z"],["dc.date.issued","2007"],["dc.format.extent","228"],["dc.identifier.isi","000249873600120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","5-HTTLPR polymorphism influences amygdala volume"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Menzel, Patrick"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T10:57:22Z"],["dc.date.available","2018-11-07T10:57:22Z"],["dc.date.issued","2007"],["dc.format.extent","276"],["dc.identifier.isi","000253318800700"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50229"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0028-2804"],["dc.title","The 5HTTLPR Genotype influences the size of Amygdala"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","263"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Platz, B."],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Ekawardhani, Savira"],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:28:39Z"],["dc.date.available","2018-11-07T09:28:39Z"],["dc.date.issued","2013"],["dc.description.abstract","DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction is one of the major neuropathological findings in this severe disorder. Consistent with these findings, the encoded protein dysbindin-1 has been shown to be diminished in glutamatergic hippocampal neurons in schizophrenic patients. The aim of this study was to investigate the effects of two single nucleotide polymorphisms of DTNBP1 on grey matter volumes in human subjects using voxel-based morphometry. Seventy-two subjects were included and genotyped with respect to two single nucleotide polymorphisms of DTNBP1 (rs2619522 and rs1018381). All participants underwent structural magnetic resonance imaging (MRI). MRI data were preprocessed and statistically analysed using standard procedures as implemented in SPM5 (Statistical Parametric Mapping), in particular the voxel-based morphometry (VBM) toolbox. We found significant effects of the DTNBP1 SNP rs2619522 bilaterally in the hippocampus as well as in the anterior middle frontal gyrus and the intraparietal cortex. Carriers of the G allele showed significantly higher grey matter volumes in these brain regions than T/T homozygotes. Compatible with previous findings on a role of dysbindin in hippocampal functions as well as in major psychoses, the present study provides first direct in vivo evidence that the DTNBP1 SNP rs2619522 is associated with variation of grey matter volumes bilaterally in the hippocampus."],["dc.identifier.doi","10.1007/s00406-012-0320-0"],["dc.identifier.isi","000314296300006"],["dc.identifier.pmid","22580710"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30828"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0940-1334"],["dc.title","The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1513"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","1518"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Zill, Peter"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Reith, Wolfgang"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Moeller, Hans-Juergen"],["dc.contributor.author","Bondy, Brigitta"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:09:33Z"],["dc.date.available","2018-11-07T11:09:33Z"],["dc.date.issued","2008"],["dc.description.abstract","The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls neurotransmitter release. Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD). Thirty-eight patients with schizophrenia, BD or obsessive-compulsive disorder and 17 healthy controls participated in the study. Proton magnetic resonance spectroscopy in left hippocampus was performed in each individual. Three single nucleotide polymorphisms (SNP) of the SNAP-25 gene were genotyped. Individuals with the homozygous CC genotype of the DdeI SNP presented a significantly higher ratio of N-acetyl-aspartate (NAA)/choline-containing compounds (Cho) in the left hippocampus compared to the group of individuals with the homozygous TT genotype. The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus."],["dc.description.sponsorship","Saarland University Hospital, Germany [HOMFOR A/2003/21]"],["dc.identifier.doi","10.1007/s00702-008-0103-y"],["dc.identifier.isi","000260525900004"],["dc.identifier.pmid","18726138"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3560"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53031"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","1435-1463"],["dc.relation.issn","0300-9564"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","SNAP-25 genotype influences NAA/Cho in left hippocampus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","212"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","217"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Menzel, Patrick"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Kemmer, Claudia"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Reith, Wolfgang"],["dc.contributor.author","Meyer, Jobst"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T08:29:07Z"],["dc.date.available","2018-11-07T08:29:07Z"],["dc.date.issued","2009"],["dc.description.abstract","Functional imaging studies in healthy individuals revealed an association between 5-HTTLPR genotype and neuronal activity in the amygdala. The aim of this study was firstly to investigate a possible overall impact of the 5-HTTLPR on amygdala volume in patients with bipolar disorder and healthy individuals and secondly to test a diagnosis specific influence of the 5-HTTLPR on amygdala volume. We performed a region of interest analysis of amygdala volume in 37 patients with bipolar I disorder and 37 healthy control subjects. The 5-HTTLPR genotype of each proband was determined and the subjects were separated according to 5-HTTLPR genotype and for statistical analyses the groups SS and SL were combined and compared with the group LL. This study shows that carriers of the short allele (SL or SS) of the 5-HTTLPR polymorphism exhibit a relatively increased volume of the right amygdala compared to homozygous L-allele carriers irrespective of diagnosis status. However, further analyses with the factors genotype and diagnosis were not able to reproduce this result. The present findings are consistent with the view that the 5-HTTLPR polymorphism might modulate neuronal size or number in the amygdala. It would be worthwhile investigating the relationship between serotonin transporter function and amygdala function and volume in further studies."],["dc.identifier.doi","10.1007/s00406-008-0853-4"],["dc.identifier.isi","000265383100003"],["dc.identifier.pmid","19224115"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16573"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0940-1334"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","5-HTTLPR genotype influences amygdala volume"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","601"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","607"],["dc.bibliographiccitation.volume","260"],["dc.contributor.author","Radenbach, Katrin E."],["dc.contributor.author","Flaig, V."],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Scherk, Harald"],["dc.date.accessioned","2018-11-07T08:36:09Z"],["dc.date.available","2018-11-07T08:36:09Z"],["dc.date.issued","2010"],["dc.description.abstract","There are several hypotheses on functional neuronal networks that modulate mood states and which might form the neuroanatomical basis of bipolar disorder. The thalamus has been reported to be a key structure within the circuits that modulate mood states and might thus play an important role within the aetiology of the bipolar affective disorder. Nevertheless, structural brain imaging studies on the thalamus volume of bipolar patients have shown heterogeneous results. Using structural MRI scanning, we compared the thalamus volume of 41 euthymic bipolar patients to the thalamus volume of 41 well-matched healthy controls. Taking the concomitant medication as a co-variable within the patient group, the analysis of variance revealed a significantly smaller relative volume of the right thalamus in patients not treated with lithium when compared with healthy controls. In contrast, there are no significant differences concerning the thalamus volume between all euthymic bipolar patients and healthy controls. The study only shows findings of a transverse section. No longitudinal analysis was performed. More detailed information on patients' pharmacological histories could not be obtained. In conclusion, this result may be interpreted as an indication of the impact of the thalamus in the pathogenesis of the bipolar I disorder and emphasises the need for further longitudinal studies in bipolar patients with special attention paid to the concomitant medication, in particular to the role of lithium."],["dc.description.sponsorship","Saarland University Hospital, Germany [HOMFOR A/2003/21]"],["dc.identifier.doi","10.1007/s00406-010-0100-7"],["dc.identifier.isi","000284898200005"],["dc.identifier.pmid","20127489"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5975"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18242"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0940-1334"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Thalamic volumes in patients with bipolar disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]